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Auteur Suzanne MACARI |
Documents disponibles écrits par cet auteur (11)



Attention to audiovisual speech does not facilitate language acquisition in infants with familial history of autism / Katarzyna CHAWARSKA in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)
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Titre : Attention to audiovisual speech does not facilitate language acquisition in infants with familial history of autism Type de document : Texte imprimé et/ou numérique Auteurs : Katarzyna CHAWARSKA, Auteur ; David LEWKOWICZ, Auteur ; Hannah FEINER, Auteur ; Suzanne MACARI, Auteur ; Angelina VERNETTI, Auteur Article en page(s) : p.1466-1476 Langues : Anglais (eng) Mots-clés : Infant Child Humans Speech Autistic Disorder Genetic Predisposition to Disease Language Development Language Development Disorders Autism Spectrum Disorder Infancy attention audiovisual speech autism eye-tracking Index. décimale : PER Périodiques Résumé : BACKGROUND: Due to familial liability, siblings of children with ASD exhibit elevated risk for language delays. The processes contributing to language delays in this population remain unclear. METHODS: Considering well-established links between attention to dynamic audiovisual cues inherent in a speaker's face and speech processing, we investigated if attention to a speaker's face and mouth differs in 12-month-old infants at high familial risk for ASD but without ASD diagnosis (hr-sib; n=91) and in infants at low familial risk (lr-sib; n=62) for ASD and whether attention at 12 months predicts language outcomes at 18 months. RESULTS: At 12 months, hr-sib and lr-sib infants did not differ in attention to face (p = .14), mouth preference (p = .30), or in receptive and expressive language scores (p = .36, p = .33). At 18 months, the hr-sib infants had lower receptive (p = .01) but not expressive (p = .84) language scores than the lr-sib infants. In the lr-sib infants, greater attention to the face (p = .022) and a mouth preference (p = .025) contributed to better language outcomes at 18 months. In the hr-sib infants, neither attention to the face nor a mouth preference was associated with language outcomes at 18 months. CONCLUSIONS: Unlike low-risk infants, high-risk infants do not appear to benefit from audiovisual prosodic and speech cues in the service of language acquisition despite intact attention to these cues. We propose that impaired processing of audiovisual cues may constitute the link between genetic risk factors and poor language outcomes observed across the autism risk spectrum and may represent a promising endophenotype in autism. En ligne : http://dx.doi.org/10.1111/jcpp.13595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1466-1476[article] Attention to audiovisual speech does not facilitate language acquisition in infants with familial history of autism [Texte imprimé et/ou numérique] / Katarzyna CHAWARSKA, Auteur ; David LEWKOWICZ, Auteur ; Hannah FEINER, Auteur ; Suzanne MACARI, Auteur ; Angelina VERNETTI, Auteur . - p.1466-1476.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1466-1476
Mots-clés : Infant Child Humans Speech Autistic Disorder Genetic Predisposition to Disease Language Development Language Development Disorders Autism Spectrum Disorder Infancy attention audiovisual speech autism eye-tracking Index. décimale : PER Périodiques Résumé : BACKGROUND: Due to familial liability, siblings of children with ASD exhibit elevated risk for language delays. The processes contributing to language delays in this population remain unclear. METHODS: Considering well-established links between attention to dynamic audiovisual cues inherent in a speaker's face and speech processing, we investigated if attention to a speaker's face and mouth differs in 12-month-old infants at high familial risk for ASD but without ASD diagnosis (hr-sib; n=91) and in infants at low familial risk (lr-sib; n=62) for ASD and whether attention at 12 months predicts language outcomes at 18 months. RESULTS: At 12 months, hr-sib and lr-sib infants did not differ in attention to face (p = .14), mouth preference (p = .30), or in receptive and expressive language scores (p = .36, p = .33). At 18 months, the hr-sib infants had lower receptive (p = .01) but not expressive (p = .84) language scores than the lr-sib infants. In the lr-sib infants, greater attention to the face (p = .022) and a mouth preference (p = .025) contributed to better language outcomes at 18 months. In the hr-sib infants, neither attention to the face nor a mouth preference was associated with language outcomes at 18 months. CONCLUSIONS: Unlike low-risk infants, high-risk infants do not appear to benefit from audiovisual prosodic and speech cues in the service of language acquisition despite intact attention to these cues. We propose that impaired processing of audiovisual cues may constitute the link between genetic risk factors and poor language outcomes observed across the autism risk spectrum and may represent a promising endophenotype in autism. En ligne : http://dx.doi.org/10.1111/jcpp.13595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Atypical Emotional Electrodermal Activity in Toddlers with Autism Spectrum Disorder / Angelina VERNETTI in Autism Research, 13-9 (September 2020)
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Titre : Atypical Emotional Electrodermal Activity in Toddlers with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Angelina VERNETTI, Auteur ; Frederick SHIC, Auteur ; Laura BOCCANFUSO, Auteur ; Suzanne MACARI, Auteur ; Finola KANE-GRADE, Auteur ; Anna MILGRAMM, Auteur ; Emily HILTON, Auteur ; Perrine HEYMANN, Auteur ; Matthew S GOODWIN, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.1476-1488 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Past studies in autism spectrum disorder (ASD) indicate atypical peripheral physiological arousal. However, the conditions under which these atypicalities arise and their link with behavioral emotional expressions and core ASD symptoms remain uncertain. Given the importance of physiological arousal in affective, learning, and cognitive processes, the current study examined changes in skin conductance level (?SCL) in 41 toddlers with ASD (mean age: 22.7?months, SD: 2.9) and 32 age-matched toddlers with typical development (TD) (mean age: 21.6 months, SD: 3.6) in response to probes designed to induce anger, joy, and fear emotions. The magnitude of ?SCL was comparable during anger (P =?0.206, d =?0.30) and joy (P =?0.996, d =?0.01) conditions, but significantly lower during the fear condition (P =?0.001, d =?0.83) in toddlers with ASD compared to TD peers. In the combined samples, ?SCL positively correlated with intensity of behavioral emotional expressivity during the anger (r[71] = 0.36, P =?0.002) and fear (r[68] = 0.32, P =?0.007) conditions, but not in the joy (r[69] = ?0.15, P =?0.226) condition. Finally, ?SCL did not associate with autism symptom severity in any emotion-eliciting condition in the ASD group. Toddlers with ASD displayed attenuated ?SCL to situations aimed at eliciting fear, which may forecast the emergence of highly prevalent internalizing and externalizing problems in this population. The study putatively identifies ?SCL as a dimension not associated with severity of autism but with behavioral responses in negatively emotionally challenging events and provides support for the feasibility, validity, and incipient utility of examining ?SCL in response to emotional challenges in very young children. Lay Summary Physiological arousal was measured in toddlers with autism exposed to frustrating, pleasant, and threatening tasks. Compared to typically developing peers, toddlers with autism showed comparable arousal responses to frustrating and pleasant events, but lower responses to threatening events. Importantly, physiological arousal and behavioral expressions were aligned during frustrating and threatening events, inviting exploration of physiological arousal to measure responses to emotional challenges. Furthermore, this study advances the understanding of precursors to emotional and behavioral problems common in older children with autism. Autism Res 2020, 13: 1476–1488. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2374 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431
in Autism Research > 13-9 (September 2020) . - p.1476-1488[article] Atypical Emotional Electrodermal Activity in Toddlers with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Angelina VERNETTI, Auteur ; Frederick SHIC, Auteur ; Laura BOCCANFUSO, Auteur ; Suzanne MACARI, Auteur ; Finola KANE-GRADE, Auteur ; Anna MILGRAMM, Auteur ; Emily HILTON, Auteur ; Perrine HEYMANN, Auteur ; Matthew S GOODWIN, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.1476-1488.
Langues : Anglais (eng)
in Autism Research > 13-9 (September 2020) . - p.1476-1488
Index. décimale : PER Périodiques Résumé : Past studies in autism spectrum disorder (ASD) indicate atypical peripheral physiological arousal. However, the conditions under which these atypicalities arise and their link with behavioral emotional expressions and core ASD symptoms remain uncertain. Given the importance of physiological arousal in affective, learning, and cognitive processes, the current study examined changes in skin conductance level (?SCL) in 41 toddlers with ASD (mean age: 22.7?months, SD: 2.9) and 32 age-matched toddlers with typical development (TD) (mean age: 21.6 months, SD: 3.6) in response to probes designed to induce anger, joy, and fear emotions. The magnitude of ?SCL was comparable during anger (P =?0.206, d =?0.30) and joy (P =?0.996, d =?0.01) conditions, but significantly lower during the fear condition (P =?0.001, d =?0.83) in toddlers with ASD compared to TD peers. In the combined samples, ?SCL positively correlated with intensity of behavioral emotional expressivity during the anger (r[71] = 0.36, P =?0.002) and fear (r[68] = 0.32, P =?0.007) conditions, but not in the joy (r[69] = ?0.15, P =?0.226) condition. Finally, ?SCL did not associate with autism symptom severity in any emotion-eliciting condition in the ASD group. Toddlers with ASD displayed attenuated ?SCL to situations aimed at eliciting fear, which may forecast the emergence of highly prevalent internalizing and externalizing problems in this population. The study putatively identifies ?SCL as a dimension not associated with severity of autism but with behavioral responses in negatively emotionally challenging events and provides support for the feasibility, validity, and incipient utility of examining ?SCL in response to emotional challenges in very young children. Lay Summary Physiological arousal was measured in toddlers with autism exposed to frustrating, pleasant, and threatening tasks. Compared to typically developing peers, toddlers with autism showed comparable arousal responses to frustrating and pleasant events, but lower responses to threatening events. Importantly, physiological arousal and behavioral expressions were aligned during frustrating and threatening events, inviting exploration of physiological arousal to measure responses to emotional challenges. Furthermore, this study advances the understanding of precursors to emotional and behavioral problems common in older children with autism. Autism Res 2020, 13: 1476–1488. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2374 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 Developmental delays in emotion regulation strategies in preschoolers with autism / Heather J. NUSKE in Autism Research, 10-11 (November 2017)
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Titre : Developmental delays in emotion regulation strategies in preschoolers with autism Type de document : Texte imprimé et/ou numérique Auteurs : Heather J. NUSKE, Auteur ; Darren HEDLEY, Auteur ; Alexandra WOOLLACOTT, Auteur ; Phoebe THOMSON, Auteur ; Suzanne MACARI, Auteur ; Cheryl DISSANAYAKE, Auteur Article en page(s) : p.1808-1822 Langues : Anglais (eng) Mots-clés : emotion regulation strategies autism mental health wellbeing self-development preschool independence child emotional wellbeing scale Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) commonly present with difficulty regulating negative emotions, which has been found to impact their behavioral and mental health. Little research has documented the strategies that children with ASD use to regulate their emotion to understand whether they use qualitatively different strategies to children without ASD, whether these are developmentally delayed, or both. Forty-four children with ASD and 29 typically-developing children (2–4 years) were given tasks designed to mimic everyday life experiences requiring children to manage low-level stress (e.g., waiting for a snack) and children's emotion regulation strategies were coded. Parents reported on their child's mental health, wellbeing, and self-development. The results suggest differences in using emotion regulation strategies in children with ASD, reflecting a delay, rather than a deviance when compared to those used by children without ASD. Only children with ASD relied on their family members for physical and communicative soothing; the typically developing children relied on people outside of their family for help regulating their emotion. More frequent approach/less frequent avoidance was related to a higher self-evaluation in both groups, but was only additionally related to higher self-recognition and autonomy in the ASD group. These findings help to identify important emotion regulation intervention targets for this population, including supporting communication with people outside of the family and independence. Autism Res 2017, 10: 1808–1822. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Results suggest that children with autism had more difficulty using communication strategies to manage stress only with people outside the family; they used these strategies with family members as often as children without autism. For all children, more task approach/less avoidance was related to children's higher self-evaluation. These findings suggest targeting communication with people outside of the family and personality development as appropriate intervention goals. En ligne : http://dx.doi.org/10.1002/aur.1827 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-11 (November 2017) . - p.1808-1822[article] Developmental delays in emotion regulation strategies in preschoolers with autism [Texte imprimé et/ou numérique] / Heather J. NUSKE, Auteur ; Darren HEDLEY, Auteur ; Alexandra WOOLLACOTT, Auteur ; Phoebe THOMSON, Auteur ; Suzanne MACARI, Auteur ; Cheryl DISSANAYAKE, Auteur . - p.1808-1822.
Langues : Anglais (eng)
in Autism Research > 10-11 (November 2017) . - p.1808-1822
Mots-clés : emotion regulation strategies autism mental health wellbeing self-development preschool independence child emotional wellbeing scale Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) commonly present with difficulty regulating negative emotions, which has been found to impact their behavioral and mental health. Little research has documented the strategies that children with ASD use to regulate their emotion to understand whether they use qualitatively different strategies to children without ASD, whether these are developmentally delayed, or both. Forty-four children with ASD and 29 typically-developing children (2–4 years) were given tasks designed to mimic everyday life experiences requiring children to manage low-level stress (e.g., waiting for a snack) and children's emotion regulation strategies were coded. Parents reported on their child's mental health, wellbeing, and self-development. The results suggest differences in using emotion regulation strategies in children with ASD, reflecting a delay, rather than a deviance when compared to those used by children without ASD. Only children with ASD relied on their family members for physical and communicative soothing; the typically developing children relied on people outside of their family for help regulating their emotion. More frequent approach/less frequent avoidance was related to a higher self-evaluation in both groups, but was only additionally related to higher self-recognition and autonomy in the ASD group. These findings help to identify important emotion regulation intervention targets for this population, including supporting communication with people outside of the family and independence. Autism Res 2017, 10: 1808–1822. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Results suggest that children with autism had more difficulty using communication strategies to manage stress only with people outside the family; they used these strategies with family members as often as children without autism. For all children, more task approach/less avoidance was related to children's higher self-evaluation. These findings suggest targeting communication with people outside of the family and personality development as appropriate intervention goals. En ligne : http://dx.doi.org/10.1002/aur.1827 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 Elevated symptoms of executive dysfunction predict lower adaptive functioning in 3-year-olds with autism spectrum disorder / Kelly POWELL in Autism Research, 15-7 (July 2022)
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Titre : Elevated symptoms of executive dysfunction predict lower adaptive functioning in 3-year-olds with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kelly POWELL, Auteur ; Suzanne MACARI, Auteur ; Emma BRENNAN-WYDRA, Auteur ; Hannah FEINER, Auteur ; Maureen BUTLER, Auteur ; Diogo GONCALVES FORTES, Auteur ; Alexandra BOXBERGER, Auteur ; Mariana TORRES-VISO, Auteur ; Chelsea MORGAN, Auteur ; Megan LYONS, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.1336-1347 Langues : Anglais (eng) Mots-clés : autism executive function sibling toddlers Index. décimale : PER Périodiques Résumé : Executive functioning (EF) deficits co-occur frequently with autism spectrum disorder (ASD) and have a long-term detrimental impact on quality of life of children and their families. Timely identification of risk for EF vulnerabilities may hasten access to early intervention and alleviate their long-term consequences. This study examines (1) if EF deficits are elevated in toddlers with ASD compared to nonautistic siblings of children with ASD, typically developing (TYP) toddlers, and toddlers with atypical developmental presentation; and (2) if EF deficits have a detrimental effect on adaptive functioning in ASD. Participants were recruited between September 2014 and October 2019 and included 73 toddlers with ASD, 33 nonautistic siblings of children with ASD, 35 toddlers with atypical development, and 28 TYP toddlers matched on chronological age (M = 39.01?months, SD = 3.11). EF deficits were measured using the BRIEF-P; adaptive skills were measured using the VABS-II. Whenever appropriate, analyses were controlled for MSEL verbal and nonverbal developmental quotient, ADOS-2 autism severity scores, and sex. Analyses revealed that toddlers with ASD exhibited elevated BRIEF-P scores across all domains compared to each of the three comparison groups. Higher BRIEF-P scores were associated with lower adaptive social, communication, and daily living skills while controlling for symptom severity, verbal and nonverbal functioning, and sex. In conclusion, marked vulnerabilities in EF are already present in 3-year-old toddlers with ASD and are predictive of the level of adaptive functioning in ASD. EF vulnerabilities in toddlers should be targeted for intervention to improve long-term outcomes in ASD. LAY SUMMARY: Many children with autism experience vulnerabilities in executive functioning (EF), which may include challenges with inhibition, working memory, cognitive flexibility, and planning. The study shows that these vulnerabilities can already be detected at age three and that their presence is linked with lower social, communication, and daily living skills. Screening children with ASD for EF challenges and helping those who have difficulties may improve their long-term outcomes. En ligne : http://dx.doi.org/10.1002/aur.2715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Autism Research > 15-7 (July 2022) . - p.1336-1347[article] Elevated symptoms of executive dysfunction predict lower adaptive functioning in 3-year-olds with autism spectrum disorder [Texte imprimé et/ou numérique] / Kelly POWELL, Auteur ; Suzanne MACARI, Auteur ; Emma BRENNAN-WYDRA, Auteur ; Hannah FEINER, Auteur ; Maureen BUTLER, Auteur ; Diogo GONCALVES FORTES, Auteur ; Alexandra BOXBERGER, Auteur ; Mariana TORRES-VISO, Auteur ; Chelsea MORGAN, Auteur ; Megan LYONS, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.1336-1347.
Langues : Anglais (eng)
in Autism Research > 15-7 (July 2022) . - p.1336-1347
Mots-clés : autism executive function sibling toddlers Index. décimale : PER Périodiques Résumé : Executive functioning (EF) deficits co-occur frequently with autism spectrum disorder (ASD) and have a long-term detrimental impact on quality of life of children and their families. Timely identification of risk for EF vulnerabilities may hasten access to early intervention and alleviate their long-term consequences. This study examines (1) if EF deficits are elevated in toddlers with ASD compared to nonautistic siblings of children with ASD, typically developing (TYP) toddlers, and toddlers with atypical developmental presentation; and (2) if EF deficits have a detrimental effect on adaptive functioning in ASD. Participants were recruited between September 2014 and October 2019 and included 73 toddlers with ASD, 33 nonautistic siblings of children with ASD, 35 toddlers with atypical development, and 28 TYP toddlers matched on chronological age (M = 39.01?months, SD = 3.11). EF deficits were measured using the BRIEF-P; adaptive skills were measured using the VABS-II. Whenever appropriate, analyses were controlled for MSEL verbal and nonverbal developmental quotient, ADOS-2 autism severity scores, and sex. Analyses revealed that toddlers with ASD exhibited elevated BRIEF-P scores across all domains compared to each of the three comparison groups. Higher BRIEF-P scores were associated with lower adaptive social, communication, and daily living skills while controlling for symptom severity, verbal and nonverbal functioning, and sex. In conclusion, marked vulnerabilities in EF are already present in 3-year-old toddlers with ASD and are predictive of the level of adaptive functioning in ASD. EF vulnerabilities in toddlers should be targeted for intervention to improve long-term outcomes in ASD. LAY SUMMARY: Many children with autism experience vulnerabilities in executive functioning (EF), which may include challenges with inhibition, working memory, cognitive flexibility, and planning. The study shows that these vulnerabilities can already be detected at age three and that their presence is linked with lower social, communication, and daily living skills. Screening children with ASD for EF challenges and helping those who have difficulties may improve their long-term outcomes. En ligne : http://dx.doi.org/10.1002/aur.2715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Examining the phenotypic heterogeneity of early autism spectrum disorder: subtypes and short-term outcomes / So Hyun KIM in Journal of Child Psychology and Psychiatry, 57-1 (January 2016)
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Titre : Examining the phenotypic heterogeneity of early autism spectrum disorder: subtypes and short-term outcomes Type de document : Texte imprimé et/ou numérique Auteurs : So Hyun KIM, Auteur ; Suzanne MACARI, Auteur ; Judah KOLLER, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.93-102 Langues : Anglais (eng) Mots-clés : ASD toddlers diagnosis clinical outcomes Index. décimale : PER Périodiques Résumé : Background Phenotypic heterogeneity among toddlers presenting with ASD symptoms complicates diagnostic considerations and limits our ability to predict long-term outcomes. To address this concern, we sought to identify more homogeneous subgroups within ASD based on toddlers’ clinical profiles in the second year of life, evaluating diagnostic stability and clinical outcomes within the subgroups 1–2 years later. Methods One hundred toddlers referred for suspected ASD underwent comprehensive assessments at 22 months (SD = 3) and 37 months (SD = 4). At 22 months, they were clustered based on symptom severity, developmental skills, and adaptive functioning. Diagnostic stability and clinical outcomes were evaluated within the clusters. Results Four clusters characterized by distinct clinical profiles at the time of the first diagnosis were identified. Diagnostic stability was excellent in 3 out of 4 clusters (93%–100%) and was lowest in the initially least affected cluster (85%). Autism symptom severity was stable, except for one group where it increased over time (16% of the sample). A large proportion of toddlers showed significant improvements in verbal and communication skills. Only a small group (17%) exhibited very low levels of functioning and limited gains over time. Conclusions Diagnostic stability and developmental progression from the second to third year of life in toddlers with ASD vary depending on their initial early profiles of relative strengths and deficits. Although a small minority of toddlers with more complex clinical presentations may not retain their diagnoses by the age of three, most children continue to exhibit symptoms of autism. Despite limited improvements in symptom severity, many children show significant gains in verbal functioning. Only a small proportion of children (17%) exhibit very limited gains despite intensive intervention. These findings support continued efforts to examine determinants of developmental trajectories including factors mediating and moderating response to treatment. En ligne : http://dx.doi.org/10.1111/jcpp.12448 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273
in Journal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.93-102[article] Examining the phenotypic heterogeneity of early autism spectrum disorder: subtypes and short-term outcomes [Texte imprimé et/ou numérique] / So Hyun KIM, Auteur ; Suzanne MACARI, Auteur ; Judah KOLLER, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.93-102.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.93-102
Mots-clés : ASD toddlers diagnosis clinical outcomes Index. décimale : PER Périodiques Résumé : Background Phenotypic heterogeneity among toddlers presenting with ASD symptoms complicates diagnostic considerations and limits our ability to predict long-term outcomes. To address this concern, we sought to identify more homogeneous subgroups within ASD based on toddlers’ clinical profiles in the second year of life, evaluating diagnostic stability and clinical outcomes within the subgroups 1–2 years later. Methods One hundred toddlers referred for suspected ASD underwent comprehensive assessments at 22 months (SD = 3) and 37 months (SD = 4). At 22 months, they were clustered based on symptom severity, developmental skills, and adaptive functioning. Diagnostic stability and clinical outcomes were evaluated within the clusters. Results Four clusters characterized by distinct clinical profiles at the time of the first diagnosis were identified. Diagnostic stability was excellent in 3 out of 4 clusters (93%–100%) and was lowest in the initially least affected cluster (85%). Autism symptom severity was stable, except for one group where it increased over time (16% of the sample). A large proportion of toddlers showed significant improvements in verbal and communication skills. Only a small group (17%) exhibited very low levels of functioning and limited gains over time. Conclusions Diagnostic stability and developmental progression from the second to third year of life in toddlers with ASD vary depending on their initial early profiles of relative strengths and deficits. Although a small minority of toddlers with more complex clinical presentations may not retain their diagnoses by the age of three, most children continue to exhibit symptoms of autism. Despite limited improvements in symptom severity, many children show significant gains in verbal functioning. Only a small proportion of children (17%) exhibit very limited gains despite intensive intervention. These findings support continued efforts to examine determinants of developmental trajectories including factors mediating and moderating response to treatment. En ligne : http://dx.doi.org/10.1111/jcpp.12448 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 Face-to-face live eye-tracking in toddlers with autism: Feasibility and impact of familiarity and face covering / Maureen BUTLER ; Chitra BANARJEE ; Alexandra BOXBERGER ; Katherine ALL ; Suzanne MACARI ; Katarzyna CHAWARSKA in Autism Research, 17-7 (July 2024)
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PermalinkFamily history of psychiatric conditions and development of siblings of children with autism / Joseph CHANG ; Zeyan LIEW ; Angelina VERNETTI ; Suzanne MACARI ; Kelly POWELL ; Katarzyna CHAWARSKA in Autism Research, 17-8 (August 2024)
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PermalinkFunctional Outcomes of Children Identified Early in the Developmental Period as at Risk for ASD Utilizing the The Norwegian Mother, Father and Child Cohort Study (MoBa) / Nina STENBERG in Journal of Autism and Developmental Disorders, 51-3 (March 2021)
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PermalinkInterest level in 2-year-olds with autism spectrum disorder predicts rate of verbal, nonverbal, and adaptive skill acquisition / Lars KLINTWALL in Autism, 19-8 (November 2015)
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PermalinkNon-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study / Tony CHARMAN in Autism Research, 10-1 (January 2017)
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PermalinkScreening for Autism Spectrum Disorders in 12-Month-Old High-Risk Siblings by Parental Report / Justin ROWBERRY in Journal of Autism and Developmental Disorders, 45-1 (January 2015)
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