Common and unique multimodal covarying patterns in autism spectrum disorder subtypes / Shile QI in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) Titre : Common and unique multimodal covarying patterns in autism spectrum disorder subtypes Type de document : Texte imprimé et/ou numérique Auteurs : Shile QI, Auteur ; Robin MORRIS, Auteur ; Jessica A TURNER, Auteur ; Zening FU, Auteur ; Rongtao JIANG, Auteur ; Thomas P. DERAMUS, Auteur ; Dongmei ZHI, Auteur ; Vince D. CALHOUN, Auteur ; Jing SUI, Auteur Année de publication : 2020 Langues : Anglais (eng) Mots-clés : Asperger’s disorder  Autism spectrum disorder  Autistic disorder  Heterogeneity  Multimodal fusion  Pervasive developmental disorder-not otherwise specified (PDD-NOS) Index. décimale : PER Périodiques Résumé : BACKGROUND: The heterogeneity inherent in autism spectrum disorder (ASD) presents a substantial challenge to diagnosis and precision treatment. Heterogeneity across biological etiologies, genetics, neural systems, neurocognitive attributes and clinical subtypes or phenotypes has been observed across individuals with ASD. METHODS: In this study, we aim to investigate the heterogeneity in ASD from a multimodal brain imaging perspective. The Autism Diagnostic Observation Schedule (ADOS) was used as a reference to guide functional and structural MRI fusion. DSM-IV-TR diagnosed Asperger's disorder (n?=?79), pervasive developmental disorder-not otherwise specified [PDD-NOS] (n?=?58) and Autistic disorder (n?=?92) from ABIDE II were used as discovery cohort, and ABIDE I (n?=?400) was used for replication. RESULTS: Dorsolateral prefrontal cortex and superior/middle temporal cortex are the primary common functional-structural covarying cortical brain areas shared among Asperger's, PDD-NOS and Autistic subgroups. Key differences among the three subtypes are negative functional features within subcortical brain areas, including negative putamen-parahippocampus fractional amplitude of low-frequency fluctuations (fALFF) unique to the Asperger's subtype; negative fALFF in anterior cingulate cortex unique to PDD-NOS subtype; and negative thalamus-amygdala-caudate fALFF unique to the Autistic subtype. Furthermore, each subtype-specific brain pattern is correlated with different ADOS subdomains, with social interaction as the common subdomain. The identified subtype-specific patterns are only predictive for ASD symptoms manifested in the corresponding subtypes, but not the other subtypes. CONCLUSIONS: Although ASD has a common neural basis with core deficits linked to social interaction, each ASD subtype is strongly linked to unique brain systems and subdomain symptoms, which may help to better understand the underlying mechanisms of ASD heterogeneity from a multimodal neuroimaging perspective. LIMITATIONS: This study is male based, which cannot be generalized to the female or the general ASD population. En ligne : http://dx.doi.org/10.1186/s13229-020-00397-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Common and unique multimodal covarying patterns in autism spectrum disorder subtypes [Texte imprimé et/ou numérique] / Shile QI, Auteur ; Robin MORRIS, Auteur ; Jessica A TURNER, Auteur ; Zening FU, Auteur ; Rongtao JIANG, Auteur ; Thomas P. DERAMUS, Auteur ; Dongmei ZHI, Auteur ; Vince D. CALHOUN, Auteur ; Jing SUI, Auteur . - 2020. Langues : Anglais (eng) in Molecular Autism > 11 (2020) Mots-clés : Asperger’s disorder  Autism spectrum disorder  Autistic disorder  Heterogeneity  Multimodal fusion  Pervasive developmental disorder-not otherwise specified (PDD-NOS) Index. décimale : PER Périodiques Résumé : BACKGROUND: The heterogeneity inherent in autism spectrum disorder (ASD) presents a substantial challenge to diagnosis and precision treatment. Heterogeneity across biological etiologies, genetics, neural systems, neurocognitive attributes and clinical subtypes or phenotypes has been observed across individuals with ASD. METHODS: In this study, we aim to investigate the heterogeneity in ASD from a multimodal brain imaging perspective. The Autism Diagnostic Observation Schedule (ADOS) was used as a reference to guide functional and structural MRI fusion. DSM-IV-TR diagnosed Asperger's disorder (n?=?79), pervasive developmental disorder-not otherwise specified [PDD-NOS] (n?=?58) and Autistic disorder (n?=?92) from ABIDE II were used as discovery cohort, and ABIDE I (n?=?400) was used for replication. RESULTS: Dorsolateral prefrontal cortex and superior/middle temporal cortex are the primary common functional-structural covarying cortical brain areas shared among Asperger's, PDD-NOS and Autistic subgroups. Key differences among the three subtypes are negative functional features within subcortical brain areas, including negative putamen-parahippocampus fractional amplitude of low-frequency fluctuations (fALFF) unique to the Asperger's subtype; negative fALFF in anterior cingulate cortex unique to PDD-NOS subtype; and negative thalamus-amygdala-caudate fALFF unique to the Autistic subtype. Furthermore, each subtype-specific brain pattern is correlated with different ADOS subdomains, with social interaction as the common subdomain. The identified subtype-specific patterns are only predictive for ASD symptoms manifested in the corresponding subtypes, but not the other subtypes. CONCLUSIONS: Although ASD has a common neural basis with core deficits linked to social interaction, each ASD subtype is strongly linked to unique brain systems and subdomain symptoms, which may help to better understand the underlying mechanisms of ASD heterogeneity from a multimodal neuroimaging perspective. LIMITATIONS: This study is male based, which cannot be generalized to the female or the general ASD population. En ligne : http://dx.doi.org/10.1186/s13229-020-00397-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions / Eva MENNIGEN ; Daniel GEISLER ; Nico W. POLLER ; Katrin GRAMATKE ; Vince D. CALHOUN ; Veit ROESSNER ; Joseph A. KING ; Stefan EHRLICH in Journal of Child Psychology and Psychiatry, 65-10 (October 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1299-1310 Titre : Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions Type de document : Texte imprimé et/ou numérique Auteurs : Eva MENNIGEN, Auteur ; Daniel GEISLER, Auteur ; Nico W. POLLER, Auteur ; Katrin GRAMATKE, Auteur ; Vince D. CALHOUN, Auteur ; Veit ROESSNER, Auteur ; Joseph A. KING, Auteur ; Stefan EHRLICH, Auteur Article en page(s) : p.1299-1310 Langues : Anglais (eng) Mots-clés : Eating disorder  anorexia nervosa  dynamic functional connectivity  resting state Index. décimale : PER Périodiques Résumé : Background The onset of anorexia nervosa (AN) frequently occurs during adolescence and is associated with preoccupation with body weight and shape and extreme underweight. Altered resting state functional connectivity in the brain has been described in individuals with AN, but only from a static perspective. The current study investigated the temporal dynamics of functional connectivity in adolescents with AN and how it relates to clinical features. Method 99 female patients acutely ill with AN and 99 pairwise age-matched female healthy control (HC) participants were included in the study. Using resting-state functional MRI data and an established sliding-window analytic approach, we identified dynamic resting-state functional connectivity states and extracted dynamic indices such as dwell time (the duration spent in a state), fraction time (the proportion of the total time occupied by a state), and number of transitions (number of switches) from one state to another, to test for group differences. Results Individuals with AN had relatively reduced fraction time in a mildly connected state with pronounced connectivity within the default mode network (DMN) and an overall reduced number of transitions between states. Conclusions These findings revealed by a dynamic, but not static analytic approach might hint towards a more ?rigid? connectivity, a phenomenon commonly observed in internalizing mental disorders, and in AN possibly related to a reduction in energetic costs as a result of nutritional deprivation. En ligne : https://doi.org/10.1111/jcpp.13970 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions [Texte imprimé et/ou numérique] / Eva MENNIGEN, Auteur ; Daniel GEISLER, Auteur ; Nico W. POLLER, Auteur ; Katrin GRAMATKE, Auteur ; Vince D. CALHOUN, Auteur ; Veit ROESSNER, Auteur ; Joseph A. KING, Auteur ; Stefan EHRLICH, Auteur . - p.1299-1310. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1299-1310 Mots-clés : Eating disorder  anorexia nervosa  dynamic functional connectivity  resting state Index. décimale : PER Périodiques Résumé : Background The onset of anorexia nervosa (AN) frequently occurs during adolescence and is associated with preoccupation with body weight and shape and extreme underweight. Altered resting state functional connectivity in the brain has been described in individuals with AN, but only from a static perspective. The current study investigated the temporal dynamics of functional connectivity in adolescents with AN and how it relates to clinical features. Method 99 female patients acutely ill with AN and 99 pairwise age-matched female healthy control (HC) participants were included in the study. Using resting-state functional MRI data and an established sliding-window analytic approach, we identified dynamic resting-state functional connectivity states and extracted dynamic indices such as dwell time (the duration spent in a state), fraction time (the proportion of the total time occupied by a state), and number of transitions (number of switches) from one state to another, to test for group differences. Results Individuals with AN had relatively reduced fraction time in a mildly connected state with pronounced connectivity within the default mode network (DMN) and an overall reduced number of transitions between states. Conclusions These findings revealed by a dynamic, but not static analytic approach might hint towards a more ?rigid? connectivity, a phenomenon commonly observed in internalizing mental disorders, and in AN possibly related to a reduction in energetic costs as a result of nutritional deprivation. En ligne : https://doi.org/10.1111/jcpp.13970 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio / Esther WALTON in Journal of Child Psychology and Psychiatry, 58-12 (December 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1341-1350 Titre : Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio Type de document : Texte imprimé et/ou numérique Auteurs : Esther WALTON, Auteur ; Charlotte A. M. CECIL, Auteur ; Matthew SUDERMAN, Auteur ; Jingyu LIU, Auteur ; Jessica A TURNER, Auteur ; Vince D. CALHOUN, Auteur ; Stefan EHRLICH, Auteur ; Caroline L. RELTON, Auteur ; Edward D. BARKER, Auteur Article en page(s) : p.1341-1350 Langues : Anglais (eng) Mots-clés : DNA methylation  methylome-wide  amygdala  hippocampus  longitudinal  Avon Longitudinal Study of Parents and Children Index. décimale : PER Périodiques Résumé : Background The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (a) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (b) whether significant DNA methylation markers are influenced by prenatal risk factors. Methods Analyses were based on a subsample (n = 109 males) from the Avon Longitudinal Study of Parents and Children, which included measures of prenatal risk, DNA methylation (Infinium Illumina 450k), T1-weighted brain scans and psychopathology in early adulthood (age 18–21). Amygdala and hippocampus measures were derived using Freesurfer 5.3.0. Methylation markers related to AH volume ratio across time were identified using longitudinal multilevel modeling. Results Amygdala:hippocampal volume ratio correlated positively with age 18 psychosis-like symptoms (p = .007). Methylation of a probe in the gene SP6 associated longitudinally with (a) higher AH volume ratio (FDR q-value = .01) and (b) higher stressful life events during pregnancy (p = .046). SP6 is expressed in the hippocampus and amygdala and has been implicated in cognitive decline in Alzheimer's disease. The association between SP6 DNA methylation, AH volume ratio and psychopathology was replicated in an independent dataset of 101 patients with schizophrenia and 111 healthy controls. Conclusions Our findings suggest that epigenetic alterations in genes implicated in neurodevelopment may contribute to a brain-based biomarker of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326 [article] Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio [Texte imprimé et/ou numérique] / Esther WALTON, Auteur ; Charlotte A. M. CECIL, Auteur ; Matthew SUDERMAN, Auteur ; Jingyu LIU, Auteur ; Jessica A TURNER, Auteur ; Vince D. CALHOUN, Auteur ; Stefan EHRLICH, Auteur ; Caroline L. RELTON, Auteur ; Edward D. BARKER, Auteur . - p.1341-1350. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1341-1350 Mots-clés : DNA methylation  methylome-wide  amygdala  hippocampus  longitudinal  Avon Longitudinal Study of Parents and Children Index. décimale : PER Périodiques Résumé : Background The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (a) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (b) whether significant DNA methylation markers are influenced by prenatal risk factors. Methods Analyses were based on a subsample (n = 109 males) from the Avon Longitudinal Study of Parents and Children, which included measures of prenatal risk, DNA methylation (Infinium Illumina 450k), T1-weighted brain scans and psychopathology in early adulthood (age 18–21). Amygdala and hippocampus measures were derived using Freesurfer 5.3.0. Methylation markers related to AH volume ratio across time were identified using longitudinal multilevel modeling. Results Amygdala:hippocampal volume ratio correlated positively with age 18 psychosis-like symptoms (p = .007). Methylation of a probe in the gene SP6 associated longitudinally with (a) higher AH volume ratio (FDR q-value = .01) and (b) higher stressful life events during pregnancy (p = .046). SP6 is expressed in the hippocampus and amygdala and has been implicated in cognitive decline in Alzheimer's disease. The association between SP6 DNA methylation, AH volume ratio and psychopathology was replicated in an independent dataset of 101 patients with schizophrenia and 111 healthy controls. Conclusions Our findings suggest that epigenetic alterations in genes implicated in neurodevelopment may contribute to a brain-based biomarker of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326

Transdiagnostic indicators predict developmental changes in cognitive control resting-state networks / Giorgia PICCI in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1698-1708 Titre : Transdiagnostic indicators predict developmental changes in cognitive control resting-state networks Type de document : Texte imprimé et/ou numérique Auteurs : Giorgia PICCI, Auteur ; Nathan M. PETRO, Auteur ; Jake J. SON, Auteur ; Oktay AGCAOGLU, Auteur ; Jacob A. EASTMAN, Auteur ; Yu-Ping WANG, Auteur ; Julia M. STEPHEN, Auteur ; Vince D. CALHOUN, Auteur ; Brittany K. TAYLOR, Auteur ; Tony W. WILSON, Auteur Article en page(s) : p.1698-1708 Langues : Anglais (eng) Mots-clés : brain development  developmental psychopathology  fMRI  trauma Index. décimale : PER Périodiques Résumé : Over the past decade, transdiagnostic indicators in relation to neurobiological processes have provided extensive insight into youth?s risk for psychopathology. During development, exposure to childhood trauma and dysregulation (i.e., so-called AAA symptomology: anxiety, aggression, and attention problems) puts individuals at a disproportionate risk for developing psychopathology and altered network-level neural functioning. Evidence for the latter has emerged from resting-state fMRI studies linking mental health symptoms and aberrations in functional networks (e.g., cognitive control (CCN), default mode networks (DMN)) in youth, although few of these investigations have used longitudinal designs. Herein, we leveraged a three-year longitudinal study to identify whether traumatic exposures and concomitant dysregulation trigger changes in the developmental trajectories of resting-state functional networks involved in cognitive control (N = 190; 91 females; time 1 Mage = 11.81). Findings from latent growth curve analyses revealed that greater trauma exposure predicted increasing connectivity between the CCN and DMN across time. Greater levels of dysregulation predicted reductions in within-network connectivity in the CCN. These findings presented in typically developing youth corroborate connectivity patterns reported in clinical populations, suggesting there is predictive utility in using transdiagnostic indicators to forecast alterations in resting-state networks implicated in psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579423001013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Transdiagnostic indicators predict developmental changes in cognitive control resting-state networks [Texte imprimé et/ou numérique] / Giorgia PICCI, Auteur ; Nathan M. PETRO, Auteur ; Jake J. SON, Auteur ; Oktay AGCAOGLU, Auteur ; Jacob A. EASTMAN, Auteur ; Yu-Ping WANG, Auteur ; Julia M. STEPHEN, Auteur ; Vince D. CALHOUN, Auteur ; Brittany K. TAYLOR, Auteur ; Tony W. WILSON, Auteur . - p.1698-1708. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1698-1708 Mots-clés : brain development  developmental psychopathology  fMRI  trauma Index. décimale : PER Périodiques Résumé : Over the past decade, transdiagnostic indicators in relation to neurobiological processes have provided extensive insight into youth?s risk for psychopathology. During development, exposure to childhood trauma and dysregulation (i.e., so-called AAA symptomology: anxiety, aggression, and attention problems) puts individuals at a disproportionate risk for developing psychopathology and altered network-level neural functioning. Evidence for the latter has emerged from resting-state fMRI studies linking mental health symptoms and aberrations in functional networks (e.g., cognitive control (CCN), default mode networks (DMN)) in youth, although few of these investigations have used longitudinal designs. Herein, we leveraged a three-year longitudinal study to identify whether traumatic exposures and concomitant dysregulation trigger changes in the developmental trajectories of resting-state functional networks involved in cognitive control (N = 190; 91 females; time 1 Mage = 11.81). Findings from latent growth curve analyses revealed that greater trauma exposure predicted increasing connectivity between the CCN and DMN across time. Greater levels of dysregulation predicted reductions in within-network connectivity in the CCN. These findings presented in typically developing youth corroborate connectivity patterns reported in clinical populations, suggesting there is predictive utility in using transdiagnostic indicators to forecast alterations in resting-state networks implicated in psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579423001013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

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