Otitis media, antibiotics, and risk of autism spectrum disorder / Theresa WIMBERLEY in Autism Research, 11-10 (October 2018)  

Public ISBD [article]  inAutism Research > 11-10 (October 2018) . - p.1432-1440 Titre : Otitis media, antibiotics, and risk of autism spectrum disorder Type de document : texte imprimé Auteurs : Theresa WIMBERLEY, Auteur ; Esben AGERBO, Auteur ; Carsten B. PEDERSEN, Auteur ; Soeren DALSGAARD, Auteur ; Henriette Thisted HORSDAL, Auteur ; Preben Bo MORTENSEN, Auteur ; Wesley K. THOMPSON, Auteur ; O. KOHLER-FORSBERG, Auteur ; Robert H. YOLKEN, Auteur Article en page(s) : p.1432-1440 Langues : Anglais (eng) Mots-clés : antibiotics  autism spectrum disorder  epidemiology  otitis media Index. décimale : PER Périodiques Résumé : Otitis media infections and antibiotic treatment have been linked to the risk of developing autism spectrum disorder. Broad-spectrum antibiotics may alter the composition of the gut flora microbiota, which is hypothesized to be involved in the regulation of the immune system. This study examines the interplay among otitis media, antibiotics, and the subsequent risk of developing autism. Based on the entire Danish population, 780,547 children were followed from birth (January 1, 1997 to December 31, 2008) until December 31, 2012. We calculated adjusted hazard ratios and absolute risks of autism with 95% confidence intervals (CIs) related to previous otitis media diagnoses and antibiotic prescriptions redeemed at Danish pharmacies. The absolute risk of autism before age 10 was increased among children with otitis media (1.2% for females and 3.3% for males) and in children who had redeemed an antibiotic prescription (0.6% and 2.7% for females and males) compared to children without a history of otitis media and antibiotics usage (0.4% for females and 1.9% for males). Similarly, we found an increased hazard ratio of autism associated with otitis media (1.83 95% CI 1.71-1.95) and antibiotics usage (1.29 95% CI 1.17-1.43). A history of both otitis media and antibiotic treatment did not further increase the risk of autism. Although the risk of autism was associated with otitis media and treatment with antibiotics, we found little evidence of a synergistic effect between otitis media infections and treatment with antibiotics. Autism Res 2018, 11: 1432-1440. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We investigated whether otitis media ear infections and antibiotic treatment were associated with autism spectrum disorder. Autism was more common in children who had had an otitis media infection or who had been treated with antibiotics. Given the observational nature of our data, our study cannot be used to conclude that otitis media or use of antibiotics cause autism, as our findings may be subject to unobserved confounding. En ligne : http://dx.doi.org/10.1002/aur.2015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Otitis media, antibiotics, and risk of autism spectrum disorder [texte imprimé] / Theresa WIMBERLEY, Auteur ; Esben AGERBO, Auteur ; Carsten B. PEDERSEN, Auteur ; Soeren DALSGAARD, Auteur ; Henriette Thisted HORSDAL, Auteur ; Preben Bo MORTENSEN, Auteur ; Wesley K. THOMPSON, Auteur ; O. KOHLER-FORSBERG, Auteur ; Robert H. YOLKEN, Auteur . - p.1432-1440. Langues : Anglais (eng) in Autism Research > 11-10 (October 2018) . - p.1432-1440 Mots-clés : antibiotics  autism spectrum disorder  epidemiology  otitis media Index. décimale : PER Périodiques Résumé : Otitis media infections and antibiotic treatment have been linked to the risk of developing autism spectrum disorder. Broad-spectrum antibiotics may alter the composition of the gut flora microbiota, which is hypothesized to be involved in the regulation of the immune system. This study examines the interplay among otitis media, antibiotics, and the subsequent risk of developing autism. Based on the entire Danish population, 780,547 children were followed from birth (January 1, 1997 to December 31, 2008) until December 31, 2012. We calculated adjusted hazard ratios and absolute risks of autism with 95% confidence intervals (CIs) related to previous otitis media diagnoses and antibiotic prescriptions redeemed at Danish pharmacies. The absolute risk of autism before age 10 was increased among children with otitis media (1.2% for females and 3.3% for males) and in children who had redeemed an antibiotic prescription (0.6% and 2.7% for females and males) compared to children without a history of otitis media and antibiotics usage (0.4% for females and 1.9% for males). Similarly, we found an increased hazard ratio of autism associated with otitis media (1.83 95% CI 1.71-1.95) and antibiotics usage (1.29 95% CI 1.17-1.43). A history of both otitis media and antibiotic treatment did not further increase the risk of autism. Although the risk of autism was associated with otitis media and treatment with antibiotics, we found little evidence of a synergistic effect between otitis media infections and treatment with antibiotics. Autism Res 2018, 11: 1432-1440. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We investigated whether otitis media ear infections and antibiotic treatment were associated with autism spectrum disorder. Autism was more common in children who had had an otitis media infection or who had been treated with antibiotics. Given the observational nature of our data, our study cannot be used to conclude that otitis media or use of antibiotics cause autism, as our findings may be subject to unobserved confounding. En ligne : http://dx.doi.org/10.1002/aur.2015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Unique prediction of developmental psychopathology from genetic and familial risk / Robert J. LOUGHNAN in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1631-1643 Titre : Unique prediction of developmental psychopathology from genetic and familial risk Type de document : texte imprimé Auteurs : Robert J. LOUGHNAN, Auteur ; Clare E. PALMER, Auteur ; Carolina MAKOWSKI, Auteur ; Wesley K. THOMPSON, Auteur ; Deanna M. BARCH, Auteur ; Terry L. JERNIGAN, Auteur ; Anders M. DALE, Auteur ; Chun Chieh FAN, Auteur Article en page(s) : p.1631-1643 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Genetic Predisposition to Disease  Longitudinal Studies  Multifactorial Inheritance  Psychopathology  Attention Deficit Disorder with Hyperactivity/diagnosis  Risk Factors  Genetics  behavioural  family history Index. décimale : PER Périodiques Résumé : BACKGROUND: Early detection is critical for easing the rising burden of psychiatric disorders. However, the specificity of psychopathological measurements and genetic predictors is unclear among youth. METHODS: We measured associations between genetic risk for psychopathology (polygenic risk scores (PRS) and family history (FH) measures) and a wide range of behavioral measures in a large sample (n=5,204) of early adolescent participants (9-11 years) from the Adolescent Brain and Cognitive Development Study(SM) . Associations were measured both with and without accounting for shared variance across measures of genetic risk. RESULTS: When controlling for genetic risk for other psychiatric disorders, polygenic risk for problematic opioid use (POU) is uniquely associated with lower behavioral inhibition. Attention deficit hyperactivity disorder (ADHD), depression (DEP), and attempted suicide (SUIC) PRS shared many significant associations with externalizing, internalizing, and psychosis-related behaviors. However, when accounting for all measures of genetic and familial risk, these PRS also showed clear, unique patterns of association. Polygenic risk for ASD, BIP, and SCZ, and attempted suicide uniquely predicted variability in cognitive performance. FH accounted for unique variability in behavior above and beyond PRS and vice versa, with FH measures explaining a greater proportion of unique variability compared to the PRS. CONCLUSION: Our results indicate that, among youth, many behaviors show shared genetic influences; however, there is also specificity in the profile of emerging psychopathologies for individuals with high genetic risk for particular disorders. This may be useful for quantifying early, differential risk for psychopathology in development. En ligne : http://dx.doi.org/10.1111/jcpp.13649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Unique prediction of developmental psychopathology from genetic and familial risk [texte imprimé] / Robert J. LOUGHNAN, Auteur ; Clare E. PALMER, Auteur ; Carolina MAKOWSKI, Auteur ; Wesley K. THOMPSON, Auteur ; Deanna M. BARCH, Auteur ; Terry L. JERNIGAN, Auteur ; Anders M. DALE, Auteur ; Chun Chieh FAN, Auteur . - p.1631-1643. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1631-1643 Mots-clés : Adolescent  Humans  Genetic Predisposition to Disease  Longitudinal Studies  Multifactorial Inheritance  Psychopathology  Attention Deficit Disorder with Hyperactivity/diagnosis  Risk Factors  Genetics  behavioural  family history Index. décimale : PER Périodiques Résumé : BACKGROUND: Early detection is critical for easing the rising burden of psychiatric disorders. However, the specificity of psychopathological measurements and genetic predictors is unclear among youth. METHODS: We measured associations between genetic risk for psychopathology (polygenic risk scores (PRS) and family history (FH) measures) and a wide range of behavioral measures in a large sample (n=5,204) of early adolescent participants (9-11 years) from the Adolescent Brain and Cognitive Development Study(SM) . Associations were measured both with and without accounting for shared variance across measures of genetic risk. RESULTS: When controlling for genetic risk for other psychiatric disorders, polygenic risk for problematic opioid use (POU) is uniquely associated with lower behavioral inhibition. Attention deficit hyperactivity disorder (ADHD), depression (DEP), and attempted suicide (SUIC) PRS shared many significant associations with externalizing, internalizing, and psychosis-related behaviors. However, when accounting for all measures of genetic and familial risk, these PRS also showed clear, unique patterns of association. Polygenic risk for ASD, BIP, and SCZ, and attempted suicide uniquely predicted variability in cognitive performance. FH accounted for unique variability in behavior above and beyond PRS and vice versa, with FH measures explaining a greater proportion of unique variability compared to the PRS. CONCLUSION: Our results indicate that, among youth, many behaviors show shared genetic influences; however, there is also specificity in the profile of emerging psychopathologies for individuals with high genetic risk for particular disorders. This may be useful for quantifying early, differential risk for psychopathology in development. En ligne : http://dx.doi.org/10.1111/jcpp.13649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

---

1 (1 - 2 / 2) Par page : 25 50 100 200