Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children / Annelies A. DE BILDT in Journal of Autism and Developmental Disorders, 45-7 (July 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2076-2091 Titre : Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children Type de document : Texte imprimé et/ou numérique Auteurs : Annelies A. DE BILDT, Auteur ; Sjoerd SYTEMA, Auteur ; Eric ZANDER, Auteur ; Sven BÖLTE, Auteur ; Harald STURM, Auteur ; Nurit YIRMIYA, Auteur ; Maya YAARI, Auteur ; Tony CHARMAN, Auteur ; Erica SALOMONE, Auteur ; Ann LECOUTEUR, Auteur ; Jonathan GREEN, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Emma VAN DAALEN, Auteur ; Maretha V. DE JONGE, Auteur ; Emilía GUÐMUNDSDÓTTIR, Auteur ; Sigurrós JÓHANNSDÓTTIR, Auteur ; Marija RALEVA, Auteur ; Meri BOSKOVSKA, Auteur ; Bernadette ROGE, Auteur ; Sophie BADUEL, Auteur ; Irma MOILANEN, Auteur ; Anneli YLIHERVA, Auteur ; Jan K. BUITELAAR, Auteur ; IrisJ OOSTERLING, Auteur Année de publication : 2015 Article en page(s) : p.2076-2091 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Early diagnosis  Assessment Index. décimale : PER Périodiques Résumé : The current study aimed to investigate the Autism Diagnostic Interview-Revised (ADI-R) algorithms for toddlers and young preschoolers (Kim and Lord, J Autism Dev Disord 42(1):82–93, 2012) in a non-US sample from ten sites in nine countries (n = 1,104). The construct validity indicated a good fit of the algorithms. The diagnostic validity was lower, with satisfactorily high specificities but moderate sensitivities. Young children with clinical ASD and lower language ability were largely in the mild-to-moderate or moderate-to-severe concern ranges of the ADI-R, nearly half of the older and phrase speech ASD-group fell into the little-to-no concern range. Although broadly the findings support the toddler algorithms, further work is required to understand why they might have different properties in different samples to further inform research and clinical use. En ligne : http://dx.doi.org/10.1007/s10803-015-2372-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 [article] Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children [Texte imprimé et/ou numérique] / Annelies A. DE BILDT, Auteur ; Sjoerd SYTEMA, Auteur ; Eric ZANDER, Auteur ; Sven BÖLTE, Auteur ; Harald STURM, Auteur ; Nurit YIRMIYA, Auteur ; Maya YAARI, Auteur ; Tony CHARMAN, Auteur ; Erica SALOMONE, Auteur ; Ann LECOUTEUR, Auteur ; Jonathan GREEN, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Emma VAN DAALEN, Auteur ; Maretha V. DE JONGE, Auteur ; Emilía GUÐMUNDSDÓTTIR, Auteur ; Sigurrós JÓHANNSDÓTTIR, Auteur ; Marija RALEVA, Auteur ; Meri BOSKOVSKA, Auteur ; Bernadette ROGE, Auteur ; Sophie BADUEL, Auteur ; Irma MOILANEN, Auteur ; Anneli YLIHERVA, Auteur ; Jan K. BUITELAAR, Auteur ; IrisJ OOSTERLING, Auteur . - 2015 . - p.2076-2091. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2076-2091 Mots-clés : Autism spectrum disorders  Early diagnosis  Assessment Index. décimale : PER Périodiques Résumé : The current study aimed to investigate the Autism Diagnostic Interview-Revised (ADI-R) algorithms for toddlers and young preschoolers (Kim and Lord, J Autism Dev Disord 42(1):82–93, 2012) in a non-US sample from ten sites in nine countries (n = 1,104). The construct validity indicated a good fit of the algorithms. The diagnostic validity was lower, with satisfactorily high specificities but moderate sensitivities. Young children with clinical ASD and lower language ability were largely in the mild-to-moderate or moderate-to-severe concern ranges of the ADI-R, nearly half of the older and phrase speech ASD-group fell into the little-to-no concern range. Although broadly the findings support the toddler algorithms, further work is required to understand why they might have different properties in different samples to further inform research and clinical use. En ligne : http://dx.doi.org/10.1007/s10803-015-2372-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261

Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD) / Wouter G. STAAL in Journal of Autism and Developmental Disorders, 42-5 (May 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.885-888 Titre : Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD) Type de document : Texte imprimé et/ou numérique Auteurs : Wouter G. STAAL, Auteur ; Mariken DE KROM, Auteur ; Maretha V. DE JONGE, Auteur Année de publication : 2012 Article en page(s) : p.885-888 Langues : Anglais (eng) Mots-clés : DRD3  rs167771  Autism  Stereotyped behavior Index. décimale : PER Périodiques Résumé : Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor “insistence on sameness” (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind that these results would not be statistically significant if corrected for multiple testing. En ligne : http://dx.doi.org/10.1007/s10803-011-1312-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 [article] Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD) [Texte imprimé et/ou numérique] / Wouter G. STAAL, Auteur ; Mariken DE KROM, Auteur ; Maretha V. DE JONGE, Auteur . - 2012 . - p.885-888. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.885-888 Mots-clés : DRD3  rs167771  Autism  Stereotyped behavior Index. décimale : PER Périodiques Résumé : Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor “insistence on sameness” (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind that these results would not be statistically significant if corrected for multiple testing. En ligne : http://dx.doi.org/10.1007/s10803-011-1312-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154

Effects of Bumetanide on Neurocognitive Functioning in Children with Autism Spectrum Disorder: Secondary Analysis of a Randomized Placebo-Controlled Trial / Dorinde M. VAN ANDEL in Journal of Autism and Developmental Disorders, 54-3 (March 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-3 (March 2024) . - p.894-904 Titre : Effects of Bumetanide on Neurocognitive Functioning in Children with Autism Spectrum Disorder: Secondary Analysis of a Randomized Placebo-Controlled Trial Type de document : Texte imprimé et/ou numérique Auteurs : Dorinde M. VAN ANDEL, Auteur ; Jan J. SPRENGERS, Auteur ; Marsh KÖNIGS, Auteur ; Maretha V. DE JONGE, Auteur ; Hilgo BRUINING, Auteur Article en page(s) : p.894-904 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We present the secondary-analysis of neurocognitive tests in the 'Bumetanide in Autism Medication and Biomarker' (BAMBI;EUDRA-CT-2014-001560-35) study, a randomized double-blind placebo-controlled (1:1) trial testing 3-months bumetanide treatment (??1 mg twice-daily) in unmedicated children 7-15 years with ASD. Children with IQ???70 were analyzed for baseline deficits and treatment-effects on the intention-to-treat-population with generalized-linear-models, principal component analysis and network analysis. Ninety-two children were allocated to treatment and 83 eligible for analyses. Heterogeneous neurocognitive impairments were found that were unaffected by bumetanide treatment. Network analysis showed higher modularity after treatment (mean difference:-0.165, 95%CI:-0.317 to ??0.013,p = .034) and changes in the relative importance of response inhibition in the neurocognitive network (mean difference:-0.037, 95%CI:-0.073 to ??0.001,p = .042). This study offers perspectives to include neurocognitive tests in ASD trials. En ligne : https://doi.org/10.1007/s10803-022-05841-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] Effects of Bumetanide on Neurocognitive Functioning in Children with Autism Spectrum Disorder: Secondary Analysis of a Randomized Placebo-Controlled Trial [Texte imprimé et/ou numérique] / Dorinde M. VAN ANDEL, Auteur ; Jan J. SPRENGERS, Auteur ; Marsh KÖNIGS, Auteur ; Maretha V. DE JONGE, Auteur ; Hilgo BRUINING, Auteur . - p.894-904. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-3 (March 2024) . - p.894-904 Index. décimale : PER Périodiques Résumé : We present the secondary-analysis of neurocognitive tests in the 'Bumetanide in Autism Medication and Biomarker' (BAMBI;EUDRA-CT-2014-001560-35) study, a randomized double-blind placebo-controlled (1:1) trial testing 3-months bumetanide treatment (??1 mg twice-daily) in unmedicated children 7-15 years with ASD. Children with IQ???70 were analyzed for baseline deficits and treatment-effects on the intention-to-treat-population with generalized-linear-models, principal component analysis and network analysis. Ninety-two children were allocated to treatment and 83 eligible for analyses. Heterogeneous neurocognitive impairments were found that were unaffected by bumetanide treatment. Network analysis showed higher modularity after treatment (mean difference:-0.165, 95%CI:-0.317 to ??0.013,p = .034) and changes in the relative importance of response inhibition in the neurocognitive network (mean difference:-0.037, 95%CI:-0.073 to ??0.001,p = .042). This study offers perspectives to include neurocognitive tests in ASD trials. En ligne : https://doi.org/10.1007/s10803-022-05841-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

Evaluation of the ADOS Revised Algorithm: The Applicability in 558 Dutch Children and Adolescents / Annelies A. DE BILDT in Journal of Autism and Developmental Disorders, 39-9 (September 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-9 (September 2009) . - p.1350-1358 Titre : Evaluation of the ADOS Revised Algorithm: The Applicability in 558 Dutch Children and Adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Annelies A. DE BILDT, Auteur ; Natasja D.J. VAN LANG, Auteur ; Sjoerd SYTEMA, Auteur ; Ruud B. MINDERAA, Auteur ; Herman VAN ENGELAND, Auteur ; Maretha V. DE JONGE, Auteur Année de publication : 2009 Article en page(s) : p.1350-1358 Note générale : Open Access Langues : Anglais (eng) Mots-clés : ADOS Autism ASD Diagnosis Index. décimale : PER Périodiques Résumé : The revised ADOS algorithms, proposed by Gotham et al. (J Autism Dev Disord 37:613–627, 2007), were investigated in an independent sample of 558 Dutch children (modules 1, 2 and 3). The revised algorithms lead to better balanced sensitivity and specificity for modules 2 and 3, without losing efficiency of the classification. Including the restricted repetitive behaviour domain in the algorithm contributes to a clinical ASD classification in modules 2 and 3. For module 1, the results indicate less improvement, probably due to the low-functioning population. In most groups, the advantages of the revised algorithms are achieved without losing the strength of the original algorithm. En ligne : http://dx.doi.org/10.1007/s10803-009-0749-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=815 [article] Evaluation of the ADOS Revised Algorithm: The Applicability in 558 Dutch Children and Adolescents [Texte imprimé et/ou numérique] / Annelies A. DE BILDT, Auteur ; Natasja D.J. VAN LANG, Auteur ; Sjoerd SYTEMA, Auteur ; Ruud B. MINDERAA, Auteur ; Herman VAN ENGELAND, Auteur ; Maretha V. DE JONGE, Auteur . - 2009 . - p.1350-1358. Open Access Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-9 (September 2009) . - p.1350-1358 Mots-clés : ADOS Autism ASD Diagnosis Index. décimale : PER Périodiques Résumé : The revised ADOS algorithms, proposed by Gotham et al. (J Autism Dev Disord 37:613–627, 2007), were investigated in an independent sample of 558 Dutch children (modules 1, 2 and 3). The revised algorithms lead to better balanced sensitivity and specificity for modules 2 and 3, without losing efficiency of the classification. Including the restricted repetitive behaviour domain in the algorithm contributes to a clinical ASD classification in modules 2 and 3. For module 1, the results indicate less improvement, probably due to the low-functioning population. In most groups, the advantages of the revised algorithms are achieved without losing the strength of the original algorithm. En ligne : http://dx.doi.org/10.1007/s10803-009-0749-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=815

How useful is the Social Communication Questionnaire in toddlers at risk of autism spectrum disorder? / Iris J. OOSTERLING in Journal of Child Psychology and Psychiatry, 51-11 (November 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-11 (November 2010) . - p.1260-1268 Titre : How useful is the Social Communication Questionnaire in toddlers at risk of autism spectrum disorder? Type de document : Texte imprimé et/ou numérique Auteurs : Iris J. OOSTERLING, Auteur ; Sophie H. N. SWINKELS, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur ; Maretha V. DE JONGE, Auteur ; Janne C. VISSER, Auteur ; Sascha ROOS, Auteur Année de publication : 2010 Article en page(s) : p.1260-1268 Langues : Anglais (eng) Mots-clés : SCQ ADI-R ADOS review validity toddlers autism Index. décimale : PER Périodiques Résumé : Background:  The Social Communication Questionnaire (SCQ) is a screening instrument with established validity against the Autism Diagnostic Interview-Revised (ADI-R) in children aged 4 years and older. Indices of diagnostic accuracy have been shown to be strong in school-aged samples; however, relatively little is known about the performance of the SCQ in toddlers at risk of autism spectrum disorder (ASD). Methods:  This study replicates and extends previous research by Corsello et al. (2007) in a comparatively large (N = 208), substantially younger (20–40 months) sample of children at high risk of ASD. The usefulness of the SCQ as a second-level screening instrument with different cut-off scores was evaluated in relation to IQ, age, and type of ASD diagnosis. The use of the SCQ as compared to the ADI-R was evaluated against clinical diagnosis, both alone and in combination with the ADOS. Results:  The SCQ with different cut-offs consistently showed an unsatisfactory balance between sensitivity and specificity in screening for ASD in high-risk toddlers, with only a few exceptions for specific age, IQ, or diagnostic groups. Even though the SCQ and ADI-R were highly correlated, diagnostic agreement with the best evidence clinical diagnosis was poor for both measures. The ADOS used alone consistently had the highest predictive value. For autism versus not-autism, the combined SCQ and ADOS performed as well as the ADOS alone and notably better than the combination ADI-R and ADOS. Conclusions:  The SCQ is likely to result in a number of false-positive findings, particularly in children with autism symptomatology, and the balance between sensitivity and specificity is poor. The ADOS should be considered the most valid and reliable diagnostic instrument in these very young at-risk children. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02246.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110 [article] How useful is the Social Communication Questionnaire in toddlers at risk of autism spectrum disorder? [Texte imprimé et/ou numérique] / Iris J. OOSTERLING, Auteur ; Sophie H. N. SWINKELS, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur ; Maretha V. DE JONGE, Auteur ; Janne C. VISSER, Auteur ; Sascha ROOS, Auteur . - 2010 . - p.1260-1268. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-11 (November 2010) . - p.1260-1268 Mots-clés : SCQ ADI-R ADOS review validity toddlers autism Index. décimale : PER Périodiques Résumé : Background:  The Social Communication Questionnaire (SCQ) is a screening instrument with established validity against the Autism Diagnostic Interview-Revised (ADI-R) in children aged 4 years and older. Indices of diagnostic accuracy have been shown to be strong in school-aged samples; however, relatively little is known about the performance of the SCQ in toddlers at risk of autism spectrum disorder (ASD). Methods:  This study replicates and extends previous research by Corsello et al. (2007) in a comparatively large (N = 208), substantially younger (20–40 months) sample of children at high risk of ASD. The usefulness of the SCQ as a second-level screening instrument with different cut-off scores was evaluated in relation to IQ, age, and type of ASD diagnosis. The use of the SCQ as compared to the ADI-R was evaluated against clinical diagnosis, both alone and in combination with the ADOS. Results:  The SCQ with different cut-offs consistently showed an unsatisfactory balance between sensitivity and specificity in screening for ASD in high-risk toddlers, with only a few exceptions for specific age, IQ, or diagnostic groups. Even though the SCQ and ADI-R were highly correlated, diagnostic agreement with the best evidence clinical diagnosis was poor for both measures. The ADOS used alone consistently had the highest predictive value. For autism versus not-autism, the combined SCQ and ADOS performed as well as the ADOS alone and notably better than the combination ADI-R and ADOS. Conclusions:  The SCQ is likely to result in a number of false-positive findings, particularly in children with autism symptomatology, and the balance between sensitivity and specificity is poor. The ADOS should be considered the most valid and reliable diagnostic instrument in these very young at-risk children. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02246.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110

Improved Diagnostic Validity of the ADOS Revised Algorithms: A Replication Study in an Independent Sample / Iris J. OOSTERLING in Journal of Autism and Developmental Disorders, 40-6 (June 2010)  

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New Interview and Observation Measures of the Broader Autism Phenotype: Description of Strategy and Reliability Findings for the Interview Measures / Jeremy R. PARR in Autism Research, 8-5 (October 2015)  

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A new symptom model for autism cross-validated in an independent sample / Anne BOOMSMA in Journal of Child Psychology and Psychiatry, 49-8 (August 2008)  

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A Novel 6.14 Mb Duplication of Chromosome 8p21 in a Patient with Autism and Self Mutilation / Heval M. OZGEN in Journal of Autism and Developmental Disorders, 39-2 (February 2009)  

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Standardized ADOS Scores: Measuring Severity of Autism Spectrum Disorders in a Dutch Sample / Annelies A. DE BILDT in Journal of Autism and Developmental Disorders, 41-3 (March 2011)  

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Stop and Change: Inhibition and Flexibility Skills Are Related to Repetitive Behavior in Children and Young Adults with Autism Spectrum Disorders / Mandy A. L. MOSTERT-KERCKHOFFS in Journal of Autism and Developmental Disorders, 45-10 (October 2015)  

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