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Auteur David J. POSEY
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Documents disponibles écrits par cet auteur (9)
Faire une suggestion Affiner la rechercheAutism and immune factors: A comprehensive review / Kimberly A. STIGLER in Research in Autism Spectrum Disorders, 3-4 (October-December 2009)
Titre : Autism and immune factors: A comprehensive review Type de document : texte imprimé Auteurs : Kimberly A. STIGLER, Auteur ; Thayne L. SWEETEN, Auteur ; Christopher J. MCDOUGLE, Auteur ; David J. POSEY, Auteur Année de publication : 2009 Article en page(s) : p.840-860 Langues : Anglais (eng) Mots-clés : Autism Immune Infection Immunogenetics Cytokines Gastrointestinal Autoimmune Index. décimale : PER Périodiques Résumé : Cases of autistic disorder (autism) have frequently been reported in association with congenital rubella and other infections. These observations stimulated further investigation into markers of immune function in autism. Postinfectious and autoimmune mechanisms of pathophysiology have been proposed. This review comprehensively addresses immune findings to date, including the role of viruses, neuroimmune factors, cellular and humoral immunity, immunogenetics, and immunotherapy in relation to autism. Although numerous immune abnormalities have been identified in autism, inconsistent results have often been reported. To date, research in this area has largely involved small, uncontrolled studies. In order to bring clarity to this field, high-quality, systematic research is needed to explore the role of neuroimmunologic factors in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2009.01.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=816
in Research in Autism Spectrum Disorders > 3-4 (October-December 2009) . - p.840-860[article] Autism and immune factors: A comprehensive review [texte imprimé] / Kimberly A. STIGLER, Auteur ; Thayne L. SWEETEN, Auteur ; Christopher J. MCDOUGLE, Auteur ; David J. POSEY, Auteur . - 2009 . - p.840-860.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 3-4 (October-December 2009) . - p.840-860
Mots-clés : Autism Immune Infection Immunogenetics Cytokines Gastrointestinal Autoimmune Index. décimale : PER Périodiques Résumé : Cases of autistic disorder (autism) have frequently been reported in association with congenital rubella and other infections. These observations stimulated further investigation into markers of immune function in autism. Postinfectious and autoimmune mechanisms of pathophysiology have been proposed. This review comprehensively addresses immune findings to date, including the role of viruses, neuroimmune factors, cellular and humoral immunity, immunogenetics, and immunotherapy in relation to autism. Although numerous immune abnormalities have been identified in autism, inconsistent results have often been reported. To date, research in this area has largely involved small, uncontrolled studies. In order to bring clarity to this field, high-quality, systematic research is needed to explore the role of neuroimmunologic factors in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2009.01.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=816
Titre : d-Cycloserine enhances durability of social skills training in autism spectrum disorder Type de document : texte imprimé Auteurs : Logan K. WINK, Auteur ; Noha F. MINSHAWI, Auteur ; Rebecca C. SHAFFER, Auteur ; Martin H. PLAWECKI, Auteur ; David J. POSEY, Auteur ; Paul S. HORN, Auteur ; Ryan ADAMS, Auteur ; Ernest V. PEDAPATI, Auteur ; Tori L. SCHAEFER, Auteur ; Christopher J. MCDOUGLE, Auteur ; Naomi B. SWIEZY, Auteur ; Craig ERICKSON, Auteur Article en page(s) : 2p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/*drug therapy/psychology Child Child, Preschool Cycloserine/*administration & dosage/pharmacology Double-Blind Method Drug Administration Schedule Female Humans Learning/*drug effects Male Severity of Illness Index Social Behavior Treatment Outcome *Autism *Autism spectrum disorder *Social skills training *d-Cycloserine Index. décimale : PER Périodiques Résumé : BACKGROUND: d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability. METHODS: Study participants included 60 outpatient youth with ASD, ages 5-11 years, all with IQ above 70, and significantly impaired social functioning who completed a 10-week active treatment phase during which they received weekly single doses of 50 mg of DCS or placebo administered 30 min prior to group social skills training. Following the 10-week active treatment phase, blinded follow-up assessments occurred at week 11 and week 22. The primary outcome measure for our durability of treatment evaluation was the parent-rated social responsiveness scale (SRS) total raw score at week 22. RESULTS: Analysis of the SRS total raw score demonstrated significant decrease for the DCS group compared to the placebo group (p = 0.042) indicating greater maintenance of treatment effect in the DCS group. DCS was well tolerated, with irritability being the most frequently reported adverse effect in both groups. CONCLUSIONS: The findings of this study suggest that DCS may help youth with ASD to maintain skills gained during sort-term social skills training. Larger-scale studies with longer follow-up will be necessary to further understand the long-term impact of DCS paired with structured social skills training. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01086475. En ligne : http://dx.doi.org/10.1186/s13229-017-0116-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331
in Molecular Autism > 8 (2017) . - 2p.[article] d-Cycloserine enhances durability of social skills training in autism spectrum disorder [texte imprimé] / Logan K. WINK, Auteur ; Noha F. MINSHAWI, Auteur ; Rebecca C. SHAFFER, Auteur ; Martin H. PLAWECKI, Auteur ; David J. POSEY, Auteur ; Paul S. HORN, Auteur ; Ryan ADAMS, Auteur ; Ernest V. PEDAPATI, Auteur ; Tori L. SCHAEFER, Auteur ; Christopher J. MCDOUGLE, Auteur ; Naomi B. SWIEZY, Auteur ; Craig ERICKSON, Auteur . - 2p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 2p.
Mots-clés : Autism Spectrum Disorder/*drug therapy/psychology Child Child, Preschool Cycloserine/*administration & dosage/pharmacology Double-Blind Method Drug Administration Schedule Female Humans Learning/*drug effects Male Severity of Illness Index Social Behavior Treatment Outcome *Autism *Autism spectrum disorder *Social skills training *d-Cycloserine Index. décimale : PER Périodiques Résumé : BACKGROUND: d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability. METHODS: Study participants included 60 outpatient youth with ASD, ages 5-11 years, all with IQ above 70, and significantly impaired social functioning who completed a 10-week active treatment phase during which they received weekly single doses of 50 mg of DCS or placebo administered 30 min prior to group social skills training. Following the 10-week active treatment phase, blinded follow-up assessments occurred at week 11 and week 22. The primary outcome measure for our durability of treatment evaluation was the parent-rated social responsiveness scale (SRS) total raw score at week 22. RESULTS: Analysis of the SRS total raw score demonstrated significant decrease for the DCS group compared to the placebo group (p = 0.042) indicating greater maintenance of treatment effect in the DCS group. DCS was well tolerated, with irritability being the most frequently reported adverse effect in both groups. CONCLUSIONS: The findings of this study suggest that DCS may help youth with ASD to maintain skills gained during sort-term social skills training. Larger-scale studies with longer follow-up will be necessary to further understand the long-term impact of DCS paired with structured social skills training. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01086475. En ligne : http://dx.doi.org/10.1186/s13229-017-0116-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331
Titre : Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders Type de document : texte imprimé Auteurs : Roumen N. NIKOLOV, Auteur ; Lawrence SCAHILL, Auteur ; Bhavik SHAH, Auteur ; Maria RODOWSKI, Auteur ; Craig ERICKSON, Auteur ; Jelle LETTINGA, Auteur ; Karen E. BEARSS, Auteur ; David J. POSEY, Auteur ; Louise RITZ, Auteur ; Elaine TIERNEY, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2009 Article en page(s) : p.405-413 Langues : Anglais (eng) Mots-clés : Autism Chronic-gastrointestinal-problems Pervasive-developmental-disorders Index. décimale : PER Périodiques Résumé : Objective To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed comprehensively prior to starting treatment and classified with regard to GI symptoms. Results Thirty nine (22.7%) were positive for GI problems, primarily constipation and diarrhea. Those with GI problems were no different from subjects without GI problems in demographic characteristics, measures of adaptive functioning, or autism symptom severity. Compared to children without GI problems, those with GI problems showed greater symptom severity on measures of irritability, anxiety, and social withdrawal. Those with GI problems were also less likely to respond to treatment. En ligne : http://dx.doi.org/10.1007/s10803-008-0637-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695
in Journal of Autism and Developmental Disorders > 39-3 (March 2009) . - p.405-413[article] Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders [texte imprimé] / Roumen N. NIKOLOV, Auteur ; Lawrence SCAHILL, Auteur ; Bhavik SHAH, Auteur ; Maria RODOWSKI, Auteur ; Craig ERICKSON, Auteur ; Jelle LETTINGA, Auteur ; Karen E. BEARSS, Auteur ; David J. POSEY, Auteur ; Louise RITZ, Auteur ; Elaine TIERNEY, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur . - 2009 . - p.405-413.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-3 (March 2009) . - p.405-413
Mots-clés : Autism Chronic-gastrointestinal-problems Pervasive-developmental-disorders Index. décimale : PER Périodiques Résumé : Objective To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed comprehensively prior to starting treatment and classified with regard to GI symptoms. Results Thirty nine (22.7%) were positive for GI problems, primarily constipation and diarrhea. Those with GI problems were no different from subjects without GI problems in demographic characteristics, measures of adaptive functioning, or autism symptom severity. Compared to children without GI problems, those with GI problems showed greater symptom severity on measures of irritability, anxiety, and social withdrawal. Those with GI problems were also less likely to respond to treatment. En ligne : http://dx.doi.org/10.1007/s10803-008-0637-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695
Titre : Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity Type de document : texte imprimé Auteurs : Laudan B. JAHROMI, Auteur ; Connie KASARI, Auteur ; David J. POSEY, Auteur ; Jaswinder GHUMAN, Auteur ; Erin KUSTAN, Auteur ; Louise RITZ, Auteur ; Elaine TIERNEY, Auteur ; Lisa S.Y. LEE, Auteur ; Andrea N. WITWER, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2009 Article en page(s) : p.395-404 Langues : Anglais (eng) Mots-clés : Methylphenidate Pervasive-developmental-disorders Hyperactivity Autism-spectrum-disorder Index. décimale : PER Périodiques Résumé : This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children’s social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children’s use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity. En ligne : http://dx.doi.org/10.1007/s10803-008-0636-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695
in Journal of Autism and Developmental Disorders > 39-3 (March 2009) . - p.395-404[article] Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity [texte imprimé] / Laudan B. JAHROMI, Auteur ; Connie KASARI, Auteur ; David J. POSEY, Auteur ; Jaswinder GHUMAN, Auteur ; Erin KUSTAN, Auteur ; Louise RITZ, Auteur ; Elaine TIERNEY, Auteur ; Lisa S.Y. LEE, Auteur ; Andrea N. WITWER, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur . - 2009 . - p.395-404.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-3 (March 2009) . - p.395-404
Mots-clés : Methylphenidate Pervasive-developmental-disorders Hyperactivity Autism-spectrum-disorder Index. décimale : PER Périodiques Résumé : This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children’s social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children’s use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity. En ligne : http://dx.doi.org/10.1007/s10803-008-0636-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695
Titre : Psychopharmacological Treatment of Autism Type de document : texte imprimé Auteurs : Kelly BLANKENSHIP, Auteur ; Craig ERICKSON, Auteur ; Kimberly A. STIGLER, Auteur ; David J. POSEY, Auteur ; Christopher J. MCDOUGLE, Auteur Année de publication : 2011 Importance : p.1196-1214 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 Psychopharmacological Treatment of Autism [texte imprimé] / Kelly BLANKENSHIP, Auteur ; Craig ERICKSON, Auteur ; Kimberly A. STIGLER, Auteur ; David J. POSEY, Auteur ; Christopher J. MCDOUGLE, Auteur . - 2011 . - p.1196-1214.
Langues : Anglais (eng)
Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 Exemplaires(0)
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