4 recherche sur le mot-clé 'Anxiety/complications'

An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions / Y. C. CHEN in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2287-2299 Titre : An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions Type de document : Texte imprimé et/ou numérique Auteurs : Y. C. CHEN, Auteur ; C. CHEN, Auteur ; R. M. MARTÍNEZ, Auteur ; Y. T. FAN, Auteur ; C. C. LIU, Auteur ; C. Y. CHEN, Auteur ; Y. CHENG, Auteur Article en page(s) : p.2287-2299 Langues : Anglais (eng) Mots-clés : Adolescent  Amygdala/diagnostic imaging  Anxiety/complications  Autism Spectrum Disorder/complications/diagnostic imaging  Autistic Disorder  Case-Control Studies  Facial Recognition  Humans  Magnetic Resonance Imaging  amygdala  autism spectrum condition (ASC)  explicit  implicit  threat Index. décimale : PER Périodiques Résumé : Anxiety is exceedingly prevalent among individuals with an autism spectrum condition (ASC). While recent literature postulates anxiety as a mechanism encompassing an underlying amygdala-related elevated baseline level of arousal even to nonthreatening cues, whether this same mechanism contributes to anxiety in those with an ASC and supports the transdiagnostic nature of anxiety remains elusive. In this case-control study of 51 youths (26 ASC), we assessed autism and anxiety via the Autism-Spectrum Quotient and the State-Trait Anxiety Inventory, respectively. Hemodynamic responses, including amygdala reactivity, to explicit and implicit (backwardly masked) perception of threatening faces were acquired using functional Magnetic Resonance Imaging (fMRI). For explicit fear, ASC individuals showed significantly greater negative correlations between the amygdala and the attentional deployment-parietal network. For implicit fear, ASC individuals showed significantly stronger correlations of the amygdala with the prefrontal networks, temporal pole, and hippocampus. Additionally, an fMRI-based neurologic signature for anxiety in ASCs was identified via the LibSVM machine learning model using amygdala-centered functional connectivity during the emotional processing of explicit and implicit stimuli. Hypervigilance to implicit threat in ASCs comorbid with anxiety might exacerbate explicit threat reactivity; hence the use of attentional avoidance patterns to restrict affective hyperarousal for explicitly perceived socioemotional stimuli. Consequently, developing an attention-independent behavioral/neural marker identifying anxiety in ASCs is highly warranted. LAY SUMMARY: This study identifies a dissociation of amygdala reactivity dependent on explicit and implicit threat processing. Implicit anxiety in individuals with an autism spectrum condition (ASC) could outweigh explicitly induced threat. When explicitly perceiving socioemotional stimuli, ASC individuals with anxiety might use attentional avoidance patterns to restrict affective hyperarousal. En ligne : http://dx.doi.org/10.1002/aur.2595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions [Texte imprimé et/ou numérique] / Y. C. CHEN, Auteur ; C. CHEN, Auteur ; R. M. MARTÍNEZ, Auteur ; Y. T. FAN, Auteur ; C. C. LIU, Auteur ; C. Y. CHEN, Auteur ; Y. CHENG, Auteur . - p.2287-2299. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2287-2299 Mots-clés : Adolescent  Amygdala/diagnostic imaging  Anxiety/complications  Autism Spectrum Disorder/complications/diagnostic imaging  Autistic Disorder  Case-Control Studies  Facial Recognition  Humans  Magnetic Resonance Imaging  amygdala  autism spectrum condition (ASC)  explicit  implicit  threat Index. décimale : PER Périodiques Résumé : Anxiety is exceedingly prevalent among individuals with an autism spectrum condition (ASC). While recent literature postulates anxiety as a mechanism encompassing an underlying amygdala-related elevated baseline level of arousal even to nonthreatening cues, whether this same mechanism contributes to anxiety in those with an ASC and supports the transdiagnostic nature of anxiety remains elusive. In this case-control study of 51 youths (26 ASC), we assessed autism and anxiety via the Autism-Spectrum Quotient and the State-Trait Anxiety Inventory, respectively. Hemodynamic responses, including amygdala reactivity, to explicit and implicit (backwardly masked) perception of threatening faces were acquired using functional Magnetic Resonance Imaging (fMRI). For explicit fear, ASC individuals showed significantly greater negative correlations between the amygdala and the attentional deployment-parietal network. For implicit fear, ASC individuals showed significantly stronger correlations of the amygdala with the prefrontal networks, temporal pole, and hippocampus. Additionally, an fMRI-based neurologic signature for anxiety in ASCs was identified via the LibSVM machine learning model using amygdala-centered functional connectivity during the emotional processing of explicit and implicit stimuli. Hypervigilance to implicit threat in ASCs comorbid with anxiety might exacerbate explicit threat reactivity; hence the use of attentional avoidance patterns to restrict affective hyperarousal for explicitly perceived socioemotional stimuli. Consequently, developing an attention-independent behavioral/neural marker identifying anxiety in ASCs is highly warranted. LAY SUMMARY: This study identifies a dissociation of amygdala reactivity dependent on explicit and implicit threat processing. Implicit anxiety in individuals with an autism spectrum condition (ASC) could outweigh explicitly induced threat. When explicitly perceiving socioemotional stimuli, ASC individuals with anxiety might use attentional avoidance patterns to restrict affective hyperarousal. En ligne : http://dx.doi.org/10.1002/aur.2595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study / O. W. H. WONG in Autism Research, 14-10 (October 2021)  

Public ISBD [article]  inAutism Research > 14-10 (October 2021) . - p.2131-2142 Titre : An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study Type de document : Texte imprimé et/ou numérique Auteurs : O. W. H. WONG, Auteur ; A. M. W. LAM, Auteur ; Kelly Y. C. LAI, Auteur ; S. L. MA, Auteur ; S. F. HUNG, Auteur ; S. CHAN, Auteur ; S. WONG, Auteur ; P. W. L. LEUNG, Auteur Article en page(s) : p.2131-2142 Langues : Anglais (eng) Mots-clés : Anxiety/complications  Autism Spectrum Disorder/complications/epidemiology  Autistic Disorder/complications/epidemiology  Case-Control Studies  Child  Child, Preschool  Gastrointestinal Diseases/complications/epidemiology  Humans  Male  abdominal pain  anxiety  autism  constipation  functional gastrointestinal disorder  gut-brain axis  nausea Index. décimale : PER Périodiques Résumé : Children with autism commonly suffer from comorbid functional gastrointestinal disorders (FGID) and anxiety. The raised prevalence of both conditions in autism suggests complex reciprocal relationships, which are seldom explored in non-treatment-seeking FGID. The relationships between subtypes of FGID and anxiety are also unclear. This study recruited boys with autism and age-matched typically developing (TD) boys, aged 4-11?years, who were not actively seeking help for gastrointestinal problems. Their parents completed the Rome IV Diagnostic Questionnaires for Pediatric FGID. Four groups of children with and without autism/FGID were identified and compared on their anxiety level using the Spence children's anxiety scale. In 69 boys with autism and 69 age-matched TD boys, FGID were identified in 22 and 16 boys, respectively. ANCOVA demonstrated a significant interaction effect of autism and FGID on anxiety (F[1, 129] = 5.43, p = 0.021), while conditional logistic regression identified an interaction effect of autism and anxiety on the odds of FGID (OR 1.038, 95% CI 1.002-1.075, p = 0.038). Explorative post hoc analysis showed higher anxiety in functional nausea and vomiting disorder (p = 0.033) and functional abdominal pain disorder (p = 0.029) among boys with autism than TD boys with the same respective subtypes of FGID. In summary, among prepubertal boys with autism, the presence of FGID that are non-treatment-seeking in nature, has a significantly stronger association with higher levels of anxiety than TD boys. The strength of association may be more prominent in subtypes of FGID. Possible pathomechanisms including the underlying microbiota spectra and inflammatory paths should be explored in future studies. LAY SUMMARY: Anxiety and gastrointestinal problems are common symptoms in autism. Given that gut health could be linked to emotions, their association in young boys with autism was studied. The presence of nausea vomiting, or abdominal pain were associated with raised anxiety among boys with autism, yet this was not observed in typically developing boys. This suggests that anxiety among autistic children could be partly explained by the presence of FGID. En ligne : http://dx.doi.org/10.1002/aur.2555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study [Texte imprimé et/ou numérique] / O. W. H. WONG, Auteur ; A. M. W. LAM, Auteur ; Kelly Y. C. LAI, Auteur ; S. L. MA, Auteur ; S. F. HUNG, Auteur ; S. CHAN, Auteur ; S. WONG, Auteur ; P. W. L. LEUNG, Auteur . - p.2131-2142. Langues : Anglais (eng) in Autism Research > 14-10 (October 2021) . - p.2131-2142 Mots-clés : Anxiety/complications  Autism Spectrum Disorder/complications/epidemiology  Autistic Disorder/complications/epidemiology  Case-Control Studies  Child  Child, Preschool  Gastrointestinal Diseases/complications/epidemiology  Humans  Male  abdominal pain  anxiety  autism  constipation  functional gastrointestinal disorder  gut-brain axis  nausea Index. décimale : PER Périodiques Résumé : Children with autism commonly suffer from comorbid functional gastrointestinal disorders (FGID) and anxiety. The raised prevalence of both conditions in autism suggests complex reciprocal relationships, which are seldom explored in non-treatment-seeking FGID. The relationships between subtypes of FGID and anxiety are also unclear. This study recruited boys with autism and age-matched typically developing (TD) boys, aged 4-11?years, who were not actively seeking help for gastrointestinal problems. Their parents completed the Rome IV Diagnostic Questionnaires for Pediatric FGID. Four groups of children with and without autism/FGID were identified and compared on their anxiety level using the Spence children's anxiety scale. In 69 boys with autism and 69 age-matched TD boys, FGID were identified in 22 and 16 boys, respectively. ANCOVA demonstrated a significant interaction effect of autism and FGID on anxiety (F[1, 129] = 5.43, p = 0.021), while conditional logistic regression identified an interaction effect of autism and anxiety on the odds of FGID (OR 1.038, 95% CI 1.002-1.075, p = 0.038). Explorative post hoc analysis showed higher anxiety in functional nausea and vomiting disorder (p = 0.033) and functional abdominal pain disorder (p = 0.029) among boys with autism than TD boys with the same respective subtypes of FGID. In summary, among prepubertal boys with autism, the presence of FGID that are non-treatment-seeking in nature, has a significantly stronger association with higher levels of anxiety than TD boys. The strength of association may be more prominent in subtypes of FGID. Possible pathomechanisms including the underlying microbiota spectra and inflammatory paths should be explored in future studies. LAY SUMMARY: Anxiety and gastrointestinal problems are common symptoms in autism. Given that gut health could be linked to emotions, their association in young boys with autism was studied. The presence of nausea vomiting, or abdominal pain were associated with raised anxiety among boys with autism, yet this was not observed in typically developing boys. This suggests that anxiety among autistic children could be partly explained by the presence of FGID. En ligne : http://dx.doi.org/10.1002/aur.2555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

"Intolerance of uncertainty" mediates the relationship between social profile and anxiety in both Williams syndrome and autism / M. SOUTH in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.1986-1995 Titre : "Intolerance of uncertainty" mediates the relationship between social profile and anxiety in both Williams syndrome and autism Type de document : Texte imprimé et/ou numérique Auteurs : M. SOUTH, Auteur ; M. HANLEY, Auteur ; K. NORMANSELL-MOSSA, Auteur ; N. C. C. RUSSELL, Auteur ; Thomas CAWTHORNE, Auteur ; D. M. RIBY, Auteur Article en page(s) : p.1986-1995 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Anxiety/complications  Autism Spectrum Disorder/complications  Autistic Disorder/complications  Child  Child, Preschool  Cross-Sectional Studies  Humans  Uncertainty  Williams Syndrome/complications  Young Adult  Intolerance of Uncertainty  Williams syndrome  anxiety  autism  children  social function  social profile Index. décimale : PER Périodiques Résumé : Anxiety is the most significant mental health concern for both Williams syndrome (WS) and autism. Whilst WS and autism are characterized by some syndrome-specific social differences, less is known about cross-syndrome profiles of anxiety symptoms. Previous research has shown that Intolerance of Uncertainty (IU) is a core mechanism of anxiety maintenance for clinically anxious populations and for autistic children, adolescents, and adults. The only published study in this area for WS has shown some similar patterns-with an added emphasis on the role of sensory sensitivities-in a sample of older teens and adults (mean age = 24), with the authors highlighting the need for younger samples to consider developmental influences. Here we report a cross-syndrome, cross-sectional mediation analyses of children diagnosed with WS or autism, including data from parent surveys of 90 children with WS (n = 48) or autism (n = 42). Group differences showed higher trait levels on all measures for the autism group. Importantly, the relationship between social profile and anxiety was fully mediated by IU level for both groups. This suggests possible similar core mechanisms underlying anxiety in these conditions, and the possibility of generalized intervention approaches especially related to managing distress related to uncertainty in multiple contexts. LAY SUMMARY: Autism and Williams Syndrome share some similarities in social profile and also in anxiety traits, but there are also some key differences as well. Comparing them side-by-side at the same time improved identification of ways to reduce feelings of anxiety. We found that the intolerance of uncertainty affected the relationship between social profile and anxiety in the same way for young children diagnosed with autism or Williams syndrome, meaning that intervention approaches could be similar for both. En ligne : http://dx.doi.org/10.1002/aur.2554 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] "Intolerance of uncertainty" mediates the relationship between social profile and anxiety in both Williams syndrome and autism [Texte imprimé et/ou numérique] / M. SOUTH, Auteur ; M. HANLEY, Auteur ; K. NORMANSELL-MOSSA, Auteur ; N. C. C. RUSSELL, Auteur ; Thomas CAWTHORNE, Auteur ; D. M. RIBY, Auteur . - p.1986-1995. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.1986-1995 Mots-clés : Adolescent  Adult  Anxiety/complications  Autism Spectrum Disorder/complications  Autistic Disorder/complications  Child  Child, Preschool  Cross-Sectional Studies  Humans  Uncertainty  Williams Syndrome/complications  Young Adult  Intolerance of Uncertainty  Williams syndrome  anxiety  autism  children  social function  social profile Index. décimale : PER Périodiques Résumé : Anxiety is the most significant mental health concern for both Williams syndrome (WS) and autism. Whilst WS and autism are characterized by some syndrome-specific social differences, less is known about cross-syndrome profiles of anxiety symptoms. Previous research has shown that Intolerance of Uncertainty (IU) is a core mechanism of anxiety maintenance for clinically anxious populations and for autistic children, adolescents, and adults. The only published study in this area for WS has shown some similar patterns-with an added emphasis on the role of sensory sensitivities-in a sample of older teens and adults (mean age = 24), with the authors highlighting the need for younger samples to consider developmental influences. Here we report a cross-syndrome, cross-sectional mediation analyses of children diagnosed with WS or autism, including data from parent surveys of 90 children with WS (n = 48) or autism (n = 42). Group differences showed higher trait levels on all measures for the autism group. Importantly, the relationship between social profile and anxiety was fully mediated by IU level for both groups. This suggests possible similar core mechanisms underlying anxiety in these conditions, and the possibility of generalized intervention approaches especially related to managing distress related to uncertainty in multiple contexts. LAY SUMMARY: Autism and Williams Syndrome share some similarities in social profile and also in anxiety traits, but there are also some key differences as well. Comparing them side-by-side at the same time improved identification of ways to reduce feelings of anxiety. We found that the intolerance of uncertainty affected the relationship between social profile and anxiety in the same way for young children diagnosed with autism or Williams syndrome, meaning that intervention approaches could be similar for both. En ligne : http://dx.doi.org/10.1002/aur.2554 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

The impact of COVID-19 on stress, anxiety, and coping in youth with and without autism and their parents / B. A. CORBETT in Autism Research, 14-7 (July 2021)  

Public ISBD [article]  inAutism Research > 14-7 (July 2021) . - p.1496-1511 Titre : The impact of COVID-19 on stress, anxiety, and coping in youth with and without autism and their parents Type de document : Texte imprimé et/ou numérique Auteurs : B. A. CORBETT, Auteur ; R. A. MUSCATELLO, Auteur ; M. E. KLEMENCIC, Auteur ; Jessica M. SCHWARTZMAN, Auteur Article en page(s) : p.1496-1511 Langues : Anglais (eng) Mots-clés : Adaptation, Psychological  Adolescent  Adult  Anxiety/complications  Autism Spectrum Disorder/complications/epidemiology  Autistic Disorder  Covid-19  Humans  Pandemics  Parents  SARS-CoV-2  anxiety  autism  coping  stress Index. décimale : PER Périodiques Résumé : In the wake of COVID-19, the world has become a more uncertain environment-a breeding ground for stress and anxiety, especially for individuals with autism spectrum disorder (ASD). The study examined stress, anxiety, and coping in a data-driven, real-time assessment of 122 youth with and without ASD and their parents at the height of the COVID-19 shutdown and three-months later. Standardized measures were administered to ascertain stress and coping explicitly related to the pandemic (RSQ COVID-19-Child [self-report], Adult [self-report from the guardian of youth], Parent [report about child]) and anxiety (STAI-C, STAI-A). Multivariate, univariate analyses of variance and hierarchical regression were used. ASD youth endorsed more Trait anxiety and response to specific stressors (e.g., virus). Caregivers of youth with ASD (Adults) self-reported higher anxiety, yet scores were elevated for both groups. Adults of youth with ASD reported more stress, especially related to the virus, access to healthcare, and concern for the future. In the TD group, youth and adults used more Primary and Secondary Control Coping whereas ASD youth and adults used more Disengagement Coping. Adult stress was the primary predictor of parent perception of child stress as well as Child self-reported stress. While the ASD group was consistently high compared to the TD group, there were no significant changes over time for stress or anxiety. Results reveal striking differences in youth with ASD and their parents regarding stress, anxiety, and coping. Findings highlight the need for essential support, access to services, and strategies to enhance psychological and emotional well-being. LAY SUMMARY: This study examined stress, anxiety, and coping related to the COVID-19 pandemic in 61 youth with autism spectrum disorder (ASD) and 61 youth with typical development (TD) and their parents. Results showed that ASD youth reported more anxiety and stress. Adults of youth with ASD indicated higher self-reported anxiety and stress than adults of TD youth. TD youth and their parents reported using more adaptive coping strategies. Findings highlight the need for strategies to enhance psychological and emotional well-being. En ligne : http://dx.doi.org/10.1002/aur.2521 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] The impact of COVID-19 on stress, anxiety, and coping in youth with and without autism and their parents [Texte imprimé et/ou numérique] / B. A. CORBETT, Auteur ; R. A. MUSCATELLO, Auteur ; M. E. KLEMENCIC, Auteur ; Jessica M. SCHWARTZMAN, Auteur . - p.1496-1511. Langues : Anglais (eng) in Autism Research > 14-7 (July 2021) . - p.1496-1511 Mots-clés : Adaptation, Psychological  Adolescent  Adult  Anxiety/complications  Autism Spectrum Disorder/complications/epidemiology  Autistic Disorder  Covid-19  Humans  Pandemics  Parents  SARS-CoV-2  anxiety  autism  coping  stress Index. décimale : PER Périodiques Résumé : In the wake of COVID-19, the world has become a more uncertain environment-a breeding ground for stress and anxiety, especially for individuals with autism spectrum disorder (ASD). The study examined stress, anxiety, and coping in a data-driven, real-time assessment of 122 youth with and without ASD and their parents at the height of the COVID-19 shutdown and three-months later. Standardized measures were administered to ascertain stress and coping explicitly related to the pandemic (RSQ COVID-19-Child [self-report], Adult [self-report from the guardian of youth], Parent [report about child]) and anxiety (STAI-C, STAI-A). Multivariate, univariate analyses of variance and hierarchical regression were used. ASD youth endorsed more Trait anxiety and response to specific stressors (e.g., virus). Caregivers of youth with ASD (Adults) self-reported higher anxiety, yet scores were elevated for both groups. Adults of youth with ASD reported more stress, especially related to the virus, access to healthcare, and concern for the future. In the TD group, youth and adults used more Primary and Secondary Control Coping whereas ASD youth and adults used more Disengagement Coping. Adult stress was the primary predictor of parent perception of child stress as well as Child self-reported stress. While the ASD group was consistently high compared to the TD group, there were no significant changes over time for stress or anxiety. Results reveal striking differences in youth with ASD and their parents regarding stress, anxiety, and coping. Findings highlight the need for essential support, access to services, and strategies to enhance psychological and emotional well-being. LAY SUMMARY: This study examined stress, anxiety, and coping related to the COVID-19 pandemic in 61 youth with autism spectrum disorder (ASD) and 61 youth with typical development (TD) and their parents. Results showed that ASD youth reported more anxiety and stress. Adults of youth with ASD indicated higher self-reported anxiety and stress than adults of TD youth. TD youth and their parents reported using more adaptive coping strategies. Findings highlight the need for strategies to enhance psychological and emotional well-being. En ligne : http://dx.doi.org/10.1002/aur.2521 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449