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Autism as a disconnection syndrome: A qualitative and quantitative review of diffusion tensor imaging studies / Margot HOPPENBROUWERS in Research in Autism Spectrum Disorders, 8-4 (April 2014)
[article]
Titre : Autism as a disconnection syndrome: A qualitative and quantitative review of diffusion tensor imaging studies Type de document : Texte imprimé et/ou numérique Auteurs : Margot HOPPENBROUWERS, Auteur ; Maaike VANDERMOSTEN, Auteur ; Bart BOETS, Auteur Article en page(s) : p.387-412 Mots-clés : Autism spectrum disorder Diffusion tensor imaging Review Brain connectivity Fibre tracking Index. décimale : PER Périodiques Résumé : This review aims at evaluating the leading hypothesis of lower long-range and greater short-range cortical connectivity in individuals with autism spectrum disorder (ASD) by the available literature on diffusion tensor imaging (DTI) studies. DTI, coupled with tractography, assesses the structural connections between cortical regions and quantifies their white matter integrity. First, we provide an extensive qualitative overview of DTI findings in ASD. Next, to reveal convergence between studies, results are quantitatively analyzed using Activation Likelihood Estimation (ALE) and fibre tracking is performed to visualize the white matter tracts running through the obtained ALE clusters. Finally, findings from DTI research are related to specific symptoms characteristic of ASD. Overall, the qualitative analysis yields a widespread disruption of white matter integrity in the brain of individuals with ASD as compared to typically developing controls. This is the case for both the long-range and the local short-range connections, partially contradicting the leading hypothesis. However, several studies investigating very young children with ASD report greater structural connectivity, suggesting a developmental switch in white matter integrity in the ASD brain. Based on the combined qualitative and quantitative analysis, the corpus callosum and the ventral tracts emerge as particularly affected connections in individuals with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226
in Research in Autism Spectrum Disorders > 8-4 (April 2014) . - p.387-412[article] Autism as a disconnection syndrome: A qualitative and quantitative review of diffusion tensor imaging studies [Texte imprimé et/ou numérique] / Margot HOPPENBROUWERS, Auteur ; Maaike VANDERMOSTEN, Auteur ; Bart BOETS, Auteur . - p.387-412.
in Research in Autism Spectrum Disorders > 8-4 (April 2014) . - p.387-412
Mots-clés : Autism spectrum disorder Diffusion tensor imaging Review Brain connectivity Fibre tracking Index. décimale : PER Périodiques Résumé : This review aims at evaluating the leading hypothesis of lower long-range and greater short-range cortical connectivity in individuals with autism spectrum disorder (ASD) by the available literature on diffusion tensor imaging (DTI) studies. DTI, coupled with tractography, assesses the structural connections between cortical regions and quantifies their white matter integrity. First, we provide an extensive qualitative overview of DTI findings in ASD. Next, to reveal convergence between studies, results are quantitatively analyzed using Activation Likelihood Estimation (ALE) and fibre tracking is performed to visualize the white matter tracts running through the obtained ALE clusters. Finally, findings from DTI research are related to specific symptoms characteristic of ASD. Overall, the qualitative analysis yields a widespread disruption of white matter integrity in the brain of individuals with ASD as compared to typically developing controls. This is the case for both the long-range and the local short-range connections, partially contradicting the leading hypothesis. However, several studies investigating very young children with ASD report greater structural connectivity, suggesting a developmental switch in white matter integrity in the ASD brain. Based on the combined qualitative and quantitative analysis, the corpus callosum and the ventral tracts emerge as particularly affected connections in individuals with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226 Autism spectrum disorders: Neuroimaging findings from systematic reviews / Emmanuel Peng Kiat PUA in Research in Autism Spectrum Disorders, 34 (February 2017)
[article]
Titre : Autism spectrum disorders: Neuroimaging findings from systematic reviews Type de document : Texte imprimé et/ou numérique Auteurs : Emmanuel Peng Kiat PUA, Auteur ; Stephen C. BOWDEN, Auteur ; Marc L. SEAL, Auteur Article en page(s) : p.28-33 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Brain structure Brain function Brain connectivity Neuroimaging Magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Abstract Autism Spectrum Disorders (ASD) are a cluster of neurodevelopmental conditions associated with core deficits in social communication, social interaction, and restricted and repetitive behaviours. Current evidence suggests a complex interaction between genetic and environmental factors that underlie the heterogeneity of neuroanatomy and clinical symptomatology of ASD across a spectrum. Although abnormalities in brain structure and function have been implicated in the neurodevelopmental trajectory of ASD, the search for definitive neuroimaging markers remains obscured by inconsistent or incompatible findings. Specifically, discrepancies between independent studies impede reliable identification of the nature and form of atypical alterations in grey-matter structural morphometry and intrinsic functional networks in ASD. This review aims to illustrate the heterogeneity in ASD neuroimaging literature by comparing systematic reviews and meta-analyses of neuroimaging investigations in ASD over the last several decades, with particular emphasis on structural morphometry, structural connectivity and resting-state intrinsic connectivity techniques. Given the unique challenges in ASD research, standardized methodologies to validate potential neuroimaging markers will be an important step towards advancing clinical and research methods to investigate complex aetiological mechanisms and risk factors underlying ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.11.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298
in Research in Autism Spectrum Disorders > 34 (February 2017) . - p.28-33[article] Autism spectrum disorders: Neuroimaging findings from systematic reviews [Texte imprimé et/ou numérique] / Emmanuel Peng Kiat PUA, Auteur ; Stephen C. BOWDEN, Auteur ; Marc L. SEAL, Auteur . - p.28-33.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 34 (February 2017) . - p.28-33
Mots-clés : Autism spectrum disorders Brain structure Brain function Brain connectivity Neuroimaging Magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Abstract Autism Spectrum Disorders (ASD) are a cluster of neurodevelopmental conditions associated with core deficits in social communication, social interaction, and restricted and repetitive behaviours. Current evidence suggests a complex interaction between genetic and environmental factors that underlie the heterogeneity of neuroanatomy and clinical symptomatology of ASD across a spectrum. Although abnormalities in brain structure and function have been implicated in the neurodevelopmental trajectory of ASD, the search for definitive neuroimaging markers remains obscured by inconsistent or incompatible findings. Specifically, discrepancies between independent studies impede reliable identification of the nature and form of atypical alterations in grey-matter structural morphometry and intrinsic functional networks in ASD. This review aims to illustrate the heterogeneity in ASD neuroimaging literature by comparing systematic reviews and meta-analyses of neuroimaging investigations in ASD over the last several decades, with particular emphasis on structural morphometry, structural connectivity and resting-state intrinsic connectivity techniques. Given the unique challenges in ASD research, standardized methodologies to validate potential neuroimaging markers will be an important step towards advancing clinical and research methods to investigate complex aetiological mechanisms and risk factors underlying ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.11.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder / Dinesh K. SHUKLA in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)
[article]
Titre : Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Dinesh K. SHUKLA, Auteur ; Brandon KEEHN, Auteur ; Ralph-Axel MULLER, Auteur Année de publication : 2011 Article en page(s) : p.286-295 Langues : Anglais (eng) Mots-clés : Diffusion tensor imaging autism spectrum disorder brain connectivity fractional anisotropy mean diffusion axial diffusion radial diffusion Index. décimale : PER Périodiques Résumé : Background: Previous diffusion tensor imaging (DTI) studies have shown white matter compromise in children and adults with autism spectrum disorder (ASD), which may relate to reduced connectivity and impaired function of distributed networks. However, tract-specific evidence remains limited in ASD. We applied tract-based spatial statistics (TBSS) for an unbiased whole-brain quantitative estimation of the fractional anisotropy (FA), mean diffusion (MD) and axial and radial diffusion of the white matter tracts in children and adolescents with ASD.
Methods: DTI was performed in 26 ASD and 24 typically developing (TD) participants, aged 9–20 years. Groups were matched for age and IQ. Each participant’s aligned FA, MD and axial and radial diffusion data were projected onto the mean FA skeleton representing the centers of all tracts and the resulting data fed into voxelwise group statistics.
Results: TBSS revealed decreased FA and increased MD and radial diffusion in the ASD group compared to the TD group in the corpus callosum, anterior and posterior limbs of the internal capsule, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, superior longitudinal fasciculus, cingulum, anterior thalamic radiation, and corticospinal tract. No single site with inverse effects (increased FA, reduced MD or radial diffusion in the ASD group) was detected. In clusters of significant group difference, age was positively correlated with FA and negatively correlated with MD and radial diffusion in the TD, but not the ASD group.
Conclusions: Our findings reveal white matter compromise affecting numerous tracts in children and adolescents with ASD. Slightly varying patterns of diffusion abnormalities detected for some tracts may suggest tract-specific patterns of white matter abnormalities associated with ASD. Age-dependent effects further show that maturational changes (increasing FA, decreasing MD and radial diffusion with age) are diminished in ASD from school-age childhood into young adulthood.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02342.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118
in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.286-295[article] Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder [Texte imprimé et/ou numérique] / Dinesh K. SHUKLA, Auteur ; Brandon KEEHN, Auteur ; Ralph-Axel MULLER, Auteur . - 2011 . - p.286-295.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.286-295
Mots-clés : Diffusion tensor imaging autism spectrum disorder brain connectivity fractional anisotropy mean diffusion axial diffusion radial diffusion Index. décimale : PER Périodiques Résumé : Background: Previous diffusion tensor imaging (DTI) studies have shown white matter compromise in children and adults with autism spectrum disorder (ASD), which may relate to reduced connectivity and impaired function of distributed networks. However, tract-specific evidence remains limited in ASD. We applied tract-based spatial statistics (TBSS) for an unbiased whole-brain quantitative estimation of the fractional anisotropy (FA), mean diffusion (MD) and axial and radial diffusion of the white matter tracts in children and adolescents with ASD.
Methods: DTI was performed in 26 ASD and 24 typically developing (TD) participants, aged 9–20 years. Groups were matched for age and IQ. Each participant’s aligned FA, MD and axial and radial diffusion data were projected onto the mean FA skeleton representing the centers of all tracts and the resulting data fed into voxelwise group statistics.
Results: TBSS revealed decreased FA and increased MD and radial diffusion in the ASD group compared to the TD group in the corpus callosum, anterior and posterior limbs of the internal capsule, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, superior longitudinal fasciculus, cingulum, anterior thalamic radiation, and corticospinal tract. No single site with inverse effects (increased FA, reduced MD or radial diffusion in the ASD group) was detected. In clusters of significant group difference, age was positively correlated with FA and negatively correlated with MD and radial diffusion in the TD, but not the ASD group.
Conclusions: Our findings reveal white matter compromise affecting numerous tracts in children and adolescents with ASD. Slightly varying patterns of diffusion abnormalities detected for some tracts may suggest tract-specific patterns of white matter abnormalities associated with ASD. Age-dependent effects further show that maturational changes (increasing FA, decreasing MD and radial diffusion with age) are diminished in ASD from school-age childhood into young adulthood.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02342.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 Annual Research Review: Neural contributions to risk-taking in adolescence – developmental changes and individual differences / Eveline A. CRONE in Journal of Child Psychology and Psychiatry, 57-3 (March 2016)
[article]
Titre : Annual Research Review: Neural contributions to risk-taking in adolescence – developmental changes and individual differences Type de document : Texte imprimé et/ou numérique Auteurs : Eveline A. CRONE, Auteur ; Anna C. K. VAN DUIJVENVOORDE, Auteur ; Jiska S. PEPER, Auteur Article en page(s) : p.353-368 Langues : Anglais (eng) Mots-clés : Risk-taking behavior adolescence developmental changes individual differences externalizing disorders brain connectivity ventral striatum Index. décimale : PER Périodiques Résumé : Background Risk-taking, which involves voluntary choices for behaviors where outcomes remain uncertain, undergoes considerable developmental changes during childhood, adolescence, and early adulthood. In addition, risk-taking is thought to be a key element of many externalizing disorders, such as ADHD, delinquency, conduct disorder, and substance abuse. In this review, we will discuss the potential adaptive and nonadaptive properties of risk-taking in childhood and adolescence. Findings We propose that the changes in brain architecture and function are a crucial element underlying these developmental trajectories. We first identify how subcortical and cortical interactions are important for understanding risk-taking behavior in adults. Next, we show how developmental changes in this network underlie changes in risk-taking behavior. Finally, we explore how these differences can be important for understanding externalizing behavioral disorders in childhood and adolescence. Conclusions We conclude that longitudinal studies are of crucial importance for understanding these developmental trajectories, and many of these studies are currently underway. En ligne : http://dx.doi.org/10.1111/jcpp.12502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Journal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.353-368[article] Annual Research Review: Neural contributions to risk-taking in adolescence – developmental changes and individual differences [Texte imprimé et/ou numérique] / Eveline A. CRONE, Auteur ; Anna C. K. VAN DUIJVENVOORDE, Auteur ; Jiska S. PEPER, Auteur . - p.353-368.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.353-368
Mots-clés : Risk-taking behavior adolescence developmental changes individual differences externalizing disorders brain connectivity ventral striatum Index. décimale : PER Périodiques Résumé : Background Risk-taking, which involves voluntary choices for behaviors where outcomes remain uncertain, undergoes considerable developmental changes during childhood, adolescence, and early adulthood. In addition, risk-taking is thought to be a key element of many externalizing disorders, such as ADHD, delinquency, conduct disorder, and substance abuse. In this review, we will discuss the potential adaptive and nonadaptive properties of risk-taking in childhood and adolescence. Findings We propose that the changes in brain architecture and function are a crucial element underlying these developmental trajectories. We first identify how subcortical and cortical interactions are important for understanding risk-taking behavior in adults. Next, we show how developmental changes in this network underlie changes in risk-taking behavior. Finally, we explore how these differences can be important for understanding externalizing behavioral disorders in childhood and adolescence. Conclusions We conclude that longitudinal studies are of crucial importance for understanding these developmental trajectories, and many of these studies are currently underway. En ligne : http://dx.doi.org/10.1111/jcpp.12502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Brief Report: Reduced Temporal-Central EEG Alpha Coherence During Joint Attention Perception in Adolescents with Autism Spectrum Disorder / Mark JAIME in Journal of Autism and Developmental Disorders, 46-4 (April 2016)
[article]
Titre : Brief Report: Reduced Temporal-Central EEG Alpha Coherence During Joint Attention Perception in Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mark JAIME, Auteur ; Camilla M. MCMAHON, Auteur ; Bridget C. DAVIDSON, Auteur ; Lisa C. NEWELL, Auteur ; Peter C. MUNDY, Auteur ; Heather A. HENDERSON, Auteur Article en page(s) : p.1477-1489 Langues : Anglais (eng) Mots-clés : EEG coherence Joint attention Brain connectivity Cortical connectivity Joint attention network connectivity Neurocognitive features of joint attention in ASD Adolescents with ASD Adolescent autistic brain Index. décimale : PER Périodiques Résumé : Although prior studies have demonstrated reduced resting state EEG coherence in adults with autism spectrum disorder (ASD), no studies have explored the nature of EEG coherence during joint attention. We examined the EEG coherence of the joint attention network in adolescents with and without ASD during congruent and incongruent joint attention perception and an eyes-open resting condition. Across conditions, adolescents with ASD showed reduced right hemisphere temporal–central alpha coherence compared to typically developing adolescents. Greater right temporal–central alpha coherence during joint attention was positively associated with social cognitive performance in typical development but not in ASD. These results suggest that, in addition to a resting state, EEG coherence during joint attention perception is reduced in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2667-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284
in Journal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1477-1489[article] Brief Report: Reduced Temporal-Central EEG Alpha Coherence During Joint Attention Perception in Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Mark JAIME, Auteur ; Camilla M. MCMAHON, Auteur ; Bridget C. DAVIDSON, Auteur ; Lisa C. NEWELL, Auteur ; Peter C. MUNDY, Auteur ; Heather A. HENDERSON, Auteur . - p.1477-1489.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1477-1489
Mots-clés : EEG coherence Joint attention Brain connectivity Cortical connectivity Joint attention network connectivity Neurocognitive features of joint attention in ASD Adolescents with ASD Adolescent autistic brain Index. décimale : PER Périodiques Résumé : Although prior studies have demonstrated reduced resting state EEG coherence in adults with autism spectrum disorder (ASD), no studies have explored the nature of EEG coherence during joint attention. We examined the EEG coherence of the joint attention network in adolescents with and without ASD during congruent and incongruent joint attention perception and an eyes-open resting condition. Across conditions, adolescents with ASD showed reduced right hemisphere temporal–central alpha coherence compared to typically developing adolescents. Greater right temporal–central alpha coherence during joint attention was positively associated with social cognitive performance in typical development but not in ASD. These results suggest that, in addition to a resting state, EEG coherence during joint attention perception is reduced in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2667-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284