Exploring autism via the retina: Comparative insights in children with autism spectrum disorder and typical development / Yuexuan WANG ; Huiyun GAO ; Zhengwang XIA ; Chaofan ZENG ; Kun HUANG ; Zhaoqi ZHU ; Jianfeng LU ; Qiang CHEN ; Xiaoyan KE ; Weiwei ZHANG in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1520-1533 Titre : Exploring autism via the retina: Comparative insights in children with autism spectrum disorder and typical development Type de document : texte imprimé Auteurs : Yuexuan WANG, Auteur ; Huiyun GAO, Auteur ; Zhengwang XIA, Auteur ; Chaofan ZENG, Auteur ; Kun HUANG, Auteur ; Zhaoqi ZHU, Auteur ; Jianfeng LU, Auteur ; Qiang CHEN, Auteur ; Xiaoyan KE, Auteur ; Weiwei ZHANG, Auteur Article en page(s) : p.1520-1533 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a widely recognized neurodevelopmental disorder, yet the identification of reliable imaging biomarkers for its early diagnosis remains a challenge. Considering the specific manifestations of ASD in the eyes and the interconnectivity between the brain and the eyes, this study investigates ASD through the lens of retinal analysis. We specifically examined differences in the macular region of the retina using optical coherence tomography (OCT)/optical coherence tomography angiography (OCTA) images between children diagnosed with ASD and those with typical development (TD). Our findings present potential novel characteristics of ASD: the thickness of the ellipsoid zone (EZ) with cone photoreceptors was significantly increased in ASD; the large-caliber arteriovenous of the inner retina was significantly reduced in ASD; these changes in the EZ and arteriovenous were more significant in the left eye than in the right eye. These observations of photoreceptor alterations, vascular function changes, and lateralization phenomena in ASD warrant further investigation, and we hope that this work can advance interdisciplinary understanding of ASD. En ligne : https://doi.org/10.1002/aur.3204 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Exploring autism via the retina: Comparative insights in children with autism spectrum disorder and typical development [texte imprimé] / Yuexuan WANG, Auteur ; Huiyun GAO, Auteur ; Zhengwang XIA, Auteur ; Chaofan ZENG, Auteur ; Kun HUANG, Auteur ; Zhaoqi ZHU, Auteur ; Jianfeng LU, Auteur ; Qiang CHEN, Auteur ; Xiaoyan KE, Auteur ; Weiwei ZHANG, Auteur . - p.1520-1533. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1520-1533 Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a widely recognized neurodevelopmental disorder, yet the identification of reliable imaging biomarkers for its early diagnosis remains a challenge. Considering the specific manifestations of ASD in the eyes and the interconnectivity between the brain and the eyes, this study investigates ASD through the lens of retinal analysis. We specifically examined differences in the macular region of the retina using optical coherence tomography (OCT)/optical coherence tomography angiography (OCTA) images between children diagnosed with ASD and those with typical development (TD). Our findings present potential novel characteristics of ASD: the thickness of the ellipsoid zone (EZ) with cone photoreceptors was significantly increased in ASD; the large-caliber arteriovenous of the inner retina was significantly reduced in ASD; these changes in the EZ and arteriovenous were more significant in the left eye than in the right eye. These observations of photoreceptor alterations, vascular function changes, and lateralization phenomena in ASD warrant further investigation, and we hope that this work can advance interdisciplinary understanding of ASD. En ligne : https://doi.org/10.1002/aur.3204 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Fundus Peripapillary Vascular Changes in Autism Spectrum Disorder: A Cross-Sectional Study / Yuexuan WANG in Autism Research, 18-9 (September 2025)  

Public ISBD [article]  inAutism Research > 18-9 (September 2025) . - p.1775-1795 Titre : Fundus Peripapillary Vascular Changes in Autism Spectrum Disorder: A Cross-Sectional Study Type de document : texte imprimé Auteurs : Yuexuan WANG, Auteur ; Yonglu WANG, Auteur ; Zhaoqi ZHU, Auteur ; Zhengwang XIA, Auteur ; Ningyu WANG, Auteur ; Mingchao LI, Auteur ; Ziyun JIAO, Auteur ; Nairong PAN, Auteur ; Youqiang ZHANG, Auteur ; Qiang CHEN, Auteur ; Xiaoyan KE, Auteur ; Weiwei ZHANG, Auteur Article en page(s) : p.1775-1795 Langues : Anglais (eng) Mots-clés : angiography  autism spectrum disorder  functional magnetic resonance imaging  interdisciplinary understanding  optic disc  optical coherence tomography  retinal vasculature Index. décimale : PER Périodiques Résumé : ABSTRACT In this cross-sectional study, participants were recruited through convenience sampling from the Children's Mental Health Research Center at The Affiliated Brain Hospital of Nanjing Medical University and the Department of Ophthalmology at The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, between December 2019 and October 2024. A total of 200 eyes were ultimately enrolled in this study, sourced from 53 individuals with ASD, aged between 7 and 13 years, and an equal number of age- and sex-matched neurotypical (NT) controls. The aim of this research is to explore the changes in retinal and choroidal vasculature in children with ASD, evaluated through optical coherence tomography and its angiography, and to further investigate the potential value of retinal vascular characteristics in the auxiliary screening and diagnosis of ASD. We analyzed intergroup differences in perfusion density (PD), vessel density, flux index (FI), fractal dimension (FD), and vessel diameter (Dm) in the peripapillary region, further stratified by subquadrants and vessel types. The results show that ASD children exhibited significant differences compared to neurotypical controls, including increased PD and Dm in the supero-nasal quadrant (p=0.01), changes in capillary FI in the nasal quadrant (p=0.008), increased venous FD (p=0.009), and abnormal choroidal FI in the temporal quadrant (p=0.008). A random forest classification model constructed based on these key features demonstrated promising performance (AUC=0.7853) in distinguishing ASD from NT individuals, highlighting the potential of retinal vascular characteristics for auxiliary ASD screening. Moreover, retinal vascular parameters were significantly correlated (p=0.01) with blood oxygen level-dependent signals from functional magnetic resonance imaging in several brain regions, such as the amygdala (p=0.004 0.009) and temporal lobe (p=0.000 0.009). Further stepwise regression analysis indicates that key retinal vascular characteristics could partially predict core clinical features of ASD, such as social functioning (adjusted R 2 =0.091 0.104, quantified by total and subscale scores of Social Responsiveness Scale) and cognitive ability (adjusted R 2 =0.2785, quantified by total intelligence quotient scores). This study underscores the potential of retinal vascular features as biomarkers for ASD and provides a basis for future research on non-invasive retinal imaging-based approaches for ASD screening and diagnosis, while offering new perspectives for understanding the pathological mechanisms and clinical applications of ASD. En ligne : https://doi.org/10.1002/aur.70094 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Fundus Peripapillary Vascular Changes in Autism Spectrum Disorder: A Cross-Sectional Study [texte imprimé] / Yuexuan WANG, Auteur ; Yonglu WANG, Auteur ; Zhaoqi ZHU, Auteur ; Zhengwang XIA, Auteur ; Ningyu WANG, Auteur ; Mingchao LI, Auteur ; Ziyun JIAO, Auteur ; Nairong PAN, Auteur ; Youqiang ZHANG, Auteur ; Qiang CHEN, Auteur ; Xiaoyan KE, Auteur ; Weiwei ZHANG, Auteur . - p.1775-1795. Langues : Anglais (eng) in Autism Research > 18-9 (September 2025) . - p.1775-1795 Mots-clés : angiography  autism spectrum disorder  functional magnetic resonance imaging  interdisciplinary understanding  optic disc  optical coherence tomography  retinal vasculature Index. décimale : PER Périodiques Résumé : ABSTRACT In this cross-sectional study, participants were recruited through convenience sampling from the Children's Mental Health Research Center at The Affiliated Brain Hospital of Nanjing Medical University and the Department of Ophthalmology at The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, between December 2019 and October 2024. A total of 200 eyes were ultimately enrolled in this study, sourced from 53 individuals with ASD, aged between 7 and 13 years, and an equal number of age- and sex-matched neurotypical (NT) controls. The aim of this research is to explore the changes in retinal and choroidal vasculature in children with ASD, evaluated through optical coherence tomography and its angiography, and to further investigate the potential value of retinal vascular characteristics in the auxiliary screening and diagnosis of ASD. We analyzed intergroup differences in perfusion density (PD), vessel density, flux index (FI), fractal dimension (FD), and vessel diameter (Dm) in the peripapillary region, further stratified by subquadrants and vessel types. The results show that ASD children exhibited significant differences compared to neurotypical controls, including increased PD and Dm in the supero-nasal quadrant (p=0.01), changes in capillary FI in the nasal quadrant (p=0.008), increased venous FD (p=0.009), and abnormal choroidal FI in the temporal quadrant (p=0.008). A random forest classification model constructed based on these key features demonstrated promising performance (AUC=0.7853) in distinguishing ASD from NT individuals, highlighting the potential of retinal vascular characteristics for auxiliary ASD screening. Moreover, retinal vascular parameters were significantly correlated (p=0.01) with blood oxygen level-dependent signals from functional magnetic resonance imaging in several brain regions, such as the amygdala (p=0.004 0.009) and temporal lobe (p=0.000 0.009). Further stepwise regression analysis indicates that key retinal vascular characteristics could partially predict core clinical features of ASD, such as social functioning (adjusted R 2 =0.091 0.104, quantified by total and subscale scores of Social Responsiveness Scale) and cognitive ability (adjusted R 2 =0.2785, quantified by total intelligence quotient scores). This study underscores the potential of retinal vascular features as biomarkers for ASD and provides a basis for future research on non-invasive retinal imaging-based approaches for ASD screening and diagnosis, while offering new perspectives for understanding the pathological mechanisms and clinical applications of ASD. En ligne : https://doi.org/10.1002/aur.70094 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

Socioeconomic factors and autism among 16- to 30-month-old children: Evidence from a national survey of China / Muqing CAO in Autism, 27-5 (July 2023)  

Public ISBD [article]  inAutism > 27-5 (July 2023) . - p.1283-1294 Titre : Socioeconomic factors and autism among 16- to 30-month-old children: Evidence from a national survey of China Type de document : texte imprimé Auteurs : Muqing CAO, Auteur ; Li LI, Auteur ; Hein RAAT, Auteur ; Amy VAN GRIEKEN, Auteur ; Xin WANG, Auteur ; Lizi LIN, Auteur ; Qiang CHEN, Auteur ; Jin JING, Auteur Article en page(s) : p.1283-1294 Langues : Anglais (eng) Mots-clés : autism;socioeconomic factors;toddlers Index. décimale : PER Périodiques Résumé : We examined the association of socioeconomic status with the diagnosis of autism during 16-30 months of age. Using data from a national survey in China, we included 6049 children (55.6% male) in the final analysis, among which 71 of them were clinically diagnosed with autism. Adjusted for covariates, the odds ratios for having the diagnosis of autism (2.46, 95% confidence interval: [1.32, 4.59]) among children whose mother?s level is "junior middle school or below" were significantly higher than children whose mother?s level is "college or above." Among children of lower educated mothers, there is a higher risk of being diagnosed with autism at a young age. We recommend more support for families with a low socioeconomic status to early detect, diagnose, and manage autism. Lay abstract Does being born in a family of high socioeconomic status mean a higher risk of being diagnosed with autism? The evidence from the Asian area is lacking. This research was conducted among 6049 toddlers who went through an evaluation-diagnose procedure of autism and whose parents were surveyed during the national survey of China, 2016-2017. Parents reported their education levels, occupations, family income, and ethnic background. We recruited the toddlers and parents from kindergartens, communities, and hospitals in five geographically representative areas of China. On average, these toddlers were 23 months of age. We found toddlers whose mothers had less than 9 years of education (junior middle school or below) had 2.46 times the chance to get a diagnosis of autism, compared with toddlers whose mothers had more than 15 years of education (college or above). We also found that 1.17 toddlers could be diagnosed with autism in each 100 Chinese toddlers. These findings have important implications for providing support to families that have low socioeconomic status, especially families with a mother who did not complete 9 years of education. Early detection programs focused on children from low socioeconomic backgrounds should be promoted. En ligne : http://dx.doi.org/10.1177/13623613221132743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507 [article] Socioeconomic factors and autism among 16- to 30-month-old children: Evidence from a national survey of China [texte imprimé] / Muqing CAO, Auteur ; Li LI, Auteur ; Hein RAAT, Auteur ; Amy VAN GRIEKEN, Auteur ; Xin WANG, Auteur ; Lizi LIN, Auteur ; Qiang CHEN, Auteur ; Jin JING, Auteur . - p.1283-1294. Langues : Anglais (eng) in Autism > 27-5 (July 2023) . - p.1283-1294 Mots-clés : autism;socioeconomic factors;toddlers Index. décimale : PER Périodiques Résumé : We examined the association of socioeconomic status with the diagnosis of autism during 16-30 months of age. Using data from a national survey in China, we included 6049 children (55.6% male) in the final analysis, among which 71 of them were clinically diagnosed with autism. Adjusted for covariates, the odds ratios for having the diagnosis of autism (2.46, 95% confidence interval: [1.32, 4.59]) among children whose mother?s level is "junior middle school or below" were significantly higher than children whose mother?s level is "college or above." Among children of lower educated mothers, there is a higher risk of being diagnosed with autism at a young age. We recommend more support for families with a low socioeconomic status to early detect, diagnose, and manage autism. Lay abstract Does being born in a family of high socioeconomic status mean a higher risk of being diagnosed with autism? The evidence from the Asian area is lacking. This research was conducted among 6049 toddlers who went through an evaluation-diagnose procedure of autism and whose parents were surveyed during the national survey of China, 2016-2017. Parents reported their education levels, occupations, family income, and ethnic background. We recruited the toddlers and parents from kindergartens, communities, and hospitals in five geographically representative areas of China. On average, these toddlers were 23 months of age. We found toddlers whose mothers had less than 9 years of education (junior middle school or below) had 2.46 times the chance to get a diagnosis of autism, compared with toddlers whose mothers had more than 15 years of education (college or above). We also found that 1.17 toddlers could be diagnosed with autism in each 100 Chinese toddlers. These findings have important implications for providing support to families that have low socioeconomic status, especially families with a mother who did not complete 9 years of education. Early detection programs focused on children from low socioeconomic backgrounds should be promoted. En ligne : http://dx.doi.org/10.1177/13623613221132743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507

The validity and reliability of the simplified Chinese version of the Social Communication Questionnaire / Si-Yu LIU in Autism Research, 15-9 (September 2022)  

Public ISBD [article]  inAutism Research > 15-9 (September 2022) . - p.1732-1741 Titre : The validity and reliability of the simplified Chinese version of the Social Communication Questionnaire Type de document : texte imprimé Auteurs : Si-Yu LIU, Auteur ; Xin WANG, Auteur ; Qiang CHEN, Auteur ; Jia-Jie CHEN, Auteur ; Cheng-Kai JIN, Auteur ; Xiao-Ling ZHAN, Auteur ; Cui-Hua GUO, Auteur ; Xiu-Hong LI, Auteur ; Li-Zi LIN, Auteur ; Jin JING, Auteur Article en page(s) : p.1732-1741 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Child, Preschool  China  Communication  Humans  Psychometrics  Reproducibility of Results  Surveys and Questionnaires  Social Communication Questionnaire  autism spectrum disorder  reliability  validity Index. décimale : PER Périodiques Résumé : This study aims to validate the simplified Chinese version of the Social Communication Questionnaire (SCQ) in children aged 2-12years from both general and clinical populations. We recruited 819 Chinese children in this study, including 505 typically developing (TD) children, 202 children with autism spectrum disorder (ASD) and 112 children with non-ASD neurodevelopmental disorders. All the children's parents completed the simplified Chinese version of the SCQ and all children with ASD were additionally assessed for intelligence and the Childhood Autism Rating Scale to confirm their diagnosis. We have developed a 40-item, 4-factor structure of SCQ with two domains (social communication and social interaction; and restricted, repetitive, and stereotyped patterns of behavior), which showed adequate goodness of fit (comparative fit index [CFI] = 0.96, Tucker-Lewisindex [TLI] = 0.95, standardized root mean squared residual [SRMR] = 0.07, root mean square error of approximation [RMSEA] = 0.05), with good internal consistency (Cronbach's alpha = 0.92). We have provided different cut-offs to distinguish ASD cases from TD children (11 for children under 4years [sensitivity: 0.96, specificity: 0.95], 12 for children 4years and above [sensitivity: 0.93, specificity: 0.98]) or children with other neurodevelopmental disorders (14 [sensitivity: 0.85, specificity: 0.88]). Through this large sample validation, we confirmed that the simplified Chinese version of the SCQ could be used for children aged 2-12years with relatively good psychometric properties. LAY SUMMARY: We aimed to develop the simplified Chinese version of the Social Communication Questionnaire (SCQ) for Chinese children aged 2-12years as a screening tool to identified potential risk of autism spectrum disorder (ASD). We have developed a 40-item, 4-factor structure of SCQ with two domains, which showed adequate goodness of fit and good psychometric properties. We also provided different cut-offs to identify ASD cases in general or clinical populations. En ligne : http://dx.doi.org/10.1002/aur.2726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] The validity and reliability of the simplified Chinese version of the Social Communication Questionnaire [texte imprimé] / Si-Yu LIU, Auteur ; Xin WANG, Auteur ; Qiang CHEN, Auteur ; Jia-Jie CHEN, Auteur ; Cheng-Kai JIN, Auteur ; Xiao-Ling ZHAN, Auteur ; Cui-Hua GUO, Auteur ; Xiu-Hong LI, Auteur ; Li-Zi LIN, Auteur ; Jin JING, Auteur . - p.1732-1741. Langues : Anglais (eng) in Autism Research > 15-9 (September 2022) . - p.1732-1741 Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Child, Preschool  China  Communication  Humans  Psychometrics  Reproducibility of Results  Surveys and Questionnaires  Social Communication Questionnaire  autism spectrum disorder  reliability  validity Index. décimale : PER Périodiques Résumé : This study aims to validate the simplified Chinese version of the Social Communication Questionnaire (SCQ) in children aged 2-12years from both general and clinical populations. We recruited 819 Chinese children in this study, including 505 typically developing (TD) children, 202 children with autism spectrum disorder (ASD) and 112 children with non-ASD neurodevelopmental disorders. All the children's parents completed the simplified Chinese version of the SCQ and all children with ASD were additionally assessed for intelligence and the Childhood Autism Rating Scale to confirm their diagnosis. We have developed a 40-item, 4-factor structure of SCQ with two domains (social communication and social interaction; and restricted, repetitive, and stereotyped patterns of behavior), which showed adequate goodness of fit (comparative fit index [CFI] = 0.96, Tucker-Lewisindex [TLI] = 0.95, standardized root mean squared residual [SRMR] = 0.07, root mean square error of approximation [RMSEA] = 0.05), with good internal consistency (Cronbach's alpha = 0.92). We have provided different cut-offs to distinguish ASD cases from TD children (11 for children under 4years [sensitivity: 0.96, specificity: 0.95], 12 for children 4years and above [sensitivity: 0.93, specificity: 0.98]) or children with other neurodevelopmental disorders (14 [sensitivity: 0.85, specificity: 0.88]). Through this large sample validation, we confirmed that the simplified Chinese version of the SCQ could be used for children aged 2-12years with relatively good psychometric properties. LAY SUMMARY: We aimed to develop the simplified Chinese version of the Social Communication Questionnaire (SCQ) for Chinese children aged 2-12years as a screening tool to identified potential risk of autism spectrum disorder (ASD). We have developed a 40-item, 4-factor structure of SCQ with two domains, which showed adequate goodness of fit and good psychometric properties. We also provided different cut-offs to identify ASD cases in general or clinical populations. En ligne : http://dx.doi.org/10.1002/aur.2726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

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