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Auteur Evdokia ANAGNOSTOU |
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Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities / Stephania ASSIMOPOULOS in Autism Research, 15-7 (July 2022)
[article]
Titre : Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities Type de document : Texte imprimé et/ou numérique Auteurs : Stephania ASSIMOPOULOS, Auteur ; Christopher HAMMILL, Auteur ; Darren J. FERNANDES, Auteur ; Tara LEIGH SPENCER NOAKES, Auteur ; Yu-Qing ZHOU, Auteur ; Lauryl M J. NUTTER, Auteur ; Jacob ELLEGOOD, Auteur ; Evdokia ANAGNOSTOU, Auteur ; John G. SLED, Auteur ; Jason P. LERCH, Auteur Article en page(s) : p.1189-1208 Langues : Anglais (eng) Mots-clés : autism cardiac phenotype/cardiology comorbidities genetic mouse models phenotyping ultrasound biomicroscopy Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked on a functional and genetic level. Most work has investigated CHD-related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied. We investigated the prevalence of cardiac comorbidities relative to ASD genetic contributors. Using high frequency ultrasound imaging, we screened 9 ASD-related genetic mouse models (Arid1b((+/-)) , Chd8((+/-)) , 16p11.2 (deletion), Sgsh((+/-)) , Sgsh((-/-)) , Shank3 ?exon 4-9((+/-)) , Shank3 ?exon 4-9((-/-)) , Fmr1((-/-)) , Vps13b((+/-)) ), and pooled wild-type littermates (WTs). We measured heart rate (HR), aorta diameter (AoD), thickness and thickening of the left-ventricular (LV) anterior and posterior walls, LV chamber diameter, fractional shortening, stroke volume and cardiac output, mitral inflow Peak E and A velocity ratio, ascending aorta velocity time integral (VTI). Mutant groups presented small-scale alterations in cardiac structure and function compared to WTs (LV anterior wall thickness and thickening, chamber diameter and fractional shortening, HR). A greater number of significant differences was observed among mutant groups than between mutant groups and WTs. Mutant groups differed primarily in structural measures (LV chamber diameter and anterior wall thickness, HR, AoD). The mutant groups with most differences to WTs were 16p11.2 (deletion), Fmr1((-/-)) , Arid1b((+/-)) . The mutant groups with most differences from other mutant groups were 16p11.2 (deletion), Sgsh((+/-)) , Fmr1((-/-)) . Our results recapitulate the associated clinical findings. The characteristic ASD heterogeneity was recapitulated in the cardiac phenotype. The type of abnormal measures (morphological, functional) can highlight common underlying mechanisms. Clinically, knowledge of cardiac abnormalities in ASD can be essential as even non-lethal abnormalities impact normal development. LAY SUMMARY: Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked functionally and genetically. ASD cardiac phenotyping is limited. We assessed the cardiac phenotype of 9 ASD-related mouse models. We found subtle heterogenous cardiac abnormalities compared to controls, with more differences within ASD than between ASD and controls, mirroring clinical findings. Clinically, knowing the cardiac abnormalities in ASD is vital as even non-lethal cardiac abnormalities can impact development. En ligne : http://dx.doi.org/10.1002/aur.2728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Autism Research > 15-7 (July 2022) . - p.1189-1208[article] Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities [Texte imprimé et/ou numérique] / Stephania ASSIMOPOULOS, Auteur ; Christopher HAMMILL, Auteur ; Darren J. FERNANDES, Auteur ; Tara LEIGH SPENCER NOAKES, Auteur ; Yu-Qing ZHOU, Auteur ; Lauryl M J. NUTTER, Auteur ; Jacob ELLEGOOD, Auteur ; Evdokia ANAGNOSTOU, Auteur ; John G. SLED, Auteur ; Jason P. LERCH, Auteur . - p.1189-1208.
Langues : Anglais (eng)
in Autism Research > 15-7 (July 2022) . - p.1189-1208
Mots-clés : autism cardiac phenotype/cardiology comorbidities genetic mouse models phenotyping ultrasound biomicroscopy Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked on a functional and genetic level. Most work has investigated CHD-related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied. We investigated the prevalence of cardiac comorbidities relative to ASD genetic contributors. Using high frequency ultrasound imaging, we screened 9 ASD-related genetic mouse models (Arid1b((+/-)) , Chd8((+/-)) , 16p11.2 (deletion), Sgsh((+/-)) , Sgsh((-/-)) , Shank3 ?exon 4-9((+/-)) , Shank3 ?exon 4-9((-/-)) , Fmr1((-/-)) , Vps13b((+/-)) ), and pooled wild-type littermates (WTs). We measured heart rate (HR), aorta diameter (AoD), thickness and thickening of the left-ventricular (LV) anterior and posterior walls, LV chamber diameter, fractional shortening, stroke volume and cardiac output, mitral inflow Peak E and A velocity ratio, ascending aorta velocity time integral (VTI). Mutant groups presented small-scale alterations in cardiac structure and function compared to WTs (LV anterior wall thickness and thickening, chamber diameter and fractional shortening, HR). A greater number of significant differences was observed among mutant groups than between mutant groups and WTs. Mutant groups differed primarily in structural measures (LV chamber diameter and anterior wall thickness, HR, AoD). The mutant groups with most differences to WTs were 16p11.2 (deletion), Fmr1((-/-)) , Arid1b((+/-)) . The mutant groups with most differences from other mutant groups were 16p11.2 (deletion), Sgsh((+/-)) , Fmr1((-/-)) . Our results recapitulate the associated clinical findings. The characteristic ASD heterogeneity was recapitulated in the cardiac phenotype. The type of abnormal measures (morphological, functional) can highlight common underlying mechanisms. Clinically, knowledge of cardiac abnormalities in ASD can be essential as even non-lethal abnormalities impact normal development. LAY SUMMARY: Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked functionally and genetically. ASD cardiac phenotyping is limited. We assessed the cardiac phenotype of 9 ASD-related mouse models. We found subtle heterogenous cardiac abnormalities compared to controls, with more differences within ASD than between ASD and controls, mirroring clinical findings. Clinically, knowing the cardiac abnormalities in ASD is vital as even non-lethal cardiac abnormalities can impact development. En ligne : http://dx.doi.org/10.1002/aur.2728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 "Girls don't have big tummies": The experiences of weight-related discussions for children with autism spectrum disorders / P. JACHYRA in Autism, 23-5 (July 2019)
[article]
Titre : "Girls don't have big tummies": The experiences of weight-related discussions for children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : P. JACHYRA, Auteur ; Evdokia ANAGNOSTOU, Auteur ; T. J. KNIBBE, Auteur ; C. PETTA, Auteur ; S. COSGROVE, Auteur ; L. CHEN, Auteur ; L. CAPANO, Auteur ; L. MOLTISANTI, Auteur ; A. C. MCPHERSON, Auteur Article en page(s) : p.1096-1105 Langues : Anglais (eng) Mots-clés : autism spectrum disorders children and youth health communication obesity qualitative research Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders appear to be at a higher risk of having obesity than their typically developing peers. Although it has been recommended that healthcare providers speak to children with autism spectrum disorders about the potential health risks of unhealthy weight, no previous research has explored how healthcare providers communicate with them about this topic. The purpose of this study was to explore children's perspectives and experiences of discussing weight-related topics in healthcare consultations. Eight children were interviewed, and an interpretive phenomenological analysis informed the research approach and analysis of the data. Results indicated that weight-related discussions with healthcare providers were often met with trepidation, anxiety, anger, and frustration. Children also expressed that they experienced weight stigma in clinical visits and everyday interactions. Weight stigma was often (unwittingly) projected by healthcare providers during appointments and had debilitating effects on children. Finally, higher weights emerged as a repetitive/restricted interest, and children reported body image challenges regarding their higher weights. Frameworks and tools that are specific to the needs and abilities of children with autism spectrum disorders are needed for healthcare providers to foster positive conversations about weight-related topics in an effort to promote lifelong wellness. En ligne : http://dx.doi.org/10.1177/1362361318793020 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Autism > 23-5 (July 2019) . - p.1096-1105[article] "Girls don't have big tummies": The experiences of weight-related discussions for children with autism spectrum disorders [Texte imprimé et/ou numérique] / P. JACHYRA, Auteur ; Evdokia ANAGNOSTOU, Auteur ; T. J. KNIBBE, Auteur ; C. PETTA, Auteur ; S. COSGROVE, Auteur ; L. CHEN, Auteur ; L. CAPANO, Auteur ; L. MOLTISANTI, Auteur ; A. C. MCPHERSON, Auteur . - p.1096-1105.
Langues : Anglais (eng)
in Autism > 23-5 (July 2019) . - p.1096-1105
Mots-clés : autism spectrum disorders children and youth health communication obesity qualitative research Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders appear to be at a higher risk of having obesity than their typically developing peers. Although it has been recommended that healthcare providers speak to children with autism spectrum disorders about the potential health risks of unhealthy weight, no previous research has explored how healthcare providers communicate with them about this topic. The purpose of this study was to explore children's perspectives and experiences of discussing weight-related topics in healthcare consultations. Eight children were interviewed, and an interpretive phenomenological analysis informed the research approach and analysis of the data. Results indicated that weight-related discussions with healthcare providers were often met with trepidation, anxiety, anger, and frustration. Children also expressed that they experienced weight stigma in clinical visits and everyday interactions. Weight stigma was often (unwittingly) projected by healthcare providers during appointments and had debilitating effects on children. Finally, higher weights emerged as a repetitive/restricted interest, and children reported body image challenges regarding their higher weights. Frameworks and tools that are specific to the needs and abilities of children with autism spectrum disorders are needed for healthcare providers to foster positive conversations about weight-related topics in an effort to promote lifelong wellness. En ligne : http://dx.doi.org/10.1177/1362361318793020 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 Handwriting Difficulties in Children with Autism Spectrum Disorders: A Scoping Review / Azadeh KUSHKI in Journal of Autism and Developmental Disorders, 41-12 (December 2011)
[article]
Titre : Handwriting Difficulties in Children with Autism Spectrum Disorders: A Scoping Review Type de document : Texte imprimé et/ou numérique Auteurs : Azadeh KUSHKI, Auteur ; Tom CHAU, Auteur ; Evdokia ANAGNOSTOU, Auteur Année de publication : 2011 Article en page(s) : 1706-1716 Langues : Anglais (eng) Mots-clés : Handwriting Autism Fine motor control Visual perception Visual-motor integration Kinesthesia Index. décimale : PER Périodiques Résumé : Functional handwriting involves complex interactions among physical, cognitive and sensory systems. Impairments in many aspects of these systems are associated with Autism spectrum disorders (ASD), suggesting a heightened risk of handwriting difficulties in children with ASD. This scoping review aimed to: (1) survey the existing evidence about potential contributions to compromised handwriting function in children with ASD, and (2) map out the existing studies documenting handwriting difficulties in children with ASD. The current evidence implicates impairments in fine motor control and visual-motor integration as likely contributors to handwriting difficulties in children with ASD, though the role of the latter is not well-understood. Moreover, diminished overall legibility and compromised letter formation are emerging points of convergence among existing studies of handwriting quality in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1206-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148
in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - 1706-1716[article] Handwriting Difficulties in Children with Autism Spectrum Disorders: A Scoping Review [Texte imprimé et/ou numérique] / Azadeh KUSHKI, Auteur ; Tom CHAU, Auteur ; Evdokia ANAGNOSTOU, Auteur . - 2011 . - 1706-1716.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - 1706-1716
Mots-clés : Handwriting Autism Fine motor control Visual perception Visual-motor integration Kinesthesia Index. décimale : PER Périodiques Résumé : Functional handwriting involves complex interactions among physical, cognitive and sensory systems. Impairments in many aspects of these systems are associated with Autism spectrum disorders (ASD), suggesting a heightened risk of handwriting difficulties in children with ASD. This scoping review aimed to: (1) survey the existing evidence about potential contributions to compromised handwriting function in children with ASD, and (2) map out the existing studies documenting handwriting difficulties in children with ASD. The current evidence implicates impairments in fine motor control and visual-motor integration as likely contributors to handwriting difficulties in children with ASD, though the role of the latter is not well-understood. Moreover, diminished overall legibility and compromised letter formation are emerging points of convergence among existing studies of handwriting quality in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1206-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148 Hyperbaric oxygen therapy for the treatment of children and youth with Autism Spectrum Disorders: An evidence-based systematic review / Cynthia GOLDFARB in Research in Autism Spectrum Disorders, 29-30 (September–October 2016)
[article]
Titre : Hyperbaric oxygen therapy for the treatment of children and youth with Autism Spectrum Disorders: An evidence-based systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Cynthia GOLDFARB, Auteur ; Lisa GENORE, Auteur ; Carolyn HUNT, Auteur ; Janine FLANAGAN, Auteur ; Mark HANDLEY-DERRY, Auteur ; Anita JETHWA, Auteur ; Nicola JONES-STOKREEF, Auteur ; S. M. L. KIRKPATRICK, Auteur ; A. RICHARDS, Auteur ; Lillian ROJNICA, Auteur ; Clive SCHWARTZ, Auteur ; David SHAWN, Auteur ; Diann SUPERINA-BELL, Auteur ; Elizabeth YOUNG, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.1-7 Langues : Anglais (eng) Mots-clés : Autism Hyperbaric oxygen therapy Treatment Review Index. décimale : PER Périodiques Résumé : AbstractBackground Autism Spectrum Disorder (ASD) is a common disorder that has a complex and heterogeneous etiology. Some evidence suggests that inflammation and oxidative stress may have a pathophysiological link. Hyperbaric Oxygen Therapy (HBOT) has been proposed as a possible therapy. Because HBOT is an expensive treatment with significant commercial opportunity, it is essential for it to have a research evidence base prior to widespread use. Objective To conduct a systematic review of the literature evaluating the clinical impact of HBOT on behavior and development in ASD with a view to inform practice. Methods A literature search of electronic scientific databases focusing on clinical outcomes of HBOT in ASD was performed. Articles meeting inclusion criteria were independently assessed by reviewers and were classified according to the American Academy of Neurology Guidelines. Recommendations were made based on the evidence. Results Five articles were reviewed with data extraction. Based on the AAN Classification of Recommendations the data supported a rating of “A”, indicating that HBOT is not effective for treating children and youth with ASD. Conclusions Current evidence does not support HBOT as an effective treatment for children and youth with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.05.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Research in Autism Spectrum Disorders > 29-30 (September–October 2016) . - p.1-7[article] Hyperbaric oxygen therapy for the treatment of children and youth with Autism Spectrum Disorders: An evidence-based systematic review [Texte imprimé et/ou numérique] / Cynthia GOLDFARB, Auteur ; Lisa GENORE, Auteur ; Carolyn HUNT, Auteur ; Janine FLANAGAN, Auteur ; Mark HANDLEY-DERRY, Auteur ; Anita JETHWA, Auteur ; Nicola JONES-STOKREEF, Auteur ; S. M. L. KIRKPATRICK, Auteur ; A. RICHARDS, Auteur ; Lillian ROJNICA, Auteur ; Clive SCHWARTZ, Auteur ; David SHAWN, Auteur ; Diann SUPERINA-BELL, Auteur ; Elizabeth YOUNG, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.1-7.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 29-30 (September–October 2016) . - p.1-7
Mots-clés : Autism Hyperbaric oxygen therapy Treatment Review Index. décimale : PER Périodiques Résumé : AbstractBackground Autism Spectrum Disorder (ASD) is a common disorder that has a complex and heterogeneous etiology. Some evidence suggests that inflammation and oxidative stress may have a pathophysiological link. Hyperbaric Oxygen Therapy (HBOT) has been proposed as a possible therapy. Because HBOT is an expensive treatment with significant commercial opportunity, it is essential for it to have a research evidence base prior to widespread use. Objective To conduct a systematic review of the literature evaluating the clinical impact of HBOT on behavior and development in ASD with a view to inform practice. Methods A literature search of electronic scientific databases focusing on clinical outcomes of HBOT in ASD was performed. Articles meeting inclusion criteria were independently assessed by reviewers and were classified according to the American Academy of Neurology Guidelines. Recommendations were made based on the evidence. Results Five articles were reviewed with data extraction. Based on the AAN Classification of Recommendations the data supported a rating of “A”, indicating that HBOT is not effective for treating children and youth with ASD. Conclusions Current evidence does not support HBOT as an effective treatment for children and youth with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.05.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 Identifying Children and Youth With Autism Spectrum Disorder in Electronic Medical Records: Examining Health System Utilization and Comorbidities / Jennifer D. BROOKS in Autism Research, 14-2 (February 2021)
[article]
Titre : Identifying Children and Youth With Autism Spectrum Disorder in Electronic Medical Records: Examining Health System Utilization and Comorbidities Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer D. BROOKS, Auteur ; Susan E. BRONSKILL, Auteur ; Longdi FU, Auteur ; Farah E. SAXENA, Auteur ; Jasleen ARNEJA, Auteur ; Virgiliu Bogdan PINZARU, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Kirk NYLEN, Auteur ; John MCLAUGHLIN, Auteur ; Karen TU, Auteur Article en page(s) : p.400-410 Langues : Anglais (eng) Mots-clés : Asd algorithm autism comorbidity electronic medical record health system use Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder requiring significant health and educational resources for affected individuals. A reference standard for ASD was generated from an existing population-based cohort of 10,000 children and youth aged 1-24?years who were randomly selected for chart abstraction from 29,256 patients from 119 family physicians. We developed and validated an algorithm to identify children and youth with ASD within an electronic medical record system (N = 80,237, aged 1-24?years) in order to examine the prevalence of comorbidities and quantify health system utilization within the cohort. We identified 1,062 children and youth with ASD representing a prevalence of 1.32%. Compared to individuals without ASD, those with ASD had a higher prevalence of asthma, were more likely to visit a specialist, undergo surgery, and be hospitalized for psychiatric reasons. Children and youth with ASD in Ontario have complex health system needs, illustrated through a significant burden of comorbidities and increased health system utilization. LAY SUMMARY: Our paper generates population-based estimates of health system use by children and youth with ASD, who have a higher burden of comorbidities than the general population. We developed a case-finding algorithm and applied it in electronic medical records to create a cohort of children and youth with ASD, thereby generating an important resource to further study the health care needs of individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.2419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441
in Autism Research > 14-2 (February 2021) . - p.400-410[article] Identifying Children and Youth With Autism Spectrum Disorder in Electronic Medical Records: Examining Health System Utilization and Comorbidities [Texte imprimé et/ou numérique] / Jennifer D. BROOKS, Auteur ; Susan E. BRONSKILL, Auteur ; Longdi FU, Auteur ; Farah E. SAXENA, Auteur ; Jasleen ARNEJA, Auteur ; Virgiliu Bogdan PINZARU, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Kirk NYLEN, Auteur ; John MCLAUGHLIN, Auteur ; Karen TU, Auteur . - p.400-410.
Langues : Anglais (eng)
in Autism Research > 14-2 (February 2021) . - p.400-410
Mots-clés : Asd algorithm autism comorbidity electronic medical record health system use Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder requiring significant health and educational resources for affected individuals. A reference standard for ASD was generated from an existing population-based cohort of 10,000 children and youth aged 1-24?years who were randomly selected for chart abstraction from 29,256 patients from 119 family physicians. We developed and validated an algorithm to identify children and youth with ASD within an electronic medical record system (N = 80,237, aged 1-24?years) in order to examine the prevalence of comorbidities and quantify health system utilization within the cohort. We identified 1,062 children and youth with ASD representing a prevalence of 1.32%. Compared to individuals without ASD, those with ASD had a higher prevalence of asthma, were more likely to visit a specialist, undergo surgery, and be hospitalized for psychiatric reasons. Children and youth with ASD in Ontario have complex health system needs, illustrated through a significant burden of comorbidities and increased health system utilization. LAY SUMMARY: Our paper generates population-based estimates of health system use by children and youth with ASD, who have a higher burden of comorbidities than the general population. We developed a case-finding algorithm and applied it in electronic medical records to create a cohort of children and youth with ASD, thereby generating an important resource to further study the health care needs of individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.2419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 Inattention and hyperactive/impulsive component scores do not differentiate between autism spectrum disorder and attention-deficit/hyperactivity disorder in a clinical sample / Aneta D. KRAKOWSKI in Molecular Autism, 11 (2020)
PermalinkIntranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial / Evdokia ANAGNOSTOU in Molecular Autism, (December 2012)
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PermalinkMagnetoencephalographic (MEG) brain activity during a mental flexibility task suggests some shared neurobiology in children with neurodevelopmental disorders / A. MOGADAM in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)
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