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The longitudinal bidirectional relationship between autistic traits and brain morphology from childhood to adolescence: a population-based cohort study / Melisa DURKUT in Molecular Autism, 13 (2022)
[article]
Titre : The longitudinal bidirectional relationship between autistic traits and brain morphology from childhood to adolescence: a population-based cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Melisa DURKUT, Auteur ; Elisabet BLOK, Auteur ; Anna SULERI, Auteur ; Tonya WHITE, Auteur Article en page(s) : 31 p. Langues : Anglais (eng) Mots-clés : Adolescent Autistic Disorder/complications/diagnostic imaging Brain/diagnostic imaging Child Cohort Studies Cross-Sectional Studies Humans Longitudinal Studies Autism spectrum disorder Child/adolescent psychiatry Development Neurodevelopmental disorders Neuroimaging Index. décimale : PER Périodiques Résumé : OBJECTIVE: Autistic traits are associated with alterations in brain morphology. However, the anatomic location of these differences and their developmental trajectories are unclear. The primary objective of this longitudinal study was to explore the bidirectional relationship between autistic traits and brain morphology from childhood to adolescence. METHOD: Participants were drawn from a population-based cohort. Cross-sectional and longitudinal analyses included 1950 (mean age 13.5) and 304 participants (mean ages 6.2 and 13.5), respectively. Autistic traits were measured with the Social Responsiveness Scale. Global brain measures and surface-based measures of gyrification, cortical thickness and surface area were obtained from T(1)-weighted MRI scans. Cross-sectional associations were assessed using linear regression analyses. Cross-lagged panel models were used to determine the longitudinal bidirectional relationship between autistic traits and brain morphology. RESULTS: Cross-sectionally, higher levels of autistic traits in adolescents are associated with lower gyrification in the pars opercularis, insula and superior temporal cortex; smaller surface area in the middle temporal and postcentral cortex; larger cortical thickness in the superior frontal cortex; and smaller cerebellum cortex volume. Longitudinally, both autistic traits and brain measures were quite stable, with neither brain measures predicting changes in autistic traits, nor vice-versa. LIMITATIONS: Autistic traits were assessed at only two time points, and thus we could not distinguish within- versus between-person effects. Furthermore, two different MRI scanners were used between baseline and follow-up for imaging data acquisition. CONCLUSIONS: Our findings point to early changes in brain morphology in children with autistic symptoms that remain quite stable over time. The observed relationship did not change substantially after excluding children with high levels of autistic traits, bolstering the evidence for the extension of the neurobiology of autistic traits to the general population. En ligne : http://dx.doi.org/10.1186/s13229-022-00504-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Molecular Autism > 13 (2022) . - 31 p.[article] The longitudinal bidirectional relationship between autistic traits and brain morphology from childhood to adolescence: a population-based cohort study [Texte imprimé et/ou numérique] / Melisa DURKUT, Auteur ; Elisabet BLOK, Auteur ; Anna SULERI, Auteur ; Tonya WHITE, Auteur . - 31 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 31 p.
Mots-clés : Adolescent Autistic Disorder/complications/diagnostic imaging Brain/diagnostic imaging Child Cohort Studies Cross-Sectional Studies Humans Longitudinal Studies Autism spectrum disorder Child/adolescent psychiatry Development Neurodevelopmental disorders Neuroimaging Index. décimale : PER Périodiques Résumé : OBJECTIVE: Autistic traits are associated with alterations in brain morphology. However, the anatomic location of these differences and their developmental trajectories are unclear. The primary objective of this longitudinal study was to explore the bidirectional relationship between autistic traits and brain morphology from childhood to adolescence. METHOD: Participants were drawn from a population-based cohort. Cross-sectional and longitudinal analyses included 1950 (mean age 13.5) and 304 participants (mean ages 6.2 and 13.5), respectively. Autistic traits were measured with the Social Responsiveness Scale. Global brain measures and surface-based measures of gyrification, cortical thickness and surface area were obtained from T(1)-weighted MRI scans. Cross-sectional associations were assessed using linear regression analyses. Cross-lagged panel models were used to determine the longitudinal bidirectional relationship between autistic traits and brain morphology. RESULTS: Cross-sectionally, higher levels of autistic traits in adolescents are associated with lower gyrification in the pars opercularis, insula and superior temporal cortex; smaller surface area in the middle temporal and postcentral cortex; larger cortical thickness in the superior frontal cortex; and smaller cerebellum cortex volume. Longitudinally, both autistic traits and brain measures were quite stable, with neither brain measures predicting changes in autistic traits, nor vice-versa. LIMITATIONS: Autistic traits were assessed at only two time points, and thus we could not distinguish within- versus between-person effects. Furthermore, two different MRI scanners were used between baseline and follow-up for imaging data acquisition. CONCLUSIONS: Our findings point to early changes in brain morphology in children with autistic symptoms that remain quite stable over time. The observed relationship did not change substantially after excluding children with high levels of autistic traits, bolstering the evidence for the extension of the neurobiology of autistic traits to the general population. En ligne : http://dx.doi.org/10.1186/s13229-022-00504-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism / R. TUNG in Autism Research, 14-10 (October 2021)
[article]
Titre : Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism Type de document : Texte imprimé et/ou numérique Auteurs : R. TUNG, Auteur ; M. A. REITER, Auteur ; A. LINKE, Auteur ; J. S. KOHLI, Auteur ; M. K. KINNEAR, Auteur ; R. A. MULLER, Auteur ; Ruth A. CARPER, Auteur Article en page(s) : p.2100-2112 Langues : Anglais (eng) Mots-clés : Adult Anxiety/complications/diagnostic imaging Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder/complications/diagnostic imaging Brain/diagnostic imaging Brain Mapping Humans Magnetic Resonance Imaging Male Middle Aged Neural Pathways/diagnostic imaging Asd adults anxiety autism functional connectivity resting state fMRI Index. décimale : PER Périodiques Résumé : Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle-aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40-64?years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty-two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting-state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta-analysis in TC individuals and two studies on anxiety in ASDs. We tested for main effects of group and group by anxiety interactions on connectivity within this anxiety network, controlling for head motion using ANCOVA. Results are reported at an FDR adjusted threshold of q?0.1 (corrected) and p?0.05 (uncorrected). Adults with ASDs showed higher anxiety and underconnectivity within the anxiety network, mostly involving bilateral insula. Connectivity within the anxiety network in the ASD group showed distinct relationships with anxiety symptoms that did not relate to ASD symptom severity. Functional connectivity involving the bilateral posterior insula was positively correlated with anxiety in the ASD (but not the TC) group. Increased anxiety in middle-aged adults with ASD is associated with atypical functional connectivity, predominantly involving bilateral insula. Results were not related to ASD symptom severity suggesting independence of anxiety-related effects. LAY SUMMARY: Anxiety is very common in adults with autism but the brain basis of this difference is not well understood. We compared functional connectivity between anxiety-related brain regions in middle-aged adults with and without autism. Adults with autism were more anxious and showed weaker functional connections between these regions. Some relationships between functional connectivity and higher anxiety were specific to the autism group. Results suggest that anxiety functions differently in autism. En ligne : http://dx.doi.org/10.1002/aur.2579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-10 (October 2021) . - p.2100-2112[article] Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism [Texte imprimé et/ou numérique] / R. TUNG, Auteur ; M. A. REITER, Auteur ; A. LINKE, Auteur ; J. S. KOHLI, Auteur ; M. K. KINNEAR, Auteur ; R. A. MULLER, Auteur ; Ruth A. CARPER, Auteur . - p.2100-2112.
Langues : Anglais (eng)
in Autism Research > 14-10 (October 2021) . - p.2100-2112
Mots-clés : Adult Anxiety/complications/diagnostic imaging Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder/complications/diagnostic imaging Brain/diagnostic imaging Brain Mapping Humans Magnetic Resonance Imaging Male Middle Aged Neural Pathways/diagnostic imaging Asd adults anxiety autism functional connectivity resting state fMRI Index. décimale : PER Périodiques Résumé : Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle-aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40-64?years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty-two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting-state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta-analysis in TC individuals and two studies on anxiety in ASDs. We tested for main effects of group and group by anxiety interactions on connectivity within this anxiety network, controlling for head motion using ANCOVA. Results are reported at an FDR adjusted threshold of q?0.1 (corrected) and p?0.05 (uncorrected). Adults with ASDs showed higher anxiety and underconnectivity within the anxiety network, mostly involving bilateral insula. Connectivity within the anxiety network in the ASD group showed distinct relationships with anxiety symptoms that did not relate to ASD symptom severity. Functional connectivity involving the bilateral posterior insula was positively correlated with anxiety in the ASD (but not the TC) group. Increased anxiety in middle-aged adults with ASD is associated with atypical functional connectivity, predominantly involving bilateral insula. Results were not related to ASD symptom severity suggesting independence of anxiety-related effects. LAY SUMMARY: Anxiety is very common in adults with autism but the brain basis of this difference is not well understood. We compared functional connectivity between anxiety-related brain regions in middle-aged adults with and without autism. Adults with autism were more anxious and showed weaker functional connections between these regions. Some relationships between functional connectivity and higher anxiety were specific to the autism group. Results suggest that anxiety functions differently in autism. En ligne : http://dx.doi.org/10.1002/aur.2579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450