Characteristics, Early Development and Outcome of Parent-Reported Regression in Autism Spectrum Disorder / Sofie BOTERBERG in Journal of Autism and Developmental Disorders, 49-11 (November 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4603-4625 Titre : Characteristics, Early Development and Outcome of Parent-Reported Regression in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Sofie BOTERBERG, Auteur ; Rudy VAN COSTER, Auteur ; Herbert ROEYERS, Auteur Article en page(s) : p.4603-4625 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Early development  Onset patterns  Outcome  Regression Index. décimale : PER Périodiques Résumé : This study explored regression patterns in 100 children with ASD (3-11 years) using several approaches to enhance the validity of retrospective parent report. Both early development and outcome were examined in regression groups defined by 36 months age cut-off and two underlying empirical patterns based on type and onset age. Results over regression groups were generally consistent. During early development, children with regression showed a similar amount of social atypicalities and stereotyped behaviour as compared to children without regression. However, parents indicated less communication skills which could be a valuable predictor of regression. Development after regression was characterised by early language delay and more restricted and repetitive behaviour. The findings provide insight into the diagnosis and prognosis of regression in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04183-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Characteristics, Early Development and Outcome of Parent-Reported Regression in Autism Spectrum Disorder [texte imprimé] / Sofie BOTERBERG, Auteur ; Rudy VAN COSTER, Auteur ; Herbert ROEYERS, Auteur . - p.4603-4625. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4603-4625 Mots-clés : Autism spectrum disorder  Early development  Onset patterns  Outcome  Regression Index. décimale : PER Périodiques Résumé : This study explored regression patterns in 100 children with ASD (3-11 years) using several approaches to enhance the validity of retrospective parent report. Both early development and outcome were examined in regression groups defined by 36 months age cut-off and two underlying empirical patterns based on type and onset age. Results over regression groups were generally consistent. During early development, children with regression showed a similar amount of social atypicalities and stereotyped behaviour as compared to children without regression. However, parents indicated less communication skills which could be a valuable predictor of regression. Development after regression was characterised by early language delay and more restricted and repetitive behaviour. The findings provide insight into the diagnosis and prognosis of regression in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04183-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism / Sarah SCHAUBROECK in Journal of Autism and Developmental Disorders, 56-2 (February 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-2 (February 2026) . - p.633-647 Titre : Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism Type de document : texte imprimé Auteurs : Sarah SCHAUBROECK, Auteur ; Ellen DEMURIE, Auteur ; Jannath BEGUM-ALI, Auteur ; Sven BÖLTE, Auteur ; Sofie BOTERBERG, Auteur ; Jan BUITELAAR, Auteur ; Tony CHARMAN, Auteur ; Terje FALCK-YTTER, Auteur ; Sabine HUNNIUS, Auteur ; Mark JOHNSON, Auteur ; Emily JONES, Auteur ; Greg PASCO, Auteur ; Carlijn VAN DEN BOOMEN, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur Article en page(s) : p.633-647 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined the recurrence rate of autism in siblings at elevated likelihood (EL) and the predictive validity of the Q-CHAT and ADOS-2 at 14 and 24 months (m) for a clinical best estimate (CBE) autism diagnosis at 3 years. 331 EL-siblings (47.9% girls) from the prospective longitudinal EuroSibs study underwent ADOS-2 assessments and caregivers completed the Q-CHAT at 14 m and 24 m. At 3 years CBE was determined using DSM-5 criteria. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were estimated. Autism recurrence rate was 25.7% [95% CI (21.1, 30.6)]. Q-CHAT sensitivity was 31.8% [95% CI (21.4, 43.6)] at 14 m and 30.6% [95% CI (20.7, 41.7)] at 24 m. Specificity was 81.2% [95% CI (75.4, 86.2)] at 14 m and 94.8% [95% CI (91.2, 97.2)] at 24 m. PPV was 35.6% [95% CI (24.2, 48.2)] at 14 m and 66.7% [95% CI (49.8, 81.1)] at 24 m. NPV was 78.5% [95% CI (72.6, 83.7)] and 79.9% [95% CI (74.7, 84.6)] respectively. ADOS-2 demonstrated a of 64.3% [95% CI (45.9, 80.2)] and 69.3% [95% CI (58.4, 79.0)] and a specificity of 71.1% [95% CI (60.3, 80.4)] and 68.7% [95% CI (62.5, 74.5)] at 14 m and 24 m respectively. PPV was 45% [95% CI (30.3, 60.4)] at 14 m and 41.9% [95% CI (33.5, 50.7)] at 24 m. NPV was 84.4% [95% CI (74.2, 91.8)] at 14 m and 87.3% [95% CI (81.9, 91.6)] at 24 m. Q-CHAT and ADOS-2 at 14 m and 24 m can aid in early differentiation between EL-siblings who need further assessment and those who do not, but neither has sufficient sensitivity and PPV for standalone CBE diagnosis prediction. En ligne : https://doi.org/10.1007/s10803-024-06585-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580 [article] Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism [texte imprimé] / Sarah SCHAUBROECK, Auteur ; Ellen DEMURIE, Auteur ; Jannath BEGUM-ALI, Auteur ; Sven BÖLTE, Auteur ; Sofie BOTERBERG, Auteur ; Jan BUITELAAR, Auteur ; Tony CHARMAN, Auteur ; Terje FALCK-YTTER, Auteur ; Sabine HUNNIUS, Auteur ; Mark JOHNSON, Auteur ; Emily JONES, Auteur ; Greg PASCO, Auteur ; Carlijn VAN DEN BOOMEN, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur . - p.633-647. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-2 (February 2026) . - p.633-647 Index. décimale : PER Périodiques Résumé : This study examined the recurrence rate of autism in siblings at elevated likelihood (EL) and the predictive validity of the Q-CHAT and ADOS-2 at 14 and 24 months (m) for a clinical best estimate (CBE) autism diagnosis at 3 years. 331 EL-siblings (47.9% girls) from the prospective longitudinal EuroSibs study underwent ADOS-2 assessments and caregivers completed the Q-CHAT at 14 m and 24 m. At 3 years CBE was determined using DSM-5 criteria. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were estimated. Autism recurrence rate was 25.7% [95% CI (21.1, 30.6)]. Q-CHAT sensitivity was 31.8% [95% CI (21.4, 43.6)] at 14 m and 30.6% [95% CI (20.7, 41.7)] at 24 m. Specificity was 81.2% [95% CI (75.4, 86.2)] at 14 m and 94.8% [95% CI (91.2, 97.2)] at 24 m. PPV was 35.6% [95% CI (24.2, 48.2)] at 14 m and 66.7% [95% CI (49.8, 81.1)] at 24 m. NPV was 78.5% [95% CI (72.6, 83.7)] and 79.9% [95% CI (74.7, 84.6)] respectively. ADOS-2 demonstrated a of 64.3% [95% CI (45.9, 80.2)] and 69.3% [95% CI (58.4, 79.0)] and a specificity of 71.1% [95% CI (60.3, 80.4)] and 68.7% [95% CI (62.5, 74.5)] at 14 m and 24 m respectively. PPV was 45% [95% CI (30.3, 60.4)] at 14 m and 41.9% [95% CI (33.5, 50.7)] at 24 m. NPV was 84.4% [95% CI (74.2, 91.8)] at 14 m and 87.3% [95% CI (81.9, 91.6)] at 24 m. Q-CHAT and ADOS-2 at 14 m and 24 m can aid in early differentiation between EL-siblings who need further assessment and those who do not, but neither has sufficient sensitivity and PPV for standalone CBE diagnosis prediction. En ligne : https://doi.org/10.1007/s10803-024-06585-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580

Play in Relation to Autism Traits in Young Children at Elevated Likelihood for Autism Spectrum Disorder / Floor MOERMAN in Journal of Autism and Developmental Disorders, 53-4 (April 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1413-1430 Titre : Play in Relation to Autism Traits in Young Children at Elevated Likelihood for Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Floor MOERMAN, Auteur ; Petra WARREYN, Auteur ; Ellen DEMURIE, Auteur ; Sofie BOTERBERG, Auteur ; Julie VERMEIRSCH, Auteur ; Chloè BONTINCK, Auteur ; Eva BRUYNEEL, Auteur ; Marjolein MUÈS, Auteur ; Liedewij VERHAEGHE, Auteur ; Herbert ROEYERS, Auteur ; Team BABY STUDY, Auteur Article en page(s) : p.1413-1430 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Play of younger siblings of children with autism spectrum disorder (ASD) (siblings; n=44), very preterm children (preterms; n=44), and children at typical likelihood for ASD (n=36) was observed at 24 months. Children with ASD and atypical development engaged less in spontaneous (pre-)symbolic play than typically developing children. Total duration of spontaneous and elicited (pre-)symbolic play was associated with later ASD traits in siblings. However, no association between most play variables and ASD traits was found in preterms. This suggests possible different ASD-trajectories between siblings and preterms. Thus, spontaneous (pre-)symbolic play may be indicative of developmental challenges across several populations, and results highlight the need to move beyond studying only siblings in order to broaden our understanding of ASD. En ligne : https://doi.org/10.1007/s10803-021-05326-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] Play in Relation to Autism Traits in Young Children at Elevated Likelihood for Autism Spectrum Disorder [texte imprimé] / Floor MOERMAN, Auteur ; Petra WARREYN, Auteur ; Ellen DEMURIE, Auteur ; Sofie BOTERBERG, Auteur ; Julie VERMEIRSCH, Auteur ; Chloè BONTINCK, Auteur ; Eva BRUYNEEL, Auteur ; Marjolein MUÈS, Auteur ; Liedewij VERHAEGHE, Auteur ; Herbert ROEYERS, Auteur ; Team BABY STUDY, Auteur . - p.1413-1430. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1413-1430 Index. décimale : PER Périodiques Résumé : Play of younger siblings of children with autism spectrum disorder (ASD) (siblings; n=44), very preterm children (preterms; n=44), and children at typical likelihood for ASD (n=36) was observed at 24 months. Children with ASD and atypical development engaged less in spontaneous (pre-)symbolic play than typically developing children. Total duration of spontaneous and elicited (pre-)symbolic play was associated with later ASD traits in siblings. However, no association between most play variables and ASD traits was found in preterms. This suggests possible different ASD-trajectories between siblings and preterms. Thus, spontaneous (pre-)symbolic play may be indicative of developmental challenges across several populations, and results highlight the need to move beyond studying only siblings in order to broaden our understanding of ASD. En ligne : https://doi.org/10.1007/s10803-021-05326-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

Social Interactions Between 24-Month-Old Children and Their Older Sibling with Autism Spectrum Disorder: Characteristics and Association with Social-Communicative Development / Chloè BONTINCK in Journal of Autism and Developmental Disorders, 48-12 (December 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-12 (December 2018) . - p.4118-4137 Titre : Social Interactions Between 24-Month-Old Children and Their Older Sibling with Autism Spectrum Disorder: Characteristics and Association with Social-Communicative Development Type de document : texte imprimé Auteurs : Chloè BONTINCK, Auteur ; Petra WARREYN, Auteur ; Ellen DEMURIE, Auteur ; Eva BRUYNEEL, Auteur ; Sofie BOTERBERG, Auteur ; Herbert ROEYERS, Auteur Article en page(s) : p.4118-4137 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  High-risk siblings  Language  Sibling interaction  Social communication Index. décimale : PER Périodiques Résumé : This study compared sibling interactions between 24-month-old children and their older sibling with ASD (high-risk; n = 24) with 24-month-old children and their typically developing older sibling (low-risk; n = 32). First, high-risk sibling pairs showed lower levels of positive behaviour and younger siblings of children with ASD imitated their older sibling less. Second, in the high-risk group positive interactions were positively associated with the youngest child's language abilities. However, this association was no longer significant after controlling for language abilities at 14 months. Third, more total interactions in the high-risk group, both negative and positive, were associated with more ASD characteristics. Thus, early sibling interactions might reveal interesting information in light of the (atypical) developmental trajectories of younger siblings of children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3660-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] Social Interactions Between 24-Month-Old Children and Their Older Sibling with Autism Spectrum Disorder: Characteristics and Association with Social-Communicative Development [texte imprimé] / Chloè BONTINCK, Auteur ; Petra WARREYN, Auteur ; Ellen DEMURIE, Auteur ; Eva BRUYNEEL, Auteur ; Sofie BOTERBERG, Auteur ; Herbert ROEYERS, Auteur . - p.4118-4137. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-12 (December 2018) . - p.4118-4137 Mots-clés : Autism spectrum disorder  High-risk siblings  Language  Sibling interaction  Social communication Index. décimale : PER Périodiques Résumé : This study compared sibling interactions between 24-month-old children and their older sibling with ASD (high-risk; n = 24) with 24-month-old children and their typically developing older sibling (low-risk; n = 32). First, high-risk sibling pairs showed lower levels of positive behaviour and younger siblings of children with ASD imitated their older sibling less. Second, in the high-risk group positive interactions were positively associated with the youngest child's language abilities. However, this association was no longer significant after controlling for language abilities at 14 months. Third, more total interactions in the high-risk group, both negative and positive, were associated with more ASD characteristics. Thus, early sibling interactions might reveal interesting information in light of the (atypical) developmental trajectories of younger siblings of children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3660-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

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