Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation / Sarah J. GOODMAN in Journal of Neurodevelopmental Disorders, 12 (2020)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 12 (2020) Titre : Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation Type de document : texte imprimé Auteurs : Sarah J. GOODMAN, Auteur ; Christie L. BURTON, Auteur ; Darci T. BUTCHER, Auteur ; Michelle T. SIU, Auteur ; Mathieu LEMIRE, Auteur ; Eric CHATER-DIEHL, Auteur ; Andrei L. TURINSKY, Auteur ; Michael BRUDNO, Auteur ; Noam SORENI, Auteur ; David ROSENBERG, Auteur ; Kate D. FITZGERALD, Auteur ; Gregory L. HANNA, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Paul D. ARNOLD, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Rosanna WEKSBERG, Auteur Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/genetics  DNA Methylation/genetics  Genetic Variation/genetics  Humans  Obsessive-Compulsive Disorder/genetics  Adhd  Biomarker  DNA methylation  Epigenetics  Ocd Index. décimale : PER Périodiques Résumé : BACKGROUND: A growing body of research has demonstrated associations between specific neurodevelopmental disorders and variation in DNA methylation (DNAm), implicating this molecular mark as a possible contributor to the molecular etiology of these disorders and/or as a novel disease biomarker. Furthermore, genetic risk variants of neurodevelopmental disorders have been found to be enriched at loci associated with DNAm patterns, referred to as methylation quantitative trait loci (mQTLs). METHODS: We conducted two epigenome-wide association studies in individuals with attention-deficit/hyperactivity disorder (ADHD) or obsessive-compulsive disorder (OCD) (aged 4-18 years) using DNA extracted from saliva. DNAm data generated on the Illumina Human Methylation 450 K array were used to examine the interaction between genetic variation and DNAm patterns associated with these disorders. RESULTS: Using linear regression followed by principal component analysis, individuals with the most endorsed symptoms of ADHD or OCD were found to have significantly more distinct DNAm patterns from controls, as compared to all cases. This suggested that the phenotypic heterogeneity of these disorders is reflected in altered DNAm at specific sites. Further investigations of the DNAm sites associated with each disorder revealed that despite little overlap of these DNAm sites across the two disorders, both disorders were significantly enriched for mQTLs within our sample. CONCLUSIONS: Our DNAm data provide insights into the regulatory changes associated with genetic variation, highlighting their potential utility both in directing GWAS and in elucidating the pathophysiology of neurodevelopmental disorders. En ligne : https://dx.doi.org/10.1186/s11689-020-09324-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation [texte imprimé] / Sarah J. GOODMAN, Auteur ; Christie L. BURTON, Auteur ; Darci T. BUTCHER, Auteur ; Michelle T. SIU, Auteur ; Mathieu LEMIRE, Auteur ; Eric CHATER-DIEHL, Auteur ; Andrei L. TURINSKY, Auteur ; Michael BRUDNO, Auteur ; Noam SORENI, Auteur ; David ROSENBERG, Auteur ; Kate D. FITZGERALD, Auteur ; Gregory L. HANNA, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Paul D. ARNOLD, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Rosanna WEKSBERG, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 12 (2020) Mots-clés : Attention Deficit Disorder with Hyperactivity/genetics  DNA Methylation/genetics  Genetic Variation/genetics  Humans  Obsessive-Compulsive Disorder/genetics  Adhd  Biomarker  DNA methylation  Epigenetics  Ocd Index. décimale : PER Périodiques Résumé : BACKGROUND: A growing body of research has demonstrated associations between specific neurodevelopmental disorders and variation in DNA methylation (DNAm), implicating this molecular mark as a possible contributor to the molecular etiology of these disorders and/or as a novel disease biomarker. Furthermore, genetic risk variants of neurodevelopmental disorders have been found to be enriched at loci associated with DNAm patterns, referred to as methylation quantitative trait loci (mQTLs). METHODS: We conducted two epigenome-wide association studies in individuals with attention-deficit/hyperactivity disorder (ADHD) or obsessive-compulsive disorder (OCD) (aged 4-18 years) using DNA extracted from saliva. DNAm data generated on the Illumina Human Methylation 450 K array were used to examine the interaction between genetic variation and DNAm patterns associated with these disorders. RESULTS: Using linear regression followed by principal component analysis, individuals with the most endorsed symptoms of ADHD or OCD were found to have significantly more distinct DNAm patterns from controls, as compared to all cases. This suggested that the phenotypic heterogeneity of these disorders is reflected in altered DNAm at specific sites. Further investigations of the DNAm sites associated with each disorder revealed that despite little overlap of these DNAm sites across the two disorders, both disorders were significantly enriched for mQTLs within our sample. CONCLUSIONS: Our DNAm data provide insights into the regulatory changes associated with genetic variation, highlighting their potential utility both in directing GWAS and in elucidating the pathophysiology of neurodevelopmental disorders. En ligne : https://dx.doi.org/10.1186/s11689-020-09324-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Predictors of risk and resilience to psychopathology in refugee youth: A longitudinal study / Liza M. HINCHEY in Development and Psychopathology, 38-2 (May 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-2 (May 2026) . - p.582-593 Titre : Predictors of risk and resilience to psychopathology in refugee youth: A longitudinal study Type de document : texte imprimé Auteurs : Liza M. HINCHEY, Auteur ; Rasheed ALAHMAD, Auteur ; Kathleen GORSKI, Auteur ; Mackenzie JENUWINE, Auteur ; Nicole NUGENT, Auteur ; David ROSENBERG, Auteur ; Tuka MOHIDDIN, Auteur ; Arash JAVANBAKHT, Auteur Article en page(s) : p.582-593 Langues : Anglais (eng) Mots-clés : Anxiety  children  posttraumatic stress  refugees  youth Index. décimale : PER Périodiques Résumé : Refugee youth are at high risk for trauma-related disorders – outcomes not only the result of pre-migration trauma, but consequences of diverse post-migration stressors. This study identified individual, parental, and environmental factors – some potentially modifiable – associated with trajectories of psychological risk and resilience in 291 Syrian and Iraqi refugee youth during resettlement in the U.S. Data was collected at arrival and at two follow-up visits up to 7 years post-arrival. Linear mixed modeling assessed predictors of posttraumatic stress disorder (PTSD), anxiety, and depression trajectories. Victimization trauma (i.e., assault) and lower maternal subjective social status predicted more severe PTSD (p = .046, f 2 = .07; p < .001, f 2 = .23) and anxiety (p = .008, f2 = .05; p = .002, f 2 = .11) trajectories in youth. Paternal unemployment predicted less stable PTSD (p = .009, f2 = .13) and anxiety (p < .001, f 2 = .10) trajectories. More severe depression trajectories were associated with female sex (p = .045, f 2 = .06) and death threat traumas (p = .014, f 2 = .07). Findings identified predictors of long-term risk and resilience for refugee youth, as well as potentially modifiable ecological risk factors. Victimization and death threat trauma exposure could be salient in identifying youth at high risk for trauma-related symptoms early in resettlement. Indicators of financial security were also associated with symptoms, suggesting environmental intervention targets. En ligne : https://dx.doi.org/10.1017/S0954579425100576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Predictors of risk and resilience to psychopathology in refugee youth: A longitudinal study [texte imprimé] / Liza M. HINCHEY, Auteur ; Rasheed ALAHMAD, Auteur ; Kathleen GORSKI, Auteur ; Mackenzie JENUWINE, Auteur ; Nicole NUGENT, Auteur ; David ROSENBERG, Auteur ; Tuka MOHIDDIN, Auteur ; Arash JAVANBAKHT, Auteur . - p.582-593. Langues : Anglais (eng) in Development and Psychopathology > 38-2 (May 2026) . - p.582-593 Mots-clés : Anxiety  children  posttraumatic stress  refugees  youth Index. décimale : PER Périodiques Résumé : Refugee youth are at high risk for trauma-related disorders – outcomes not only the result of pre-migration trauma, but consequences of diverse post-migration stressors. This study identified individual, parental, and environmental factors – some potentially modifiable – associated with trajectories of psychological risk and resilience in 291 Syrian and Iraqi refugee youth during resettlement in the U.S. Data was collected at arrival and at two follow-up visits up to 7 years post-arrival. Linear mixed modeling assessed predictors of posttraumatic stress disorder (PTSD), anxiety, and depression trajectories. Victimization trauma (i.e., assault) and lower maternal subjective social status predicted more severe PTSD (p = .046, f 2 = .07; p < .001, f 2 = .23) and anxiety (p = .008, f2 = .05; p = .002, f 2 = .11) trajectories in youth. Paternal unemployment predicted less stable PTSD (p = .009, f2 = .13) and anxiety (p < .001, f 2 = .10) trajectories. More severe depression trajectories were associated with female sex (p = .045, f 2 = .06) and death threat traumas (p = .014, f 2 = .07). Findings identified predictors of long-term risk and resilience for refugee youth, as well as potentially modifiable ecological risk factors. Victimization and death threat trauma exposure could be salient in identifying youth at high risk for trauma-related symptoms early in resettlement. Indicators of financial security were also associated with symptoms, suggesting environmental intervention targets. En ligne : https://dx.doi.org/10.1017/S0954579425100576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

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