Epilepsy in Autism Spectrum Disorders: Clinical Aspects and Implications for Treatment / Roberto CANITANO

Public ISBD contenu dans New Autism Research Developments / Barbara S. MESMERE Titre : Epilepsy in Autism Spectrum Disorders: Clinical Aspects and Implications for Treatment Type de document : texte imprimé Auteurs : Roberto CANITANO, Auteur ; Valeria SCANDURRA, Auteur Année de publication : 2008 Importance : p.197-209 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=670 contenu dans New Autism Research Developments / Barbara S. MESMERE Epilepsy in Autism Spectrum Disorders: Clinical Aspects and Implications for Treatment [texte imprimé] / Roberto CANITANO, Auteur ; Valeria SCANDURRA, Auteur . - 2008 . - p.197-209. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=670

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Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder / Julian TILLMANN in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2490-2505 Titre : Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Julian TILLMANN, Auteur ; Karen L. ASHWOOD, Auteur ; Michael ABSOUD, Auteur ; Sven BÖLTE, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Jan K. BUITELAAR, Auteur ; Sara CALDERONI, Auteur ; Rosa CALVO, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Roberto CANITANO, Auteur ; Annelies A. DE BILDT, Auteur ; Marie GOMOT, Auteur ; Pieter J. HOEKSTRA, Auteur ; Anett KAALE, Auteur ; Helen MCCONACHIE, Auteur ; Declan G.M. MURPHY, Auteur ; Antonio NARZISI, Auteur ; Iris J. OOSTERLING, Auteur ; M. PEJOVIC-MILOVANCEVIC, Auteur ; Antonio M. PERSICO, Auteur ; Olga PUIG, Auteur ; Herbert ROEYERS, Auteur ; Nanda N. ROMMELSE, Auteur ; Roberto SACCO, Auteur ; Valeria SCANDURRA, Auteur ; Andrew C. STANFIELD, Auteur ; E. ZANDER, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.2490-2505 Langues : Anglais (eng) Mots-clés : Age  Autism Spectrum Disorder  Phenotype  Sex  Symptom severity Index. décimale : PER Périodiques Résumé : Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology. En ligne : http://dx.doi.org/10.1007/s10803-018-3510-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder [texte imprimé] / Julian TILLMANN, Auteur ; Karen L. ASHWOOD, Auteur ; Michael ABSOUD, Auteur ; Sven BÖLTE, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Jan K. BUITELAAR, Auteur ; Sara CALDERONI, Auteur ; Rosa CALVO, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Roberto CANITANO, Auteur ; Annelies A. DE BILDT, Auteur ; Marie GOMOT, Auteur ; Pieter J. HOEKSTRA, Auteur ; Anett KAALE, Auteur ; Helen MCCONACHIE, Auteur ; Declan G.M. MURPHY, Auteur ; Antonio NARZISI, Auteur ; Iris J. OOSTERLING, Auteur ; M. PEJOVIC-MILOVANCEVIC, Auteur ; Antonio M. PERSICO, Auteur ; Olga PUIG, Auteur ; Herbert ROEYERS, Auteur ; Nanda N. ROMMELSE, Auteur ; Roberto SACCO, Auteur ; Valeria SCANDURRA, Auteur ; Andrew C. STANFIELD, Auteur ; E. ZANDER, Auteur ; Tony CHARMAN, Auteur . - p.2490-2505. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2490-2505 Mots-clés : Age  Autism Spectrum Disorder  Phenotype  Sex  Symptom severity Index. décimale : PER Périodiques Résumé : Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology. En ligne : http://dx.doi.org/10.1007/s10803-018-3510-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Glutamatergic agents in Autism Spectrum Disorders: Current trends / Roberto CANITANO in Research in Autism Spectrum Disorders, 8-3 (March 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-3 (March 2014) . - p.255-265 Titre : Glutamatergic agents in Autism Spectrum Disorders: Current trends Type de document : texte imprimé Auteurs : Roberto CANITANO, Auteur ; Valeria SCANDURRA, Auteur Article en page(s) : p.255-265 Langues : Anglais (eng) Mots-clés : Glutamate  Autism Spectrum Disorders  Novel treatments  Childhood and adolescence Index. décimale : PER Périodiques Résumé : Abstract Glutamate transmission dysfunction has been found in various preclinical models of Autism Spectrum Disorders (ASD), thus the glutamate system is a target for therapeutics. This report reviews current treatments for glutamate dysfunction in ASD models and clinical trials. Antagonists of metabotropic glutamate receptor subtype 5 (mGluR5) have been tested in preclinical models of autism. Black and Tan Bachyuric (BTBR) mice model behavioral phenotypes of the three core diagnostic domains of autism, e.g. social deficits, impaired language and communication, and repetitive behaviors. A significant reduction in repetitive self-grooming was observed after mGluR5 antagonist administration in BTBR mice. SHANK 3 deficient mice which have altered synaptic transmission and plasticity, were administered IGF-1 treatment to reverse these deficits based on the hypothesis that reduced AMPA receptor levels reflect less mature synapses. Clinical trials have been carried out in ASD with glutamate NMDA receptors, but current findings are not sufficient for conclusions on safety and efficacy. Memantine is an NMDA antagonist under investigation in controlled trials that hopefully will provide new insight on its use in autism. Studies using novel treatments with other glutamatergic agents are also underway and encouraging results have been observed with N-acetylcysteine in treating irritability in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=224 [article] Glutamatergic agents in Autism Spectrum Disorders: Current trends [texte imprimé] / Roberto CANITANO, Auteur ; Valeria SCANDURRA, Auteur . - p.255-265. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-3 (March 2014) . - p.255-265 Mots-clés : Glutamate  Autism Spectrum Disorders  Novel treatments  Childhood and adolescence Index. décimale : PER Périodiques Résumé : Abstract Glutamate transmission dysfunction has been found in various preclinical models of Autism Spectrum Disorders (ASD), thus the glutamate system is a target for therapeutics. This report reviews current treatments for glutamate dysfunction in ASD models and clinical trials. Antagonists of metabotropic glutamate receptor subtype 5 (mGluR5) have been tested in preclinical models of autism. Black and Tan Bachyuric (BTBR) mice model behavioral phenotypes of the three core diagnostic domains of autism, e.g. social deficits, impaired language and communication, and repetitive behaviors. A significant reduction in repetitive self-grooming was observed after mGluR5 antagonist administration in BTBR mice. SHANK 3 deficient mice which have altered synaptic transmission and plasticity, were administered IGF-1 treatment to reverse these deficits based on the hypothesis that reduced AMPA receptor levels reflect less mature synapses. Clinical trials have been carried out in ASD with glutamate NMDA receptors, but current findings are not sufficient for conclusions on safety and efficacy. Memantine is an NMDA antagonist under investigation in controlled trials that hopefully will provide new insight on its use in autism. Studies using novel treatments with other glutamatergic agents are also underway and encouraging results have been observed with N-acetylcysteine in treating irritability in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=224

Identification of a Novel Pathogenic Variant in the NAGLU Gene in a Child with Neurodevelopmental Delay / Lucia Pia BRUNO in Journal of Autism and Developmental Disorders, 52-10 (October 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4605-4607 Titre : Identification of a Novel Pathogenic Variant in the NAGLU Gene in a Child with Neurodevelopmental Delay Type de document : texte imprimé Auteurs : Lucia Pia BRUNO, Auteur ; Francesca FAVA, Auteur ; Margherita BALDASSARRI, Auteur ; Virginia M. SALVATI, Auteur ; Valeria SCANDURRA, Auteur ; Roberto CANITANO, Auteur ; Floriana VALENTINO, Auteur ; Gabriella DODDATO, Auteur ; Rossella TITA, Auteur ; Annarita GILIBERTI, Auteur ; Alessandra RENIERI, Auteur ; Francesca ARIANI, Auteur Article en page(s) : p.4605-4607 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-021-05332-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Identification of a Novel Pathogenic Variant in the NAGLU Gene in a Child with Neurodevelopmental Delay [texte imprimé] / Lucia Pia BRUNO, Auteur ; Francesca FAVA, Auteur ; Margherita BALDASSARRI, Auteur ; Virginia M. SALVATI, Auteur ; Valeria SCANDURRA, Auteur ; Roberto CANITANO, Auteur ; Floriana VALENTINO, Auteur ; Gabriella DODDATO, Auteur ; Rossella TITA, Auteur ; Annarita GILIBERTI, Auteur ; Alessandra RENIERI, Auteur ; Francesca ARIANI, Auteur . - p.4605-4607. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4605-4607 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-021-05332-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

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