Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults / Jinni SU in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1763-1775 Titre : Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults Type de document : texte imprimé Auteurs : Jinni SU, Auteur ; Sally I. Chun KUO, Auteur ; Fazil ALIEV, Auteur ; Jill A. RABINOWITZ, Auteur ; Belal JAMIL, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Meredith FRANCIS, Auteur ; Victor HESSELBROCK, Auteur ; Chella KAMARAJAN, Auteur ; Sivan KINREICH, Auteur ; John KRAMER, Auteur ; Donbing LAI, Auteur ; Vivia MCCUTCHEON, Auteur ; Jacquelyn MEYERS, Auteur ; Ashwini PANDEY, Auteur ; Gayathri PANDEY, Auteur ; Martin H. PLAWECKI, Auteur ; Marc SCHUCKIT, Auteur ; Jay TISCHFIELD, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1763-1775 Langues : Anglais (eng) Mots-clés : COGA  alcohol use  gene-environment interaction  polygenic scores  social support Index. décimale : PER Périodiques Résumé : Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use. En ligne : https://dx.doi.org/10.1017/S0954579423001141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults [texte imprimé] / Jinni SU, Auteur ; Sally I. Chun KUO, Auteur ; Fazil ALIEV, Auteur ; Jill A. RABINOWITZ, Auteur ; Belal JAMIL, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Meredith FRANCIS, Auteur ; Victor HESSELBROCK, Auteur ; Chella KAMARAJAN, Auteur ; Sivan KINREICH, Auteur ; John KRAMER, Auteur ; Donbing LAI, Auteur ; Vivia MCCUTCHEON, Auteur ; Jacquelyn MEYERS, Auteur ; Ashwini PANDEY, Auteur ; Gayathri PANDEY, Auteur ; Martin H. PLAWECKI, Auteur ; Marc SCHUCKIT, Auteur ; Jay TISCHFIELD, Auteur ; Danielle M. DICK, Auteur . - p.1763-1775. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1763-1775 Mots-clés : COGA  alcohol use  gene-environment interaction  polygenic scores  social support Index. décimale : PER Périodiques Résumé : Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use. En ligne : https://dx.doi.org/10.1017/S0954579423001141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance / Sally I. Chun KUO in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1865-1875 Titre : The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance Type de document : texte imprimé Auteurs : Sally I. Chun KUO, Auteur ; Holly E. POORE, Auteur ; Peter B. BARR, Auteur ; Isabella S. CHIRICO, Auteur ; Fazil ALIEV, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Chella KAMARAJAN, Auteur ; John R. KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Martin H. PLAWECKI, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1865-1875 Langues : Anglais (eng) Mots-clés : adolescent externalizing  gene-environment correlation  genetic nurture  parenting  polygenic score Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine possible pathways by which genetic risk associated with externalizing is transmitted in families. We used molecular data to disentangle the genetic and environmental pathways contributing to adolescent externalizing behavior in a sample of 1,111 adolescents (50% female; 719 European and 392 African ancestry) and their parents from the Collaborative Study on the Genetics of Alcoholism. We found evidence for genetic nurture such that parental externalizing polygenic scores were associated with adolescent externalizing behavior, over and above the effect of adolescents’ own externalizing polygenic scores. Mediation analysis indicated that parental externalizing psychopathology partly explained the effect of parental genotype on children’s externalizing behavior. We also found evidence for evocative gene-environment correlation, whereby adolescent externalizing polygenic scores were associated with lower parent “child communication, less parent “child closeness, and lower parental knowledge, controlling for parental genotype. These effects were observed among participants of European ancestry but not African ancestry, likely due to the limited predictive power of polygenic scores across ancestral background. These results demonstrate that in addition to genetic transmission, genes influence offspring behavior through the influence of parental genotypes on their children’s environmental experiences, and the role of children’s genotypes in shaping parent “child relationships. En ligne : http://dx.doi.org/10.1017/S0954579422000700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance [texte imprimé] / Sally I. Chun KUO, Auteur ; Holly E. POORE, Auteur ; Peter B. BARR, Auteur ; Isabella S. CHIRICO, Auteur ; Fazil ALIEV, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Chella KAMARAJAN, Auteur ; John R. KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Martin H. PLAWECKI, Auteur ; Danielle M. DICK, Auteur . - p.1865-1875. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1865-1875 Mots-clés : adolescent externalizing  gene-environment correlation  genetic nurture  parenting  polygenic score Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine possible pathways by which genetic risk associated with externalizing is transmitted in families. We used molecular data to disentangle the genetic and environmental pathways contributing to adolescent externalizing behavior in a sample of 1,111 adolescents (50% female; 719 European and 392 African ancestry) and their parents from the Collaborative Study on the Genetics of Alcoholism. We found evidence for genetic nurture such that parental externalizing polygenic scores were associated with adolescent externalizing behavior, over and above the effect of adolescents’ own externalizing polygenic scores. Mediation analysis indicated that parental externalizing psychopathology partly explained the effect of parental genotype on children’s externalizing behavior. We also found evidence for evocative gene-environment correlation, whereby adolescent externalizing polygenic scores were associated with lower parent “child communication, less parent “child closeness, and lower parental knowledge, controlling for parental genotype. These effects were observed among participants of European ancestry but not African ancestry, likely due to the limited predictive power of polygenic scores across ancestral background. These results demonstrate that in addition to genetic transmission, genes influence offspring behavior through the influence of parental genotypes on their children’s environmental experiences, and the role of children’s genotypes in shaping parent “child relationships. En ligne : http://dx.doi.org/10.1017/S0954579422000700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk / Seung Bin CHO in Development and Psychopathology, 33-3 (August 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-3 (August 2021) . - p.1097-1106 Titre : Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk Type de document : texte imprimé Auteurs : Seung Bin CHO, Auteur ; Rebecca L. SMITH, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Victor HESSELBROCK, Auteur ; John KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; John NURNBERGER, Auteur ; Marc SCHUCKIT, Auteur ; Yong ZANG, Auteur ; Danielle M. DICK, Auteur ; Jessica E. SALVATORE, Auteur Article en page(s) : p.1097-1106 Langues : Anglais (eng) Mots-clés : alcohol  development  genetics  marital status  young adults Index. décimale : PER Périodiques Résumé : Many studies demonstrate that marriage protects against risky alcohol use and moderates genetic influences on alcohol outcomes; however, previous work has not considered these effects from a developmental perspective or in high-risk individuals. These represent important gaps, as it cannot be assumed that marriage has uniform effects across development or in high-risk samples. We took a longitudinal developmental approach to examine whether marital status was associated with heavy episodic drinking (HED), and whether marital status moderated polygenic influences on HED. Our sample included 937 individuals (53.25% female) from the Collaborative Study on the Genetics of Alcoholism who reported their HED and marital status biennially between the ages of 21 and 25. Polygenic risk scores (PRS) were derived from a genome-wide association study of alcohol consumption. Marital status was not associated with HED; however, we observed pathogenic gene-by-environment effects that changed across young adulthood. Among those who married young (age 21), individuals with higher PRS reported more HED; however, these effects decayed over time. The same pattern was found in supplementary analyses using parental history of alcohol use disorder as the index of genetic liability. Our findings indicate that early marriage may exacerbate risk for those with higher polygenic load. En ligne : http://dx.doi.org/10.1017/S0954579420000371 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk [texte imprimé] / Seung Bin CHO, Auteur ; Rebecca L. SMITH, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Victor HESSELBROCK, Auteur ; John KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; John NURNBERGER, Auteur ; Marc SCHUCKIT, Auteur ; Yong ZANG, Auteur ; Danielle M. DICK, Auteur ; Jessica E. SALVATORE, Auteur . - p.1097-1106. Langues : Anglais (eng) in Development and Psychopathology > 33-3 (August 2021) . - p.1097-1106 Mots-clés : alcohol  development  genetics  marital status  young adults Index. décimale : PER Périodiques Résumé : Many studies demonstrate that marriage protects against risky alcohol use and moderates genetic influences on alcohol outcomes; however, previous work has not considered these effects from a developmental perspective or in high-risk individuals. These represent important gaps, as it cannot be assumed that marriage has uniform effects across development or in high-risk samples. We took a longitudinal developmental approach to examine whether marital status was associated with heavy episodic drinking (HED), and whether marital status moderated polygenic influences on HED. Our sample included 937 individuals (53.25% female) from the Collaborative Study on the Genetics of Alcoholism who reported their HED and marital status biennially between the ages of 21 and 25. Polygenic risk scores (PRS) were derived from a genome-wide association study of alcohol consumption. Marital status was not associated with HED; however, we observed pathogenic gene-by-environment effects that changed across young adulthood. Among those who married young (age 21), individuals with higher PRS reported more HED; however, these effects decayed over time. The same pattern was found in supplementary analyses using parental history of alcohol use disorder as the index of genetic liability. Our findings indicate that early marriage may exacerbate risk for those with higher polygenic load. En ligne : http://dx.doi.org/10.1017/S0954579420000371 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk – CORRIGENDUM / Seung Bin CHO in Development and Psychopathology, 34-3 (August 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-3 (August 2022) . - p.1201-1201 Titre : Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk – CORRIGENDUM Type de document : texte imprimé Auteurs : Seung Bin CHO, Auteur ; Rebecca L. SMITH, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Victor HESSELBROCK, Auteur ; John KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; John NURNBERGER, Auteur ; Marc SCHUCKIT, Auteur ; Yong ZANG, Auteur ; Danielle M. DICK, Auteur ; Jessica E. SALVATORE, Auteur Article en page(s) : p.1201-1201 Langues : Anglais (eng) Mots-clés : alcohol  development  genetics  marital status  young adults Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579421001127 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk – CORRIGENDUM [texte imprimé] / Seung Bin CHO, Auteur ; Rebecca L. SMITH, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Victor HESSELBROCK, Auteur ; John KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; John NURNBERGER, Auteur ; Marc SCHUCKIT, Auteur ; Yong ZANG, Auteur ; Danielle M. DICK, Auteur ; Jessica E. SALVATORE, Auteur . - p.1201-1201. Langues : Anglais (eng) in Development and Psychopathology > 34-3 (August 2022) . - p.1201-1201 Mots-clés : alcohol  development  genetics  marital status  young adults Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579421001127 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Validation of the Developmental, Dimensional and Diagnostic Interview (3Di) Among Chinese Children in a Child Psychiatry Clinic in Hong Kong / Kelly Y. C. LAI in Journal of Autism and Developmental Disorders, 45-5 (May 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1230-1237 Titre : Validation of the Developmental, Dimensional and Diagnostic Interview (3Di) Among Chinese Children in a Child Psychiatry Clinic in Hong Kong Type de document : texte imprimé Auteurs : Kelly Y. C. LAI, Auteur ; Patrick W. L. LEUNG, Auteur ; Flora Y. M. MO, Auteur ; Marshall M. C. LEE, Auteur ; Caroline K. S. SHEA, Auteur ; Grace CHAN, Auteur ; Kiti K. I. CHE, Auteur ; Ernest S. L. LUK, Auteur ; Arthur D. P. MAK, Auteur ; Richard WARRINGTON, Auteur ; David SKUSE, Auteur Article en page(s) : p.1230-1237 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  3Di  Chinese  Validation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a disorder with high levels of co-morbidities. The Developmental, Dimensional and Diagnostic Interview (3Di) is a relatively new instrument designed to provide dimensional as well as categorical assessment of autistic behaviours among children with normal intelligence. Its sound psychometric properties and relatively short administration time make it a versatile instrument. The 3Di was translated into Chinese (Cantonese) and its applicability among 194 clinic children was examined. Results found excellent reliability and validity, and achieved a sensitivity of 95 % and specificity of 77 %. It was able to capture the diagnosis of ASD among children presenting with attention deficit hyperactivity disorder. However, although the disorder of ASD is considered universal, the use of a western instrument in a Chinese context should also take note of cultural influences that may impact on the manifestation of its symptoms. En ligne : http://dx.doi.org/10.1007/s10803-014-2284-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Validation of the Developmental, Dimensional and Diagnostic Interview (3Di) Among Chinese Children in a Child Psychiatry Clinic in Hong Kong [texte imprimé] / Kelly Y. C. LAI, Auteur ; Patrick W. L. LEUNG, Auteur ; Flora Y. M. MO, Auteur ; Marshall M. C. LEE, Auteur ; Caroline K. S. SHEA, Auteur ; Grace CHAN, Auteur ; Kiti K. I. CHE, Auteur ; Ernest S. L. LUK, Auteur ; Arthur D. P. MAK, Auteur ; Richard WARRINGTON, Auteur ; David SKUSE, Auteur . - p.1230-1237. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1230-1237 Mots-clés : Autism spectrum disorder  3Di  Chinese  Validation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a disorder with high levels of co-morbidities. The Developmental, Dimensional and Diagnostic Interview (3Di) is a relatively new instrument designed to provide dimensional as well as categorical assessment of autistic behaviours among children with normal intelligence. Its sound psychometric properties and relatively short administration time make it a versatile instrument. The 3Di was translated into Chinese (Cantonese) and its applicability among 194 clinic children was examined. Results found excellent reliability and validity, and achieved a sensitivity of 95 % and specificity of 77 %. It was able to capture the diagnosis of ASD among children presenting with attention deficit hyperactivity disorder. However, although the disorder of ASD is considered universal, the use of a western instrument in a Chinese context should also take note of cultural influences that may impact on the manifestation of its symptoms. En ligne : http://dx.doi.org/10.1007/s10803-014-2284-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

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