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Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs / Cen CHEN in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)
[article]
Titre : Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs Type de document : Texte imprimé et/ou numérique Auteurs : Cen CHEN, Auteur ; Yi LU, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Erik PETTERSSON, Auteur Article en page(s) : p.1513-1522 Langues : Anglais (eng) Mots-clés : Adolescent Humans Twins, Dizygotic Longitudinal Studies Psychopathology Mental Disorders/epidemiology/genetics Risk Factors Attention Deficit Disorder with Hyperactivity/epidemiology General factor of psychopathology genetic nurture multi-polygenic score polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS-psychiatric symptom associations were attributable to indirect versus direct pathways. METHODS: The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence (n=2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (Î2) and then within DZ twin pairs (Î2(w) ), which controls for indirect pathways. RESULTS: In childhood, the PRS for ADHD predicted general psychopathology (Î2=0.09, 95% CI: [0.06, 0.12]; Î2(w) =0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (Î2=0.04 [0.00, 0.08]; Î2(w) =0.09 [0.01, 0.17]) and specific hyperactivity (Î2=0.07 [0.04, 0.11]; Î2(w) =0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (Î2=0.08 [0.03, 0.13]; Î2(w) =0.19 [0.08, 0.30]) and specific inattention problems (Î2=0.05 [0.01, 0.09]; Î2(w) =0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (Î2=0.06 [0.02, 0.10]; Î2(w) =0.06 [0.00, 0.12]). Overall, the PRS-general factor associations were similar between individuals and within twin pairs, whereas the PRS-specific factors associations amplified by 84% within pairs. CONCLUSIONS: This implies that PRS-psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology. En ligne : http://dx.doi.org/10.1111/jcpp.13605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1513-1522[article] Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs [Texte imprimé et/ou numérique] / Cen CHEN, Auteur ; Yi LU, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Erik PETTERSSON, Auteur . - p.1513-1522.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1513-1522
Mots-clés : Adolescent Humans Twins, Dizygotic Longitudinal Studies Psychopathology Mental Disorders/epidemiology/genetics Risk Factors Attention Deficit Disorder with Hyperactivity/epidemiology General factor of psychopathology genetic nurture multi-polygenic score polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS-psychiatric symptom associations were attributable to indirect versus direct pathways. METHODS: The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence (n=2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (Î2) and then within DZ twin pairs (Î2(w) ), which controls for indirect pathways. RESULTS: In childhood, the PRS for ADHD predicted general psychopathology (Î2=0.09, 95% CI: [0.06, 0.12]; Î2(w) =0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (Î2=0.04 [0.00, 0.08]; Î2(w) =0.09 [0.01, 0.17]) and specific hyperactivity (Î2=0.07 [0.04, 0.11]; Î2(w) =0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (Î2=0.08 [0.03, 0.13]; Î2(w) =0.19 [0.08, 0.30]) and specific inattention problems (Î2=0.05 [0.01, 0.09]; Î2(w) =0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (Î2=0.06 [0.02, 0.10]; Î2(w) =0.06 [0.00, 0.12]). Overall, the PRS-general factor associations were similar between individuals and within twin pairs, whereas the PRS-specific factors associations amplified by 84% within pairs. CONCLUSIONS: This implies that PRS-psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology. En ligne : http://dx.doi.org/10.1111/jcpp.13605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Eating Problems in Autistic Females and Males: A Co-twin Control Study / K. LUNDIN REMNÉLIUS in Journal of Autism and Developmental Disorders, 52-7 (July 2022)
[article]
Titre : Eating Problems in Autistic Females and Males: A Co-twin Control Study Type de document : Texte imprimé et/ou numérique Auteurs : K. LUNDIN REMNÉLIUS, Auteur ; Janina NEUFELD, Auteur ; Johan ISAKSSON, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.3153-3168 Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/genetics Autistic Disorder/genetics Diseases in Twins/genetics Female Humans Male Twins, Dizygotic Twins, Monozygotic Autism Co-twin control design Eating Gender differences lecturer for Medice and Roche. He receives royalties for textbooks and diagnostic tools from Hogrefe. KLR, JN, and JI have no conflicts of interest to declare that are relevant to the content of this article. Index. décimale : PER Périodiques Résumé : This study investigated the association between autism and self-reported eating problems and the influence of gender on the association, in a sample of adolescent and adult twins (N=192). Autistic traits and autism diagnosis were associated with both total and specific eating problems, including selective eating and sensory sensitivity during mealtimes. Interaction effects indicated a stronger association between autistic traits and total eating problems in females, as well as more difficulties with eating in social contexts among autistic females. In within-pair analyses, where unmeasured confounders including genes and shared environment are implicitly controlled for, the association was lost within monozygotic pairs, which might further indicate a genetic influence on the relationship between autism and eating problems. En ligne : http://dx.doi.org/10.1007/s10803-021-05198-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3153-3168[article] Eating Problems in Autistic Females and Males: A Co-twin Control Study [Texte imprimé et/ou numérique] / K. LUNDIN REMNÉLIUS, Auteur ; Janina NEUFELD, Auteur ; Johan ISAKSSON, Auteur ; Sven BÖLTE, Auteur . - p.3153-3168.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3153-3168
Mots-clés : Adolescent Adult Autism Spectrum Disorder/genetics Autistic Disorder/genetics Diseases in Twins/genetics Female Humans Male Twins, Dizygotic Twins, Monozygotic Autism Co-twin control design Eating Gender differences lecturer for Medice and Roche. He receives royalties for textbooks and diagnostic tools from Hogrefe. KLR, JN, and JI have no conflicts of interest to declare that are relevant to the content of this article. Index. décimale : PER Périodiques Résumé : This study investigated the association between autism and self-reported eating problems and the influence of gender on the association, in a sample of adolescent and adult twins (N=192). Autistic traits and autism diagnosis were associated with both total and specific eating problems, including selective eating and sensory sensitivity during mealtimes. Interaction effects indicated a stronger association between autistic traits and total eating problems in females, as well as more difficulties with eating in social contexts among autistic females. In within-pair analyses, where unmeasured confounders including genes and shared environment are implicitly controlled for, the association was lost within monozygotic pairs, which might further indicate a genetic influence on the relationship between autism and eating problems. En ligne : http://dx.doi.org/10.1007/s10803-021-05198-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477