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Auteur Raphael BERNIER |
Documents disponibles écrits par cet auteur (49)
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The gap between IQ and adaptive functioning in autism spectrum disorder: Disentangling diagnostic and sex differences / G. A. MCQUAID in Autism, 25-6 (August 2021)
[article]
Titre : The gap between IQ and adaptive functioning in autism spectrum disorder: Disentangling diagnostic and sex differences Type de document : Texte imprimé et/ou numérique Auteurs : G. A. MCQUAID, Auteur ; Kevin A. PELPHREY, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; S. J. WEBB, Auteur ; Raphael BERNIER, Auteur ; J. C. MCPARTLAND, Auteur ; J. D. VAN HORN, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.1565-1579 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder Autistic Disorder Female Humans Intellectual Disability Male Sex Characteristics Social Skills Iq adaptive functioning autism sex differences of interest with respect to the research, authorship, and/or publication of this article. Index. décimale : PER Périodiques Résumé : Adaptive functioning refers to skills that are vital to success in day-to-day life, including daily living (e.g. grocery shopping, food preparation, transportation use), communication (e.g. verbal expression of needs), and socialization skills (e.g. interpersonal skills, including expressing and recognizing emotions, and understanding turn-taking in conversation). Among autistic individuals without intellectual disability, adaptive functioning is not commensurate with intellectual ability (IQ), and instead a gap exists between these individuals' intellectual ability and their adaptive skills. Further, these autistic individuals show a widening of this gap with increasing age. Existing studies of the gap between IQ and adaptive functioning have studied predominantly male samples. Thus, we do not know if the gap also exists in autistic females. We therefore looked at adaptive functioning and the gap between IQ and adaptive functioning in a large sample of autistic girls and boys without intellectual disability. To disentangle effects of group (autistic vs typically developing) from effects of sex (girls vs boys), we compared autistic girls and boys to one another as well as to their same-sex typically developing peers. Analyses took into consideration differences in IQ between autistic and typically developing youth. We found autistic girls, like autistic boys, show lower adaptive functioning than their same-sex typically developing peers. Results underscore the need to evaluate adaptive functioning in autistic individuals without intellectual disability and to provide necessary supports. The large gap between intellectual ability and socialization skills, in particular, may be of critical importance in improving our understanding of outcomes and mental health difficulties among autistic females. En ligne : http://dx.doi.org/10.1177/1362361321995620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451
in Autism > 25-6 (August 2021) . - p.1565-1579[article] The gap between IQ and adaptive functioning in autism spectrum disorder: Disentangling diagnostic and sex differences [Texte imprimé et/ou numérique] / G. A. MCQUAID, Auteur ; Kevin A. PELPHREY, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; S. J. WEBB, Auteur ; Raphael BERNIER, Auteur ; J. C. MCPARTLAND, Auteur ; J. D. VAN HORN, Auteur ; Gregory L. WALLACE, Auteur . - p.1565-1579.
Langues : Anglais (eng)
in Autism > 25-6 (August 2021) . - p.1565-1579
Mots-clés : Adolescent Autism Spectrum Disorder Autistic Disorder Female Humans Intellectual Disability Male Sex Characteristics Social Skills Iq adaptive functioning autism sex differences of interest with respect to the research, authorship, and/or publication of this article. Index. décimale : PER Périodiques Résumé : Adaptive functioning refers to skills that are vital to success in day-to-day life, including daily living (e.g. grocery shopping, food preparation, transportation use), communication (e.g. verbal expression of needs), and socialization skills (e.g. interpersonal skills, including expressing and recognizing emotions, and understanding turn-taking in conversation). Among autistic individuals without intellectual disability, adaptive functioning is not commensurate with intellectual ability (IQ), and instead a gap exists between these individuals' intellectual ability and their adaptive skills. Further, these autistic individuals show a widening of this gap with increasing age. Existing studies of the gap between IQ and adaptive functioning have studied predominantly male samples. Thus, we do not know if the gap also exists in autistic females. We therefore looked at adaptive functioning and the gap between IQ and adaptive functioning in a large sample of autistic girls and boys without intellectual disability. To disentangle effects of group (autistic vs typically developing) from effects of sex (girls vs boys), we compared autistic girls and boys to one another as well as to their same-sex typically developing peers. Analyses took into consideration differences in IQ between autistic and typically developing youth. We found autistic girls, like autistic boys, show lower adaptive functioning than their same-sex typically developing peers. Results underscore the need to evaluate adaptive functioning in autistic individuals without intellectual disability and to provide necessary supports. The large gap between intellectual ability and socialization skills, in particular, may be of critical importance in improving our understanding of outcomes and mental health difficulties among autistic females. En ligne : http://dx.doi.org/10.1177/1362361321995620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 The Role of Mirror Neuron Dysfunction in Autism / Raphael BERNIER
Titre : The Role of Mirror Neuron Dysfunction in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Raphael BERNIER, Auteur ; Geraldine DAWSON, Auteur Année de publication : 2009 Importance : p.261-286 Langues : Anglais (eng) Index. décimale : PAR-G PAR-G - Imitation Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=996 The Role of Mirror Neuron Dysfunction in Autism [Texte imprimé et/ou numérique] / Raphael BERNIER, Auteur ; Geraldine DAWSON, Auteur . - 2009 . - p.261-286.
Langues : Anglais (eng)
Index. décimale : PAR-G PAR-G - Imitation Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=996 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) feasibility study / Erin C. BARNEY ; Adam J. NAPLES ; Kelsey J. DOMMER ; Shou An CHANG ; Beibin LI ; Takumi MCALLISTER ; Adham ATYABI ; Quan WANG ; Raphael BERNIER ; Geraldine DAWSON ; James DZIURA ; Susan FAJA ; Shafali Spurling JESTE ; Michael MURIAS ; Scott P. JOHNSON ; Maura SABATOS-DEVITO ; Gerhard HELLEMAN ; Damla SENTURK ; Catherine A. SUGAR ; Sara Jane WEBB ; James C. MCPARTLAND ; Katarzyna CHAWARSKA ; The Autism Biomarkers Consortium for Clinical TRIALS in Autism Research, 16-11 (November 2023)
[article]
Titre : The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) feasibility study Type de document : Texte imprimé et/ou numérique Auteurs : Erin C. BARNEY, Auteur ; Adam J. NAPLES, Auteur ; Kelsey J. DOMMER, Auteur ; Shou An CHANG, Auteur ; Beibin LI, Auteur ; Takumi MCALLISTER, Auteur ; Adham ATYABI, Auteur ; Quan WANG, Auteur ; Raphael BERNIER, Auteur ; Geraldine DAWSON, Auteur ; James DZIURA, Auteur ; Susan FAJA, Auteur ; Shafali Spurling JESTE, Auteur ; Michael MURIAS, Auteur ; Scott P. JOHNSON, Auteur ; Maura SABATOS-DEVITO, Auteur ; Gerhard HELLEMAN, Auteur ; Damla SENTURK, Auteur ; Catherine A. SUGAR, Auteur ; Sara Jane WEBB, Auteur ; James C. MCPARTLAND, Auteur ; Katarzyna CHAWARSKA, Auteur ; The Autism Biomarkers Consortium for Clinical TRIALS, Auteur Article en page(s) : p.2150-2159 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The Selective Social Attention (SSA) task is a brief eye-tracking task involving experimental conditions varying along socio-communicative axes. Traditionally the SSA has been used to probe socially-specific attentional patterns in infants and toddlers who develop autism spectrum disorder (ASD). This current work extends these findings to preschool and school-age children. Children 4- to 12-years-old with ASD (N=23) and a typically-developing comparison group (TD; N=25) completed the SSA task as well as standardized clinical assessments. Linear mixed models examined group and condition effects on two outcome variables: percent of time spent looking at the scene relative to scene presentation time (%Valid), and percent of time looking at the face relative to time spent looking at the scene (%Face). Age and IQ were included as covariates. Outcome variables' relationships to clinical data were assessed via correlation analysis. The ASD group, compared to the TD group, looked less at the scene and focused less on the actress' face during the most socially-engaging experimental conditions. Additionally, within the ASD group, %Face negatively correlated with SRS total T-scores with a particularly strong negative correlation with the Autistic Mannerism subscale T-score. These results highlight the extensibility of the SSA to older children with ASD, including replication of between-group differences previously seen in infants and toddlers, as well as its ability to capture meaningful clinical variation within the autism spectrum across a wide developmental span inclusive of preschool and school-aged children. The properties suggest that the SSA may have broad potential as a biomarker for ASD. En ligne : https://doi.org/10.1002/aur.3026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517
in Autism Research > 16-11 (November 2023) . - p.2150-2159[article] The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) feasibility study [Texte imprimé et/ou numérique] / Erin C. BARNEY, Auteur ; Adam J. NAPLES, Auteur ; Kelsey J. DOMMER, Auteur ; Shou An CHANG, Auteur ; Beibin LI, Auteur ; Takumi MCALLISTER, Auteur ; Adham ATYABI, Auteur ; Quan WANG, Auteur ; Raphael BERNIER, Auteur ; Geraldine DAWSON, Auteur ; James DZIURA, Auteur ; Susan FAJA, Auteur ; Shafali Spurling JESTE, Auteur ; Michael MURIAS, Auteur ; Scott P. JOHNSON, Auteur ; Maura SABATOS-DEVITO, Auteur ; Gerhard HELLEMAN, Auteur ; Damla SENTURK, Auteur ; Catherine A. SUGAR, Auteur ; Sara Jane WEBB, Auteur ; James C. MCPARTLAND, Auteur ; Katarzyna CHAWARSKA, Auteur ; The Autism Biomarkers Consortium for Clinical TRIALS, Auteur . - p.2150-2159.
Langues : Anglais (eng)
in Autism Research > 16-11 (November 2023) . - p.2150-2159
Index. décimale : PER Périodiques Résumé : Abstract The Selective Social Attention (SSA) task is a brief eye-tracking task involving experimental conditions varying along socio-communicative axes. Traditionally the SSA has been used to probe socially-specific attentional patterns in infants and toddlers who develop autism spectrum disorder (ASD). This current work extends these findings to preschool and school-age children. Children 4- to 12-years-old with ASD (N=23) and a typically-developing comparison group (TD; N=25) completed the SSA task as well as standardized clinical assessments. Linear mixed models examined group and condition effects on two outcome variables: percent of time spent looking at the scene relative to scene presentation time (%Valid), and percent of time looking at the face relative to time spent looking at the scene (%Face). Age and IQ were included as covariates. Outcome variables' relationships to clinical data were assessed via correlation analysis. The ASD group, compared to the TD group, looked less at the scene and focused less on the actress' face during the most socially-engaging experimental conditions. Additionally, within the ASD group, %Face negatively correlated with SRS total T-scores with a particularly strong negative correlation with the Autistic Mannerism subscale T-score. These results highlight the extensibility of the SSA to older children with ASD, including replication of between-group differences previously seen in infants and toddlers, as well as its ability to capture meaningful clinical variation within the autism spectrum across a wide developmental span inclusive of preschool and school-aged children. The properties suggest that the SSA may have broad potential as a biomarker for ASD. En ligne : https://doi.org/10.1002/aur.3026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 Transcriptional subtyping explains phenotypic variability in genetic subtypes of autism spectrum disorder / Sandy TRINH in Development and Psychopathology, 32-4 (October 2020)
[article]
Titre : Transcriptional subtyping explains phenotypic variability in genetic subtypes of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sandy TRINH, Auteur ; Anne B. ARNETT, Auteur ; Evangeline KURTZ-NELSON, Auteur ; Jennifer BEIGHLEY, Auteur ; Marta PICOTO, Auteur ; Raphael BERNIER, Auteur Article en page(s) : p.1353-1361 Langues : Anglais (eng) Mots-clés : autism genetics mutation organization or entity with any financial interest in the outcome of this project. Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by deficits in social communication and presence of restricted, repetitive behaviors, and interests. However, individuals with ASD vary significantly in their challenges and abilities in these and other developmental domains. Gene discovery in ASD has accelerated in the past decade, and genetic subtyping has yielded preliminary evidence of utility in parsing phenotypic heterogeneity through genomic subtypes. Recent advances in transcriptomics have provided additional dimensions with which to refine genetic subtyping efforts. In the current study, we investigate phenotypic differences among transcriptional subtypes defined by neurobiological spatiotemporal co-expression patterns. Of the four transcriptional subtypes examined, participants with mutations to genes typically expressed highly in all brain regions prenatally, and those with differential postnatal cerebellar expression relative to other brain regions, showed lower cognitive and adaptive skills, higher severity of social communication deficits, and later acquisition of speech and motor milestones, compared to those with mutations to genes highly expressed during the postnatal period across brain regions. These findings suggest higher-order characterization of genetic subtypes based on neurobiological expression patterns may be a promising approach to parsing phenotypic heterogeneity among those with ASD and related neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1017/s0954579420000784 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433
in Development and Psychopathology > 32-4 (October 2020) . - p.1353-1361[article] Transcriptional subtyping explains phenotypic variability in genetic subtypes of autism spectrum disorder [Texte imprimé et/ou numérique] / Sandy TRINH, Auteur ; Anne B. ARNETT, Auteur ; Evangeline KURTZ-NELSON, Auteur ; Jennifer BEIGHLEY, Auteur ; Marta PICOTO, Auteur ; Raphael BERNIER, Auteur . - p.1353-1361.
Langues : Anglais (eng)
in Development and Psychopathology > 32-4 (October 2020) . - p.1353-1361
Mots-clés : autism genetics mutation organization or entity with any financial interest in the outcome of this project. Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by deficits in social communication and presence of restricted, repetitive behaviors, and interests. However, individuals with ASD vary significantly in their challenges and abilities in these and other developmental domains. Gene discovery in ASD has accelerated in the past decade, and genetic subtyping has yielded preliminary evidence of utility in parsing phenotypic heterogeneity through genomic subtypes. Recent advances in transcriptomics have provided additional dimensions with which to refine genetic subtyping efforts. In the current study, we investigate phenotypic differences among transcriptional subtypes defined by neurobiological spatiotemporal co-expression patterns. Of the four transcriptional subtypes examined, participants with mutations to genes typically expressed highly in all brain regions prenatally, and those with differential postnatal cerebellar expression relative to other brain regions, showed lower cognitive and adaptive skills, higher severity of social communication deficits, and later acquisition of speech and motor milestones, compared to those with mutations to genes highly expressed during the postnatal period across brain regions. These findings suggest higher-order characterization of genetic subtypes based on neurobiological expression patterns may be a promising approach to parsing phenotypic heterogeneity among those with ASD and related neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1017/s0954579420000784 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433