6 recherche sur le mot-clé 'Microcephaly'

Microcephaly in preschool children with Autism Spectrum Disorder / Mats CEDERLUND in Research in Autism Spectrum Disorders, 88 (October 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 88 (October 2021) . - 101845 Titre : Microcephaly in preschool children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Mats CEDERLUND, Auteur Article en page(s) : 101845 Langues : Anglais (eng) Mots-clés : Macrocephaly  Microcephaly  Autism Spectrum Disorders  Vineland Adaptive Behavior Scales-II  Diagnostic Interview for Social and Communication Disorders-11 Index. décimale : PER Périodiques Résumé : Background The present study presents results of head circumference (HC) measurements in a group of children being part of a larger group of children referred for neuropsychiatric assessment to a neuropsychiatric assessment team in Sweden. Methods Of the 126 children included in the present study HC was possible to measure in 114 individuals. However, two of these children were not diagnosed since they did not conclude the study, leaving 112 children for further assessment. In addition, birth data was recovered either from the digital birth sheet used in Sweden for the registration of birth data, or in a few cases from the Child Care Centers or medical journals if the child had been admitted to hospital care after birth. Results Of the 112 individuals, only one individual, a boy, diagnosed with ICD-10 Autism, had a HC above the 97.5th percentile at birth. At the physical assessment included in the study one individual, a boy (not the same boy as mentioned above) was found to have a HC above the 97.5th percentile. Hence, 1.2 % of the boys in this study with an ICD-10 ASD diagnosis were macrocephalic. In contrast, 6.7 % of the boys, and 8% of the girls, who received an ICD-10 ASD diagnosis had a HC below the 2.5th percentile and were considered microcephalic at the assessment. Conclusions The results from this study could not confirm previous research arguing macrocephaly to be considerably more common in ASD than in the general population. However, in contrast, the results from this study indicated that microcephaly could be more common in children with ICD-10 ASD, for both sexes, than in the general population. Since none of the children had been microcephalic at birth the results indicate a relative decrease in HC over time in these individuals. En ligne : https://doi.org/10.1016/j.rasd.2021.101845 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Microcephaly in preschool children with Autism Spectrum Disorder [texte imprimé] / Mats CEDERLUND, Auteur . - 101845. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 88 (October 2021) . - 101845 Mots-clés : Macrocephaly  Microcephaly  Autism Spectrum Disorders  Vineland Adaptive Behavior Scales-II  Diagnostic Interview for Social and Communication Disorders-11 Index. décimale : PER Périodiques Résumé : Background The present study presents results of head circumference (HC) measurements in a group of children being part of a larger group of children referred for neuropsychiatric assessment to a neuropsychiatric assessment team in Sweden. Methods Of the 126 children included in the present study HC was possible to measure in 114 individuals. However, two of these children were not diagnosed since they did not conclude the study, leaving 112 children for further assessment. In addition, birth data was recovered either from the digital birth sheet used in Sweden for the registration of birth data, or in a few cases from the Child Care Centers or medical journals if the child had been admitted to hospital care after birth. Results Of the 112 individuals, only one individual, a boy, diagnosed with ICD-10 Autism, had a HC above the 97.5th percentile at birth. At the physical assessment included in the study one individual, a boy (not the same boy as mentioned above) was found to have a HC above the 97.5th percentile. Hence, 1.2 % of the boys in this study with an ICD-10 ASD diagnosis were macrocephalic. In contrast, 6.7 % of the boys, and 8% of the girls, who received an ICD-10 ASD diagnosis had a HC below the 2.5th percentile and were considered microcephalic at the assessment. Conclusions The results from this study could not confirm previous research arguing macrocephaly to be considerably more common in ASD than in the general population. However, in contrast, the results from this study indicated that microcephaly could be more common in children with ICD-10 ASD, for both sexes, than in the general population. Since none of the children had been microcephalic at birth the results indicate a relative decrease in HC over time in these individuals. En ligne : https://doi.org/10.1016/j.rasd.2021.101845 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Brief Report: Macrocephaly Phenotype and Psychiatric Comorbidity in a Clinical Sample of Mexican Children and Adolescents with Autism Spectrum Disorders / Lilia ALBORES-GALLO in Journal of Autism and Developmental Disorders, 47-9 (September 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-9 (September 2017) . - p.2911-2917 Titre : Brief Report: Macrocephaly Phenotype and Psychiatric Comorbidity in a Clinical Sample of Mexican Children and Adolescents with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Lilia ALBORES-GALLO, Auteur ; Laura FRITSCHE-GARCÍA, Auteur ; Arturo Pabel MIRANDA-AGUIRRE, Auteur ; Montserrat AVILA-ACOSTA, Auteur Article en page(s) : p.2911-2917 Langues : Anglais (eng) Mots-clés : Macrocephaly  Microcephaly  Phenotype  Autism spectrum disorders  Comorbidity Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) may present with macrocephaly. Few studies have analyzed the association with psychiatric comorbidity. Participants were 94 children with any ASD with an age range from 2 to 16 years (Mdn 6 years), 82% were boys. It was found that 20% of the sample had macrocephaly and 1% microcephaly. There was no association between the presence of macrocephaly and subtype of ASD. The most associated comorbidity was attention-deficit/hyperactivity disorder (ADHD) 54.2%, followed by specific phobia 34%, dysthimia 29.7%, oppositional defiant disorder 13.83% motor tics 11.7%, separation anxiety 9.5% and Gilles de la Tourette 8.5%. In conclusion, macrocephaly and psychiatric comorbidity in this clinical sample of children with ASD is similar to the international literature results. En ligne : https://doi.org/10.1007/s10803-017-3175-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Brief Report: Macrocephaly Phenotype and Psychiatric Comorbidity in a Clinical Sample of Mexican Children and Adolescents with Autism Spectrum Disorders [texte imprimé] / Lilia ALBORES-GALLO, Auteur ; Laura FRITSCHE-GARCÍA, Auteur ; Arturo Pabel MIRANDA-AGUIRRE, Auteur ; Montserrat AVILA-ACOSTA, Auteur . - p.2911-2917. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-9 (September 2017) . - p.2911-2917 Mots-clés : Macrocephaly  Microcephaly  Phenotype  Autism spectrum disorders  Comorbidity Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) may present with macrocephaly. Few studies have analyzed the association with psychiatric comorbidity. Participants were 94 children with any ASD with an age range from 2 to 16 years (Mdn 6 years), 82% were boys. It was found that 20% of the sample had macrocephaly and 1% microcephaly. There was no association between the presence of macrocephaly and subtype of ASD. The most associated comorbidity was attention-deficit/hyperactivity disorder (ADHD) 54.2%, followed by specific phobia 34%, dysthimia 29.7%, oppositional defiant disorder 13.83% motor tics 11.7%, separation anxiety 9.5% and Gilles de la Tourette 8.5%. In conclusion, macrocephaly and psychiatric comorbidity in this clinical sample of children with ASD is similar to the international literature results. En ligne : https://doi.org/10.1007/s10803-017-3175-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

Developmental functioning and medical Co-morbidity profile of children with complex and essential autism / Jaimie FLOR in Autism Research, 10-8 (August 2017)  

Public ISBD [article]  inAutism Research > 10-8 (August 2017) . - p.1344-1352 Titre : Developmental functioning and medical Co-morbidity profile of children with complex and essential autism Type de document : texte imprimé Auteurs : Jaimie FLOR, Auteur ; Jayne BELLANDO, Auteur ; Maya LOPEZ, Auteur ; Amy SHUI, Auteur Article en page(s) : p.1344-1352 Langues : Anglais (eng) Mots-clés : autism  developmental  children  microcephaly  dysmorphology  essential autism complex autism Index. décimale : PER Périodiques Résumé : Children with Autism Spectrum Disorders (ASD) may be characterized as “complex” (those with microcephaly and/or dysmorphology) or “essential” (those with neither of these two). Previous studies found subjects in the complex group exhibited lower IQ scores, poorer response to behavioral intervention, more seizures and more abnormal EEGs and brain MRIs compared to the essential group. The objective of this study was to determine if there are differences in complex versus essential subjects based on several developmental/psychological measures as well as certain medical comorbidities. This study utilized data from 1,347 individuals (2–17 years old) well-characterized subjects enrolled in Autism Treatment Network (ATN) Registry. Head circumference measurement and the Autism Dysmorphology Measure (ADM) were used by trained physicians to classify subjects as complex or essential. Significantly lower scores were seen for complex subjects in cognitive level, adaptive behavior and quality of life. Complex subjects showed significantly increased physician-documented GI symptoms and were on a higher number of medications. No significant differences in autism severity scores, behavioral ratings and parent-reported sleep problems were found. After adjusting for multiple comparisons made, adaptive scores remained significantly lower for the complex group, and the complex group used a significantly higher number of medications and had increased GI symptoms. Complex and essential autism subtypes may have distinct developmental and medical correlates and thus underlines the importance of looking for microcephaly and dysmorphology, when evaluating a child with autism. Determining this distinction in autism may have implications in prognosis, identifying medical co-morbidities, directing diagnostic evaluations and treatment interventions. En ligne : http://dx.doi.org/10.1002/aur.1779 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 [article] Developmental functioning and medical Co-morbidity profile of children with complex and essential autism [texte imprimé] / Jaimie FLOR, Auteur ; Jayne BELLANDO, Auteur ; Maya LOPEZ, Auteur ; Amy SHUI, Auteur . - p.1344-1352. Langues : Anglais (eng) in Autism Research > 10-8 (August 2017) . - p.1344-1352 Mots-clés : autism  developmental  children  microcephaly  dysmorphology  essential autism complex autism Index. décimale : PER Périodiques Résumé : Children with Autism Spectrum Disorders (ASD) may be characterized as “complex” (those with microcephaly and/or dysmorphology) or “essential” (those with neither of these two). Previous studies found subjects in the complex group exhibited lower IQ scores, poorer response to behavioral intervention, more seizures and more abnormal EEGs and brain MRIs compared to the essential group. The objective of this study was to determine if there are differences in complex versus essential subjects based on several developmental/psychological measures as well as certain medical comorbidities. This study utilized data from 1,347 individuals (2–17 years old) well-characterized subjects enrolled in Autism Treatment Network (ATN) Registry. Head circumference measurement and the Autism Dysmorphology Measure (ADM) were used by trained physicians to classify subjects as complex or essential. Significantly lower scores were seen for complex subjects in cognitive level, adaptive behavior and quality of life. Complex subjects showed significantly increased physician-documented GI symptoms and were on a higher number of medications. No significant differences in autism severity scores, behavioral ratings and parent-reported sleep problems were found. After adjusting for multiple comparisons made, adaptive scores remained significantly lower for the complex group, and the complex group used a significantly higher number of medications and had increased GI symptoms. Complex and essential autism subtypes may have distinct developmental and medical correlates and thus underlines the importance of looking for microcephaly and dysmorphology, when evaluating a child with autism. Determining this distinction in autism may have implications in prognosis, identifying medical co-morbidities, directing diagnostic evaluations and treatment interventions. En ligne : http://dx.doi.org/10.1002/aur.1779 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310

Head Growth Trajectories During the First Year of Life and Risk of Autism Spectrum Disorder / Rewaa BALAUM in Autism Research, 19-2 (February 2026)  

Public ISBD [article]  inAutism Research > 19-2 (February 2026) . - e70172 Titre : Head Growth Trajectories During the First Year of Life and Risk of Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Rewaa BALAUM, Auteur ; Leena ELBEDOUR, Auteur ; Einav ALHOZYEL, Auteur ; Gal MEIRI, Auteur ; Dikla ZIGDON, Auteur ; Analya MICHAELOVSKI, Auteur ; Orly KERUB, Auteur ; Idan MENASHE, Auteur Article en page(s) : e70172 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  growth trajectories  head circumference  height  macrocephaly  microcephaly Index. décimale : PER Périodiques Résumé : ABSTRACT Atypical infant head circumference (HC)?including increased rates of macrocephaly and microcephaly?has been linked to autism spectrum disorder (ASD). However, specific head growth trajectories associated with ASD remain poorly defined. This retrospective case?control study aimed to delineate these trajectories and examine their relationship to height. The study sample included 262 children diagnosed with ASD and 560 matched controls. Growth measures at 1, 2, 4, 6, 9, and 12?months of age were obtained from health clinics in southern Israel. The sample was classified into seven clusters based on HC patterns across these six time points, and associations with ASD were estimated using conditional logistic regression. Results demonstrated significant correlations between HC and height throughout the study period (Pearson correlation r?=?0.44?0.55, p? En ligne : https://doi.org/10.1002/aur.70172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582 [article] Head Growth Trajectories During the First Year of Life and Risk of Autism Spectrum Disorder [texte imprimé] / Rewaa BALAUM, Auteur ; Leena ELBEDOUR, Auteur ; Einav ALHOZYEL, Auteur ; Gal MEIRI, Auteur ; Dikla ZIGDON, Auteur ; Analya MICHAELOVSKI, Auteur ; Orly KERUB, Auteur ; Idan MENASHE, Auteur . - e70172. Langues : Anglais (eng) in Autism Research > 19-2 (February 2026) . - e70172 Mots-clés : autism spectrum disorder  growth trajectories  head circumference  height  macrocephaly  microcephaly Index. décimale : PER Périodiques Résumé : ABSTRACT Atypical infant head circumference (HC)?including increased rates of macrocephaly and microcephaly?has been linked to autism spectrum disorder (ASD). However, specific head growth trajectories associated with ASD remain poorly defined. This retrospective case?control study aimed to delineate these trajectories and examine their relationship to height. The study sample included 262 children diagnosed with ASD and 560 matched controls. Growth measures at 1, 2, 4, 6, 9, and 12?months of age were obtained from health clinics in southern Israel. The sample was classified into seven clusters based on HC patterns across these six time points, and associations with ASD were estimated using conditional logistic regression. Results demonstrated significant correlations between HC and height throughout the study period (Pearson correlation r?=?0.44?0.55, p? En ligne : https://doi.org/10.1002/aur.70172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582

Specific Neurological Phenotypes in Autism Spectrum Disorders Are Associated with Sex Representation / Esther BEN-ITZCHAK in Autism Research, 6-6 (December 2013)  

Public ISBD [article]  inAutism Research > 6-6 (December 2013) . - p.596-604 Titre : Specific Neurological Phenotypes in Autism Spectrum Disorders Are Associated with Sex Representation Type de document : texte imprimé Auteurs : Esther BEN-ITZCHAK, Auteur ; Shay BEN-SHACHAR, Auteur ; Ditza A. ZACHOR, Auteur Année de publication : 2013 Article en page(s) : p.596-604 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  male:female ratio  microcephaly  macrocephaly  developmental regression, minor neurological and musculoskeletal deficits, seizures Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heritable disorder occurring predominantly in males. The aim of this study was to compare sex differences in the prevalence of specific neurological phenotypes commonly described in ASD. The study included 663 participants, aged 18 months to 15 years, diagnosed with ASD. Neurological and behavioral assessments were performed using standardized tests, and obtaining medical, developmental, and familial histories from the parents. Phenotypes under investigation were macro- and microcephaly, developmental regression, minor neurological and musculoskeletal deficits (MNMD), and seizures. Male : female ratio in the ASD group was 6.7:1. No sex differences in autism severity, cognitive ability, and adaptive functioning were noted. Mean head circumference percentile for males (50.1 ± 25.6) was significantly larger than females (43.4 ± 30.2). Micro- and macrocephaly were more frequent in ASD than expected (5.9%; 18.1%, respectively). Microcephaly in females (15.1%) was significantly more prevalent than in males (4.5%). The prevalence of macrocephaly in both sexes did not differ significantly. Regression was noted in 30.2% of the females with ASD, significantly higher than in males (18.9%). MNMD was documented in 73.8% of the females, significantly higher than in males (57.1%). M:F ratio decreased in a group with two or more phenotypes (3.6:1), while male predominance was more significant in the group without phenotypes (13.6:1). Neurological phenotypes associated with ASD are more prevalent in females than in males, resulting in more complex clinical and neurological manifestations in females. Therefore, involvement of different etiologies is suggested in ASD in females. En ligne : http://dx.doi.org/10.1002/aur.1319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Specific Neurological Phenotypes in Autism Spectrum Disorders Are Associated with Sex Representation [texte imprimé] / Esther BEN-ITZCHAK, Auteur ; Shay BEN-SHACHAR, Auteur ; Ditza A. ZACHOR, Auteur . - 2013 . - p.596-604. Langues : Anglais (eng) in Autism Research > 6-6 (December 2013) . - p.596-604 Mots-clés : autism spectrum disorder  male:female ratio  microcephaly  macrocephaly  developmental regression, minor neurological and musculoskeletal deficits, seizures Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heritable disorder occurring predominantly in males. The aim of this study was to compare sex differences in the prevalence of specific neurological phenotypes commonly described in ASD. The study included 663 participants, aged 18 months to 15 years, diagnosed with ASD. Neurological and behavioral assessments were performed using standardized tests, and obtaining medical, developmental, and familial histories from the parents. Phenotypes under investigation were macro- and microcephaly, developmental regression, minor neurological and musculoskeletal deficits (MNMD), and seizures. Male : female ratio in the ASD group was 6.7:1. No sex differences in autism severity, cognitive ability, and adaptive functioning were noted. Mean head circumference percentile for males (50.1 ± 25.6) was significantly larger than females (43.4 ± 30.2). Micro- and macrocephaly were more frequent in ASD than expected (5.9%; 18.1%, respectively). Microcephaly in females (15.1%) was significantly more prevalent than in males (4.5%). The prevalence of macrocephaly in both sexes did not differ significantly. Regression was noted in 30.2% of the females with ASD, significantly higher than in males (18.9%). MNMD was documented in 73.8% of the females, significantly higher than in males (57.1%). M:F ratio decreased in a group with two or more phenotypes (3.6:1), while male predominance was more significant in the group without phenotypes (13.6:1). Neurological phenotypes associated with ASD are more prevalent in females than in males, resulting in more complex clinical and neurological manifestations in females. Therefore, involvement of different etiologies is suggested in ASD in females. En ligne : http://dx.doi.org/10.1002/aur.1319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

Comparative profiling of white matter development in the human and mouse brain reveals volumetric deficits and delayed myelination in Angelman syndrome / Ridthi K-R PATEL ; Tasmai VULLI ; Audrey L SMITH ; Martin A. STYNER ; Li-Ming HSU ; Sung-Ho LEE ; Yen-Yu Ian SHIH ; Heather C. HAZLETT ; Mark D. SHEN ; Alain C BURETTE ; Benjamin D. PHILPOT in Molecular Autism, 15 (2024)  

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