Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study / Paul MADLEY-DOWD in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 44 p. Titre : Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study Type de document : texte imprimé Auteurs : Paul MADLEY-DOWD, Auteur ; Christina DARDANI, Auteur ; Robyn E. WOOTTON, Auteur ; Kyle DACK, Auteur ; Tom PALMER, Auteur ; Rupert THURSTON, Auteur ; Alexandra HAVDAHL, Auteur ; Jean GOLDING, Auteur ; Deborah LAWLOR, Auteur ; Dheeraj RAI, Auteur Article en page(s) : 44 p. Langues : Anglais (eng) Mots-clés : Child  Pregnancy  Female  Humans  Autistic Disorder/epidemiology/etiology  Longitudinal Studies  Cohort Studies  Prospective Studies  Vitamin D  Alspac  Autism  Mendelian randomization Index. décimale : PER Périodiques Résumé : BACKGROUND: There has been a growing interest in the association between maternal levels of vitamin D during pregnancy and offspring autism. However, whether any associations reflect causal effects is still inconclusive. METHODS: We used data from a UK-based pregnancy cohort study (Avon Longitudinal Study of Parents and Children) comprising 7689 births between 1991 and 1992 with maternal blood vitamin D levels recorded during pregnancy and at least one recorded outcome measure, including autism diagnosis and autism-associated traits. The association between each outcome with seasonal and gestational age-adjusted maternal serum 25-hydroxyvitamin D during pregnancy was estimated using confounder-adjusted regression models. Multiple imputation was used to account for missing data, and restricted cubic splines were used to investigate nonlinear associations. Mendelian randomization was used to strengthen causal inference. RESULTS: No strong evidence of an association between maternal serum 25-hydroxyvitamin D during pregnancy and any offspring autism-associated outcome was found using multivariable regression analysis (autism diagnosis: adjusted OR=0.98, 95% CI=0.90-1.06), including with multiple imputation (autism diagnosis: adjusted OR=0.99, 95% CI=0.93-1.06), and no evidence of a causal effect was suggested by Mendelian randomization (autism diagnosis: causal OR=1.08, 95% CI=0.46-2.55). Some evidence of increased odds of autism-associated traits at lower levels of maternal serum 25-hydroxyvitamin D was found using spline analysis. LIMITATIONS: Our study was potentially limited by low power, particularly for diagnosed autism cases as an outcome. The cohort may not have captured the extreme lows of the distribution of serum 25-hydroxyvitamin D, and our analyses may have been biased by residual confounding and missing data. CONCLUSIONS: The present study found no strong evidence of a causal link between maternal vitamin D levels in pregnancy and offspring diagnosis or traits of autism. En ligne : http://dx.doi.org/10.1186/s13229-022-00523-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study [texte imprimé] / Paul MADLEY-DOWD, Auteur ; Christina DARDANI, Auteur ; Robyn E. WOOTTON, Auteur ; Kyle DACK, Auteur ; Tom PALMER, Auteur ; Rupert THURSTON, Auteur ; Alexandra HAVDAHL, Auteur ; Jean GOLDING, Auteur ; Deborah LAWLOR, Auteur ; Dheeraj RAI, Auteur . - 44 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 44 p. Mots-clés : Child  Pregnancy  Female  Humans  Autistic Disorder/epidemiology/etiology  Longitudinal Studies  Cohort Studies  Prospective Studies  Vitamin D  Alspac  Autism  Mendelian randomization Index. décimale : PER Périodiques Résumé : BACKGROUND: There has been a growing interest in the association between maternal levels of vitamin D during pregnancy and offspring autism. However, whether any associations reflect causal effects is still inconclusive. METHODS: We used data from a UK-based pregnancy cohort study (Avon Longitudinal Study of Parents and Children) comprising 7689 births between 1991 and 1992 with maternal blood vitamin D levels recorded during pregnancy and at least one recorded outcome measure, including autism diagnosis and autism-associated traits. The association between each outcome with seasonal and gestational age-adjusted maternal serum 25-hydroxyvitamin D during pregnancy was estimated using confounder-adjusted regression models. Multiple imputation was used to account for missing data, and restricted cubic splines were used to investigate nonlinear associations. Mendelian randomization was used to strengthen causal inference. RESULTS: No strong evidence of an association between maternal serum 25-hydroxyvitamin D during pregnancy and any offspring autism-associated outcome was found using multivariable regression analysis (autism diagnosis: adjusted OR=0.98, 95% CI=0.90-1.06), including with multiple imputation (autism diagnosis: adjusted OR=0.99, 95% CI=0.93-1.06), and no evidence of a causal effect was suggested by Mendelian randomization (autism diagnosis: causal OR=1.08, 95% CI=0.46-2.55). Some evidence of increased odds of autism-associated traits at lower levels of maternal serum 25-hydroxyvitamin D was found using spline analysis. LIMITATIONS: Our study was potentially limited by low power, particularly for diagnosed autism cases as an outcome. The cohort may not have captured the extreme lows of the distribution of serum 25-hydroxyvitamin D, and our analyses may have been biased by residual confounding and missing data. CONCLUSIONS: The present study found no strong evidence of a causal link between maternal vitamin D levels in pregnancy and offspring diagnosis or traits of autism. En ligne : http://dx.doi.org/10.1186/s13229-022-00523-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study / Tamara VAN BATENBURG-EDDES in Journal of Child Psychology and Psychiatry, 54-5 (May 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.591-600 Titre : Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study Type de document : texte imprimé Auteurs : Tamara VAN BATENBURG-EDDES, Auteur ; M.J. BRION, Auteur ; Jens HENRICHS, Auteur ; Vincent W.V. JADDOE, Auteur ; A. HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Deborah LAWLOR, Auteur ; George DAVEY SMITH, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.591-600 Langues : Anglais (eng) Mots-clés : Parental depression or anxiety  child attention problems  cohort studies  intrauterine effect Index. décimale : PER Périodiques Résumé : Background: Maternal depression and anxiety during pregnancy have been associated with offspring-attention deficit problems. Aim: We explored possible intrauterine effects by comparing maternal and paternal symptoms during pregnancy, by investigating cross-cohort consistency, and by investigating whether parental symptoms in early childhood may explain any observed intrauterine effect. Methods: This study was conducted in two cohorts (Generation R, n = 2,280 and ALSPAC, n = 3,442). Pregnant women and their partners completed questionnaires to assess symptoms of depression and anxiety. Child attention problems were measured in Generation R at age 3 with the Child Behavior Checklist, and in ALSPAC at age 4 with the Strengths and Difficulties Questionnaire. Results: In both cohorts, antenatal maternal symptoms of depression (Generation R: OR 1.23, 95% CI 1.05–1.43; ALSPAC: OR 1.33, 95% CI 1.19–1.48) and anxiety (Generation R: OR 1.24, 95% CI 1.06–1.46; ALSPAC: OR 1.32, 95% CI 1.19–1.47) were associated with a higher risk of child attention problems. In ALSPAC, paternal depression was also associated with a higher risk of child attention problems (OR 1.11, 95% CI 1.00–1.24). After adjusting for maternal symptoms after giving birth, antenatal maternal depression and anxiety were no longer associated with child attention problems in Generation R. Moreover, there was little statistical evidence that antenatal maternal and paternal depression and anxiety had a substantially different effect on attention problems of the child. Conclusions: The apparent intrauterine effect of maternal depression and anxiety on offspring-behavioural problems may be partly explained by residual confounding. There was little evidence of a difference between the strength of associations of maternal and paternal symptoms during pregnancy with offspring-attention problems. That maternal symptoms after childbirth were also associated with offspring-behavioural problems may indicate a contribution of genetic influences to the association. En ligne : http://dx.doi.org/10.1111/jcpp.12023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196 [article] Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study [texte imprimé] / Tamara VAN BATENBURG-EDDES, Auteur ; M.J. BRION, Auteur ; Jens HENRICHS, Auteur ; Vincent W.V. JADDOE, Auteur ; A. HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Deborah LAWLOR, Auteur ; George DAVEY SMITH, Auteur ; Henning TIEMEIER, Auteur . - p.591-600. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.591-600 Mots-clés : Parental depression or anxiety  child attention problems  cohort studies  intrauterine effect Index. décimale : PER Périodiques Résumé : Background: Maternal depression and anxiety during pregnancy have been associated with offspring-attention deficit problems. Aim: We explored possible intrauterine effects by comparing maternal and paternal symptoms during pregnancy, by investigating cross-cohort consistency, and by investigating whether parental symptoms in early childhood may explain any observed intrauterine effect. Methods: This study was conducted in two cohorts (Generation R, n = 2,280 and ALSPAC, n = 3,442). Pregnant women and their partners completed questionnaires to assess symptoms of depression and anxiety. Child attention problems were measured in Generation R at age 3 with the Child Behavior Checklist, and in ALSPAC at age 4 with the Strengths and Difficulties Questionnaire. Results: In both cohorts, antenatal maternal symptoms of depression (Generation R: OR 1.23, 95% CI 1.05–1.43; ALSPAC: OR 1.33, 95% CI 1.19–1.48) and anxiety (Generation R: OR 1.24, 95% CI 1.06–1.46; ALSPAC: OR 1.32, 95% CI 1.19–1.47) were associated with a higher risk of child attention problems. In ALSPAC, paternal depression was also associated with a higher risk of child attention problems (OR 1.11, 95% CI 1.00–1.24). After adjusting for maternal symptoms after giving birth, antenatal maternal depression and anxiety were no longer associated with child attention problems in Generation R. Moreover, there was little statistical evidence that antenatal maternal and paternal depression and anxiety had a substantially different effect on attention problems of the child. Conclusions: The apparent intrauterine effect of maternal depression and anxiety on offspring-behavioural problems may be partly explained by residual confounding. There was little evidence of a difference between the strength of associations of maternal and paternal symptoms during pregnancy with offspring-attention problems. That maternal symptoms after childbirth were also associated with offspring-behavioural problems may indicate a contribution of genetic influences to the association. En ligne : http://dx.doi.org/10.1111/jcpp.12023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196

The association of serum 25-hydroxyvitamin D3 and D2 with depressive symptoms in childhood – a prospective cohort study / Anna-Maija TOLPPANEN in Journal of Child Psychology and Psychiatry, 53-7 (July 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.757-766 Titre : The association of serum 25-hydroxyvitamin D3 and D2 with depressive symptoms in childhood – a prospective cohort study Type de document : texte imprimé Auteurs : Anna-Maija TOLPPANEN, Auteur ; Adrian SAYERS, Auteur ; William D. FRASER, Auteur ; Glyn LEWIS, Auteur ; Stanley ZAMMIT, Auteur ; Deborah LAWLOR, Auteur Année de publication : 2012 Article en page(s) : p.757-766 Langues : Anglais (eng) Mots-clés : 25-Hydroxyvitamin D  calcium  parathyroid hormone  child  depression  ALSPAC Index. décimale : PER Périodiques Résumé : Background:  Depression in adolescence is common and early onset predicts worse outcome in adulthood. Studies in adults have suggested a link between higher total 25-hydroxyvitamin D [25(OH)D] concentrations and lower risk of depression. Objectives:  To investigate (a) the association between serum 25(OH)D2 and 25(OH)D3 concentrations and depressive symptoms in children, and (b) whether the associations of 25(OH)D2 and 25(OH)D3 are different from, and independent of, each other. Methods:  Prospective cohort study with serum 25(OH)D2 and 25(OH)D3 concentrations measured at mean age of 9.8 years and depressive symptoms assessed with the Mood and Feelings Questionnaire by a trained interviewer at the mean ages of 10.6 years (n = 2,759) and 13.8 years (n = 2,752). Results:  Higher concentrations of 25(OH)D3 assessed at mean age 9.8 years were associated with lower levels of depressive symptoms at age 13.8 years [adjusted risk ratio (RR; 95% confidence interval (CI)): 0.90 (0.86–0.95)], but not at age 10.6 years [adjusted RR (95% CI): 0.98 (0.93–1.03)] and with increased odds of decreasing symptoms between age 10.6 and 13.8 years [adjusted RR (95% CI): 1.08 (1.01–1.16)]. Serum 25(OH)D2 concentrations were not associated with depressive symptoms. Conclusions:  This is the first study in children to suggest that the association between 25(OH)D3 concentrations and depression emerges in childhood. The association is independent of a wide range of potential confounding factors, and appears to be stronger with greater time separation between assessment of 25(OH)D3 and assessment of depressive symptoms. Confirmation of our findings in large prospective studies and trials would be valuable. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02518.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] The association of serum 25-hydroxyvitamin D3 and D2 with depressive symptoms in childhood – a prospective cohort study [texte imprimé] / Anna-Maija TOLPPANEN, Auteur ; Adrian SAYERS, Auteur ; William D. FRASER, Auteur ; Glyn LEWIS, Auteur ; Stanley ZAMMIT, Auteur ; Deborah LAWLOR, Auteur . - 2012 . - p.757-766. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.757-766 Mots-clés : 25-Hydroxyvitamin D  calcium  parathyroid hormone  child  depression  ALSPAC Index. décimale : PER Périodiques Résumé : Background:  Depression in adolescence is common and early onset predicts worse outcome in adulthood. Studies in adults have suggested a link between higher total 25-hydroxyvitamin D [25(OH)D] concentrations and lower risk of depression. Objectives:  To investigate (a) the association between serum 25(OH)D2 and 25(OH)D3 concentrations and depressive symptoms in children, and (b) whether the associations of 25(OH)D2 and 25(OH)D3 are different from, and independent of, each other. Methods:  Prospective cohort study with serum 25(OH)D2 and 25(OH)D3 concentrations measured at mean age of 9.8 years and depressive symptoms assessed with the Mood and Feelings Questionnaire by a trained interviewer at the mean ages of 10.6 years (n = 2,759) and 13.8 years (n = 2,752). Results:  Higher concentrations of 25(OH)D3 assessed at mean age 9.8 years were associated with lower levels of depressive symptoms at age 13.8 years [adjusted risk ratio (RR; 95% confidence interval (CI)): 0.90 (0.86–0.95)], but not at age 10.6 years [adjusted RR (95% CI): 0.98 (0.93–1.03)] and with increased odds of decreasing symptoms between age 10.6 and 13.8 years [adjusted RR (95% CI): 1.08 (1.01–1.16)]. Serum 25(OH)D2 concentrations were not associated with depressive symptoms. Conclusions:  This is the first study in children to suggest that the association between 25(OH)D3 concentrations and depression emerges in childhood. The association is independent of a wide range of potential confounding factors, and appears to be stronger with greater time separation between assessment of 25(OH)D3 and assessment of depressive symptoms. Confirmation of our findings in large prospective studies and trials would be valuable. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02518.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

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