Investigating Motor Preparation in Autism Spectrum Disorder With and Without Attention Deficit/Hyperactivity Disorder / Marta MIGO in Journal of Autism and Developmental Disorders, 52-6 (June 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-6 (June 2022) . - p.2379-2387 Titre : Investigating Motor Preparation in Autism Spectrum Disorder With and Without Attention Deficit/Hyperactivity Disorder Type de document : texte imprimé Auteurs : Marta MIGO, Auteur ; Sylvia B. GUILLORY, Auteur ; Christopher S. MCLAUGHLIN, Auteur ; Emily L. ISENSTEIN, Auteur ; Hannah E. GROSMAN, Auteur ; Katharine N. THAKKAR, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Jennifer H. FOSS-FEIG, Auteur Article en page(s) : p.2379-2387 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder (ADHD)  Autism spectrum disorder (ASD)  Eeg  Lateralized readiness potential (LRP)  Motor preparation  Prediction Index. décimale : PER Périodiques Résumé : This study investigated motor preparation and action-consequence prediction using the lateralized readiness potential (LRP). Motor impairments are common in autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which commonly co-occur. Alterations in predictive processes may impact motor planning. Whether motor planning deficits are characteristic of ASD broadly or magnified in the context of co-morbid ADHD is unclear. ASD children with (ASD+ADHD; n=12) and without (ASD?-?ADHD; n=9) comorbid ADHD and typical controls (n=29) performed voluntary motor actions that either did or did not result in auditory consequences. ASD?-?ADHD children demonstrated LRP enhancement when their action produced an effect while ASD+ADHD children had attenuated responses regardless of action-effect pairings. Findings suggest influence of ADHD comorbidity on motor preparation and prediction in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05130-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Investigating Motor Preparation in Autism Spectrum Disorder With and Without Attention Deficit/Hyperactivity Disorder [texte imprimé] / Marta MIGO, Auteur ; Sylvia B. GUILLORY, Auteur ; Christopher S. MCLAUGHLIN, Auteur ; Emily L. ISENSTEIN, Auteur ; Hannah E. GROSMAN, Auteur ; Katharine N. THAKKAR, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Jennifer H. FOSS-FEIG, Auteur . - p.2379-2387. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-6 (June 2022) . - p.2379-2387 Mots-clés : Attention-deficit/hyperactivity disorder (ADHD)  Autism spectrum disorder (ASD)  Eeg  Lateralized readiness potential (LRP)  Motor preparation  Prediction Index. décimale : PER Périodiques Résumé : This study investigated motor preparation and action-consequence prediction using the lateralized readiness potential (LRP). Motor impairments are common in autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which commonly co-occur. Alterations in predictive processes may impact motor planning. Whether motor planning deficits are characteristic of ASD broadly or magnified in the context of co-morbid ADHD is unclear. ASD children with (ASD+ADHD; n=12) and without (ASD?-?ADHD; n=9) comorbid ADHD and typical controls (n=29) performed voluntary motor actions that either did or did not result in auditory consequences. ASD?-?ADHD children demonstrated LRP enhancement when their action produced an effect while ASD+ADHD children had attenuated responses regardless of action-effect pairings. Findings suggest influence of ADHD comorbidity on motor preparation and prediction in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05130-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Prospective and detailed behavioral phenotyping in DDX3X syndrome / Lara TANG in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 36 p. Titre : Prospective and detailed behavioral phenotyping in DDX3X syndrome Type de document : texte imprimé Auteurs : Lara TANG, Auteur ; Tess LEVY, Auteur ; Sylvia B. GUILLORY, Auteur ; Danielle B. HALPERN, Auteur ; Jessica ZWEIFACH, Auteur ; Ivy GISERMAN-KISS, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Yitzchak FRANK, Auteur ; Reymundo LOZANO, Auteur ; Puneet BELANI, Auteur ; Christina LAYTON, Auteur ; Bonnie LERMAN, Auteur ; Emanuel FROWNER, Auteur ; Michael S. BREEN, Auteur ; Silvia DE RUBEIS, Auteur ; Ana KOSTIC, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; Paige M. SIPER, Auteur ; Dorothy E. GRICE, Auteur Article en page(s) : 36 p. Langues : Anglais (eng) Mots-clés : Autism  DDX3X syndrome  Developmental delay  Genotype–phenotype correlation  Intellectual disability  Therapeutics, Acadia, and Sema4. PMS is the inventor of the SAND, which is licensed  by Mount Sinai to Stoelting Co. No other competing interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: DDX3X syndrome is a recently identified genetic disorder that accounts for 1-3% of cases of unexplained developmental delay and/or intellectual disability (ID) in females, and is associated with motor and language delays, and autism spectrum disorder (ASD). To date, the published phenotypic characterization of this syndrome has primarily relied on medical record review; in addition, the behavioral dimensions of the syndrome have not been fully explored. METHODS: We carried out multi-day, prospective, detailed phenotyping of DDX3X syndrome in 14 females and 1 male, focusing on behavioral, psychological, and neurological measures. Three participants in this cohort were previously reported with limited phenotype information and were re-evaluated for this study. We compared results against population norms and contrasted phenotypes between individuals harboring either (1) protein-truncating variants or (2) missense variants or in-frame deletions. RESULTS: Eighty percent (80%) of individuals met criteria for ID, 60% for ASD and 53% for attention-deficit/hyperactivity disorder (ADHD). Motor and language delays were common as were sensory processing abnormalities. The cohort included 5 missense, 3 intronic/splice-site, 2 nonsense, 2 frameshift, 2 in-frame deletions, and one initiation codon variant. Genotype-phenotype correlations indicated that, on average, missense variants/in-frame deletions were associated with more severe language, motor, and adaptive deficits in comparison to protein-truncating variants. LIMITATIONS: Sample size is modest, however, DDX3X syndrome is a rare and underdiagnosed disorder. CONCLUSION: This study, representing a first, prospective, detailed characterization of DDX3X syndrome, extends our understanding of the neurobehavioral phenotype. Gold-standard diagnostic approaches demonstrated high rates of ID, ASD, and ADHD. In addition, sensory deficits were observed to be a key part of the syndrome. Even with a modest sample, we observe evidence for genotype-phenotype correlations with missense variants/in-frame deletions generally associated with more severe phenotypes. En ligne : http://dx.doi.org/10.1186/s13229-021-00431-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Prospective and detailed behavioral phenotyping in DDX3X syndrome [texte imprimé] / Lara TANG, Auteur ; Tess LEVY, Auteur ; Sylvia B. GUILLORY, Auteur ; Danielle B. HALPERN, Auteur ; Jessica ZWEIFACH, Auteur ; Ivy GISERMAN-KISS, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Yitzchak FRANK, Auteur ; Reymundo LOZANO, Auteur ; Puneet BELANI, Auteur ; Christina LAYTON, Auteur ; Bonnie LERMAN, Auteur ; Emanuel FROWNER, Auteur ; Michael S. BREEN, Auteur ; Silvia DE RUBEIS, Auteur ; Ana KOSTIC, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; Paige M. SIPER, Auteur ; Dorothy E. GRICE, Auteur . - 36 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 36 p. Mots-clés : Autism  DDX3X syndrome  Developmental delay  Genotype–phenotype correlation  Intellectual disability  Therapeutics, Acadia, and Sema4. PMS is the inventor of the SAND, which is licensed  by Mount Sinai to Stoelting Co. No other competing interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: DDX3X syndrome is a recently identified genetic disorder that accounts for 1-3% of cases of unexplained developmental delay and/or intellectual disability (ID) in females, and is associated with motor and language delays, and autism spectrum disorder (ASD). To date, the published phenotypic characterization of this syndrome has primarily relied on medical record review; in addition, the behavioral dimensions of the syndrome have not been fully explored. METHODS: We carried out multi-day, prospective, detailed phenotyping of DDX3X syndrome in 14 females and 1 male, focusing on behavioral, psychological, and neurological measures. Three participants in this cohort were previously reported with limited phenotype information and were re-evaluated for this study. We compared results against population norms and contrasted phenotypes between individuals harboring either (1) protein-truncating variants or (2) missense variants or in-frame deletions. RESULTS: Eighty percent (80%) of individuals met criteria for ID, 60% for ASD and 53% for attention-deficit/hyperactivity disorder (ADHD). Motor and language delays were common as were sensory processing abnormalities. The cohort included 5 missense, 3 intronic/splice-site, 2 nonsense, 2 frameshift, 2 in-frame deletions, and one initiation codon variant. Genotype-phenotype correlations indicated that, on average, missense variants/in-frame deletions were associated with more severe language, motor, and adaptive deficits in comparison to protein-truncating variants. LIMITATIONS: Sample size is modest, however, DDX3X syndrome is a rare and underdiagnosed disorder. CONCLUSION: This study, representing a first, prospective, detailed characterization of DDX3X syndrome, extends our understanding of the neurobehavioral phenotype. Gold-standard diagnostic approaches demonstrated high rates of ID, ASD, and ADHD. In addition, sensory deficits were observed to be a key part of the syndrome. Even with a modest sample, we observe evidence for genotype-phenotype correlations with missense variants/in-frame deletions generally associated with more severe phenotypes. En ligne : http://dx.doi.org/10.1186/s13229-021-00431-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Reduced engagement of visual attention in children with autism spectrum disorder / Christopher S. MCLAUGHLIN in Autism, 25-7 (October 2021)  

Public ISBD [article]  inAutism > 25-7 (October 2021) . - p.2064-2073 Titre : Reduced engagement of visual attention in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Christopher S. MCLAUGHLIN, Auteur ; Hannah E. GROSMAN, Auteur ; Sylvia B. GUILLORY, Auteur ; Emily L. ISENSTEIN, Auteur ; Ellen WILKINSON, Auteur ; Maria Del Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; Jennifer H. FOSS-FEIG, Auteur Article en page(s) : p.2064-2073 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Humans  Nonverbal Communication  autism spectrum disorders  eye-tracking  gap effect  saccade  social  visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Reduced engagement of visual attention in children with autism spectrum disorder [texte imprimé] / Christopher S. MCLAUGHLIN, Auteur ; Hannah E. GROSMAN, Auteur ; Sylvia B. GUILLORY, Auteur ; Emily L. ISENSTEIN, Auteur ; Ellen WILKINSON, Auteur ; Maria Del Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; Jennifer H. FOSS-FEIG, Auteur . - p.2064-2073. Langues : Anglais (eng) in Autism > 25-7 (October 2021) . - p.2064-2073 Mots-clés : Autism Spectrum Disorder  Child  Humans  Nonverbal Communication  autism spectrum disorders  eye-tracking  gap effect  saccade  social  visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Reduced engagement of visual attention in children with autism spectrum disorder / Christopher S. MCLAUGHLIN in Autism, 26-7 (October 2022)  

Public ISBD [article]  inAutism > 26-7 (October 2022) . - p.2064-2073 Titre : Reduced engagement of visual attention in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Christopher S. MCLAUGHLIN, Auteur ; Hannah E. GROSMAN, Auteur ; Sylvia B. GUILLORY, Auteur ; Emily L. ISENSTEIN, Auteur ; Emma WILKINSON, Auteur ; Maria Del Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; Jennifer H. FOSS-FEIG, Auteur Article en page(s) : p.2064-2073 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Humans  Nonverbal Communication  autism spectrum disorders  eye-tracking  gap effect  saccade  social  visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] Reduced engagement of visual attention in children with autism spectrum disorder [texte imprimé] / Christopher S. MCLAUGHLIN, Auteur ; Hannah E. GROSMAN, Auteur ; Sylvia B. GUILLORY, Auteur ; Emily L. ISENSTEIN, Auteur ; Emma WILKINSON, Auteur ; Maria Del Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; Joseph D. BUXBAUM, Auteur ; A. Ting WANG, Auteur ; Jennifer H. FOSS-FEIG, Auteur . - p.2064-2073. Langues : Anglais (eng) in Autism > 26-7 (October 2022) . - p.2064-2073 Mots-clés : Autism Spectrum Disorder  Child  Humans  Nonverbal Communication  autism spectrum disorders  eye-tracking  gap effect  saccade  social  visual attention Index. décimale : PER Périodiques Résumé : Limited eye contact and difficulty tracking where others are looking are common in people with autism spectrum disorder. It is unclear, however, whether these are specifically social differences; it is possible that they are a result of broader alterations in engaging and disengaging visual attention. We used eye-tracking technology with children with autism spectrum disorder (n = 35) and typical development (n = 32), showing them both social and nonsocial imaging to test their visual attention. Children with autism spectrum disorder had a significant difference in how long it took them to look from an image in the middle to one on the side, depending on whether the middle image stayed on the screen or flashed off before the one on the side appeared. This difference was present for both social and nonsocial images, and was related to cognitive ability for only the children with autism spectrum disorder. Our findings suggest that children with autism spectrum disorder have differences in general processes of engaging visual attention that are not specifically social in nature, and that these processes may relate to cognitive ability in autism spectrum disorder. Affected processes of visual engagement in autism spectrum disorder may contribute to symptoms like reduced eye contact, but social-specific symptoms of autism spectrum disorder likely do not stem from reduced visual engagement alone. En ligne : http://dx.doi.org/10.1177/13623613211010072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

Social visual attentional engagement and memory in Phelan-McDermid syndrome and autism spectrum disorder: a pilot eye tracking study / Sylvia B. GUILLORY in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Social visual attentional engagement and memory in Phelan-McDermid syndrome and autism spectrum disorder: a pilot eye tracking study Type de document : texte imprimé Auteurs : Sylvia B. GUILLORY, Auteur ; Victoria Z. BASKETT, Auteur ; Hannah E. GROSMAN, Auteur ; Christopher S. MCLAUGHLIN, Auteur ; Emily L. ISENSTEIN, Auteur ; Emma WILKINSON, Auteur ; Jordana WEISSMAN, Auteur ; Bari BRITVAN, Auteur ; M. Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Joseph D. BUXBAUM, Auteur ; Paige M. SIPER, Auteur ; A. Ting WANG, Auteur ; Alexander KOLEVZON, Auteur ; Jennifer H. FOSS-FEIG, Auteur Langues : Anglais (eng) Mots-clés : Attention  Autism Spectrum Disorder/genetics  Chromosome Deletion  Chromosome Disorders/complications/genetics  Chromosomes, Human, Pair 22  Eye-Tracking Technology  Humans  Autism spectrum disorder  Eye tracking  Phelan-McDermid syndrome  Recognition memory  Social processing  Visual attention  Therapeutics, and sema4. All other authors declare that they have no competing  interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: The current study used eye tracking to investigate attention and recognition memory in Phelan-McDermid syndrome (PMS), a rare genetic disorder characterized by intellectual disability, motor delays, and a high likelihood of comorbid autism spectrum disorder (ASD). Social deficits represent a core feature of ASD, including decreased propensity to orient to or show preference for social stimuli. METHODS: We used a visual paired-comparison task with both social and non-social images, assessing looking behavior to a novel image versus a previously viewed familiar image to characterize social attention and recognition memory in PMS (n = 22), idiopathic ASD (iASD, n = 38), and typically developing (TD) controls (n = 26). The idiopathic ASD cohort was divided into subgroups with intellectual disabilities (ID; developmental quotient < 70) and without (developmental quotient > 70) and the PMS group into those with and without a co-morbid ASD diagnosis. RESULTS: On measures of attention, the PMS group with a comorbid ASD diagnosis spent less time viewing the social images compared to non-social images; the rate of looking back and forth between images was lowest in the iASD with ID group. Furthermore, while all groups demonstrated intact recognition memory when novel non-social stimuli were initially presented (pre-switch), participants with PMS showed no preference during the post-switch memory presentation. In iASD, the group without ID, but not the group with ID, showed a novelty preference for social stimuli. Across indices, individuals with PMS and ASD performed more similarly to PMS without ASD and less similarly to the iASD group. CONCLUSION: These findings demonstrate further evidence of differences in attention and memory for social stimuli in ASD and provide contrasts between iASD and PMS. En ligne : https://dx.doi.org/10.1186/s11689-021-09400-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Social visual attentional engagement and memory in Phelan-McDermid syndrome and autism spectrum disorder: a pilot eye tracking study [texte imprimé] / Sylvia B. GUILLORY, Auteur ; Victoria Z. BASKETT, Auteur ; Hannah E. GROSMAN, Auteur ; Christopher S. MCLAUGHLIN, Auteur ; Emily L. ISENSTEIN, Auteur ; Emma WILKINSON, Auteur ; Jordana WEISSMAN, Auteur ; Bari BRITVAN, Auteur ; M. Pilar TRELLES, Auteur ; Danielle B. HALPERN, Auteur ; Joseph D. BUXBAUM, Auteur ; Paige M. SIPER, Auteur ; A. Ting WANG, Auteur ; Alexander KOLEVZON, Auteur ; Jennifer H. FOSS-FEIG, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Attention  Autism Spectrum Disorder/genetics  Chromosome Deletion  Chromosome Disorders/complications/genetics  Chromosomes, Human, Pair 22  Eye-Tracking Technology  Humans  Autism spectrum disorder  Eye tracking  Phelan-McDermid syndrome  Recognition memory  Social processing  Visual attention  Therapeutics, and sema4. All other authors declare that they have no competing  interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: The current study used eye tracking to investigate attention and recognition memory in Phelan-McDermid syndrome (PMS), a rare genetic disorder characterized by intellectual disability, motor delays, and a high likelihood of comorbid autism spectrum disorder (ASD). Social deficits represent a core feature of ASD, including decreased propensity to orient to or show preference for social stimuli. METHODS: We used a visual paired-comparison task with both social and non-social images, assessing looking behavior to a novel image versus a previously viewed familiar image to characterize social attention and recognition memory in PMS (n = 22), idiopathic ASD (iASD, n = 38), and typically developing (TD) controls (n = 26). The idiopathic ASD cohort was divided into subgroups with intellectual disabilities (ID; developmental quotient < 70) and without (developmental quotient > 70) and the PMS group into those with and without a co-morbid ASD diagnosis. RESULTS: On measures of attention, the PMS group with a comorbid ASD diagnosis spent less time viewing the social images compared to non-social images; the rate of looking back and forth between images was lowest in the iASD with ID group. Furthermore, while all groups demonstrated intact recognition memory when novel non-social stimuli were initially presented (pre-switch), participants with PMS showed no preference during the post-switch memory presentation. In iASD, the group without ID, but not the group with ID, showed a novelty preference for social stimuli. Across indices, individuals with PMS and ASD performed more similarly to PMS without ASD and less similarly to the iASD group. CONCLUSION: These findings demonstrate further evidence of differences in attention and memory for social stimuli in ASD and provide contrasts between iASD and PMS. En ligne : https://dx.doi.org/10.1186/s11689-021-09400-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

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