Associations of Down Syndrome with Autism Spectrum Disorder and Attention Deficit/ Hyperactivity Disorder Among Children and Adolescents / Xin WANG in Journal of Autism and Developmental Disorders, 56-10 (October 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-10 (October 2026) . - p. 4001-4009 Titre : Associations of Down Syndrome with Autism Spectrum Disorder and Attention Deficit/ Hyperactivity Disorder Among Children and Adolescents Type de document : texte imprimé Auteurs : Xin WANG, Auteur ; Chunhua WANG, Auteur ; Lizi LIN, Auteur ; Wei BAO, Auteur ; Buyun LIU, Auteur ; Baihua LIN, Auteur ; Lijie ZHANG, Auteur ; Guifeng XU, Auteur Article en page(s) : p. 4001-4009 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children with Down syndrome (DS) are more likely to be diagnosed with co-existing conditions, such as autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). However, the correlation has not been fully delineated to date. Our study aimed to examine the associations of DS with ASD and ADHD in children and adolescents using a national population-based database. In this cross-sectional study, we included a total of 214,300 children aged 3–17 years from the National Health Interview Survey. Physician-diagnosed DS, ASD and ADHD were reported during an in-person household interview. Logistic regression with survey sampling weights was used to estimate the odds ratios (ORs) of ASD and ADHD, along with 95% confidence intervals (CIs). Among the 214,300 children, 329 were identified as having DS. Among those, 21 children were diagnosed with ASD, 48 with ADHD, and 6 exhibited co-existing ASD and ADHD. After adjusting for demographic factors, compared to those without DS, the ORs of ASD, ADHD and the co-occurrence of ASD and ADHD in children with DS were 5.40 (95% CI: 3.04–9.59), 1.72 (95% CI: 1.17–2.53), and 3.45(95% CI:1.29–9.20), respectively. Stratified analysis revealed that significant associations of DS with ASD and ADHD were detected for both male and female, but an interaction effect was only observed between sex and ASD (P < 0.001). Our study confirmed that children with DS are more likely to have comorbidities of ASD and ADHD than the general population, and these comorbidities may vary by sex. En ligne : https://doi.org/10.1007/s10803-025-06834-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Associations of Down Syndrome with Autism Spectrum Disorder and Attention Deficit/ Hyperactivity Disorder Among Children and Adolescents [texte imprimé] / Xin WANG, Auteur ; Chunhua WANG, Auteur ; Lizi LIN, Auteur ; Wei BAO, Auteur ; Buyun LIU, Auteur ; Baihua LIN, Auteur ; Lijie ZHANG, Auteur ; Guifeng XU, Auteur . - p. 4001-4009. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-10 (October 2026) . - p. 4001-4009 Index. décimale : PER Périodiques Résumé : Children with Down syndrome (DS) are more likely to be diagnosed with co-existing conditions, such as autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). However, the correlation has not been fully delineated to date. Our study aimed to examine the associations of DS with ASD and ADHD in children and adolescents using a national population-based database. In this cross-sectional study, we included a total of 214,300 children aged 3–17 years from the National Health Interview Survey. Physician-diagnosed DS, ASD and ADHD were reported during an in-person household interview. Logistic regression with survey sampling weights was used to estimate the odds ratios (ORs) of ASD and ADHD, along with 95% confidence intervals (CIs). Among the 214,300 children, 329 were identified as having DS. Among those, 21 children were diagnosed with ASD, 48 with ADHD, and 6 exhibited co-existing ASD and ADHD. After adjusting for demographic factors, compared to those without DS, the ORs of ASD, ADHD and the co-occurrence of ASD and ADHD in children with DS were 5.40 (95% CI: 3.04–9.59), 1.72 (95% CI: 1.17–2.53), and 3.45(95% CI:1.29–9.20), respectively. Stratified analysis revealed that significant associations of DS with ASD and ADHD were detected for both male and female, but an interaction effect was only observed between sex and ASD (P < 0.001). Our study confirmed that children with DS are more likely to have comorbidities of ASD and ADHD than the general population, and these comorbidities may vary by sex. En ligne : https://doi.org/10.1007/s10803-025-06834-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

Associations of unintended pregnancy with autism spectrum disorders and the modification of folic acid supplements / Xing-Lian LIU ; Li-Zi LIN ; Xin WANG ; Ming-Hui LI ; Mei-Xia DAI ; Mu-Qing CAO ; Xiu-Hong LI ; Jing JIN ; Hai-Qing XU ; Li CAI in Autism Research, 17-1 (January 2024)  

Public ISBD [article]  inAutism Research > 17-1 (January 2024) . - p.172-181 Titre : Associations of unintended pregnancy with autism spectrum disorders and the modification of folic acid supplements Type de document : texte imprimé Auteurs : Xing-Lian LIU, Auteur ; Li-Zi LIN, Auteur ; Xin WANG, Auteur ; Ming-Hui LI, Auteur ; Mei-Xia DAI, Auteur ; Mu-Qing CAO, Auteur ; Xiu-Hong LI, Auteur ; Jing JIN, Auteur ; Hai-Qing XU, Auteur ; Li CAI, Auteur Article en page(s) : p.172-181 Index. décimale : PER Périodiques Résumé : Abstract There is limited evidence on the associations of unintended pregnancy with autism spectrum disorders (ASD). This study aimed to examine this relationship and the modification of pre-conceptional and prenatal folic acid supplements. Six thousand and five toddlers aged 16 to 30 months from seven cities of six provinces in China were eligible for participation. Information on unintended pregnancy and folic acid supplements was obtained via questionnaires from caregivers of toddlers. The diagnosis of ASD was based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and the Chinese version of the Childhood Autism Rating Scale (CARS). Of the 6005 toddlers in the study (3337 boys and 2668 girls), 71 (1.18%) received the diagnosis of ASD. Generalized linear models with a logit link function showed unintended pregnancy was positively associated with ASD (odds ratios [OR] 1.69, 95% confidence interval [CI], 1.05 2.79). Stratified estimates indicated that the association remained stable among toddlers of mothers without pre-conceptional and prenatal folic acid supplements (OR 2.75, 95% CI, 1.04 7.27; n 1243, 20.70%). Unintended pregnancy was associated with higher odds of ASD in 16 30 months of toddlers, and the association was consistent among toddlers of mothers without prenatal folic acid supplements. Our findings emphasize the need to raise awareness of the risk of unintended pregnancy and the benefits of folic acid supplements among Chinese women. En ligne : https://doi.org/10.1002/aur.3070 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Associations of unintended pregnancy with autism spectrum disorders and the modification of folic acid supplements [texte imprimé] / Xing-Lian LIU, Auteur ; Li-Zi LIN, Auteur ; Xin WANG, Auteur ; Ming-Hui LI, Auteur ; Mei-Xia DAI, Auteur ; Mu-Qing CAO, Auteur ; Xiu-Hong LI, Auteur ; Jing JIN, Auteur ; Hai-Qing XU, Auteur ; Li CAI, Auteur . - p.172-181. in Autism Research > 17-1 (January 2024) . - p.172-181 Index. décimale : PER Périodiques Résumé : Abstract There is limited evidence on the associations of unintended pregnancy with autism spectrum disorders (ASD). This study aimed to examine this relationship and the modification of pre-conceptional and prenatal folic acid supplements. Six thousand and five toddlers aged 16 to 30 months from seven cities of six provinces in China were eligible for participation. Information on unintended pregnancy and folic acid supplements was obtained via questionnaires from caregivers of toddlers. The diagnosis of ASD was based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and the Chinese version of the Childhood Autism Rating Scale (CARS). Of the 6005 toddlers in the study (3337 boys and 2668 girls), 71 (1.18%) received the diagnosis of ASD. Generalized linear models with a logit link function showed unintended pregnancy was positively associated with ASD (odds ratios [OR] 1.69, 95% confidence interval [CI], 1.05 2.79). Stratified estimates indicated that the association remained stable among toddlers of mothers without pre-conceptional and prenatal folic acid supplements (OR 2.75, 95% CI, 1.04 7.27; n 1243, 20.70%). Unintended pregnancy was associated with higher odds of ASD in 16 30 months of toddlers, and the association was consistent among toddlers of mothers without prenatal folic acid supplements. Our findings emphasize the need to raise awareness of the risk of unintended pregnancy and the benefits of folic acid supplements among Chinese women. En ligne : https://doi.org/10.1002/aur.3070 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Chronic Physical Pain in Children With and Without Autism Spectrum Disorder in the United States: Findings from the 2016 – 2021 National Survey of Children’s Health / Qianyi XIE in Journal of Autism and Developmental Disorders, 56-10 (October 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-10 (October 2026) . - p. 4010-4024 Titre : Chronic Physical Pain in Children With and Without Autism Spectrum Disorder in the United States: Findings from the 2016 – 2021 National Survey of Children’s Health Type de document : texte imprimé Auteurs : Qianyi XIE, Auteur ; Ning PAN, Auteur ; Xiaoxuan OU, Auteur ; Shuli SHEN, Auteur ; Jin JING, Auteur ; Xuchu WENG, Auteur ; Lei SHI, Auteur ; Lizi LIN, Auteur ; Jiaze YANG, Auteur ; Xiangpeng LI, Auteur ; Kai ZHANG, Auteur ; Fangfang CHEN, Auteur ; Yujie WANG, Auteur ; Jinqing WU, Auteur ; Xin WANG, Auteur Article en page(s) : p. 4010-4024 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) have long been reported to exhibit atypical pain experiences. Chronic physical pain is a significant comorbidity in ASD, leading to substantial burdens on daily functioning and quality of life. This study aims to examine the potential associations between ASD and chronic physical pain, including its specific types. The study used data on chronic physical pain and headaches from the 2016 – 2021 National Survey of Children’s Health. Participants were children aged 3 to 17 years old. Generalized linear models were used to estimate the associations between ASD and pain-related indicators (e.g., chronic physical pain, headaches, and other back or body pain). The study included 177,539 children, of whom 5311 had a current ASD diagnosis. Among children with current ASD, 14.41% experienced chronic physical pain, with 4.86% reporting headaches and 9.56% reporting other back or body pain. Compared to those without, children with current ASD had higher odds of chronic physical pain [odds ratio (OR) = 1.76, 95% confidence interval (CI): 1.40 – 2.21]. Notably, the odds of headaches (OR = 1.78, 95% CI: 1.33 – 2.38) were higher than the odds of other back or body pain (OR = 1.62, 95% CI: 1.20 – 2.19). Children with current ASD were more likely to experience chronic physical pain than those without. This trend is more pronounced in headaches compared to other back or body pain. Our findings highlight the importance of prioritizing pain management in children with ASD through thorough physical assessments. En ligne : https://doi.org/10.1007/s10803-025-06846-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Chronic Physical Pain in Children With and Without Autism Spectrum Disorder in the United States: Findings from the 2016 – 2021 National Survey of Children’s Health [texte imprimé] / Qianyi XIE, Auteur ; Ning PAN, Auteur ; Xiaoxuan OU, Auteur ; Shuli SHEN, Auteur ; Jin JING, Auteur ; Xuchu WENG, Auteur ; Lei SHI, Auteur ; Lizi LIN, Auteur ; Jiaze YANG, Auteur ; Xiangpeng LI, Auteur ; Kai ZHANG, Auteur ; Fangfang CHEN, Auteur ; Yujie WANG, Auteur ; Jinqing WU, Auteur ; Xin WANG, Auteur . - p. 4010-4024. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-10 (October 2026) . - p. 4010-4024 Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) have long been reported to exhibit atypical pain experiences. Chronic physical pain is a significant comorbidity in ASD, leading to substantial burdens on daily functioning and quality of life. This study aims to examine the potential associations between ASD and chronic physical pain, including its specific types. The study used data on chronic physical pain and headaches from the 2016 – 2021 National Survey of Children’s Health. Participants were children aged 3 to 17 years old. Generalized linear models were used to estimate the associations between ASD and pain-related indicators (e.g., chronic physical pain, headaches, and other back or body pain). The study included 177,539 children, of whom 5311 had a current ASD diagnosis. Among children with current ASD, 14.41% experienced chronic physical pain, with 4.86% reporting headaches and 9.56% reporting other back or body pain. Compared to those without, children with current ASD had higher odds of chronic physical pain [odds ratio (OR) = 1.76, 95% confidence interval (CI): 1.40 – 2.21]. Notably, the odds of headaches (OR = 1.78, 95% CI: 1.33 – 2.38) were higher than the odds of other back or body pain (OR = 1.62, 95% CI: 1.20 – 2.19). Children with current ASD were more likely to experience chronic physical pain than those without. This trend is more pronounced in headaches compared to other back or body pain. Our findings highlight the importance of prioritizing pain management in children with ASD through thorough physical assessments. En ligne : https://doi.org/10.1007/s10803-025-06846-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability / Ning PAN in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1348-1357 Titre : Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability Type de document : texte imprimé Auteurs : Ning PAN, Auteur ; Bonnie AUYEUNG, Auteur ; Xin WANG, Auteur ; Li-Zi LIN, Auteur ; Hai-Lin LI, Auteur ; Xiao-Ling ZHAN, Auteur ; Cheng-Kai JIN, Auteur ; Jin JING, Auteur ; Xiu-Hong LI, Auteur Article en page(s) : p.1348-1357 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  empathy  intellectual disability  systemizing Index. décimale : PER Périodiques Résumé : Empathizing, systemizing, and empathizing-systemizing difference can be linked to autistic traits in the general adult population and those with autism spectrum disorder (ASD), but these profiles and associations remain unclear in children with ASD, with and without intellectual disability (ASD+ID; ASD-noID). We recruited three groups including 160 boys with ASD (73 ASD+ID; 87 ASD-noID) and 99 typically developing (TD) boys (6-12 years). We measured empathizing, systemizing, and empathizing-systemizing difference using the parent-reported child Empathy and Systemizing Quotient (EQ-C/SQ-C). We measured autistic traits using the Social Responsiveness Scale (SRS). Among the three groups, children with ASD+ID and ASD-noID scored lower on the EQ-C and SQ-C than TD children (all p?< 0.001). There was no difference in the EQ-C between children with ASD+ID and ASD-noID (16.59+5.53 vs. 16.23+5.85, p = 0.973), and the difference in the SQ-C attenuated to null when adjusting for intelligence between children with ASD-noID and TD children (18.89+7.80 vs. 24.15+6.73, p = 0.089). Children with ASD+ID scored higher on empathizing-systemizing difference than TD children but lower than children with ASD-noID (all p?< 0.05). Negative associations between EQ-C and all autistic traits, null associations between SQ-C and all autistic traits, and positive associations between empathizing-systemizing difference and all autistic traits were found in all groups. We observed differences in empathizing, systemizing, and empathizing-systemizing difference and the consistency of their associations with autistic traits among the three groups. Our findings provide implication that behavioral interventions of ASD should consider the balance of empathizing and systemizing. LAY SUMMARY: We examined the profiles of empathizing, systemizing, and empathizing-systemizing difference in children with autism spectrum disorder, with and without intellectual disability (ASD+ID; ASD-noID), and typically developing (TD) children aged 6-12 years. We observed differences in these profiles and the consistency of their associations with autistic traits among the three groups. Empathizing and empathizing-systemizing difference, rather than systemizing, were associated with autistic traits within the three groups. Our findings provide implication that behavioral interventions of ASD should consider these imbalance profiles. En ligne : http://dx.doi.org/10.1002/aur.2766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability [texte imprimé] / Ning PAN, Auteur ; Bonnie AUYEUNG, Auteur ; Xin WANG, Auteur ; Li-Zi LIN, Auteur ; Hai-Lin LI, Auteur ; Xiao-Ling ZHAN, Auteur ; Cheng-Kai JIN, Auteur ; Jin JING, Auteur ; Xiu-Hong LI, Auteur . - p.1348-1357. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1348-1357 Mots-clés : autism spectrum disorder  empathy  intellectual disability  systemizing Index. décimale : PER Périodiques Résumé : Empathizing, systemizing, and empathizing-systemizing difference can be linked to autistic traits in the general adult population and those with autism spectrum disorder (ASD), but these profiles and associations remain unclear in children with ASD, with and without intellectual disability (ASD+ID; ASD-noID). We recruited three groups including 160 boys with ASD (73 ASD+ID; 87 ASD-noID) and 99 typically developing (TD) boys (6-12 years). We measured empathizing, systemizing, and empathizing-systemizing difference using the parent-reported child Empathy and Systemizing Quotient (EQ-C/SQ-C). We measured autistic traits using the Social Responsiveness Scale (SRS). Among the three groups, children with ASD+ID and ASD-noID scored lower on the EQ-C and SQ-C than TD children (all p?< 0.001). There was no difference in the EQ-C between children with ASD+ID and ASD-noID (16.59+5.53 vs. 16.23+5.85, p = 0.973), and the difference in the SQ-C attenuated to null when adjusting for intelligence between children with ASD-noID and TD children (18.89+7.80 vs. 24.15+6.73, p = 0.089). Children with ASD+ID scored higher on empathizing-systemizing difference than TD children but lower than children with ASD-noID (all p?< 0.05). Negative associations between EQ-C and all autistic traits, null associations between SQ-C and all autistic traits, and positive associations between empathizing-systemizing difference and all autistic traits were found in all groups. We observed differences in empathizing, systemizing, and empathizing-systemizing difference and the consistency of their associations with autistic traits among the three groups. Our findings provide implication that behavioral interventions of ASD should consider the balance of empathizing and systemizing. LAY SUMMARY: We examined the profiles of empathizing, systemizing, and empathizing-systemizing difference in children with autism spectrum disorder, with and without intellectual disability (ASD+ID; ASD-noID), and typically developing (TD) children aged 6-12 years. We observed differences in these profiles and the consistency of their associations with autistic traits among the three groups. Empathizing and empathizing-systemizing difference, rather than systemizing, were associated with autistic traits within the three groups. Our findings provide implication that behavioral interventions of ASD should consider these imbalance profiles. En ligne : http://dx.doi.org/10.1002/aur.2766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Prevalence of Autism Spectrum Disorder in the United States is Stable in the COVID-19 Era / Xin WANG in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3309-3312 Titre : Prevalence of Autism Spectrum Disorder in the United States is Stable in the COVID-19 Era Type de document : texte imprimé Auteurs : Xin WANG, Auteur ; Xuchu WENG, Auteur ; Ning PAN, Auteur ; Xiuhong LI, Auteur ; Lizi LIN, Auteur ; Jin JING, Auteur Article en page(s) : p.3309-3312 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although the United States (US) have been monitoring the autism spectrum disorder (ASD) prevalence, whether the prevalence has continued to increase, decrease, fluctuate or reached a stable level remained unclear during the COVID-19 pandemic. We have requested the 2016-2021 National Survey of Children s Health (NSCH) data in the United States to estimate weighted ASD prevalence and assess linearity/nonlinearity in the time trend. We did not observe linear or nonlinear trends of the ASD prevalence during the 2016-2021 periods. The current ASD prevalence experienced a 0.3% drop from 2019 to 2020 but a 0.3% uptick in 2021, suggesting a stable trend during the COVID-19 pandemic. Our findings shed lights on the need for the modified strategy of monitor ASD prevalence during the COVID-19 era. En ligne : https://doi.org/10.1007/s10803-023-05915-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Prevalence of Autism Spectrum Disorder in the United States is Stable in the COVID-19 Era [texte imprimé] / Xin WANG, Auteur ; Xuchu WENG, Auteur ; Ning PAN, Auteur ; Xiuhong LI, Auteur ; Lizi LIN, Auteur ; Jin JING, Auteur . - p.3309-3312. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3309-3312 Index. décimale : PER Périodiques Résumé : Although the United States (US) have been monitoring the autism spectrum disorder (ASD) prevalence, whether the prevalence has continued to increase, decrease, fluctuate or reached a stable level remained unclear during the COVID-19 pandemic. We have requested the 2016-2021 National Survey of Children s Health (NSCH) data in the United States to estimate weighted ASD prevalence and assess linearity/nonlinearity in the time trend. We did not observe linear or nonlinear trends of the ASD prevalence during the 2016-2021 periods. The current ASD prevalence experienced a 0.3% drop from 2019 to 2020 but a 0.3% uptick in 2021, suggesting a stable trend during the COVID-19 pandemic. Our findings shed lights on the need for the modified strategy of monitor ASD prevalence during the COVID-19 era. En ligne : https://doi.org/10.1007/s10803-023-05915-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Psychometric properties of the Chinese version of the children's empathy quotient and systemizing quotient: 4-12years / Xin WANG in Autism Research, 15-9 (September 2022)  

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Socioeconomic factors and autism among 16- to 30-month-old children: Evidence from a national survey of China / Muqing CAO in Autism, 27-5 (July 2023)  

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The association between motor coordination impairment and restricted/repetitive behaviors in autistic children: The partial mediating effect of executive function / Chengkai JIN in Research in Autism Spectrum Disorders, 99 (November)  

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The National Prevalence of Neurodevelopmental Disorders and Their Associations With Health Conditions Among General Junior High School Students in China: Findings From the China Education Panel Survey / Shu-Li SHEN in Autism Research, 18-12 (December 2025)  

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The validity and reliability of the simplified Chinese version of the Social Communication Questionnaire / Si-Yu LIU in Autism Research, 15-9 (September 2022)  

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