Autism and the broad autism phenotype: familial patterns and intergenerational transmission / Noah J. SASSON in Journal of Neurodevelopmental Disorders, 5-1 (December 2013)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 5-1 (December 2013) . - p.11 Titre : Autism and the broad autism phenotype: familial patterns and intergenerational transmission Type de document : Texte imprimé et/ou numérique Auteurs : Noah J. SASSON, Auteur ; K. S. LAM, Auteur ; M. PARLIER, Auteur ; Julie L. DANIELS, Auteur ; J. PIVEN, Auteur Article en page(s) : p.11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Features of the Broad Autism Phenotype (BAP) are disproportionately prevalent in parents of a child with autism, highlighting familial patterns indicative of heritability. It is unclear, however, whether the presence of BAP features in both parents confers an increased liability for autism. The current study explores whether the presence of BAP features in two biological parents occurs more frequently in parents of a child with autism relative to comparison parents, whether parental pairs of a child with autism more commonly consist of one or two parents with BAP features, and whether these features are associated with severity of autism behaviors in probands. METHOD: Seven hundred eleven parents of a child with an autism spectrum disorder and 981 comparison parents completed the Broad Autism Phenotype Questionnaire. Parents of a child with autism also completed the Social Communication Questionnaire. RESULTS: Although parental pairs of a child with autism were more likely than comparison parental pairs to have both parents characterized by the presence of the BAP, they more commonly consisted of a single parent with BAP features. The presence of the BAP in parents was associated with the severity of autism behaviors in probands, with the lowest severity occurring for children of parental pairs in which neither parent exhibited a BAP feature. Severity did not differ between children of two affected parents and those of just one. CONCLUSIONS: Collectively, these findings indicate that parental pairs of children with autism frequently consist of a single parent with BAP characteristics and suggest that future studies searching for implicated genes may benefit from a more narrow focus that identifies the transmitting parent. The evidence of intergenerational transmission reported here also provides further confirmation of the high heritability of autism that is unaccounted for by the contribution of de novo mutations currently emphasized in the field of autism genetics. En ligne : http://dx.doi.org/10.1186/1866-1955-5-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=345 [article] Autism and the broad autism phenotype: familial patterns and intergenerational transmission [Texte imprimé et/ou numérique] / Noah J. SASSON, Auteur ; K. S. LAM, Auteur ; M. PARLIER, Auteur ; Julie L. DANIELS, Auteur ; J. PIVEN, Auteur . - p.11. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 5-1 (December 2013) . - p.11 Index. décimale : PER Périodiques Résumé : BACKGROUND: Features of the Broad Autism Phenotype (BAP) are disproportionately prevalent in parents of a child with autism, highlighting familial patterns indicative of heritability. It is unclear, however, whether the presence of BAP features in both parents confers an increased liability for autism. The current study explores whether the presence of BAP features in two biological parents occurs more frequently in parents of a child with autism relative to comparison parents, whether parental pairs of a child with autism more commonly consist of one or two parents with BAP features, and whether these features are associated with severity of autism behaviors in probands. METHOD: Seven hundred eleven parents of a child with an autism spectrum disorder and 981 comparison parents completed the Broad Autism Phenotype Questionnaire. Parents of a child with autism also completed the Social Communication Questionnaire. RESULTS: Although parental pairs of a child with autism were more likely than comparison parental pairs to have both parents characterized by the presence of the BAP, they more commonly consisted of a single parent with BAP features. The presence of the BAP in parents was associated with the severity of autism behaviors in probands, with the lowest severity occurring for children of parental pairs in which neither parent exhibited a BAP feature. Severity did not differ between children of two affected parents and those of just one. CONCLUSIONS: Collectively, these findings indicate that parental pairs of children with autism frequently consist of a single parent with BAP characteristics and suggest that future studies searching for implicated genes may benefit from a more narrow focus that identifies the transmitting parent. The evidence of intergenerational transmission reported here also provides further confirmation of the high heritability of autism that is unaccounted for by the contribution of de novo mutations currently emphasized in the field of autism genetics. En ligne : http://dx.doi.org/10.1186/1866-1955-5-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=345

Autism spectrum disorder screening with the CBCL/11/2-5: Findings for young children at high risk for autism spectrum disorder / L. A. RESCORLA in Autism, 23-1 (January 2019)  

Public ISBD [article]  inAutism > 23-1 (January 2019) . - p.29-38 Titre : Autism spectrum disorder screening with the CBCL/11/2-5: Findings for young children at high risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : L. A. RESCORLA, Auteur ; Breanna WINDER-PATEL, Auteur ; Sarah J. PATERSON, Auteur ; J. PANDEY, Auteur ; J. J. WOLFF, Auteur ; Robert T. SCHULTZ, Auteur ; J. PIVEN, Auteur Article en page(s) : p.29-38 Langues : Anglais (eng) Mots-clés : autism spectrum disorder screening  baby sibling paradigm  CBCL/11/2-5  Diagnostic and Statistical Manual of Mental Disorders-Pervasive  Developmental Problems scale  familial high-risk  modified checklist  rating-scales  toddlers  identification  cbcl  Psychology Index. décimale : PER Périodiques Résumé : The screening power of the CBCL/11/2-5's Withdrawn and Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems (DSM-PDP) scales to identify children diagnosed with autism spectrum disorder at 24 months was tested in a longitudinal, familial high-risk study. Participants were 56 children at high risk for autism spectrum disorder due to an affected older sibling (high-risk group) and 26 low-risk children with a typically developing older sibling (low-risk group). At 24 months, 13 of the 56 high-risk children were diagnosed with autism spectrum disorder, whereas the other 43 were not. The high-risk children diagnosed with autism spectrum disorder group had significantly higher scores on the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems and Withdrawn scales than children in the low-risk and high-risk children not diagnosed with autism spectrum disorder groups (eta p2>0.50). Receiver operating characteristic analyses yielded very high area under the curve values (0.91 and 0.89), and a cut point of T > 60 yielded sensitivity of 77% and specificity of 97% to 99% between the high-risk children diagnosed with autism spectrum disorder and the combination of low-risk and high-risk children not diagnosed with autism spectrum disorder. Consistent with several previous studies, the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems scale and the Withdrawn syndrome differentiated well between children diagnosed with autism spectrum disorder and those not diagnosed. En ligne : http://dx.doi.org/10.1177/1362361317718482 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379 [article] Autism spectrum disorder screening with the CBCL/11/2-5: Findings for young children at high risk for autism spectrum disorder [Texte imprimé et/ou numérique] / L. A. RESCORLA, Auteur ; Breanna WINDER-PATEL, Auteur ; Sarah J. PATERSON, Auteur ; J. PANDEY, Auteur ; J. J. WOLFF, Auteur ; Robert T. SCHULTZ, Auteur ; J. PIVEN, Auteur . - p.29-38. Langues : Anglais (eng) in Autism > 23-1 (January 2019) . - p.29-38 Mots-clés : autism spectrum disorder screening  baby sibling paradigm  CBCL/11/2-5  Diagnostic and Statistical Manual of Mental Disorders-Pervasive  Developmental Problems scale  familial high-risk  modified checklist  rating-scales  toddlers  identification  cbcl  Psychology Index. décimale : PER Périodiques Résumé : The screening power of the CBCL/11/2-5's Withdrawn and Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems (DSM-PDP) scales to identify children diagnosed with autism spectrum disorder at 24 months was tested in a longitudinal, familial high-risk study. Participants were 56 children at high risk for autism spectrum disorder due to an affected older sibling (high-risk group) and 26 low-risk children with a typically developing older sibling (low-risk group). At 24 months, 13 of the 56 high-risk children were diagnosed with autism spectrum disorder, whereas the other 43 were not. The high-risk children diagnosed with autism spectrum disorder group had significantly higher scores on the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems and Withdrawn scales than children in the low-risk and high-risk children not diagnosed with autism spectrum disorder groups (eta p2>0.50). Receiver operating characteristic analyses yielded very high area under the curve values (0.91 and 0.89), and a cut point of T > 60 yielded sensitivity of 77% and specificity of 97% to 99% between the high-risk children diagnosed with autism spectrum disorder and the combination of low-risk and high-risk children not diagnosed with autism spectrum disorder. Consistent with several previous studies, the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems scale and the Withdrawn syndrome differentiated well between children diagnosed with autism spectrum disorder and those not diagnosed. En ligne : http://dx.doi.org/10.1177/1362361317718482 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379

Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life / A. ESTES in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.24 Titre : Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life Type de document : Texte imprimé et/ou numérique Auteurs : A. ESTES, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; H. GU, Auteur ; T. ST JOHN, Auteur ; S. PATERSON, Auteur ; J. T. ELISON, Auteur ; Heather C. HAZLETT, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Robert T. SCHULTZ, Auteur ; P. KOSTOPOULOS, Auteur ; A. EVANS, Auteur ; G. DAWSON, Auteur ; J. ELIASON, Auteur ; S. ALVAREZ, Auteur ; J. PIVEN, Auteur Article en page(s) : p.24 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: To delineate the early progression of autism spectrum disorder (ASD) symptoms, this study investigated developmental characteristics of infants at high familial risk for ASD (HR), and infants at low risk (LR). METHODS: Participants included 210 HR and 98 LR infants across 4 sites with comparable behavioral data at age 6, 12, and 24 months assessed in the domains of cognitive development (Mullen Scales of Early Learning), adaptive skills (Vineland Adaptive Behavioral Scales), and early behavioral features of ASD (Autism Observation Scale for Infants). Participants evaluated according to the DSM-IV-TR criteria at 24 months and categorized as ASD-positive or ASD-negative were further stratified by empirically derived cutoff scores using the Autism Diagnostic Observation Schedule yielding four groups: HR-ASD-High, HR-ASD-Moderate (HR-ASD-Mod), HR-ASD-Negative (HR-Neg), and LR-ASD-Negative (LR-Neg). RESULTS: The four groups demonstrated different developmental trajectories that became increasingly distinct from 6 to 24 months across all domains. At 6 months, the HR-ASD-High group demonstrated less advanced Gross Motor and Visual Reception skills compared with the LR-Neg group. By 12 months, the HR-ASD-High group demonstrated increased behavioral features of ASD and decreased cognitive and adaptive functioning compared to the HR-Neg and LR-Neg groups. By 24 months, both the HR-ASD-High and HR-ASD-Moderate groups demonstrated differences from the LR- and HR-Neg groups in all domains. CONCLUSIONS: These findings reveal atypical sensorimotor development at 6 months of age which is associated with ASD at 24 months in the most severely affected group of infants. Sensorimotor differences precede the unfolding of cognitive and adaptive deficits and behavioral features of autism across the 6- to 24-month interval. The less severely affected group demonstrates later symptom onset, in the second year of life, with initial differences in the social-communication domain. En ligne : http://dx.doi.org/10.1186/s11689-015-9117-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 [article] Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life [Texte imprimé et/ou numérique] / A. ESTES, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; H. GU, Auteur ; T. ST JOHN, Auteur ; S. PATERSON, Auteur ; J. T. ELISON, Auteur ; Heather C. HAZLETT, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Robert T. SCHULTZ, Auteur ; P. KOSTOPOULOS, Auteur ; A. EVANS, Auteur ; G. DAWSON, Auteur ; J. ELIASON, Auteur ; S. ALVAREZ, Auteur ; J. PIVEN, Auteur . - p.24. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.24 Index. décimale : PER Périodiques Résumé : BACKGROUND: To delineate the early progression of autism spectrum disorder (ASD) symptoms, this study investigated developmental characteristics of infants at high familial risk for ASD (HR), and infants at low risk (LR). METHODS: Participants included 210 HR and 98 LR infants across 4 sites with comparable behavioral data at age 6, 12, and 24 months assessed in the domains of cognitive development (Mullen Scales of Early Learning), adaptive skills (Vineland Adaptive Behavioral Scales), and early behavioral features of ASD (Autism Observation Scale for Infants). Participants evaluated according to the DSM-IV-TR criteria at 24 months and categorized as ASD-positive or ASD-negative were further stratified by empirically derived cutoff scores using the Autism Diagnostic Observation Schedule yielding four groups: HR-ASD-High, HR-ASD-Moderate (HR-ASD-Mod), HR-ASD-Negative (HR-Neg), and LR-ASD-Negative (LR-Neg). RESULTS: The four groups demonstrated different developmental trajectories that became increasingly distinct from 6 to 24 months across all domains. At 6 months, the HR-ASD-High group demonstrated less advanced Gross Motor and Visual Reception skills compared with the LR-Neg group. By 12 months, the HR-ASD-High group demonstrated increased behavioral features of ASD and decreased cognitive and adaptive functioning compared to the HR-Neg and LR-Neg groups. By 24 months, both the HR-ASD-High and HR-ASD-Moderate groups demonstrated differences from the LR- and HR-Neg groups in all domains. CONCLUSIONS: These findings reveal atypical sensorimotor development at 6 months of age which is associated with ASD at 24 months in the most severely affected group of infants. Sensorimotor differences precede the unfolding of cognitive and adaptive deficits and behavioral features of autism across the 6- to 24-month interval. The less severely affected group demonstrates later symptom onset, in the second year of life, with initial differences in the social-communication domain. En ligne : http://dx.doi.org/10.1186/s11689-015-9117-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347

Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD / Catherine A. BURROWS in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1710-1723 Titre : Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD Type de document : Texte imprimé et/ou numérique Auteurs : Catherine A. BURROWS, Auteur ; James W. BODFISH, Auteur ; J. J. WOLFF, Auteur ; E. P. VOLLMAN, Auteur ; Melody R. ALTSCHULER, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; J. R. PRUETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur ; J. T. ELISON, Auteur Article en page(s) : p.1710-1723 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child, Preschool  Family  Humans  Infant  Male  Phenotype  Risk  Siblings  attention  intense interests  problem behavior  restricted interests  toddlers Index. décimale : PER Périodiques Résumé : Intense interests are common in children with and without autism spectrum disorder (ASD), and little research has characterized aspects of interests that are unique to or shared among children with and without ASD. We aimed to characterize interests in a sample of infants at high-familial-risk (HR) and low-familial-risk (LR) for ASD using a novel interview. Participants included HR siblings who were diagnosed with ASD at 24?months (HR-ASD, n = 56), HR siblings who did not receive an ASD diagnosis at 24?months (HR-Neg, n = 187), and a LR comparison group (n = 109). We developed and collected data with the Intense Interests Inventory at 18- and 24-months of age, a semi-structured interview that measures intensity and peculiarity of interests in toddlers and preschool-aged children. Intensity of interests differed by familial risk at 24?months, with HR-ASD and HR-Neg groups demonstrating equivalent intensity of interests that were higher than the LR group. By contrast, peculiarity of interest differed by ASD diagnosis, with the HR-ASD group showing more peculiar interests than the HR-Neg and LR groups at 24?months. At 18?months the HR-ASD group had more peculiar interests than the LR group, though no differences emerged in intensity of interests. This measure may be useful in identifying clinically-relevant features of interests in young children with ASD. We also replicated previous findings of males showing more intense interests at 18?months in our non-ASD sample. These results reveal new information about the nature of interests and preoccupations in the early autism phenotype. LAY SUMMARY: Intense interests are common in young children with autism and their family members. Intense interests are also prevalent among typically-developing children, and especially boys. Here we catalog interests and features of these interests in a large sample of toddlers enriched for autism risk. Children who had family members with autism had more intense interests, and those who developed autism themselves had more unusual interests at 24?months. These results highlight the importance of different aspects of interest in autism. En ligne : http://dx.doi.org/10.1002/aur.2543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD [Texte imprimé et/ou numérique] / Catherine A. BURROWS, Auteur ; James W. BODFISH, Auteur ; J. J. WOLFF, Auteur ; E. P. VOLLMAN, Auteur ; Melody R. ALTSCHULER, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; J. R. PRUETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur ; J. T. ELISON, Auteur . - p.1710-1723. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1710-1723 Mots-clés : Autism Spectrum Disorder  Child, Preschool  Family  Humans  Infant  Male  Phenotype  Risk  Siblings  attention  intense interests  problem behavior  restricted interests  toddlers Index. décimale : PER Périodiques Résumé : Intense interests are common in children with and without autism spectrum disorder (ASD), and little research has characterized aspects of interests that are unique to or shared among children with and without ASD. We aimed to characterize interests in a sample of infants at high-familial-risk (HR) and low-familial-risk (LR) for ASD using a novel interview. Participants included HR siblings who were diagnosed with ASD at 24?months (HR-ASD, n = 56), HR siblings who did not receive an ASD diagnosis at 24?months (HR-Neg, n = 187), and a LR comparison group (n = 109). We developed and collected data with the Intense Interests Inventory at 18- and 24-months of age, a semi-structured interview that measures intensity and peculiarity of interests in toddlers and preschool-aged children. Intensity of interests differed by familial risk at 24?months, with HR-ASD and HR-Neg groups demonstrating equivalent intensity of interests that were higher than the LR group. By contrast, peculiarity of interest differed by ASD diagnosis, with the HR-ASD group showing more peculiar interests than the HR-Neg and LR groups at 24?months. At 18?months the HR-ASD group had more peculiar interests than the LR group, though no differences emerged in intensity of interests. This measure may be useful in identifying clinically-relevant features of interests in young children with ASD. We also replicated previous findings of males showing more intense interests at 18?months in our non-ASD sample. These results reveal new information about the nature of interests and preoccupations in the early autism phenotype. LAY SUMMARY: Intense interests are common in young children with autism and their family members. Intense interests are also prevalent among typically-developing children, and especially boys. Here we catalog interests and features of these interests in a large sample of toddlers enriched for autism risk. Children who had family members with autism had more intense interests, and those who developed autism themselves had more unusual interests at 24?months. These results highlight the importance of different aspects of interest in autism. En ligne : http://dx.doi.org/10.1002/aur.2543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Cover essay / J. PIVEN in Journal of Neurodevelopmental Disorders, 2-2 (June 2010)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 2-2 (June 2010) . - p.61 Titre : Cover essay Type de document : Texte imprimé et/ou numérique Auteurs : J. PIVEN, Auteur Article en page(s) : p.61 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s11689-010-9052-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 [article] Cover essay [Texte imprimé et/ou numérique] / J. PIVEN, Auteur . - p.61. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 2-2 (June 2010) . - p.61 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s11689-010-9052-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342

Cover essay / J. PIVEN in Journal of Neurodevelopmental Disorders, 2-3 (September 2010)  

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Diagnostic shifts in autism spectrum disorder can be linked to the fuzzy nature of the diagnostic boundary: a data-driven approach / B. TUNC in Journal of Child Psychology and Psychiatry, 62-10 (October 2021)  

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Distributional Properties and Criterion Validity of a Shortened Version of the Social Responsiveness Scale: Results from the ECHO Program and Implications for Social Communication Research / K. LYALL in Journal of Autism and Developmental Disorders, 51-7 (July 2021)  

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Early language exposure supports later language skills in infants with and without autism / M. R. SWANSON in Autism Research, 12-12 (December)  

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Erratum to: Cover essay / J. PIVEN in Journal of Neurodevelopmental Disorders, 2-2 (June 2010)  

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A genome-wide linkage study of autism spectrum disorder and the broad autism phenotype in extended pedigrees / M. WOODBURY-SMITH in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

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High rates of parkinsonism in adults with autism / S. STARKSTEIN in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

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Infants later diagnosed with autism have lower canonical babbling ratios in the first year of life / L. D. YANKOWITZ in Molecular Autism, 13 (2022)  

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Journal of Neurodevelopmental Disorders is now a fully open access journal / J. PIVEN in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

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Language delay aggregates in toddler siblings of children with autism spectrum disorder / N. MARRUS in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

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