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Fish Oil Supplementation Ameliorated Brain Lesions Induced by Diabetes and Hypercholesterolemia in Male Wistar Albino Rats / Hassan I.H. EL SAYYAD in Autism - Open Access, 5-3 ([01/06/2015])
[article]
Titre : Fish Oil Supplementation Ameliorated Brain Lesions Induced by Diabetes and Hypercholesterolemia in Male Wistar Albino Rats Type de document : Texte imprimé et/ou numérique Auteurs : Hassan I.H. EL SAYYAD, Auteur ; Iman H.M. BAKR, Auteur ; Ahmed A. EL MANSI, Auteur ; Ali H. AMIN, Auteur ; Mohamed E. EL BEEH, Auteur ; Adel M.A. ASIRI, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Cerebral Hemisphere Cerebellum Brain Function Diabetes Hypercholesterolemia Fish Oil Index. décimale : PER Périodiques Résumé : Diabetes and hypercholesterolemia are dyslipidemic diseases and have certain role in brain dysfunction, but little of works are concerning with it. In the present study we used eighty male Wistar rats weighing approximately 100 ±15 gram. The animals were arranged into 8 groups; Control (C), fish oil-treatment, hypercholesterolemic group (H), hypercholesterolemic & fish oil-treatment (HF), diabetic- group (D), diabetic and fish oil-treatment (DF), combined hypercholesterolemic and diabetic group (HD) and combined hypercholesterolemic and diabetic group and fish-oil-treatment (HDF). Diabetes was induced by streptozotocin (40mg/kg single dose in citrate buffer pH4.6). Hypercholesterolemia was carried out by feeding rats on diet containin3% cholesterol. Fish oil (Menhaden, Sigma-aldrich, highest purity) was supplemented orally every other day at 100mg/kg body weight. Treatment was carried out for 16 weeks. At the end of treatment, brain tissues were subjected for histological investigation and biochemical assessments of dopamine, serotonin, vascular endothelial growth factor, 8-deoxyhydroxy-guanosine, adhesion molecules and phospholipids beside histological investigation of cerebral hemisphere and cerebellum. The present finding revealed marked depletion of the assayed neurotransmitters and phospholipids and increased of vascular endothelial growth factor, adhesion molecules and 8-deoxy hydroxy-guanosine. Histological observations of cerebral hemisphere revealed widespread of hemorrhagic spots in hypercholesterolemia, neovascualarization in combined diabetes and hypercholesterolemia and dense lymphocytic infiltration in diabetic group. All the experimental groups possessed edematous lesions in the inner plexiform layer. Cerebellar cortex exhibited massive degeneration of Purkinje cells and granular cell layer in diabetic and or hypercholesterolemia. Fish oil supplementation improved the brain function and histological picture. The authors concluded that fish oil contain short and long chain omega-3 fatty acids fatty acid which support the brain function and scavenge the free radicals damaging brain cells. En ligne : https://dx.doi.org/10.4172/2165-7890.1000148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
in Autism - Open Access > 5-3 [01/06/2015] . - 6 p.[article] Fish Oil Supplementation Ameliorated Brain Lesions Induced by Diabetes and Hypercholesterolemia in Male Wistar Albino Rats [Texte imprimé et/ou numérique] / Hassan I.H. EL SAYYAD, Auteur ; Iman H.M. BAKR, Auteur ; Ahmed A. EL MANSI, Auteur ; Ali H. AMIN, Auteur ; Mohamed E. EL BEEH, Auteur ; Adel M.A. ASIRI, Auteur . - 6 p.
Langues : Anglais (eng)
in Autism - Open Access > 5-3 [01/06/2015] . - 6 p.
Mots-clés : Cerebral Hemisphere Cerebellum Brain Function Diabetes Hypercholesterolemia Fish Oil Index. décimale : PER Périodiques Résumé : Diabetes and hypercholesterolemia are dyslipidemic diseases and have certain role in brain dysfunction, but little of works are concerning with it. In the present study we used eighty male Wistar rats weighing approximately 100 ±15 gram. The animals were arranged into 8 groups; Control (C), fish oil-treatment, hypercholesterolemic group (H), hypercholesterolemic & fish oil-treatment (HF), diabetic- group (D), diabetic and fish oil-treatment (DF), combined hypercholesterolemic and diabetic group (HD) and combined hypercholesterolemic and diabetic group and fish-oil-treatment (HDF). Diabetes was induced by streptozotocin (40mg/kg single dose in citrate buffer pH4.6). Hypercholesterolemia was carried out by feeding rats on diet containin3% cholesterol. Fish oil (Menhaden, Sigma-aldrich, highest purity) was supplemented orally every other day at 100mg/kg body weight. Treatment was carried out for 16 weeks. At the end of treatment, brain tissues were subjected for histological investigation and biochemical assessments of dopamine, serotonin, vascular endothelial growth factor, 8-deoxyhydroxy-guanosine, adhesion molecules and phospholipids beside histological investigation of cerebral hemisphere and cerebellum. The present finding revealed marked depletion of the assayed neurotransmitters and phospholipids and increased of vascular endothelial growth factor, adhesion molecules and 8-deoxy hydroxy-guanosine. Histological observations of cerebral hemisphere revealed widespread of hemorrhagic spots in hypercholesterolemia, neovascualarization in combined diabetes and hypercholesterolemia and dense lymphocytic infiltration in diabetic group. All the experimental groups possessed edematous lesions in the inner plexiform layer. Cerebellar cortex exhibited massive degeneration of Purkinje cells and granular cell layer in diabetic and or hypercholesterolemia. Fish oil supplementation improved the brain function and histological picture. The authors concluded that fish oil contain short and long chain omega-3 fatty acids fatty acid which support the brain function and scavenge the free radicals damaging brain cells. En ligne : https://dx.doi.org/10.4172/2165-7890.1000148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 Research Review: Altered reward function in adolescent depression: what, when and how? / Erika E. FORBES in Journal of Child Psychology and Psychiatry, 53-1 (January 2012)
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Titre : Research Review: Altered reward function in adolescent depression: what, when and how? Type de document : Texte imprimé et/ou numérique Auteurs : Erika E. FORBES, Auteur ; Ronald E. DAHL, Auteur Année de publication : 2012 Article en page(s) : p.3-15 Langues : Anglais (eng) Mots-clés : Depression development reward brain function Index. décimale : PER Périodiques Résumé : Background: Conceptual models and recent evidence indicate that neural response to reward is altered in depression. Taking a developmental approach to investigating reward function in adolescent depression can elucidate the etiology, pathophysiology and course of depression, a disorder that typically begins during adolescence and has high rates of recurrence. Methods: This conceptual review describes the what, when and how of altered reward function in adolescent depression. With the goal of generating new, testable hypotheses within a developmental affective neuroscience framework, we critically review findings and suggest future directions. Peer-reviewed empirical papers for inclusion in this critical review were obtained by searching PubMed, PsycInfo and ScienceDirect for the years 1990–2010. Results: A pattern of low striatal response and high medial prefrontal response to reward is evident in adolescents and adults with depression. Given the salience of social stimuli for positive affect and depression, reward function might be especially disrupted in response to social rewards. Because of changes in the dopamine system and reward function with aging, altered reward function in depression might be more evident during adolescence than later in life; however, low reward function may also be a stable characteristic of people who experience depression. Mechanisms of altered reward function in depression could include disrupted balance of corticostriatal circuit function, with disruption occurring as aberrant adolescent brain development. Conclusions: Future studies should examine responses to social rewards; employ longitudinal and prospective designs; and investigate patterns of functional connectivity in reward circuits. Understanding altered reward function in depression has potential implications for treatment development. A more rigorous approach to investigating anhedonia, threat–reward interactions and comorbid anxiety will be valuable to future progress in describing the role of reward function in the pathophysiology of depression. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02477.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148
in Journal of Child Psychology and Psychiatry > 53-1 (January 2012) . - p.3-15[article] Research Review: Altered reward function in adolescent depression: what, when and how? [Texte imprimé et/ou numérique] / Erika E. FORBES, Auteur ; Ronald E. DAHL, Auteur . - 2012 . - p.3-15.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-1 (January 2012) . - p.3-15
Mots-clés : Depression development reward brain function Index. décimale : PER Périodiques Résumé : Background: Conceptual models and recent evidence indicate that neural response to reward is altered in depression. Taking a developmental approach to investigating reward function in adolescent depression can elucidate the etiology, pathophysiology and course of depression, a disorder that typically begins during adolescence and has high rates of recurrence. Methods: This conceptual review describes the what, when and how of altered reward function in adolescent depression. With the goal of generating new, testable hypotheses within a developmental affective neuroscience framework, we critically review findings and suggest future directions. Peer-reviewed empirical papers for inclusion in this critical review were obtained by searching PubMed, PsycInfo and ScienceDirect for the years 1990–2010. Results: A pattern of low striatal response and high medial prefrontal response to reward is evident in adolescents and adults with depression. Given the salience of social stimuli for positive affect and depression, reward function might be especially disrupted in response to social rewards. Because of changes in the dopamine system and reward function with aging, altered reward function in depression might be more evident during adolescence than later in life; however, low reward function may also be a stable characteristic of people who experience depression. Mechanisms of altered reward function in depression could include disrupted balance of corticostriatal circuit function, with disruption occurring as aberrant adolescent brain development. Conclusions: Future studies should examine responses to social rewards; employ longitudinal and prospective designs; and investigate patterns of functional connectivity in reward circuits. Understanding altered reward function in depression has potential implications for treatment development. A more rigorous approach to investigating anhedonia, threat–reward interactions and comorbid anxiety will be valuable to future progress in describing the role of reward function in the pathophysiology of depression. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02477.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148 Autism spectrum disorders: Neuroimaging findings from systematic reviews / Emmanuel Peng Kiat PUA in Research in Autism Spectrum Disorders, 34 (February 2017)
[article]
Titre : Autism spectrum disorders: Neuroimaging findings from systematic reviews Type de document : Texte imprimé et/ou numérique Auteurs : Emmanuel Peng Kiat PUA, Auteur ; Stephen C. BOWDEN, Auteur ; Marc L. SEAL, Auteur Article en page(s) : p.28-33 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Brain structure Brain function Brain connectivity Neuroimaging Magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Abstract Autism Spectrum Disorders (ASD) are a cluster of neurodevelopmental conditions associated with core deficits in social communication, social interaction, and restricted and repetitive behaviours. Current evidence suggests a complex interaction between genetic and environmental factors that underlie the heterogeneity of neuroanatomy and clinical symptomatology of ASD across a spectrum. Although abnormalities in brain structure and function have been implicated in the neurodevelopmental trajectory of ASD, the search for definitive neuroimaging markers remains obscured by inconsistent or incompatible findings. Specifically, discrepancies between independent studies impede reliable identification of the nature and form of atypical alterations in grey-matter structural morphometry and intrinsic functional networks in ASD. This review aims to illustrate the heterogeneity in ASD neuroimaging literature by comparing systematic reviews and meta-analyses of neuroimaging investigations in ASD over the last several decades, with particular emphasis on structural morphometry, structural connectivity and resting-state intrinsic connectivity techniques. Given the unique challenges in ASD research, standardized methodologies to validate potential neuroimaging markers will be an important step towards advancing clinical and research methods to investigate complex aetiological mechanisms and risk factors underlying ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.11.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298
in Research in Autism Spectrum Disorders > 34 (February 2017) . - p.28-33[article] Autism spectrum disorders: Neuroimaging findings from systematic reviews [Texte imprimé et/ou numérique] / Emmanuel Peng Kiat PUA, Auteur ; Stephen C. BOWDEN, Auteur ; Marc L. SEAL, Auteur . - p.28-33.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 34 (February 2017) . - p.28-33
Mots-clés : Autism spectrum disorders Brain structure Brain function Brain connectivity Neuroimaging Magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Abstract Autism Spectrum Disorders (ASD) are a cluster of neurodevelopmental conditions associated with core deficits in social communication, social interaction, and restricted and repetitive behaviours. Current evidence suggests a complex interaction between genetic and environmental factors that underlie the heterogeneity of neuroanatomy and clinical symptomatology of ASD across a spectrum. Although abnormalities in brain structure and function have been implicated in the neurodevelopmental trajectory of ASD, the search for definitive neuroimaging markers remains obscured by inconsistent or incompatible findings. Specifically, discrepancies between independent studies impede reliable identification of the nature and form of atypical alterations in grey-matter structural morphometry and intrinsic functional networks in ASD. This review aims to illustrate the heterogeneity in ASD neuroimaging literature by comparing systematic reviews and meta-analyses of neuroimaging investigations in ASD over the last several decades, with particular emphasis on structural morphometry, structural connectivity and resting-state intrinsic connectivity techniques. Given the unique challenges in ASD research, standardized methodologies to validate potential neuroimaging markers will be an important step towards advancing clinical and research methods to investigate complex aetiological mechanisms and risk factors underlying ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.11.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Neural features of sustained emotional information processing in autism spectrum disorder / Carla A. MAZEFSKY in Autism, 24-4 (May 2020)
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Titre : Neural features of sustained emotional information processing in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Carla A. MAZEFSKY, Auteur ; Amanda COLLIER, Auteur ; Josh GOLT, Auteur ; Greg J. SIEGLE, Auteur Article en page(s) : p.941-953 Langues : Anglais (eng) Mots-clés : adolescents autism spectrum disorder brain function emotion regulation psychiatric comorbidity Index. décimale : PER Périodiques Résumé : Many individuals with autism spectrum disorder struggle with emotions that are intense and interfering, which is referred to as emotion dysregulation. Prior research has established that individuals with autism may be more likely than individuals who are not autistic to have repetitive thoughts. It is possible that persistent thoughts about negative or distressing stimuli may contribute to emotion dysregulation in autism spectrum disorder. This study aimed to identify areas of the brain with evidence of persistent processing of negative information via functional magnetic resonance neuroimaging. We used a task that alternated between emotional processing of personally relevant negative words, neutral words, and a non-emotional task. Criteria were developed to define heightened and persistent emotional processing, and analyses were conducted to identify all brain regions satisfying these criteria. Participants included 25 adolescents with autism spectrum disorder and 23 typically developing adolescents who were similar to the autism spectrum disorder group in IQ, age, and gender ratios. Brain regions identified as having greater and continued processing following negative stimuli in the autism spectrum disorder group as compared with the typically developing group included the salience network and the prefrontal dorsolateral cortex. These areas have been previously implicated in emotion dysregulation outside of autism spectrum disorder. Collectively, brain activity in the identified regions was associated with parent-reported emotion dysregulation in the autism spectrum disorder group. These results help to identify a potential process in the brain associated with emotion dysregulation in autism spectrum disorder. This information may be useful for the development of treatments to decrease emotion dysregulation in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361320903137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425
in Autism > 24-4 (May 2020) . - p.941-953[article] Neural features of sustained emotional information processing in autism spectrum disorder [Texte imprimé et/ou numérique] / Carla A. MAZEFSKY, Auteur ; Amanda COLLIER, Auteur ; Josh GOLT, Auteur ; Greg J. SIEGLE, Auteur . - p.941-953.
Langues : Anglais (eng)
in Autism > 24-4 (May 2020) . - p.941-953
Mots-clés : adolescents autism spectrum disorder brain function emotion regulation psychiatric comorbidity Index. décimale : PER Périodiques Résumé : Many individuals with autism spectrum disorder struggle with emotions that are intense and interfering, which is referred to as emotion dysregulation. Prior research has established that individuals with autism may be more likely than individuals who are not autistic to have repetitive thoughts. It is possible that persistent thoughts about negative or distressing stimuli may contribute to emotion dysregulation in autism spectrum disorder. This study aimed to identify areas of the brain with evidence of persistent processing of negative information via functional magnetic resonance neuroimaging. We used a task that alternated between emotional processing of personally relevant negative words, neutral words, and a non-emotional task. Criteria were developed to define heightened and persistent emotional processing, and analyses were conducted to identify all brain regions satisfying these criteria. Participants included 25 adolescents with autism spectrum disorder and 23 typically developing adolescents who were similar to the autism spectrum disorder group in IQ, age, and gender ratios. Brain regions identified as having greater and continued processing following negative stimuli in the autism spectrum disorder group as compared with the typically developing group included the salience network and the prefrontal dorsolateral cortex. These areas have been previously implicated in emotion dysregulation outside of autism spectrum disorder. Collectively, brain activity in the identified regions was associated with parent-reported emotion dysregulation in the autism spectrum disorder group. These results help to identify a potential process in the brain associated with emotion dysregulation in autism spectrum disorder. This information may be useful for the development of treatments to decrease emotion dysregulation in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361320903137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 Autism and lack of D3 vitamin: A systematic review / G. PIOGGIA in Research in Autism Spectrum Disorders, 8-12 (December 2014)
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Titre : Autism and lack of D3 vitamin: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : G. PIOGGIA, Auteur ; A. TONACCI, Auteur ; G. TARTARISCO, Auteur ; Lucia BILLECI, Auteur ; F. MURATORI, Auteur ; L. RUTA, Auteur ; S. GANGEMI, Auteur Article en page(s) : p.1685-1698 Langues : Anglais (eng) Mots-clés : Autism Autoimmune disease Brain function Cholecalciferol Neurodevelopmental disorders Vitamin D3 Index. décimale : PER Périodiques Résumé : Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication deficits and restricted, repetitive patterns of behavior. Several medical conditions including gastrointestinal (GI) problems, asthma and allergies have been associated with ASD, and multiple risk factors, both genetic and environmental, have been proposed. Among them, vitamin D (VD) deficiency is probably associated with ASD, and may play a role in the condition. We conducted a systematic review of the literature for the period January 1, 2010 through June 15, 2014, according to PRISMA guidelines, aiming to investigate the complex biological interplay between VD, metabolism, immune system and nervous system in ASD. Different trends in the association between ASD and VD deficiency have been observed, and factors such as gender, ethnicity, sampling, and methodology play a role in the results and outcomes. At present, for at least a subgroup of ASD individuals, an imbalance in VD metabolism probably exists and may be associated with the condition. In this cohort, VD replacement in these individuals might contribute to improving ASD symptoms and/or associated conditions. This topic is an important challenge for future research, and could lead to a new tailored therapeutic approach for VD in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Research in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1685-1698[article] Autism and lack of D3 vitamin: A systematic review [Texte imprimé et/ou numérique] / G. PIOGGIA, Auteur ; A. TONACCI, Auteur ; G. TARTARISCO, Auteur ; Lucia BILLECI, Auteur ; F. MURATORI, Auteur ; L. RUTA, Auteur ; S. GANGEMI, Auteur . - p.1685-1698.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1685-1698
Mots-clés : Autism Autoimmune disease Brain function Cholecalciferol Neurodevelopmental disorders Vitamin D3 Index. décimale : PER Périodiques Résumé : Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication deficits and restricted, repetitive patterns of behavior. Several medical conditions including gastrointestinal (GI) problems, asthma and allergies have been associated with ASD, and multiple risk factors, both genetic and environmental, have been proposed. Among them, vitamin D (VD) deficiency is probably associated with ASD, and may play a role in the condition. We conducted a systematic review of the literature for the period January 1, 2010 through June 15, 2014, according to PRISMA guidelines, aiming to investigate the complex biological interplay between VD, metabolism, immune system and nervous system in ASD. Different trends in the association between ASD and VD deficiency have been observed, and factors such as gender, ethnicity, sampling, and methodology play a role in the results and outcomes. At present, for at least a subgroup of ASD individuals, an imbalance in VD metabolism probably exists and may be associated with the condition. In this cohort, VD replacement in these individuals might contribute to improving ASD symptoms and/or associated conditions. This topic is an important challenge for future research, and could lead to a new tailored therapeutic approach for VD in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder / Marilena M. DEMAYO in Journal of Autism and Developmental Disorders, 52-3 (March 2022)
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