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Auteur Eric R. MURPHY |
Documents disponibles écrits par cet auteur (3)
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Annual Research Review: The contributions of the RDoC research framework on understanding the neurodevelopmental origins, progression and treatment of mental illnesses / Jennifer PACHECO in Journal of Child Psychology and Psychiatry, 63-4 (April 2022)
[article]
Titre : Annual Research Review: The contributions of the RDoC research framework on understanding the neurodevelopmental origins, progression and treatment of mental illnesses Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer PACHECO, Auteur ; Marjorie A. GARVEY, Auteur ; Christopher S. SARAMPOTE, Auteur ; Elan D. COHEN, Auteur ; Eric R. MURPHY, Auteur ; Stacia R. FRIEDMAN-HILL, Auteur Article en page(s) : p.360-376 Langues : Anglais (eng) Mots-clés : Adhd autism spectrum disorders development intervention Index. décimale : PER Périodiques Résumé : The National Institute of Mental Health (NIMH) proposed the Research Domain Criteria (RDoC) initiative as an alternate way to organize research of mental illnesses, by looking at dimensions of functioning rather than being tied to categorical diagnoses. This paper briefly discusses the motivation for and organization of RDoC, and then explores the NIMH portfolio and recent work to monitor the utility and progress that RDoC has afforded developmental research. To examine how RDoC has influenced the NIMH developmental research portfolio over the last decade, we employed a natural language processing algorithm to identify the number of developmental science grants classified as incorporating an RDoC approach. Additional portfolio analyses examine temporal trends in funded RDoC-relevant grants, publications and citations, and research training opportunities. Reflecting on how RDoC has influenced the focus of grant applications, we highlight examples from research on Attention-Deficit Hyperactivity Disorder (ADHD), childhood irritability, and Autism Spectrum Disorder (ASD). Lastly, we consider how the dimensional and transdiagnostic approaches emphasized in RDoC have facilitated research on personalized intervention for heterogeneous disorders and preventive/early interventions targeting emergent or subthreshold psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475
in Journal of Child Psychology and Psychiatry > 63-4 (April 2022) . - p.360-376[article] Annual Research Review: The contributions of the RDoC research framework on understanding the neurodevelopmental origins, progression and treatment of mental illnesses [Texte imprimé et/ou numérique] / Jennifer PACHECO, Auteur ; Marjorie A. GARVEY, Auteur ; Christopher S. SARAMPOTE, Auteur ; Elan D. COHEN, Auteur ; Eric R. MURPHY, Auteur ; Stacia R. FRIEDMAN-HILL, Auteur . - p.360-376.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-4 (April 2022) . - p.360-376
Mots-clés : Adhd autism spectrum disorders development intervention Index. décimale : PER Périodiques Résumé : The National Institute of Mental Health (NIMH) proposed the Research Domain Criteria (RDoC) initiative as an alternate way to organize research of mental illnesses, by looking at dimensions of functioning rather than being tied to categorical diagnoses. This paper briefly discusses the motivation for and organization of RDoC, and then explores the NIMH portfolio and recent work to monitor the utility and progress that RDoC has afforded developmental research. To examine how RDoC has influenced the NIMH developmental research portfolio over the last decade, we employed a natural language processing algorithm to identify the number of developmental science grants classified as incorporating an RDoC approach. Additional portfolio analyses examine temporal trends in funded RDoC-relevant grants, publications and citations, and research training opportunities. Reflecting on how RDoC has influenced the focus of grant applications, we highlight examples from research on Attention-Deficit Hyperactivity Disorder (ADHD), childhood irritability, and Autism Spectrum Disorder (ASD). Lastly, we consider how the dimensional and transdiagnostic approaches emphasized in RDoC have facilitated research on personalized intervention for heterogeneous disorders and preventive/early interventions targeting emergent or subthreshold psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 Atypical Functional Connectivity of the Amygdala in Childhood Autism Spectrum Disorders during Spontaneous Attention to Eye-Gaze / Eric R. MURPHY in Autism Research and Treatment, (november 2012)
[article]
Titre : Atypical Functional Connectivity of the Amygdala in Childhood Autism Spectrum Disorders during Spontaneous Attention to Eye-Gaze Type de document : Texte imprimé et/ou numérique Auteurs : Eric R. MURPHY, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Lauren E. KENWORTHY, Auteur ; William D. GAILLARD, Auteur ; Chandan J. VAIDYA, Auteur Année de publication : 2012 Article en page(s) : 12 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examined functional connectivity of the amygdala in preadolescent children with Autism Spectrum Disorders (ASDs) during spontaneous attention to eye-gaze in emotional faces. Children responded to a target word (“LEFT/RIGHT”) printed on angry or fearful faces looking in a direction that was congruent, incongruent, or neutral with the target word. Despite being irrelevant to the task, gaze-direction facilitated (Congruent > Neutral) or interfered with (Incongruent > Congruent) performance in both groups. Despite similar behavioral performance, amygdala-connectivity was atypical and more widespread in children with ASD. In control children, the amygdala was more strongly connected with an emotional cognitive control region (subgenual cingulate) during interference, while during facilitation, no regions showed greater amygdala connectivity than in ASD children. In contrast, in children with ASD the amygdala was more strongly connected to salience and cognitive control regions (posterior and dorsal cingulate) during facilitation and with regions involved in gaze processing (superior temporal sulcus), cognitive control (inferior frontal gyrus), and processing of viscerally salient information (pregenual cingulate, anterior insula, and thalamus) during interference. These findings showing more widespread connectivity of the amygdala extend past findings of atypical functional anatomy of eye-gaze processing in children with ASD and challenge views of general underconnectivity in ASD. En ligne : http://dx.doi.org/10.1155/2012/652408 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=201
in Autism Research and Treatment > (november 2012) . - 12 p.[article] Atypical Functional Connectivity of the Amygdala in Childhood Autism Spectrum Disorders during Spontaneous Attention to Eye-Gaze [Texte imprimé et/ou numérique] / Eric R. MURPHY, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Lauren E. KENWORTHY, Auteur ; William D. GAILLARD, Auteur ; Chandan J. VAIDYA, Auteur . - 2012 . - 12 p.
Langues : Anglais (eng)
in Autism Research and Treatment > (november 2012) . - 12 p.
Index. décimale : PER Périodiques Résumé : We examined functional connectivity of the amygdala in preadolescent children with Autism Spectrum Disorders (ASDs) during spontaneous attention to eye-gaze in emotional faces. Children responded to a target word (“LEFT/RIGHT”) printed on angry or fearful faces looking in a direction that was congruent, incongruent, or neutral with the target word. Despite being irrelevant to the task, gaze-direction facilitated (Congruent > Neutral) or interfered with (Incongruent > Congruent) performance in both groups. Despite similar behavioral performance, amygdala-connectivity was atypical and more widespread in children with ASD. In control children, the amygdala was more strongly connected with an emotional cognitive control region (subgenual cingulate) during interference, while during facilitation, no regions showed greater amygdala connectivity than in ASD children. In contrast, in children with ASD the amygdala was more strongly connected to salience and cognitive control regions (posterior and dorsal cingulate) during facilitation and with regions involved in gaze processing (superior temporal sulcus), cognitive control (inferior frontal gyrus), and processing of viscerally salient information (pregenual cingulate, anterior insula, and thalamus) during interference. These findings showing more widespread connectivity of the amygdala extend past findings of atypical functional anatomy of eye-gaze processing in children with ASD and challenge views of general underconnectivity in ASD. En ligne : http://dx.doi.org/10.1155/2012/652408 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=201 Neural Basis of Visual Attentional Orienting in Childhood Autism Spectrum Disorders / Eric R. MURPHY in Journal of Autism and Developmental Disorders, 47-1 (January 2017)
[article]
Titre : Neural Basis of Visual Attentional Orienting in Childhood Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Eric R. MURPHY, Auteur ; Megan NORR, Auteur ; John F. STRANG, Auteur ; Lauren KENWORTHY, Auteur ; William D. GAILLARD, Auteur ; Chandan J. VAIDYA, Auteur Article en page(s) : p.58-67 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Attention orienting Visual salience fMRI Restricted and repetitive behavior Index. décimale : PER Périodiques Résumé : We examined spontaneous attention orienting to visual salience in stimuli without social significance using a modified Dot-Probe task during functional magnetic resonance imaging in high-functioning preadolescent children with Autism Spectrum Disorder (ASD) and age- and IQ-matched control children. While the magnitude of attentional bias (faster response to probes in the location of solid color patch) to visually salient stimuli was similar in the groups, activation differences in frontal and temporoparietal regions suggested hyper-sensitivity to visual salience or to sameness in ASD children. Further, activation in a subset of those regions was associated with symptoms of restricted and repetitive behavior. Thus, atypicalities in response to visual properties of stimuli may drive attentional orienting problems associated with ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2928-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298
in Journal of Autism and Developmental Disorders > 47-1 (January 2017) . - p.58-67[article] Neural Basis of Visual Attentional Orienting in Childhood Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Eric R. MURPHY, Auteur ; Megan NORR, Auteur ; John F. STRANG, Auteur ; Lauren KENWORTHY, Auteur ; William D. GAILLARD, Auteur ; Chandan J. VAIDYA, Auteur . - p.58-67.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-1 (January 2017) . - p.58-67
Mots-clés : Autism spectrum disorder Attention orienting Visual salience fMRI Restricted and repetitive behavior Index. décimale : PER Périodiques Résumé : We examined spontaneous attention orienting to visual salience in stimuli without social significance using a modified Dot-Probe task during functional magnetic resonance imaging in high-functioning preadolescent children with Autism Spectrum Disorder (ASD) and age- and IQ-matched control children. While the magnitude of attentional bias (faster response to probes in the location of solid color patch) to visually salient stimuli was similar in the groups, activation differences in frontal and temporoparietal regions suggested hyper-sensitivity to visual salience or to sameness in ASD children. Further, activation in a subset of those regions was associated with symptoms of restricted and repetitive behavior. Thus, atypicalities in response to visual properties of stimuli may drive attentional orienting problems associated with ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2928-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298