Assessing the Contribution of Measures of Attention and Executive Function to Diagnosis of ADHD or Autism / Kelsey HARKNESS in Journal of Autism and Developmental Disorders, 55-4 (April 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-4 (April 2024) . - p.1353-1364 Titre : Assessing the Contribution of Measures of Attention and Executive Function to Diagnosis of ADHD or Autism Type de document : texte imprimé Auteurs : Kelsey HARKNESS, Auteur ; Signe BRAY, Auteur ; Chelsea DURBER, Auteur ; Deborah DEWEY, Auteur ; Kara MURIAS, Auteur Article en page(s) : p.1353-1364 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Attention and executive function (EF) dysregulation are common in a number of disorders including autism and attention-deficit/hyperactivity disorder (ADHD). Better understanding of the relationship between indirect and direct measures of attention and EF and common neurodevelopmental diagnoses may contribute to more efficient and effective diagnostic assessment in childhood. We obtained cognitive (NIH Toolbox, Little Man Task, Matrix Reasoning Task, and Rey Delayed Recall) and symptom (CBCL, and BPMT) assessment data from the Adolescent Brain and Cognitive Development (ABCD) database for three groups, autistic (N = 110), ADHD (N = 878), and control without autism or ADHD diagnoses (N = 9130) and used ridge regression to determine which attention and EF assessments were most strongly associated with autism or ADHD. More variance was accounted for in the model for the ADHD group (31%) compared to the autism group (2.7%). Finally, we ran odds ratios (using clinical cutoffs where available and 2 standard deviations below the mean when not) for each assessment measure, which generally demonstrated a greater significance within the indirect measures when compared to the direct measures. These results add to the growing literature of symptom variably across diagnostic groups allowing for better understanding of presentations in autism and ADHD and how best to assess diagnosis. It also highlights the increased difficulty in differentiating autism and controls when compared to ADHD and controls and the importance of indirect measures of attention and EF in this differentiation. En ligne : https://doi.org/10.1007/s10803-024-06275-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550 [article] Assessing the Contribution of Measures of Attention and Executive Function to Diagnosis of ADHD or Autism [texte imprimé] / Kelsey HARKNESS, Auteur ; Signe BRAY, Auteur ; Chelsea DURBER, Auteur ; Deborah DEWEY, Auteur ; Kara MURIAS, Auteur . - p.1353-1364. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-4 (April 2024) . - p.1353-1364 Index. décimale : PER Périodiques Résumé : Attention and executive function (EF) dysregulation are common in a number of disorders including autism and attention-deficit/hyperactivity disorder (ADHD). Better understanding of the relationship between indirect and direct measures of attention and EF and common neurodevelopmental diagnoses may contribute to more efficient and effective diagnostic assessment in childhood. We obtained cognitive (NIH Toolbox, Little Man Task, Matrix Reasoning Task, and Rey Delayed Recall) and symptom (CBCL, and BPMT) assessment data from the Adolescent Brain and Cognitive Development (ABCD) database for three groups, autistic (N = 110), ADHD (N = 878), and control without autism or ADHD diagnoses (N = 9130) and used ridge regression to determine which attention and EF assessments were most strongly associated with autism or ADHD. More variance was accounted for in the model for the ADHD group (31%) compared to the autism group (2.7%). Finally, we ran odds ratios (using clinical cutoffs where available and 2 standard deviations below the mean when not) for each assessment measure, which generally demonstrated a greater significance within the indirect measures when compared to the direct measures. These results add to the growing literature of symptom variably across diagnostic groups allowing for better understanding of presentations in autism and ADHD and how best to assess diagnosis. It also highlights the increased difficulty in differentiating autism and controls when compared to ADHD and controls and the importance of indirect measures of attention and EF in this differentiation. En ligne : https://doi.org/10.1007/s10803-024-06275-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550

Atypical Tactile Perception in Early Childhood Autism / Svenja ESPENHAHN in Journal of Autism and Developmental Disorders, 53-7 (July 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-7 (July 2023) . - p.2891-2904 Titre : Atypical Tactile Perception in Early Childhood Autism Type de document : texte imprimé Auteurs : Svenja ESPENHAHN, Auteur ; Kate J. GODFREY, Auteur ; Sakshi KAUR, Auteur ; Carly A. MCMORRIS, Auteur ; Kara MURIAS, Auteur ; Mark TOMMERDAHL, Auteur ; Signe BRAY, Auteur ; Ashley D. HARRIS, Auteur Article en page(s) : p.2891-2904 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We assessed different aspects of tactile perception in young children (3-6 years) with autism. Autistic and neurotypical children completed vibrotactile tasks assessing reaction time, amplitude discrimination (sequential and simultaneous) and temporal discrimination (temporal order judgment and duration discrimination). Autistic children had elevated and more variable reaction times, suggesting slower perceptual-motor processing speed and/or greater distractibility. Children with autism also showed higher amplitude discrimination and temporal order judgement thresholds compared to neurotypical children. Tactile perceptual metrics did not associate with social or tactile sensitivities measured by parent-reports. Altered tactile behavioral responses appear in early childhood, can be quantified but appear dissociated from sensitivity. This implies these measures are complementary, but not necessarily related, phenomena of atypical tactile perception in autism. En ligne : https://doi.org/10.1007/s10803-022-05570-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Atypical Tactile Perception in Early Childhood Autism [texte imprimé] / Svenja ESPENHAHN, Auteur ; Kate J. GODFREY, Auteur ; Sakshi KAUR, Auteur ; Carly A. MCMORRIS, Auteur ; Kara MURIAS, Auteur ; Mark TOMMERDAHL, Auteur ; Signe BRAY, Auteur ; Ashley D. HARRIS, Auteur . - p.2891-2904. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-7 (July 2023) . - p.2891-2904 Index. décimale : PER Périodiques Résumé : We assessed different aspects of tactile perception in young children (3-6 years) with autism. Autistic and neurotypical children completed vibrotactile tasks assessing reaction time, amplitude discrimination (sequential and simultaneous) and temporal discrimination (temporal order judgment and duration discrimination). Autistic children had elevated and more variable reaction times, suggesting slower perceptual-motor processing speed and/or greater distractibility. Children with autism also showed higher amplitude discrimination and temporal order judgement thresholds compared to neurotypical children. Tactile perceptual metrics did not associate with social or tactile sensitivities measured by parent-reports. Altered tactile behavioral responses appear in early childhood, can be quantified but appear dissociated from sensitivity. This implies these measures are complementary, but not necessarily related, phenomena of atypical tactile perception in autism. En ligne : https://doi.org/10.1007/s10803-022-05570-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Functional connectivity based brain signatures of behavioral regulation in children with ADHD, DCD, and ADHD-DCD / Christiane S. ROHR in Development and Psychopathology, 35-1 (February 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-1 (February 2023) . - p.85-94 Titre : Functional connectivity based brain signatures of behavioral regulation in children with ADHD, DCD, and ADHD-DCD Type de document : texte imprimé Auteurs : Christiane S. ROHR, Auteur ; Signe BRAY, Auteur ; Deborah DEWEY, Auteur Article en page(s) : p.85-94 Langues : Anglais (eng) Mots-clés : attention-deficit/hyperactivity disorder  developmental coordination disorder  emotion control  emotion regulation  executive function Index. décimale : PER Périodiques Résumé : Behavioral regulation problems have been associated with daily-life and mental health challenges in children with neurodevelopmental conditions such as attention-deficit/hyperactivity disorder (ADHD) and developmental coordination disorder (DCD). Here, we investigated transdiagnostic brain signatures associated with behavioral regulation. Resting-state fMRI data were collected from 115 children (31 typically developing (TD), 35 ADHD, 21 DCD, 28 ADHD-DCD) aged 7-17 years. Behavioral regulation was measured using the Behavior Rating Inventory of Executive Function and was found to differ between children with ADHD (i.e., children with ADHD and ADHD-DCD) and without ADHD (i.e., TD children and children with DCD). Functional connectivity (FC) maps were computed for 10 regions of interest and FC maps were tested for correlations with behavioral regulation scores. Across the entire sample, greater behavioral regulation problems were associated with stronger negative FC within prefrontal pathways and visual reward pathways, as well as with weaker positive FC in frontostriatal reward pathways. These findings significantly increase our knowledge on FC in children with and without ADHD and highlight the potential of FC as brain-based signatures of behavioral regulation across children with differing neurodevelopmental conditions. En ligne : https://doi.org/10.1017/S0954579421001449 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Functional connectivity based brain signatures of behavioral regulation in children with ADHD, DCD, and ADHD-DCD [texte imprimé] / Christiane S. ROHR, Auteur ; Signe BRAY, Auteur ; Deborah DEWEY, Auteur . - p.85-94. Langues : Anglais (eng) in Development and Psychopathology > 35-1 (February 2023) . - p.85-94 Mots-clés : attention-deficit/hyperactivity disorder  developmental coordination disorder  emotion control  emotion regulation  executive function Index. décimale : PER Périodiques Résumé : Behavioral regulation problems have been associated with daily-life and mental health challenges in children with neurodevelopmental conditions such as attention-deficit/hyperactivity disorder (ADHD) and developmental coordination disorder (DCD). Here, we investigated transdiagnostic brain signatures associated with behavioral regulation. Resting-state fMRI data were collected from 115 children (31 typically developing (TD), 35 ADHD, 21 DCD, 28 ADHD-DCD) aged 7-17 years. Behavioral regulation was measured using the Behavior Rating Inventory of Executive Function and was found to differ between children with ADHD (i.e., children with ADHD and ADHD-DCD) and without ADHD (i.e., TD children and children with DCD). Functional connectivity (FC) maps were computed for 10 regions of interest and FC maps were tested for correlations with behavioral regulation scores. Across the entire sample, greater behavioral regulation problems were associated with stronger negative FC within prefrontal pathways and visual reward pathways, as well as with weaker positive FC in frontostriatal reward pathways. These findings significantly increase our knowledge on FC in children with and without ADHD and highlight the potential of FC as brain-based signatures of behavioral regulation across children with differing neurodevelopmental conditions. En ligne : https://doi.org/10.1017/S0954579421001449 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Largely Typical Electrophysiological Affective Responses to Special Interest Stimuli in Adolescents with Autism Spectrum Disorder / Keelin RIVARD in Journal of Autism and Developmental Disorders, 48-9 (September 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3133-3143 Titre : Largely Typical Electrophysiological Affective Responses to Special Interest Stimuli in Adolescents with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Keelin RIVARD, Auteur ; Andrea B. PROTZNER, Auteur ; Ford BURLES, Auteur ; Manuela SCHUETZE, Auteur ; Ivy CHO, Auteur ; Kayla TEN EYCKE, Auteur ; Adam W. MCCRIMMON, Auteur ; Deborah DEWEY, Auteur ; Filomeno CORTESE, Auteur ; Signe BRAY, Auteur Article en page(s) : p.3133-3143 Langues : Anglais (eng) Mots-clés : Affective  Autism spectrum disorder  Circumscribed interests  Eeg  Lpp Index. décimale : PER Périodiques Résumé : Circumscribed interests are a symptom of autism spectrum disorder (ASD) that may be related to exaggerated affective neural responses. However, the use of generic ASD-interest image stimuli has left an open question as to whether affective responses towards individual interests are greater in ASD compared to typically developing (TD) controls. We compared amplitudes of the late positive potential (LPP), an affective electroencephalographic response, between adolescents with ASD (N = 19) and TD adolescents (N = 20), using images tailored to individual likes and dislikes. We found an LPP response for liked and disliked images, relative to neutral, with no difference in amplitude between groups. This suggests that the LPP is not atypical in adolescents with ASD towards images of individual interests. En ligne : http://dx.doi.org/10.1007/s10803-018-3587-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Largely Typical Electrophysiological Affective Responses to Special Interest Stimuli in Adolescents with Autism Spectrum Disorder [texte imprimé] / Keelin RIVARD, Auteur ; Andrea B. PROTZNER, Auteur ; Ford BURLES, Auteur ; Manuela SCHUETZE, Auteur ; Ivy CHO, Auteur ; Kayla TEN EYCKE, Auteur ; Adam W. MCCRIMMON, Auteur ; Deborah DEWEY, Auteur ; Filomeno CORTESE, Auteur ; Signe BRAY, Auteur . - p.3133-3143. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3133-3143 Mots-clés : Affective  Autism spectrum disorder  Circumscribed interests  Eeg  Lpp Index. décimale : PER Périodiques Résumé : Circumscribed interests are a symptom of autism spectrum disorder (ASD) that may be related to exaggerated affective neural responses. However, the use of generic ASD-interest image stimuli has left an open question as to whether affective responses towards individual interests are greater in ASD compared to typically developing (TD) controls. We compared amplitudes of the late positive potential (LPP), an affective electroencephalographic response, between adolescents with ASD (N = 19) and TD adolescents (N = 20), using images tailored to individual likes and dislikes. We found an LPP response for liked and disliked images, relative to neutral, with no difference in amplitude between groups. This suggests that the LPP is not atypical in adolescents with ASD towards images of individual interests. En ligne : http://dx.doi.org/10.1007/s10803-018-3587-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum / Svenja ESPENHAHN in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 26 p. Titre : Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum Type de document : texte imprimé Auteurs : Svenja ESPENHAHN, Auteur ; Kate J. GODFREY, Auteur ; Sakshi KAUR, Auteur ; Maia ROSS, Auteur ; Niloy NATH, Auteur ; Olesya DMITRIEVA, Auteur ; Carly A. MCMORRIS, Auteur ; Filomeno CORTESE, Auteur ; Caroline WRIGHT, Auteur ; Kara MURIAS, Auteur ; Deborah DEWEY, Auteur ; Andrea B. PROTZNER, Auteur ; Adam W. MCCRIMMON, Auteur ; Signe BRAY, Auteur ; Ashley D. HARRIS, Auteur Article en page(s) : 26 p. Langues : Anglais (eng) Mots-clés : Autistic Disorder/physiopathology  Child  Child, Preschool  Electroencephalography  Evoked Potentials, Somatosensory  Female  Humans  Male  Somatosensory Cortex/physiopathology  Touch  Adaptation  Autism  Children  Eeg  Erp  Somatosensory-evoked potentials  Tactile sensitivities  Tactile stimulation Index. décimale : PER Périodiques Résumé : BACKGROUND: Unusual behavioral reactions to sensory stimuli are frequently reported in individuals on the autism spectrum (AS). Despite the early emergence of sensory features (< age 3) and their potential impact on development and quality of life, little is known about the neural mechanisms underlying sensory reactivity in early childhood autism. METHODS: Here, we used electroencephalography (EEG) to investigate tactile cortical processing in young children aged 3-6 years with autism and in neurotypical (NT) children. Scalp EEG was recorded from 33 children with autism, including those with low cognitive and/or verbal abilities, and 45 age- and sex-matched NT children during passive tactile fingertip stimulation. We compared properties of early and later somatosensory-evoked potentials (SEPs) and their adaptation with repetitive stimulation between autistic and NT children and assessed whether these neural measures are linked to "real-world" parent-reported tactile reactivity. RESULTS: As expected, we found elevated tactile reactivity in children on the autism spectrum. Our findings indicated no differences in amplitude or latency of early and mid-latency somatosensory-evoked potentials (P50, N80, P100), nor adaptation between autistic and NT children. However, latency of later processing of tactile information (N140) was shorter in young children with autism compared to NT children, suggesting faster processing speed in young autistic children. Further, correlational analyses and exploratory analyses using tactile reactivity as a grouping variable found that enhanced early neural responses were associated with greater tactile reactivity in autism. LIMITATIONS: The relatively small sample size and the inclusion of a broad range of autistic children (e.g., with low cognitive and/or verbal abilities) may have limited our power to detect subtle group differences and associations. Hence, replications are needed to verify these results. CONCLUSIONS: Our findings suggest that electrophysiological somatosensory cortex processing measures may be indices of "real-world" tactile reactivity in early childhood autism. Together, these findings advance our understanding of the neurophysiological mechanisms underlying tactile reactivity in early childhood autism and, in the clinical context, may have therapeutic implications. En ligne : http://dx.doi.org/10.1186/s13229-021-00435-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum [texte imprimé] / Svenja ESPENHAHN, Auteur ; Kate J. GODFREY, Auteur ; Sakshi KAUR, Auteur ; Maia ROSS, Auteur ; Niloy NATH, Auteur ; Olesya DMITRIEVA, Auteur ; Carly A. MCMORRIS, Auteur ; Filomeno CORTESE, Auteur ; Caroline WRIGHT, Auteur ; Kara MURIAS, Auteur ; Deborah DEWEY, Auteur ; Andrea B. PROTZNER, Auteur ; Adam W. MCCRIMMON, Auteur ; Signe BRAY, Auteur ; Ashley D. HARRIS, Auteur . - 26 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 26 p. Mots-clés : Autistic Disorder/physiopathology  Child  Child, Preschool  Electroencephalography  Evoked Potentials, Somatosensory  Female  Humans  Male  Somatosensory Cortex/physiopathology  Touch  Adaptation  Autism  Children  Eeg  Erp  Somatosensory-evoked potentials  Tactile sensitivities  Tactile stimulation Index. décimale : PER Périodiques Résumé : BACKGROUND: Unusual behavioral reactions to sensory stimuli are frequently reported in individuals on the autism spectrum (AS). Despite the early emergence of sensory features (< age 3) and their potential impact on development and quality of life, little is known about the neural mechanisms underlying sensory reactivity in early childhood autism. METHODS: Here, we used electroencephalography (EEG) to investigate tactile cortical processing in young children aged 3-6 years with autism and in neurotypical (NT) children. Scalp EEG was recorded from 33 children with autism, including those with low cognitive and/or verbal abilities, and 45 age- and sex-matched NT children during passive tactile fingertip stimulation. We compared properties of early and later somatosensory-evoked potentials (SEPs) and their adaptation with repetitive stimulation between autistic and NT children and assessed whether these neural measures are linked to "real-world" parent-reported tactile reactivity. RESULTS: As expected, we found elevated tactile reactivity in children on the autism spectrum. Our findings indicated no differences in amplitude or latency of early and mid-latency somatosensory-evoked potentials (P50, N80, P100), nor adaptation between autistic and NT children. However, latency of later processing of tactile information (N140) was shorter in young children with autism compared to NT children, suggesting faster processing speed in young autistic children. Further, correlational analyses and exploratory analyses using tactile reactivity as a grouping variable found that enhanced early neural responses were associated with greater tactile reactivity in autism. LIMITATIONS: The relatively small sample size and the inclusion of a broad range of autistic children (e.g., with low cognitive and/or verbal abilities) may have limited our power to detect subtle group differences and associations. Hence, replications are needed to verify these results. CONCLUSIONS: Our findings suggest that electrophysiological somatosensory cortex processing measures may be indices of "real-world" tactile reactivity in early childhood autism. Together, these findings advance our understanding of the neurophysiological mechanisms underlying tactile reactivity in early childhood autism and, in the clinical context, may have therapeutic implications. En ligne : http://dx.doi.org/10.1186/s13229-021-00435-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

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