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Détail de l'auteur
Auteur David G. AMARAL |
Documents disponibles écrits par cet auteur (34)
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Neural correlates of language variability in preschool-aged boys with autism spectrum disorder / Letitia R. NAIGLES in Autism Research, 10-6 (June 2017)
[article]
Titre : Neural correlates of language variability in preschool-aged boys with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Letitia R. NAIGLES, Auteur ; Ryan JOHNSON, Auteur ; Ann MASTERGEORGE, Auteur ; Sally OZONOFF, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur Article en page(s) : p.1107-1119 Langues : Anglais (eng) Mots-clés : DTI brain imaging language development preschoolers Index. décimale : PER Périodiques Résumé : Children with autism vary widely in their language abilities, yet the neural correlates of this language variability remain unclear, especially early in development. Diffusion tensor imaging (DTI) was used to examine diffusivity measures along the length of 18 major fiber tracts in 104 preschool-aged boys with autism spectrum disorder (ASD). The boys were assigned to subgroups according to their level of language development (Low: no/low language, Middle: small vocabulary, High: large vocabulary and grammar), based on their raw scores on the expressive language (EL) and receptive language (RL) sections of the Mullen Scales of Early Learning (MSEL). Results indicate that the subgroups differed in fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) along the inferior longitudinal fasciculus (ILF) in both hemispheres. Moreover, FA correlated significantly with Mullen EL and RL raw scores, but not ADOS severity score, along the left and right ILF. Subgroups also differed in MD (but not FA) along the left superior longitudinal fasiculus and left corticospinal tract, but these differences were not correlated with language scores. These findings suggest that white matter microstructure in the left and right ILF varies in relation to lexical development in young males with ASD. The findings also support the use of raw scores on language-relevant standardized tests for assessing early language-brain relationships. En ligne : http://dx.doi.org/10.1002/aur.1756 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309
in Autism Research > 10-6 (June 2017) . - p.1107-1119[article] Neural correlates of language variability in preschool-aged boys with autism spectrum disorder [Texte imprimé et/ou numérique] / Letitia R. NAIGLES, Auteur ; Ryan JOHNSON, Auteur ; Ann MASTERGEORGE, Auteur ; Sally OZONOFF, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur . - p.1107-1119.
Langues : Anglais (eng)
in Autism Research > 10-6 (June 2017) . - p.1107-1119
Mots-clés : DTI brain imaging language development preschoolers Index. décimale : PER Périodiques Résumé : Children with autism vary widely in their language abilities, yet the neural correlates of this language variability remain unclear, especially early in development. Diffusion tensor imaging (DTI) was used to examine diffusivity measures along the length of 18 major fiber tracts in 104 preschool-aged boys with autism spectrum disorder (ASD). The boys were assigned to subgroups according to their level of language development (Low: no/low language, Middle: small vocabulary, High: large vocabulary and grammar), based on their raw scores on the expressive language (EL) and receptive language (RL) sections of the Mullen Scales of Early Learning (MSEL). Results indicate that the subgroups differed in fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) along the inferior longitudinal fasciculus (ILF) in both hemispheres. Moreover, FA correlated significantly with Mullen EL and RL raw scores, but not ADOS severity score, along the left and right ILF. Subgroups also differed in MD (but not FA) along the left superior longitudinal fasiculus and left corticospinal tract, but these differences were not correlated with language scores. These findings suggest that white matter microstructure in the left and right ILF varies in relation to lexical development in young males with ASD. The findings also support the use of raw scores on language-relevant standardized tests for assessing early language-brain relationships. En ligne : http://dx.doi.org/10.1002/aur.1756 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 Neuropathology of Autism Spectrum Disorders: Postmortem Studies / Cynthia M. SCHUMANN
Titre : Neuropathology of Autism Spectrum Disorders: Postmortem Studies Type de document : Texte imprimé et/ou numérique Auteurs : Cynthia M. SCHUMANN, Auteur ; Steven C. NOCTOR, Auteur ; David G. AMARAL, Auteur Année de publication : 2011 Importance : p.539-565 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 Neuropathology of Autism Spectrum Disorders: Postmortem Studies [Texte imprimé et/ou numérique] / Cynthia M. SCHUMANN, Auteur ; Steven C. NOCTOR, Auteur ; David G. AMARAL, Auteur . - 2011 . - p.539-565.
Langues : Anglais (eng)
Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Nonhuman Primate Models for Autism Spectrum Disorders / Melissa D. BAUMAN
Titre : Nonhuman Primate Models for Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Melissa D. BAUMAN, Auteur ; David G. AMARAL, Auteur Année de publication : 2013 Importance : p.379-390 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism is a complex neurodevelopmental disorder characterized by impairments in social interaction and verbal and nonverbal communication, and the occurrence of pathological repetitive behaviors or circumscribed interests. As discussed more completely in other chapters, the defining characteristics are manifest in a spectrum of severity, leading to the term autism spectrum disorders (ASD) to encompass this heterogeneity. ASD are challenging to study in human populations because of the heterogeneity of symptoms, lack of consistent biomarkers, and the complex interplay between genetic and environmental risk factors. In recent years, some progress has been made in developing animal models of autism. These animal models provide an experimental system to evaluate hypotheses that, for ethical and practical reasons, are impossible to test using human subjects. However, a major challenge for complex brain disorders such as autism is to model a human disorder that has impairments of complex cognitive functions in a nonhuman species. In this chapter, we summarize different approaches to modeling features of autism in nonhuman primates, focusing on the rhesus macaque (Macacca mulatta). We review expectations for a valid nonhuman primate model of autism, evaluate the strengths and weaknesses of current nonhuman primate models, and highlight promising future directions for integrating neuroscience research into these models. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Nonhuman Primate Models for Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Melissa D. BAUMAN, Auteur ; David G. AMARAL, Auteur . - 2013 . - p.379-390.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism is a complex neurodevelopmental disorder characterized by impairments in social interaction and verbal and nonverbal communication, and the occurrence of pathological repetitive behaviors or circumscribed interests. As discussed more completely in other chapters, the defining characteristics are manifest in a spectrum of severity, leading to the term autism spectrum disorders (ASD) to encompass this heterogeneity. ASD are challenging to study in human populations because of the heterogeneity of symptoms, lack of consistent biomarkers, and the complex interplay between genetic and environmental risk factors. In recent years, some progress has been made in developing animal models of autism. These animal models provide an experimental system to evaluate hypotheses that, for ethical and practical reasons, are impossible to test using human subjects. However, a major challenge for complex brain disorders such as autism is to model a human disorder that has impairments of complex cognitive functions in a nonhuman species. In this chapter, we summarize different approaches to modeling features of autism in nonhuman primates, focusing on the rhesus macaque (Macacca mulatta). We review expectations for a valid nonhuman primate model of autism, evaluate the strengths and weaknesses of current nonhuman primate models, and highlight promising future directions for integrating neuroscience research into these models. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Nonhuman Primate Models of Autism / Melissa D. BAUMAN
Titre : Nonhuman Primate Models of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Melissa D. BAUMAN, Auteur ; David G. AMARAL, Auteur Année de publication : 2011 Importance : p.963-980 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 Nonhuman Primate Models of Autism [Texte imprimé et/ou numérique] / Melissa D. BAUMAN, Auteur ; David G. AMARAL, Auteur . - 2011 . - p.963-980.
Langues : Anglais (eng)
Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Offering to Share: How to Put Heads Together in Autism Neuroimaging / Matthew K. BELMONTE in Journal of Autism and Developmental Disorders, 38-1 (January 2008)
[article]
Titre : Offering to Share: How to Put Heads Together in Autism Neuroimaging Type de document : Texte imprimé et/ou numérique Auteurs : Matthew K. BELMONTE, Auteur ; Anders M. DALE, Auteur ; Christos DAVATZIKOS, Auteur ; Guido GERIG, Auteur ; Martha R. HERBERT, Auteur ; Robert T. SCHULTZ, Auteur ; Janet E. LAINHART, Auteur ; Declan G. MURPHY, Auteur ; Thomas A. ZEFFIRO, Auteur ; Susan LEVI-PEARL, Auteur ; Clara LAJONCHERE, Auteur ; Diane C. CHUGANI, Auteur ; Rita M. CANTOR, Auteur ; Elizabeth H. AYLWARD, Auteur ; Allan L. REISS, Auteur ; Joseph PIVEN, Auteur ; Nancy J. MINSHEW, Auteur ; Eric COURCHESNE, Auteur ; David G. AMARAL, Auteur ; John C. MAZZIOTTA, Auteur ; Alan C. EVANS, Auteur ; Stephen R. DAGER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Sophia A. COLAMARINO, Auteur Année de publication : 2008 Article en page(s) : p.2-13 Langues : Anglais (eng) Mots-clés : Imaging MRI PET Morphometry Segmentation Data-sharing Index. décimale : PER Périodiques Résumé : Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations for raw data, outlines a core protocol including multispectral structural and diffusion-tensor imaging and optional extensions, provides for the collection of prospective, confound-free normative data, and extends sharing and collaborative development not only to data but to the analytical tools and methods applied to these data. A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on.
En ligne : http://dx.doi.org/10.1007/s10803-006-0352-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315
in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.2-13[article] Offering to Share: How to Put Heads Together in Autism Neuroimaging [Texte imprimé et/ou numérique] / Matthew K. BELMONTE, Auteur ; Anders M. DALE, Auteur ; Christos DAVATZIKOS, Auteur ; Guido GERIG, Auteur ; Martha R. HERBERT, Auteur ; Robert T. SCHULTZ, Auteur ; Janet E. LAINHART, Auteur ; Declan G. MURPHY, Auteur ; Thomas A. ZEFFIRO, Auteur ; Susan LEVI-PEARL, Auteur ; Clara LAJONCHERE, Auteur ; Diane C. CHUGANI, Auteur ; Rita M. CANTOR, Auteur ; Elizabeth H. AYLWARD, Auteur ; Allan L. REISS, Auteur ; Joseph PIVEN, Auteur ; Nancy J. MINSHEW, Auteur ; Eric COURCHESNE, Auteur ; David G. AMARAL, Auteur ; John C. MAZZIOTTA, Auteur ; Alan C. EVANS, Auteur ; Stephen R. DAGER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Sophia A. COLAMARINO, Auteur . - 2008 . - p.2-13.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.2-13
Mots-clés : Imaging MRI PET Morphometry Segmentation Data-sharing Index. décimale : PER Périodiques Résumé : Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations for raw data, outlines a core protocol including multispectral structural and diffusion-tensor imaging and optional extensions, provides for the collection of prospective, confound-free normative data, and extends sharing and collaborative development not only to data but to the analytical tools and methods applied to these data. A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on.
En ligne : http://dx.doi.org/10.1007/s10803-006-0352-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315 Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder / Lauren E. LIBERO in Autism Research, 9-11 (November 2016)
PermalinkResponse to Mottron et al. (2023) and Woods et al. (2023) / Einat WAIZBARD-BARTOV in Autism Research, 16-9 (September 2023)
PermalinkSex differences in the corpus callosum in preschool-aged children with autism spectrum disorder / Christine W. NORDAHL in Molecular Autism, (May 2015)
PermalinkTrajectories of Autism Symptom Severity Change During Early Childhood / Einat WAIZBARD-BARTOV in Journal of Autism and Developmental Disorders, 51-1 (January 2021)
PermalinkWhat will my child's future hold? phenotypes of intellectual development in 2–8?year?olds with autism spectrum disorder / Marjorie SOLOMON in Autism Research, 11-1 (January 2018)
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