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Auteur Ana-Maria IOSIF |
Documents disponibles écrits par cet auteur (20)
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School-age outcomes of infants at risk for autism spectrum disorder / Meghan MILLER in Autism Research, 9-6 (June 2016)
[article]
Titre : School-age outcomes of infants at risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Meghan MILLER, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Monique HILL, Auteur ; Elise PHELPS HANZEL, Auteur ; Ted HUTMAN, Auteur ; Scott JOHNSON, Auteur ; Sally OZONOFF, Auteur Article en page(s) : p.632-642 Langues : Anglais (eng) Mots-clés : autism spectrum disorder broader autism phenotype psychopathology siblings school-age Index. décimale : PER Périodiques Résumé : Studies of infants at risk for autism spectrum disorder (ASD) have proliferated, but few of these samples have been followed longer-term. We conducted a follow-up study, at age 5.5–9 years, of younger siblings of children with ASD (high-risk group, n?=?79) or typical development (low-risk group, n?=?60), originally recruited as infants. Children with ASD were excluded because of the focus on understanding the range of non-ASD outcomes among high-risk siblings. Using examiner ratings, parent ratings, and standardized assessments, we evaluated differences in clinical outcomes, psychopathology symptoms, autism symptoms, language skills, and nonverbal cognitive abilities. After adjusting for covariates, the high-risk group had increased odds of any clinically elevated/impaired score across measures relative to the low-risk group (43% vs. 12%, respectively). The high-risk group also had increased odds of examiner-rated Clinical Concerns (CC) outcomes (e.g., ADHD concerns, broader autism phenotype, speech-language difficulties, anxiety/mood problems, learning problems) relative to the low-risk group (38% vs. 13%, respectively). The high-risk group with CC outcomes had higher parent-reported psychopathology and autism symptoms, and lower directly-assessed language skills, than the Low-Risk Typically Developing (TD) and High-Risk TD groups, which did not differ. There were no differences in nonverbal cognitive skills. For some in the high-risk group, clinical concerns persisted from early childhood, whereas for others clinical concerns were first evident at school-age. Results suggest continued vulnerability in at least a subgroup of school-age children with a family history of ASD and suggest that this population may benefit from continued screening and monitoring into the school-age years. Autism Res 2016, 9: 632–642. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290
in Autism Research > 9-6 (June 2016) . - p.632-642[article] School-age outcomes of infants at risk for autism spectrum disorder [Texte imprimé et/ou numérique] / Meghan MILLER, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Monique HILL, Auteur ; Elise PHELPS HANZEL, Auteur ; Ted HUTMAN, Auteur ; Scott JOHNSON, Auteur ; Sally OZONOFF, Auteur . - p.632-642.
Langues : Anglais (eng)
in Autism Research > 9-6 (June 2016) . - p.632-642
Mots-clés : autism spectrum disorder broader autism phenotype psychopathology siblings school-age Index. décimale : PER Périodiques Résumé : Studies of infants at risk for autism spectrum disorder (ASD) have proliferated, but few of these samples have been followed longer-term. We conducted a follow-up study, at age 5.5–9 years, of younger siblings of children with ASD (high-risk group, n?=?79) or typical development (low-risk group, n?=?60), originally recruited as infants. Children with ASD were excluded because of the focus on understanding the range of non-ASD outcomes among high-risk siblings. Using examiner ratings, parent ratings, and standardized assessments, we evaluated differences in clinical outcomes, psychopathology symptoms, autism symptoms, language skills, and nonverbal cognitive abilities. After adjusting for covariates, the high-risk group had increased odds of any clinically elevated/impaired score across measures relative to the low-risk group (43% vs. 12%, respectively). The high-risk group also had increased odds of examiner-rated Clinical Concerns (CC) outcomes (e.g., ADHD concerns, broader autism phenotype, speech-language difficulties, anxiety/mood problems, learning problems) relative to the low-risk group (38% vs. 13%, respectively). The high-risk group with CC outcomes had higher parent-reported psychopathology and autism symptoms, and lower directly-assessed language skills, than the Low-Risk Typically Developing (TD) and High-Risk TD groups, which did not differ. There were no differences in nonverbal cognitive skills. For some in the high-risk group, clinical concerns persisted from early childhood, whereas for others clinical concerns were first evident at school-age. Results suggest continued vulnerability in at least a subgroup of school-age children with a family history of ASD and suggest that this population may benefit from continued screening and monitoring into the school-age years. Autism Res 2016, 9: 632–642. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder / Christine W. NORDAHL in Molecular Autism, (May 2015)
[article]
Titre : Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Lee Michael PERRY, Auteur ; Robert DOUGHERTY, Auteur ; Aaron LEE, Auteur ; Deana LI, Auteur ; Michael H. BUONOCORE, Auteur ; Tony SIMON, Auteur ; Sally J ROGERS, Auteur ; Brian WANDELL, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion characteristics have also not been evaluated fully in ASD. En ligne : http://dx.doi.org/10.1186/s13229-015-0005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277
in Molecular Autism > (May 2015) . - p.1-11[article] Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder [Texte imprimé et/ou numérique] / Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Lee Michael PERRY, Auteur ; Robert DOUGHERTY, Auteur ; Aaron LEE, Auteur ; Deana LI, Auteur ; Michael H. BUONOCORE, Auteur ; Tony SIMON, Auteur ; Sally J ROGERS, Auteur ; Brian WANDELL, Auteur ; David G. AMARAL, Auteur . - p.1-11.
Langues : Anglais (eng)
in Molecular Autism > (May 2015) . - p.1-11
Index. décimale : PER Périodiques Résumé : Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion characteristics have also not been evaluated fully in ASD. En ligne : http://dx.doi.org/10.1186/s13229-015-0005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 Shared and distinct developmental pathways to ASD and ADHD phenotypes among infants at familial risk / Meghan MILLER in Development and Psychopathology, 32-4 (October 2020)
[article]
Titre : Shared and distinct developmental pathways to ASD and ADHD phenotypes among infants at familial risk Type de document : Texte imprimé et/ou numérique Auteurs : Meghan MILLER, Auteur ; Shane AUSTIN, Auteur ; Ana-Maria IOSIF, Auteur ; Leiana DE LA PAZ, Auteur ; Annie CHUANG, Auteur ; Burt HATCH, Auteur ; Sally OZONOFF, Auteur Article en page(s) : p.1323-1334 Langues : Anglais (eng) Mots-clés : Adhd autism early childhood infancy latent profile analysis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are believed to share partially overlapping causal mechanisms suggesting that early risk markers may also overlap. Using latent profile analysis (LPA) in a sample of infants enriched for ASD and ADHD, we first examined the number of distinct groups of 3-year-old children, based on ADHD and ASD symptomatology. To investigate early predictors of ASD and ADHD symptom profiles, we next examined differences in trajectories of infant behaviors among the LPA classes spanning general development, negative affect, attention, activity level, impulsivity, and social behavior. Participants included 166 infants at familial risk for ASD (n = 89), ADHD (n = 38), or low-risk for both (n = 39) evaluated at 12, 18, 24, and 36 months of age. A three-class solution was selected reflecting a Typically Developing (TD) class (low symptoms; n = 108), an ADHD class (high ADHD/low ASD symptoms; n = 39), and an ASD class (high ASD/ADHD symptoms; n = 19). Trajectories of infant behaviors were generally suggestive of a gradient pattern of differences, with the greatest impairment within the ASD class followed by the ADHD class. These findings indicate a mixture of overlapping and distinct early markers of preschool ASD- and ADHD-like profiles that can be difficult to disentangle early in life. En ligne : http://dx.doi.org/10.1017/s0954579420000735 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433
in Development and Psychopathology > 32-4 (October 2020) . - p.1323-1334[article] Shared and distinct developmental pathways to ASD and ADHD phenotypes among infants at familial risk [Texte imprimé et/ou numérique] / Meghan MILLER, Auteur ; Shane AUSTIN, Auteur ; Ana-Maria IOSIF, Auteur ; Leiana DE LA PAZ, Auteur ; Annie CHUANG, Auteur ; Burt HATCH, Auteur ; Sally OZONOFF, Auteur . - p.1323-1334.
Langues : Anglais (eng)
in Development and Psychopathology > 32-4 (October 2020) . - p.1323-1334
Mots-clés : Adhd autism early childhood infancy latent profile analysis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are believed to share partially overlapping causal mechanisms suggesting that early risk markers may also overlap. Using latent profile analysis (LPA) in a sample of infants enriched for ASD and ADHD, we first examined the number of distinct groups of 3-year-old children, based on ADHD and ASD symptomatology. To investigate early predictors of ASD and ADHD symptom profiles, we next examined differences in trajectories of infant behaviors among the LPA classes spanning general development, negative affect, attention, activity level, impulsivity, and social behavior. Participants included 166 infants at familial risk for ASD (n = 89), ADHD (n = 38), or low-risk for both (n = 39) evaluated at 12, 18, 24, and 36 months of age. A three-class solution was selected reflecting a Typically Developing (TD) class (low symptoms; n = 108), an ADHD class (high ADHD/low ASD symptoms; n = 39), and an ASD class (high ASD/ADHD symptoms; n = 19). Trajectories of infant behaviors were generally suggestive of a gradient pattern of differences, with the greatest impairment within the ASD class followed by the ADHD class. These findings indicate a mixture of overlapping and distinct early markers of preschool ASD- and ADHD-like profiles that can be difficult to disentangle early in life. En ligne : http://dx.doi.org/10.1017/s0954579420000735 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 Using the NIH Toolbox to Assess Cognition in Adolescents and Young Adults with Autism Spectrum Disorders / Marjorie SOLOMON in Autism Research, 14-3 (March 2021)
[article]
Titre : Using the NIH Toolbox to Assess Cognition in Adolescents and Young Adults with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Marjorie SOLOMON, Auteur ; Andrew GORDON, Auteur ; Ana-Maria IOSIF, Auteur ; Raphael GEDDERT, Auteur ; Marie K. KRUG, Auteur ; Peter C. MUNDY, Auteur ; David HESSL, Auteur Article en page(s) : p.500-511 Langues : Anglais (eng) Mots-clés : NIH Toolbox adolescents adults cognitive control executive control executive functions latent profile analysis phenotypes subtypes of ASD young adults Index. décimale : PER Périodiques Résumé : Despite the clinically significant impact of executive dysfunction on the outcomes of adolescents and young adults with autism spectrum disorders (ASD), we lack a clear understanding of its prevalence, profile, and development. To address this gap, we administered the NIH Toolbox Cognition Battery to a cross-sectional Intelligence Quotient (IQ) case-matched cohort with ASD (n = 66) and typical development (TD; n = 66) ages 12-22. We used a general linear model framework to examine group differences in task performance and their associations with age. Latent profile analysis (LPA) was used to identify subgroups of individuals with similar cognitive profiles. Compared to IQ case-matched controls, ASD demonstrated poorer performance on inhibitory control (P?0.001), cognitive flexibility (P?0.001), episodic memory (P?0.02), and processing speed (P?0.001) (components of Fluid Cognition), but not on vocabulary or word reading (components of Crystallized Cognition). There was a significant positive association between age and Crystallized and Fluid Cognition in both groups. For Fluid (but not Crystallized) Cognition, ASD performed more poorly than TD at all ages. A four-group LPA model based on subtest scores best fit the data. Eighty percent of ASD belonged to two groups that exhibited relatively stronger Crystallized versus Fluid Cognition. Attention deficits were not associated with Toolbox subtest scores, but were lowest in the group with the lowest proportion of autistic participants. Adaptive functioning was poorer in the groups with the greatest proportion of autistic participants. Autistic persons are especially impaired on Fluid Cognition, and this more flexible form of thinking remains poorer in the ASD group through adolescence. LAY SUMMARY: A set of brief tests of cognitive functioning called the NIH Toolbox Cognition Battery was administered to adolescents and young adults with autism spectrum disorders (ASD; n =?66) and typical development (TD; n =?66) ages 12-22?years. Compared to TD, ASD showed poorer performance in inhibiting responses, acting flexibly, memorizing events, and processing information quickly (Fluid Cognition). Groups did not differ on vocabulary or word reading (Crystallized Cognition). Crystallized and Fluid Cognition increased with age in both groups, but the ASD group showed lower Fluid, but not Crystallized, Cognition than TD at all ages. A categorization analysis including all participants showed that most participants with ASD fell into one of two categories: a group characterized by poor performance across all tasks, or a group characterized by relatively stronger Crystallized compared to Fluid Cognition. Adaptive functioning was poorer for participants in these groups, which consisted of mostly individuals with ASD, while ADHD symptoms were lowest in the group with the greatest proportion of TD participants. En ligne : http://dx.doi.org/10.1002/aur.2399 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443
in Autism Research > 14-3 (March 2021) . - p.500-511[article] Using the NIH Toolbox to Assess Cognition in Adolescents and Young Adults with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Marjorie SOLOMON, Auteur ; Andrew GORDON, Auteur ; Ana-Maria IOSIF, Auteur ; Raphael GEDDERT, Auteur ; Marie K. KRUG, Auteur ; Peter C. MUNDY, Auteur ; David HESSL, Auteur . - p.500-511.
Langues : Anglais (eng)
in Autism Research > 14-3 (March 2021) . - p.500-511
Mots-clés : NIH Toolbox adolescents adults cognitive control executive control executive functions latent profile analysis phenotypes subtypes of ASD young adults Index. décimale : PER Périodiques Résumé : Despite the clinically significant impact of executive dysfunction on the outcomes of adolescents and young adults with autism spectrum disorders (ASD), we lack a clear understanding of its prevalence, profile, and development. To address this gap, we administered the NIH Toolbox Cognition Battery to a cross-sectional Intelligence Quotient (IQ) case-matched cohort with ASD (n = 66) and typical development (TD; n = 66) ages 12-22. We used a general linear model framework to examine group differences in task performance and their associations with age. Latent profile analysis (LPA) was used to identify subgroups of individuals with similar cognitive profiles. Compared to IQ case-matched controls, ASD demonstrated poorer performance on inhibitory control (P?0.001), cognitive flexibility (P?0.001), episodic memory (P?0.02), and processing speed (P?0.001) (components of Fluid Cognition), but not on vocabulary or word reading (components of Crystallized Cognition). There was a significant positive association between age and Crystallized and Fluid Cognition in both groups. For Fluid (but not Crystallized) Cognition, ASD performed more poorly than TD at all ages. A four-group LPA model based on subtest scores best fit the data. Eighty percent of ASD belonged to two groups that exhibited relatively stronger Crystallized versus Fluid Cognition. Attention deficits were not associated with Toolbox subtest scores, but were lowest in the group with the lowest proportion of autistic participants. Adaptive functioning was poorer in the groups with the greatest proportion of autistic participants. Autistic persons are especially impaired on Fluid Cognition, and this more flexible form of thinking remains poorer in the ASD group through adolescence. LAY SUMMARY: A set of brief tests of cognitive functioning called the NIH Toolbox Cognition Battery was administered to adolescents and young adults with autism spectrum disorders (ASD; n =?66) and typical development (TD; n =?66) ages 12-22?years. Compared to TD, ASD showed poorer performance in inhibiting responses, acting flexibly, memorizing events, and processing information quickly (Fluid Cognition). Groups did not differ on vocabulary or word reading (Crystallized Cognition). Crystallized and Fluid Cognition increased with age in both groups, but the ASD group showed lower Fluid, but not Crystallized, Cognition than TD at all ages. A categorization analysis including all participants showed that most participants with ASD fell into one of two categories: a group characterized by poor performance across all tasks, or a group characterized by relatively stronger Crystallized compared to Fluid Cognition. Adaptive functioning was poorer for participants in these groups, which consisted of mostly individuals with ASD, while ADHD symptoms were lowest in the group with the greatest proportion of TD participants. En ligne : http://dx.doi.org/10.1002/aur.2399 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 Video Game Use, Aggression, and Social Impairment in Adolescents with Autism Spectrum Disorder / Konnor DAVIS in Journal of Autism and Developmental Disorders, 53-9 (September 2023)
[article]
Titre : Video Game Use, Aggression, and Social Impairment in Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Konnor DAVIS, Auteur ; Ana-Maria IOSIF, Auteur ; Christine Wu NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; Marie K. KRUG, Auteur Article en page(s) : p.3567-3580 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We used parent report data to investigate video game playing, aggression, and social impairment in adolescents with autism spectrum disorder. Parents of autistic adolescents were more likely to report that their child plays video games as a hobby compared to parents of adolescents with typical development and also reported that their children spent more time playing video games. For autistic participants, we found no differences in aggression levels or social impairment when comparing players versus non-players. However, playing video games "more than average," as compared to "average" was associated with greater aggression and greater social impairment on "awareness" and "mannerisms" subscales. Future studies should focus on how type of video game(s) played is associated with these clinically important variables. En ligne : https://doi.org/10.1007/s10803-022-05649-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511
in Journal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3567-3580[article] Video Game Use, Aggression, and Social Impairment in Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Konnor DAVIS, Auteur ; Ana-Maria IOSIF, Auteur ; Christine Wu NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; Marie K. KRUG, Auteur . - p.3567-3580.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3567-3580
Index. décimale : PER Périodiques Résumé : We used parent report data to investigate video game playing, aggression, and social impairment in adolescents with autism spectrum disorder. Parents of autistic adolescents were more likely to report that their child plays video games as a hobby compared to parents of adolescents with typical development and also reported that their children spent more time playing video games. For autistic participants, we found no differences in aggression levels or social impairment when comparing players versus non-players. However, playing video games "more than average," as compared to "average" was associated with greater aggression and greater social impairment on "awareness" and "mannerisms" subscales. Future studies should focus on how type of video game(s) played is associated with these clinically important variables. En ligne : https://doi.org/10.1007/s10803-022-05649-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511