[article]
| Titre : |
Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Sarah BANKER, Auteur ; Jadyn TRAYVICK, Auteur ; Sarah BARKLEY, Auteur ; Arabella W PETERS, Auteur ; Abigaël THINAKARAN, Auteur ; Christopher MCLAUGHLIN, Auteur ; Xiaosi GU, Auteur ; Daniela SCHILLER, Auteur ; Jennifer FOSS-FEIG, Auteur |
| Article en page(s) : |
9 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Humans Male Female Gyrus Cinguli/diagnostic imaging Depression/diagnostic imaging Adult Young Adult Autism Spectrum Disorder/diagnostic imaging/psychology Perception Magnetic Resonance Imaging Autistic Disorder/psychology/diagnostic imaging Adolescent Organ Size Social Interaction Amygdala/diagnostic imaging/pathology/physiopathology Affiliation Amygdala Anterior cingulate cortex Autism spectrum disorder Depression Self-awareness Social impairments Medicine at Mount Sinai?s Institutional Review Board approved the study protocol (#16-01089 for onsite neuroimaging & #22-00171 for online replication sample presented in Supplementary Materials). All participants gave written informed consent and received compensation for their participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: The prevalence of depression is elevated in individuals with autism spectrum disorder (ASD) compared to the general population, yet the reasons for this disparity remain unclear. While social deficits central to ASD may contribute to depression, it is uncertain whether social interaction behavior themselves or individuals' introspection about their social behaviors are more impactful. Although the anterior cingulate cortex (ACC) is frequently implicated in ASD, depression, and social functioning, it is unknown if it explains differences between ASD adults with and without co-occurring depression. METHODS: The present study contrasted observed vs. subjective perception of autism symptoms and social interaction assessed with both standardized measures and a lab task, in 65 sex-balanced (52.24% male) autistic young adults. We also quantified ACC and amygdala volume with 7-Tesla structural neuroimaging to examine correlations with self-reported depression and social functioning. RESULTS: We found that ASD individuals with self-reported depression exhibited differences in subjective evaluations including heightened self-awareness of ASD symptoms, lower subjective satisfaction with social relations, and less perceived affiliation during the social interaction task, yet no differences in corresponding observed measures, compared to those without depression. Larger ACC volume was related to depression, greater self-awareness of ASD symptoms, and worse subjective satisfaction with social relations. In contrast, amygdala volume, despite its association with clinician-rated ASD symptoms, was not related to depression. LIMITATIONS: Due to the cross-sectional nature of our study, we cannot determine the directionality of the observed relationships. Additionally, we included only individuals with an IQ over 60 to ensure participants could complete the social task. We also utilized self-reported depression indices instead of clinically diagnosed depression, which may limit the comprehensiveness of the findings. CONCLUSIONS: Our approach highlights the unique role of subjective perception of autism symptoms and social interactions, beyond the observable manifestation of social impairment in ASD, in contributing to self-reported depression, with the ACC playing a crucial role. These findings imply possible heterogeneity of ASD concerning co-occurring depression. Using neuroimaging, we were able to demarcate depressive phenotypes co-occurring alongside autistic phenotypes. |
| En ligne : |
https://dx.doi.org/10.1186/s13229-025-00638-4 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 |
in Molecular Autism > 16 (2025) . - 9
[article] Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume [Texte imprimé et/ou numérique] / Sarah BANKER, Auteur ; Jadyn TRAYVICK, Auteur ; Sarah BARKLEY, Auteur ; Arabella W PETERS, Auteur ; Abigaël THINAKARAN, Auteur ; Christopher MCLAUGHLIN, Auteur ; Xiaosi GU, Auteur ; Daniela SCHILLER, Auteur ; Jennifer FOSS-FEIG, Auteur . - 9. Langues : Anglais ( eng) in Molecular Autism > 16 (2025) . - 9
| Mots-clés : |
Humans Male Female Gyrus Cinguli/diagnostic imaging Depression/diagnostic imaging Adult Young Adult Autism Spectrum Disorder/diagnostic imaging/psychology Perception Magnetic Resonance Imaging Autistic Disorder/psychology/diagnostic imaging Adolescent Organ Size Social Interaction Amygdala/diagnostic imaging/pathology/physiopathology Affiliation Amygdala Anterior cingulate cortex Autism spectrum disorder Depression Self-awareness Social impairments Medicine at Mount Sinai?s Institutional Review Board approved the study protocol (#16-01089 for onsite neuroimaging & #22-00171 for online replication sample presented in Supplementary Materials). All participants gave written informed consent and received compensation for their participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: The prevalence of depression is elevated in individuals with autism spectrum disorder (ASD) compared to the general population, yet the reasons for this disparity remain unclear. While social deficits central to ASD may contribute to depression, it is uncertain whether social interaction behavior themselves or individuals' introspection about their social behaviors are more impactful. Although the anterior cingulate cortex (ACC) is frequently implicated in ASD, depression, and social functioning, it is unknown if it explains differences between ASD adults with and without co-occurring depression. METHODS: The present study contrasted observed vs. subjective perception of autism symptoms and social interaction assessed with both standardized measures and a lab task, in 65 sex-balanced (52.24% male) autistic young adults. We also quantified ACC and amygdala volume with 7-Tesla structural neuroimaging to examine correlations with self-reported depression and social functioning. RESULTS: We found that ASD individuals with self-reported depression exhibited differences in subjective evaluations including heightened self-awareness of ASD symptoms, lower subjective satisfaction with social relations, and less perceived affiliation during the social interaction task, yet no differences in corresponding observed measures, compared to those without depression. Larger ACC volume was related to depression, greater self-awareness of ASD symptoms, and worse subjective satisfaction with social relations. In contrast, amygdala volume, despite its association with clinician-rated ASD symptoms, was not related to depression. LIMITATIONS: Due to the cross-sectional nature of our study, we cannot determine the directionality of the observed relationships. Additionally, we included only individuals with an IQ over 60 to ensure participants could complete the social task. We also utilized self-reported depression indices instead of clinically diagnosed depression, which may limit the comprehensiveness of the findings. CONCLUSIONS: Our approach highlights the unique role of subjective perception of autism symptoms and social interactions, beyond the observable manifestation of social impairment in ASD, in contributing to self-reported depression, with the ACC playing a crucial role. These findings imply possible heterogeneity of ASD concerning co-occurring depression. Using neuroimaging, we were able to demarcate depressive phenotypes co-occurring alongside autistic phenotypes. |
| En ligne : |
https://dx.doi.org/10.1186/s13229-025-00638-4 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 |
|
Faire une suggestion Affiner la rechercheUnderstanding depression in autism: the role of subjective perception and anterior cingulate cortex volume / Sarah BANKER ; Jadyn TRAYVICK ; Sarah BARKLEY ; Arabella W PETERS ; Abigaël THINAKARAN ; Christopher MCLAUGHLIN ; Xiaosi GU ; Daniela SCHILLER ; Jennifer FOSS-FEIG in Molecular Autism, 16 (2025)
