Gestational thyroid hormones and autism-related traits in the EARLI and HOME studies / Caichen ZHONG in Autism Research, 17-4 (April 2024)  

Public ISBD [article]  inAutism Research > 17-4 (April 2024) . - p.716-727 Titre : Gestational thyroid hormones and autism-related traits in the EARLI and HOME studies Type de document : Texte imprimé et/ou numérique Auteurs : Caichen ZHONG, Auteur ; Juliette RANDO, Auteur ; Marisa A. PATTI, Auteur ; Joseph M. BRAUN, Auteur ; Aimin CHEN, Auteur ; Yingying XU, Auteur ; Bruce P. LANPHEAR, Auteur ; Kimberly YOLTON, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.716-727 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Thyroid hormones are essential for neurodevelopment. Few studies have considered associations with quantitatively measured autism spectrum disorder (ASD)-related traits, which may help elucidate associations for a broader population. Participants were drawn from two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI), enrolling pregnant women who already had a child with ASD, and the Health Outcomes and Measures of the Environment (HOME) Study, following pregnant women from the greater Cincinnati, OH area. Gestational thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were measured in mid-pregnancy 16 (+3) weeks gestation serum samples. ASD-related traits were measured using the Social Responsiveness Scale (SRS) at ages 3-8?years. The association was examined using quantile regression, adjusting for maternal and sociodemographic factors. 278 participants (132 from EARLI, 146 from HOME) were included. TSH distributions were similar across cohorts, while FT4 levels were higher in EARLI compared to HOME. In pooled analyses, particularly for those in the highest SRS quantile (95th percentile), higher FT4 levels were associated with increasing SRS scores (? = 5.21, 95% CI = 0.93, 9.48), and higher TSH levels were associated with decreasing SRS scores (? = ?6.94, 95% CI = ?11.04, ?2.83). The association between TSH and SRS remained significant in HOME for the 95% percentile of SRS scores (? = ?6.48, 95% CI = ?12.16, ?0.80), but not EARLI. Results for FT4 were attenuated when examined in the individual cohorts. Our results add to evidence that gestational thyroid hormones may be associated with ASD-related outcomes by suggesting that relationships may differ across the distribution of ASD-related traits and by familial likelihood of ASD. En ligne : https://doi.org/10.1002/aur.3115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] Gestational thyroid hormones and autism-related traits in the EARLI and HOME studies [Texte imprimé et/ou numérique] / Caichen ZHONG, Auteur ; Juliette RANDO, Auteur ; Marisa A. PATTI, Auteur ; Joseph M. BRAUN, Auteur ; Aimin CHEN, Auteur ; Yingying XU, Auteur ; Bruce P. LANPHEAR, Auteur ; Kimberly YOLTON, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur . - p.716-727. Langues : Anglais (eng) in Autism Research > 17-4 (April 2024) . - p.716-727 Index. décimale : PER Périodiques Résumé : Abstract Thyroid hormones are essential for neurodevelopment. Few studies have considered associations with quantitatively measured autism spectrum disorder (ASD)-related traits, which may help elucidate associations for a broader population. Participants were drawn from two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI), enrolling pregnant women who already had a child with ASD, and the Health Outcomes and Measures of the Environment (HOME) Study, following pregnant women from the greater Cincinnati, OH area. Gestational thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were measured in mid-pregnancy 16 (+3) weeks gestation serum samples. ASD-related traits were measured using the Social Responsiveness Scale (SRS) at ages 3-8?years. The association was examined using quantile regression, adjusting for maternal and sociodemographic factors. 278 participants (132 from EARLI, 146 from HOME) were included. TSH distributions were similar across cohorts, while FT4 levels were higher in EARLI compared to HOME. In pooled analyses, particularly for those in the highest SRS quantile (95th percentile), higher FT4 levels were associated with increasing SRS scores (? = 5.21, 95% CI = 0.93, 9.48), and higher TSH levels were associated with decreasing SRS scores (? = ?6.94, 95% CI = ?11.04, ?2.83). The association between TSH and SRS remained significant in HOME for the 95% percentile of SRS scores (? = ?6.48, 95% CI = ?12.16, ?0.80), but not EARLI. Results for FT4 were attenuated when examined in the individual cohorts. Our results add to evidence that gestational thyroid hormones may be associated with ASD-related outcomes by suggesting that relationships may differ across the distribution of ASD-related traits and by familial likelihood of ASD. En ligne : https://doi.org/10.1002/aur.3115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program / Marisa A. PATTI in Autism Research, 17-5 (May 2024)  

Public ISBD [article]  inAutism Research > 17-5 (May 2024) Titre : Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program Type de document : Texte imprimé et/ou numérique Auteurs : Marisa A. PATTI, Auteur ; Lisa A. CROEN, Auteur ; Aisha S. DICKERSON, Auteur ; Robert M. JOSEPH, Auteur ; Jennifer L. AMES, Auteur ; Christine LADD-ACOSTA, Auteur ; Sally OZONOFF, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Alison E. HIPWELL, Auteur ; Kelsey E. MAGEE, Auteur ; Margaret KARAGAS, Auteur ; Cindy MCEVOY, Auteur ; Rebecca LANDA, Auteur ; Michael R. ELLIOTT, Auteur ; Daphne Koinis MITCHELL, Auteur ; Viren D'SA, Auteur ; Sean DEONI, Auteur ; Michelle PIEVSKY, Auteur ; Pei-Chi WU, Auteur ; Fatoumata BARRY, Auteur ; Joseph B. STANFORD, Auteur ; Deborah A. BILDER, Auteur ; Leonardo TRASANDE, Auteur ; Nicole R. BUSH, Auteur ; Kristen LYALL, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable in early childhood. The Social Responsiveness Scale (SRS) measures autism-related traits and broader autism phenotype, with two age-dependent forms in childhood (preschool, 2.5-4.5?years; school age, 4-18?years). Score consistency has been observed within forms, though reliability across forms has not been evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program (n = 853), preschool, and school-age SRS scores were collected via maternal report when children were an average of 3.0 and 5.8?years, respectively. We compared reproducibility of SRS total scores (T-scores) and agreement above a clinically meaningful cutoff (T-scores???60) and examined predictors of discordance in cutoff scores across forms. Participant scores across forms were similar (mean difference: 3.3 points; standard deviation: 7), though preschool scores were on average lower than school-age scores. Most children (88%) were classified below the cutoff on both forms, and overall concordance was high (92%). However, discordance was higher in cohorts following younger siblings of autistic children (16%). Proportions of children with an autism diagnoses were also higher among those with discordant scores (27%) than among those with concordant scores (4%). Our findings indicate SRS scores are broadly reproducible across preschool and school-age forms, particularly for capturing broader, nonclinical traits, but also suggest that greater variability of autism-related traits in preschool-age children may reduce reliability with later school-age scores for those in the clinical range. En ligne : https://doi.org/10.1002/aur.3147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529 [article] Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program [Texte imprimé et/ou numérique] / Marisa A. PATTI, Auteur ; Lisa A. CROEN, Auteur ; Aisha S. DICKERSON, Auteur ; Robert M. JOSEPH, Auteur ; Jennifer L. AMES, Auteur ; Christine LADD-ACOSTA, Auteur ; Sally OZONOFF, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Alison E. HIPWELL, Auteur ; Kelsey E. MAGEE, Auteur ; Margaret KARAGAS, Auteur ; Cindy MCEVOY, Auteur ; Rebecca LANDA, Auteur ; Michael R. ELLIOTT, Auteur ; Daphne Koinis MITCHELL, Auteur ; Viren D'SA, Auteur ; Sean DEONI, Auteur ; Michelle PIEVSKY, Auteur ; Pei-Chi WU, Auteur ; Fatoumata BARRY, Auteur ; Joseph B. STANFORD, Auteur ; Deborah A. BILDER, Auteur ; Leonardo TRASANDE, Auteur ; Nicole R. BUSH, Auteur ; Kristen LYALL, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur. Langues : Anglais (eng) in Autism Research > 17-5 (May 2024) Index. décimale : PER Périodiques Résumé : Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable in early childhood. The Social Responsiveness Scale (SRS) measures autism-related traits and broader autism phenotype, with two age-dependent forms in childhood (preschool, 2.5-4.5?years; school age, 4-18?years). Score consistency has been observed within forms, though reliability across forms has not been evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program (n = 853), preschool, and school-age SRS scores were collected via maternal report when children were an average of 3.0 and 5.8?years, respectively. We compared reproducibility of SRS total scores (T-scores) and agreement above a clinically meaningful cutoff (T-scores???60) and examined predictors of discordance in cutoff scores across forms. Participant scores across forms were similar (mean difference: 3.3 points; standard deviation: 7), though preschool scores were on average lower than school-age scores. Most children (88%) were classified below the cutoff on both forms, and overall concordance was high (92%). However, discordance was higher in cohorts following younger siblings of autistic children (16%). Proportions of children with an autism diagnoses were also higher among those with discordant scores (27%) than among those with concordant scores (4%). Our findings indicate SRS scores are broadly reproducible across preschool and school-age forms, particularly for capturing broader, nonclinical traits, but also suggest that greater variability of autism-related traits in preschool-age children may reduce reliability with later school-age scores for those in the clinical range. En ligne : https://doi.org/10.1002/aur.3147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529

---

1 (1 - 2 / 2)