Mapping associations of polygenic scores with autistic and ADHD traits in a single city region / Zoe E. REED ; Richard Thomas ; Andy Boyd ; Gareth J. Griffith ; Tim T. Morris ; Dheeraj RAI ; David Manley ; George DAVEY SMITH ; Oliver S. P. DAVIS in Journal of Child Psychology and Psychiatry, 66-2 (February 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-2 (February 2025) . - p.202-213 Titre : Mapping associations of polygenic scores with autistic and ADHD traits in a single city region : Journal of Child Psychology and Psychiatry Type de document : Texte imprimé et/ou numérique Auteurs : Zoe E. REED, Auteur ; Richard Thomas, Auteur ; Andy Boyd, Auteur ; Gareth J. Griffith, Auteur ; Tim T. Morris, Auteur ; Dheeraj RAI, Auteur ; David Manley, Auteur ; George DAVEY SMITH, Auteur ; Oliver S. P. DAVIS, Auteur Article en page(s) : p.202-213 Langues : Anglais (eng) Mots-clés : Autism  ADHD  polygenic risk score  ALSPAC  spatial Index. décimale : PER Périodiques Résumé : Background The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants? Methods We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N?=?4,255?6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD. Results Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences. Conclusions These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits. En ligne : https://doi.org/10.1111/jcpp.14047 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 [article] Mapping associations of polygenic scores with autistic and ADHD traits in a single city region : Journal of Child Psychology and Psychiatry [Texte imprimé et/ou numérique] / Zoe E. REED, Auteur ; Richard Thomas, Auteur ; Andy Boyd, Auteur ; Gareth J. Griffith, Auteur ; Tim T. Morris, Auteur ; Dheeraj RAI, Auteur ; David Manley, Auteur ; George DAVEY SMITH, Auteur ; Oliver S. P. DAVIS, Auteur . - p.202-213. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-2 (February 2025) . - p.202-213 Mots-clés : Autism  ADHD  polygenic risk score  ALSPAC  spatial Index. décimale : PER Périodiques Résumé : Background The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants? Methods We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N?=?4,255?6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD. Results Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences. Conclusions These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits. En ligne : https://doi.org/10.1111/jcpp.14047 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545

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