Dépouillements

Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders / Luis F. JACOME in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.393-400 Titre : Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Luis F. JACOME, Auteur ; Jessica A. BURKET, Auteur ; Amy L. HERNDON, Auteur ; Stephen I. DEUTSCH, Auteur Année de publication : 2012 Article en page(s) : p.393-400 Langues : Anglais (eng) Mots-clés : Balb/c mouse strain  sociability  autism spectrum disorders Index. décimale : PER Périodiques Résumé : The Balb/c mouse is proposed as a model of human disorders with prominent deficits of sociability, such as autism spectrum disorders (ASDs) that may involve pathophysiological disruption of NMDA receptor-mediated neurotransmission. A standard procedure was used to measure sociability in 8-week-old male genetically inbred Balb/c and outbred Swiss Webster mice. Moreover, because impaired sociability may influence the social behavior of stimulus mice, we also measured the proportion of total episodes of social approach made by the stimulus mouse while test and stimulus mice were allowed to interact freely. Three raters with good inter-rater agreement evaluated operationally defined measures of sociability chosen because of their descriptive similarity to deficits of social behavior reported in persons with ASDs. The data support previous reports that the Balb/c mouse is a genetic mouse model of impaired sociability. The data also show that the behavior of the social stimulus mouse is influenced by the impaired sociability of the Balb/c strain. Interestingly, operationally defined measures of sociability did not necessarily correlate with each other within mouse strain and the profile of correlated measures differed between strains. Finally, “stereotypic” behaviors (i.e. rearing, grooming and wall climbing) recorded during the session of free interaction between the test and social stimulus mice were more intensely displayed by Swiss Webster than Balb/c mice, suggesting that the domains of sociability and “restricted repetitive and stereotyped patterns of behavior” are independent of each other in the Balb/c strain. En ligne : http://dx.doi.org/10.1002/aur.218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders [Texte imprimé et/ou numérique] / Luis F. JACOME, Auteur ; Jessica A. BURKET, Auteur ; Amy L. HERNDON, Auteur ; Stephen I. DEUTSCH, Auteur . - 2012 . - p.393-400. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.393-400 Mots-clés : Balb/c mouse strain  sociability  autism spectrum disorders Index. décimale : PER Périodiques Résumé : The Balb/c mouse is proposed as a model of human disorders with prominent deficits of sociability, such as autism spectrum disorders (ASDs) that may involve pathophysiological disruption of NMDA receptor-mediated neurotransmission. A standard procedure was used to measure sociability in 8-week-old male genetically inbred Balb/c and outbred Swiss Webster mice. Moreover, because impaired sociability may influence the social behavior of stimulus mice, we also measured the proportion of total episodes of social approach made by the stimulus mouse while test and stimulus mice were allowed to interact freely. Three raters with good inter-rater agreement evaluated operationally defined measures of sociability chosen because of their descriptive similarity to deficits of social behavior reported in persons with ASDs. The data support previous reports that the Balb/c mouse is a genetic mouse model of impaired sociability. The data also show that the behavior of the social stimulus mouse is influenced by the impaired sociability of the Balb/c strain. Interestingly, operationally defined measures of sociability did not necessarily correlate with each other within mouse strain and the profile of correlated measures differed between strains. Finally, “stereotypic” behaviors (i.e. rearing, grooming and wall climbing) recorded during the session of free interaction between the test and social stimulus mice were more intensely displayed by Swiss Webster than Balb/c mice, suggesting that the domains of sociability and “restricted repetitive and stereotyped patterns of behavior” are independent of each other in the Balb/c strain. En ligne : http://dx.doi.org/10.1002/aur.218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Verbal problem-solving in autism spectrum disorders: A problem of plan construction? / Ben ALDERSON-DAY in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.401-411 Titre : Verbal problem-solving in autism spectrum disorders: A problem of plan construction? Type de document : Texte imprimé et/ou numérique Auteurs : Ben ALDERSON-DAY, Auteur Année de publication : 2012 Article en page(s) : p.401-411 Langues : Anglais (eng) Mots-clés : autism  problem-solving  executive functioning  planning  categorization Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) adopt less efficient strategies than typically developing controls (TD) on verbal problem-solving tests such as the Twenty Questions Task. This study examined the hypotheses that this can be explained by differences in (i) planning processes or (ii) selective attention. Twenty-two children with ASD and 21 TD controls matched for age (Mage = 13:7) and cognitive ability (MFSIQ = 96.42) were tested on an adapted version of Twenty Questions and two planning tasks. ASD participants could recognize effective questions as well as TD participants on a forced-choice question discrimination task, but were observed to construct plans that were significantly less efficient. ASD performance was also specifically reduced when items could not be physically removed from the testing array, although this effect could be ameliorated by keeping a written record of participant questions during search. These findings indicate that ASD participants are sensitive to the within-task executive demands of Twenty Questions, but that their inefficiency in strategy relates to planning processes and question selection pretask. The implications for understanding ASD problem-solving skills and their impact on everyday functioning are discussed. En ligne : http://dx.doi.org/10.1002/aur.222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Verbal problem-solving in autism spectrum disorders: A problem of plan construction? [Texte imprimé et/ou numérique] / Ben ALDERSON-DAY, Auteur . - 2012 . - p.401-411. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.401-411 Mots-clés : autism  problem-solving  executive functioning  planning  categorization Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) adopt less efficient strategies than typically developing controls (TD) on verbal problem-solving tests such as the Twenty Questions Task. This study examined the hypotheses that this can be explained by differences in (i) planning processes or (ii) selective attention. Twenty-two children with ASD and 21 TD controls matched for age (Mage = 13:7) and cognitive ability (MFSIQ = 96.42) were tested on an adapted version of Twenty Questions and two planning tasks. ASD participants could recognize effective questions as well as TD participants on a forced-choice question discrimination task, but were observed to construct plans that were significantly less efficient. ASD performance was also specifically reduced when items could not be physically removed from the testing array, although this effect could be ameliorated by keeping a written record of participant questions during search. These findings indicate that ASD participants are sensitive to the within-task executive demands of Twenty Questions, but that their inefficiency in strategy relates to planning processes and question selection pretask. The implications for understanding ASD problem-solving skills and their impact on everyday functioning are discussed. En ligne : http://dx.doi.org/10.1002/aur.222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Abstractness and continuity in the syntactic development of young children with autism / Letitia R. NAIGLES in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.422-437 Titre : Abstractness and continuity in the syntactic development of young children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Letitia R. NAIGLES, Auteur ; Emma KELTY, Auteur ; Rose JAFFERY, Auteur ; Deborah A. FEIN, Auteur Année de publication : 2012 Article en page(s) : p.422-437 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Grammar is frequently considered to be a strength in the cognitive profile of individuals with autism spectrum disorders (ASDs); however, few studies have investigated how abstract (i.e. distinct from specific lexical items) is the grammatical knowledge of individuals with ASD. In this study, we examine the extent to which children with ASD have abstracted the transitive (SVO) frame in English. Participants in a longitudinal study of language acquisition in children with autism (17 children with ASD averaging 41 months of age, 18 TD children averaging 28 months of age) were taught two novel verbs in transitive sentences and asked (via intermodal preferential looking) whether these verbs mapped onto novel causative vs. noncausative actions. Both groups consistently mapped the verbs onto the causative actions (i.e. they engaged in syntactic bootstrapping). Moreover, the children with ASD's performance on this task was significantly and independently predicted by both vocabulary and sentence-processing measures obtained 8 months earlier. We conclude that many children with ASD are able to generalize grammatical patterns, and this ability may derive from earlier lexical and grammatical knowledge. En ligne : http://dx.doi.org/10.1002/aur.223 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Abstractness and continuity in the syntactic development of young children with autism [Texte imprimé et/ou numérique] / Letitia R. NAIGLES, Auteur ; Emma KELTY, Auteur ; Rose JAFFERY, Auteur ; Deborah A. FEIN, Auteur . - 2012 . - p.422-437. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.422-437 Index. décimale : PER Périodiques Résumé : Grammar is frequently considered to be a strength in the cognitive profile of individuals with autism spectrum disorders (ASDs); however, few studies have investigated how abstract (i.e. distinct from specific lexical items) is the grammatical knowledge of individuals with ASD. In this study, we examine the extent to which children with ASD have abstracted the transitive (SVO) frame in English. Participants in a longitudinal study of language acquisition in children with autism (17 children with ASD averaging 41 months of age, 18 TD children averaging 28 months of age) were taught two novel verbs in transitive sentences and asked (via intermodal preferential looking) whether these verbs mapped onto novel causative vs. noncausative actions. Both groups consistently mapped the verbs onto the causative actions (i.e. they engaged in syntactic bootstrapping). Moreover, the children with ASD's performance on this task was significantly and independently predicted by both vocabulary and sentence-processing measures obtained 8 months earlier. We conclude that many children with ASD are able to generalize grammatical patterns, and this ability may derive from earlier lexical and grammatical knowledge. En ligne : http://dx.doi.org/10.1002/aur.223 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Sociodemographic risk factors associated with autism spectrum disorders and intellectual disability / Judith PINBOROUGH-ZIMMERMAN in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.438-448 Titre : Sociodemographic risk factors associated with autism spectrum disorders and intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : Judith PINBOROUGH-ZIMMERMAN, Auteur ; Deborah A. BILDER, Auteur ; Amanda V. BAKIAN, Auteur ; Robert SATTERFIELD, Auteur ; Paul S. CARBONE, Auteur ; Barry E. NANGLE, Auteur ; Harper RANDALL, Auteur ; William M. MCMAHON, Auteur Année de publication : 2012 Article en page(s) : p.438-448 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined the hypotheses that (1) sociodemographic risk factors in young children with autism spectrum disorders (ASD) and/or intellectual disability (ID) significantly vary by disability type, and (2) measures of income (mean adjusted gross income, mean federal taxes paid, and mean tax exemptions) significantly increase between 1994 and 2002, and are lower in families with a child with ASD and/or ID compared with the general population. A multiple source surveillance system utilizing a retrospective record review was used to identify ASD and ID cases from a population of 26,108 eight-year-old children born in 1994 and living in Utah in 2002. ASD without ID (ASD-only, n = 99) cases were significantly more likely to be male (P<0.01) and have mothers of White non-Hispanic ethnicity (P = 0.02). ASD with ID (ASD/ID, n = 33) cases were significantly more likely to be male (P<0.01) and have mothers older than 34 years (P = 0.03). ID without ASD (ID-only, n = 113) cases were significantly more likely to have fathers older than 34 years (P<0.01) and were significantly less likely to have mothers with >13 years education (P<0.01). Measures of income for cases at birth and at 8 years of age were not significantly lower than the general population and mean adjusted income of cases significantly increased from birth to 8 years of age. Investigations focused on defining early sociodemographic risk factors by different endophenotypes of ASD may assist in identifying risk factors for this complex group of neurodevelopmental disorders. Aggregate tax information may be a unique resource to utilize for population-based analysis. En ligne : http://dx.doi.org/10.1002/aur.224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Sociodemographic risk factors associated with autism spectrum disorders and intellectual disability [Texte imprimé et/ou numérique] / Judith PINBOROUGH-ZIMMERMAN, Auteur ; Deborah A. BILDER, Auteur ; Amanda V. BAKIAN, Auteur ; Robert SATTERFIELD, Auteur ; Paul S. CARBONE, Auteur ; Barry E. NANGLE, Auteur ; Harper RANDALL, Auteur ; William M. MCMAHON, Auteur . - 2012 . - p.438-448. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.438-448 Index. décimale : PER Périodiques Résumé : This study examined the hypotheses that (1) sociodemographic risk factors in young children with autism spectrum disorders (ASD) and/or intellectual disability (ID) significantly vary by disability type, and (2) measures of income (mean adjusted gross income, mean federal taxes paid, and mean tax exemptions) significantly increase between 1994 and 2002, and are lower in families with a child with ASD and/or ID compared with the general population. A multiple source surveillance system utilizing a retrospective record review was used to identify ASD and ID cases from a population of 26,108 eight-year-old children born in 1994 and living in Utah in 2002. ASD without ID (ASD-only, n = 99) cases were significantly more likely to be male (P<0.01) and have mothers of White non-Hispanic ethnicity (P = 0.02). ASD with ID (ASD/ID, n = 33) cases were significantly more likely to be male (P<0.01) and have mothers older than 34 years (P = 0.03). ID without ASD (ID-only, n = 113) cases were significantly more likely to have fathers older than 34 years (P<0.01) and were significantly less likely to have mothers with >13 years education (P<0.01). Measures of income for cases at birth and at 8 years of age were not significantly lower than the general population and mean adjusted income of cases significantly increased from birth to 8 years of age. Investigations focused on defining early sociodemographic risk factors by different endophenotypes of ASD may assist in identifying risk factors for this complex group of neurodevelopmental disorders. Aggregate tax information may be a unique resource to utilize for population-based analysis. En ligne : http://dx.doi.org/10.1002/aur.224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders / Mikle SOUTH in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.412-421 Titre : Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Mikle SOUTH, Auteur ; Michael J. LARSON, Auteur ; Sarah E. WHITE, Auteur ; Julianne DANA, Auteur ; Michael J. CROWLEY, Auteur Année de publication : 2012 Article en page(s) : p.412-421 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  amygdala  anxiety  fear conditioning  dimensional measures Index. décimale : PER Périodiques Résumé : Evidence from behavioral and neuroimaging studies suggest that atypical amygdala function plays a critical role in the development of autism spectrum disorders (ASD). The handful of psychophysiological studies examining amygdala function in ASD using classical fear conditioning paradigms have yielded discordant results. We recorded skin conductance response (SCR) during a simple discrimination conditioning task in 30 children and adolescents (ages 8–18) diagnosed with high-functioning ASD and 30 age- and IQ-matched, typically developing controls. SCR response in the ASD group was uniquely and positively associated with social anxiety; and negatively correlated with autism symptom severity, in particular with social functioning. Fear conditioning studies have tremendous potential to aid understanding regarding the amygdale's role in the varied symptom profile of ASD. Our data demonstrate that such studies require careful attention to task-specific factors, including task complexity; and also to contributions of dimensional, within-group factors that contribute to ASD heterogeneity. En ligne : http://dx.doi.org/10.1002/aur.221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders [Texte imprimé et/ou numérique] / Mikle SOUTH, Auteur ; Michael J. LARSON, Auteur ; Sarah E. WHITE, Auteur ; Julianne DANA, Auteur ; Michael J. CROWLEY, Auteur . - 2012 . - p.412-421. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.412-421 Mots-clés : autism spectrum disorders  amygdala  anxiety  fear conditioning  dimensional measures Index. décimale : PER Périodiques Résumé : Evidence from behavioral and neuroimaging studies suggest that atypical amygdala function plays a critical role in the development of autism spectrum disorders (ASD). The handful of psychophysiological studies examining amygdala function in ASD using classical fear conditioning paradigms have yielded discordant results. We recorded skin conductance response (SCR) during a simple discrimination conditioning task in 30 children and adolescents (ages 8–18) diagnosed with high-functioning ASD and 30 age- and IQ-matched, typically developing controls. SCR response in the ASD group was uniquely and positively associated with social anxiety; and negatively correlated with autism symptom severity, in particular with social functioning. Fear conditioning studies have tremendous potential to aid understanding regarding the amygdale's role in the varied symptom profile of ASD. Our data demonstrate that such studies require careful attention to task-specific factors, including task complexity; and also to contributions of dimensional, within-group factors that contribute to ASD heterogeneity. En ligne : http://dx.doi.org/10.1002/aur.221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Face recognition performance of individuals with Asperger syndrome on the Cambridge face memory test / Darren HEDLEY in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.449-455 Titre : Face recognition performance of individuals with Asperger syndrome on the Cambridge face memory test Type de document : Texte imprimé et/ou numérique Auteurs : Darren HEDLEY, Auteur ; Neil BREWER, Auteur ; Robyn L. YOUNG, Auteur Année de publication : 2012 Article en page(s) : p.449-455 Langues : Anglais (eng) Mots-clés : face recognition  autism spectrum disorder  Asperger syndrome  CFMT  face perception Index. décimale : PER Périodiques Résumé : Although face recognition deficits in individuals with Autism Spectrum Disorder (ASD), including Asperger syndrome (AS), are widely acknowledged, the empirical evidence is mixed. This in part reflects the failure to use standardized and psychometrically sound tests. We contrasted standardized face recognition scores on the Cambridge Face Memory Test (CFMT) for 34 individuals with AS with those for 42, IQ-matched non-ASD individuals, and age-standardized scores from a large Australian cohort. We also examined the influence of IQ, autistic traits, and negative affect on face recognition performance. Overall, participants with AS performed significantly worse on the CFMT than the non-ASD participants and when evaluated against standardized test norms. However, while 24% of participants with AS presented with severe face recognition impairment (>2 SDs below the mean), many individuals performed at or above the typical level for their age: 53% scored within +/− 1 SD of the mean and 9% demonstrated superior performance (>1 SD above the mean). Regression analysis provided no evidence that IQ, autistic traits, or negative affect significantly influenced face recognition: diagnostic group membership was the only significant predictor of face recognition performance. In sum, face recognition performance in ASD is on a continuum, but with average levels significantly below non-ASD levels of performance. En ligne : http://dx.doi.org/10.1002/aur.214 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Face recognition performance of individuals with Asperger syndrome on the Cambridge face memory test [Texte imprimé et/ou numérique] / Darren HEDLEY, Auteur ; Neil BREWER, Auteur ; Robyn L. YOUNG, Auteur . - 2012 . - p.449-455. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.449-455 Mots-clés : face recognition  autism spectrum disorder  Asperger syndrome  CFMT  face perception Index. décimale : PER Périodiques Résumé : Although face recognition deficits in individuals with Autism Spectrum Disorder (ASD), including Asperger syndrome (AS), are widely acknowledged, the empirical evidence is mixed. This in part reflects the failure to use standardized and psychometrically sound tests. We contrasted standardized face recognition scores on the Cambridge Face Memory Test (CFMT) for 34 individuals with AS with those for 42, IQ-matched non-ASD individuals, and age-standardized scores from a large Australian cohort. We also examined the influence of IQ, autistic traits, and negative affect on face recognition performance. Overall, participants with AS performed significantly worse on the CFMT than the non-ASD participants and when evaluated against standardized test norms. However, while 24% of participants with AS presented with severe face recognition impairment (>2 SDs below the mean), many individuals performed at or above the typical level for their age: 53% scored within +/− 1 SD of the mean and 9% demonstrated superior performance (>1 SD above the mean). Regression analysis provided no evidence that IQ, autistic traits, or negative affect significantly influenced face recognition: diagnostic group membership was the only significant predictor of face recognition performance. In sum, face recognition performance in ASD is on a continuum, but with average levels significantly below non-ASD levels of performance. En ligne : http://dx.doi.org/10.1002/aur.214 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? / Sumi HOSHIKO in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.456-463 Titre : Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? Type de document : Texte imprimé et/ou numérique Auteurs : Sumi HOSHIKO, Auteur ; Judith K. GRETHER, Auteur ; Gayle C. WINDHAM, Auteur ; Daniel W. SMITH, Auteur ; Karen FESSEL, Auteur Année de publication : 2012 Article en page(s) : p.456-463 Langues : Anglais (eng) Mots-clés : epidemiology  autism  thyroid  environment  hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.30–5.75; 1994: OR = 1.71 (95% CI 0.57–5.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. En ligne : http://dx.doi.org/10.1002/aur.219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? [Texte imprimé et/ou numérique] / Sumi HOSHIKO, Auteur ; Judith K. GRETHER, Auteur ; Gayle C. WINDHAM, Auteur ; Daniel W. SMITH, Auteur ; Karen FESSEL, Auteur . - 2012 . - p.456-463. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.456-463 Mots-clés : epidemiology  autism  thyroid  environment  hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.30–5.75; 1994: OR = 1.71 (95% CI 0.57–5.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. En ligne : http://dx.doi.org/10.1002/aur.219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Lay abstracts in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.464-466 Titre : Lay abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2012 Article en page(s) : p.464-466 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Lay abstracts [Texte imprimé et/ou numérique] . - 2012 . - p.464-466. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.464-466 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

International Society for Autism Research news in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.467 Titre : International Society for Autism Research news Type de document : Texte imprimé et/ou numérique Année de publication : 2012 Article en page(s) : p.467 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] International Society for Autism Research news [Texte imprimé et/ou numérique] . - 2012 . - p.467. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.467 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151