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Auteur Simon BARON-COHEN |
Documents disponibles écrits par cet auteur (175)
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ADHD and autism symptoms in youth: a network analysis / L. C. FARHAT in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)
[article]
Titre : ADHD and autism symptoms in youth: a network analysis Type de document : Texte imprimé et/ou numérique Auteurs : L. C. FARHAT, Auteur ; Helena BRENTANI, Auteur ; V. H. C. DE TOLEDO, Auteur ; E. SHEPHARD, Auteur ; P. MATTOS, Auteur ; Simon BARON-COHEN, Auteur ; A. THAPAR, Auteur ; E. CASELLA, Auteur ; Guilherme V. POLANCZYK, Auteur Article en page(s) : p.143-151 Langues : Anglais (eng) Mots-clés : Attention-deficit hyperactivity disorder autism spectrum disorder comorbidity network analysis neurodevelopmental Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research investigating the overlap between attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (henceforth, autism) symptoms in population samples have relied on latent variable modeling in which averaged scores representing dimensions were derived from observed symptoms. There are no studies evaluating how ADHD and autism symptoms interact at the level of individual symptom items. METHODS: We aimed to address this gap by performing a network analysis on data from a school survey of children aged 6-17?years old (N?=?7,405). ADHD and autism symptoms were measured via parent-report on the Swanson, Nolan, Pelham-IV questionnaire and the Childhood Autism Spectrum test, respectively. RESULTS: A relatively low interconnectivity between ADHD and autism symptoms was found with only 10.06% of possible connections (edges) between one ADHD and one autism symptoms different than zero. Associations between ADHD and autism symptoms were significantly weaker than those between two symptoms pertaining to the same construct. Select ADHD symptoms, particularly those presenting in social contexts (e.g. 'talks excessively', 'does not wait turn'), showed moderate-to-strong associations with autism symptoms, but some were considered redundant to autism symptoms. CONCLUSIONS: The present findings indicate that individual ADHD and autism symptoms are largely segregated in accordance with diagnostic boundaries corresponding to these conditions in children and adolescents from the community. These findings could improve our clinical conceptualization of ADHD and autism and guide advancements in diagnosis and treatment. En ligne : http://dx.doi.org/10.1111/jcpp.13436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457
in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.143-151[article] ADHD and autism symptoms in youth: a network analysis [Texte imprimé et/ou numérique] / L. C. FARHAT, Auteur ; Helena BRENTANI, Auteur ; V. H. C. DE TOLEDO, Auteur ; E. SHEPHARD, Auteur ; P. MATTOS, Auteur ; Simon BARON-COHEN, Auteur ; A. THAPAR, Auteur ; E. CASELLA, Auteur ; Guilherme V. POLANCZYK, Auteur . - p.143-151.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.143-151
Mots-clés : Attention-deficit hyperactivity disorder autism spectrum disorder comorbidity network analysis neurodevelopmental Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research investigating the overlap between attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (henceforth, autism) symptoms in population samples have relied on latent variable modeling in which averaged scores representing dimensions were derived from observed symptoms. There are no studies evaluating how ADHD and autism symptoms interact at the level of individual symptom items. METHODS: We aimed to address this gap by performing a network analysis on data from a school survey of children aged 6-17?years old (N?=?7,405). ADHD and autism symptoms were measured via parent-report on the Swanson, Nolan, Pelham-IV questionnaire and the Childhood Autism Spectrum test, respectively. RESULTS: A relatively low interconnectivity between ADHD and autism symptoms was found with only 10.06% of possible connections (edges) between one ADHD and one autism symptoms different than zero. Associations between ADHD and autism symptoms were significantly weaker than those between two symptoms pertaining to the same construct. Select ADHD symptoms, particularly those presenting in social contexts (e.g. 'talks excessively', 'does not wait turn'), showed moderate-to-strong associations with autism symptoms, but some were considered redundant to autism symptoms. CONCLUSIONS: The present findings indicate that individual ADHD and autism symptoms are largely segregated in accordance with diagnostic boundaries corresponding to these conditions in children and adolescents from the community. These findings could improve our clinical conceptualization of ADHD and autism and guide advancements in diagnosis and treatment. En ligne : http://dx.doi.org/10.1111/jcpp.13436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 An Exact Mind / Peter MYERS
Titre : An Exact Mind : An Artist with Asperger Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Peter MYERS, Auteur ; Sally WHEELWRIGHT, Auteur ; Simon BARON-COHEN, Auteur Editeur : Londres [Angleterre] : Jessica Kingsley Publishers Année de publication : 2004 Importance : 79 p. Présentation : ill. Format : 30cm x 24cm x 0,5cm ISBN/ISSN/EAN : 978-1-84310-032-4 Langues : Anglais (eng) Index. décimale : ART-A ART-A - Artistes Autistes Résumé : Peter Myers's intricate and ornately patterned drawings are brought together for the first time in this volume, which is the fascinating result of the collaboration of an artist and two scientists. The beautiful, complex images (included in full-page colour as well as black and white reproductions) serve as a rare window into the precision and creativity of the Asperger mind at work.
Peter Myers was diagnosed with Asperger Syndrome in 1996 and his work reflects his stunning ability to plan and to organize visual information, and to embed illusions within his pictures. In explanatory text alongside the pictures, psychologists Simon Baron-Cohen and Sally Wheelright discuss the work's deep psychological significance, demonstrating in accessible language their ground-breaking systemizing theory of how the autistic mind processes information.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=385 An Exact Mind : An Artist with Asperger Syndrome [Texte imprimé et/ou numérique] / Peter MYERS, Auteur ; Sally WHEELWRIGHT, Auteur ; Simon BARON-COHEN, Auteur . - Londres [Angleterre] : Jessica Kingsley Publishers, 2004 . - 79 p. : ill. ; 30cm x 24cm x 0,5cm.
ISBN : 978-1-84310-032-4
Langues : Anglais (eng)
Index. décimale : ART-A ART-A - Artistes Autistes Résumé : Peter Myers's intricate and ornately patterned drawings are brought together for the first time in this volume, which is the fascinating result of the collaboration of an artist and two scientists. The beautiful, complex images (included in full-page colour as well as black and white reproductions) serve as a rare window into the precision and creativity of the Asperger mind at work.
Peter Myers was diagnosed with Asperger Syndrome in 1996 and his work reflects his stunning ability to plan and to organize visual information, and to embed illusions within his pictures. In explanatory text alongside the pictures, psychologists Simon Baron-Cohen and Sally Wheelright discuss the work's deep psychological significance, demonstrating in accessible language their ground-breaking systemizing theory of how the autistic mind processes information.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=385 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DOC0000209 ART-A MYE Livre Centre d'Information et de Documentation du CRA Rhône-Alpes ART - Autisme et art - Autisme en images Disponible Les abonnés qui ont emprunté ce document ont également emprunté :
A User Guide to the GF/CF Diet for Autism, Asperger Syndrome and AD/HD JACKSON, Luke Aspergirls SIMONE, Rudy Love, Sex and Long-Term Relationships HENDRICKX, Sarah Embrasser le ciel immense TAMMET, Daniel The Asperger Couple's Workbook ASTON, Maxine Un anthropologue sur Mars SACKS, Oliver An investigation of the diet, exercise, sleep, BMI, and health outcomes of autistic adults / E. WEIR in Molecular Autism, 12 (2021)
[article]
Titre : An investigation of the diet, exercise, sleep, BMI, and health outcomes of autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : E. WEIR, Auteur ; Carrie ALLISON, Auteur ; K. K. ONG, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 31 p. Langues : Anglais (eng) Mots-clés : Adult outcomes Comorbidities Exercise Healthcare Nutrition Physical health Sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: Studies of autistic children suggest that restricted eating, reduced physical activity, and sleep disorders are common; however, no studies attempt to broadly describe the diet, exercise, and sleep patterns of autistic adults or consider relationships between lifestyle behaviors and the widely reported increased risks of obesity and chronic conditions. To address this, the authors developed the largest study of lifestyle patterns of autistic adults and assessed their relationships to body mass index, health outcomes, and family history. METHODS: We administered an anonymized, online survey to n?=?2386 adults (n?=?1183 autistic) aged 16-90 years of age. We employed Fisher's exact tests and binomial logistic regression to describe diet, exercise, and sleep patterns; mediation of seizure disorders on sleep; body mass index (BMI); relationships of lifestyle factors to BMI, cardiovascular conditions, and diabetic conditions; and sex differences among autistic adults. RESULTS: Autistic adults, and particularly autistic females, exhibit unhealthy diet, exercise, and sleep patterns; they are also more likely to be underweight or obese. Limited sleep duration and high rates of sleep disturbances cannot be accounted for by epilepsy or seizure disorders. Lifestyle factors are positively related to higher risk of cardiovascular conditions among autistic males, even more than family history. LIMITATIONS: Our sample may not be representative of all autistic and non-autistic people, as it primarily comprised individuals who are white, female, have a high school education or higher, and reside in the UK. Our sampling methods may also exclude some individuals on the autism spectrum, and particularly those with moderate to severe intellectual disability. This is a cross-sectional sample that can test for relationships between factors (e.g., lifestyle factors and health outcomes) but cannot assess the direction of these relationships. CONCLUSIONS: Autistic adults are less likely to meet minimal health recommendations for diet, exercise, and sleep-and these unhealthy behaviors may relate to excess risk of cardiovascular conditions. Although the present study can only provide preliminary, correlational evidence, our findings suggest that diet, exercise, and sleep should be considered and further investigated as key targets for reducing the now widely reported and dramatically increased risks of health comorbidity and premature death among autistic individuals compared to others. Physicians should work cooperatively with patients to provide health education and develop individualized strategies for how to better manage challenges with diet, exercise, and sleep. En ligne : http://dx.doi.org/10.1186/s13229-021-00441-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 31 p.[article] An investigation of the diet, exercise, sleep, BMI, and health outcomes of autistic adults [Texte imprimé et/ou numérique] / E. WEIR, Auteur ; Carrie ALLISON, Auteur ; K. K. ONG, Auteur ; Simon BARON-COHEN, Auteur . - 31 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 31 p.
Mots-clés : Adult outcomes Comorbidities Exercise Healthcare Nutrition Physical health Sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: Studies of autistic children suggest that restricted eating, reduced physical activity, and sleep disorders are common; however, no studies attempt to broadly describe the diet, exercise, and sleep patterns of autistic adults or consider relationships between lifestyle behaviors and the widely reported increased risks of obesity and chronic conditions. To address this, the authors developed the largest study of lifestyle patterns of autistic adults and assessed their relationships to body mass index, health outcomes, and family history. METHODS: We administered an anonymized, online survey to n?=?2386 adults (n?=?1183 autistic) aged 16-90 years of age. We employed Fisher's exact tests and binomial logistic regression to describe diet, exercise, and sleep patterns; mediation of seizure disorders on sleep; body mass index (BMI); relationships of lifestyle factors to BMI, cardiovascular conditions, and diabetic conditions; and sex differences among autistic adults. RESULTS: Autistic adults, and particularly autistic females, exhibit unhealthy diet, exercise, and sleep patterns; they are also more likely to be underweight or obese. Limited sleep duration and high rates of sleep disturbances cannot be accounted for by epilepsy or seizure disorders. Lifestyle factors are positively related to higher risk of cardiovascular conditions among autistic males, even more than family history. LIMITATIONS: Our sample may not be representative of all autistic and non-autistic people, as it primarily comprised individuals who are white, female, have a high school education or higher, and reside in the UK. Our sampling methods may also exclude some individuals on the autism spectrum, and particularly those with moderate to severe intellectual disability. This is a cross-sectional sample that can test for relationships between factors (e.g., lifestyle factors and health outcomes) but cannot assess the direction of these relationships. CONCLUSIONS: Autistic adults are less likely to meet minimal health recommendations for diet, exercise, and sleep-and these unhealthy behaviors may relate to excess risk of cardiovascular conditions. Although the present study can only provide preliminary, correlational evidence, our findings suggest that diet, exercise, and sleep should be considered and further investigated as key targets for reducing the now widely reported and dramatically increased risks of health comorbidity and premature death among autistic individuals compared to others. Physicians should work cooperatively with patients to provide health education and develop individualized strategies for how to better manage challenges with diet, exercise, and sleep. En ligne : http://dx.doi.org/10.1186/s13229-021-00441-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 An investigation of the 'female camouflage effect' in autism using a computerized ADOS-2 and a test of sex/gender differences / A. RYNKIEWICZ in Molecular Autism, 7 (2016)
[article]
Titre : An investigation of the 'female camouflage effect' in autism using a computerized ADOS-2 and a test of sex/gender differences Type de document : Texte imprimé et/ou numérique Auteurs : A. RYNKIEWICZ, Auteur ; B. SCHULLER, Auteur ; E. MARCHI, Auteur ; S. PIANA, Auteur ; A. CAMURRI, Auteur ; A. LASSALLE, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 10p. Langues : Anglais (eng) Mots-clés : Asperger Syndrome/diagnosis/psychology Autistic Disorder/diagnosis/psychology Child Child, Preschool Communication Disorders/diagnosis/etiology Culture Diagnosis, Computer-Assisted/methods Diagnostic Errors Emotions Facial Expression Female Fixation, Ocular Gestures Humans Male Parents Poland Psychomotor Performance Severity of Illness Index Sex Characteristics Sex Factors Social Behavior Software Stereotyped Behavior Surveys and Questionnaires Ados-2 Computer application Diagnosis Females with autism Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum conditions (autism) are diagnosed more frequently in boys than in girls. Females with autism may have been under-identified due to not only a male-biased understanding of autism but also females' camouflaging. The study describes a new technique that allows automated coding of non-verbal mode of communication (gestures) and offers the possibility of objective, evaluation of gestures, independent of human judgment. The EyesWeb software platform and the Kinect sensor during two demonstration activities of ADOS-2 (Autism Diagnostic Observation Schedule, Second Edition) were used. METHODS: The study group consisted of 33 high-functioning Polish girls and boys with formal diagnosis of autism or Asperger syndrome aged 5-10, with fluent speech, IQ average and above and their parents (girls with autism, n = 16; boys with autism, n = 17). All children were assessed during two demonstration activities of Module 3 of ADOS-2, administered in Polish, and coded using Polish codes. Children were also assessed with Polish versions of the Eyes and Faces Tests. Parents provided information on the author-reviewed Polish research translation of SCQ (Social Communication Questionnaire, Current and Lifetime) and Polish version of AQ Child (Autism Spectrum Quotient, Child). RESULTS: Girls with autism tended to use gestures more vividly as compared to boys with autism during two demonstration activities of ADOS-2. Girls with autism made significantly more mistakes than boys with autism on the Faces Test. All children with autism had high scores in AQ Child, which confirmed the presence of autistic traits in this group. The current communication skills of boys with autism reported by parents in SCQ were significantly better than those of girls with autism. However, both girls with autism and boys with autism improved in the social and communication abilities over the lifetime. The number of stereotypic behaviours in boys significantly decreased over life whereas it remained at a comparable level in girls with autism. CONCLUSIONS: High-functioning females with autism might present better on non-verbal (gestures) mode of communication than boys with autism. It may camouflage other diagnostic features. It poses risk of under-diagnosis or not receiving the appropriate diagnosis for this population. Further research is required to examine this phenomenon so appropriate gender revisions to the diagnostic assessments might be implemented. En ligne : http://dx.doi.org/10.1186/s13229-016-0073-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 7 (2016) . - 10p.[article] An investigation of the 'female camouflage effect' in autism using a computerized ADOS-2 and a test of sex/gender differences [Texte imprimé et/ou numérique] / A. RYNKIEWICZ, Auteur ; B. SCHULLER, Auteur ; E. MARCHI, Auteur ; S. PIANA, Auteur ; A. CAMURRI, Auteur ; A. LASSALLE, Auteur ; Simon BARON-COHEN, Auteur . - 10p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 10p.
Mots-clés : Asperger Syndrome/diagnosis/psychology Autistic Disorder/diagnosis/psychology Child Child, Preschool Communication Disorders/diagnosis/etiology Culture Diagnosis, Computer-Assisted/methods Diagnostic Errors Emotions Facial Expression Female Fixation, Ocular Gestures Humans Male Parents Poland Psychomotor Performance Severity of Illness Index Sex Characteristics Sex Factors Social Behavior Software Stereotyped Behavior Surveys and Questionnaires Ados-2 Computer application Diagnosis Females with autism Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum conditions (autism) are diagnosed more frequently in boys than in girls. Females with autism may have been under-identified due to not only a male-biased understanding of autism but also females' camouflaging. The study describes a new technique that allows automated coding of non-verbal mode of communication (gestures) and offers the possibility of objective, evaluation of gestures, independent of human judgment. The EyesWeb software platform and the Kinect sensor during two demonstration activities of ADOS-2 (Autism Diagnostic Observation Schedule, Second Edition) were used. METHODS: The study group consisted of 33 high-functioning Polish girls and boys with formal diagnosis of autism or Asperger syndrome aged 5-10, with fluent speech, IQ average and above and their parents (girls with autism, n = 16; boys with autism, n = 17). All children were assessed during two demonstration activities of Module 3 of ADOS-2, administered in Polish, and coded using Polish codes. Children were also assessed with Polish versions of the Eyes and Faces Tests. Parents provided information on the author-reviewed Polish research translation of SCQ (Social Communication Questionnaire, Current and Lifetime) and Polish version of AQ Child (Autism Spectrum Quotient, Child). RESULTS: Girls with autism tended to use gestures more vividly as compared to boys with autism during two demonstration activities of ADOS-2. Girls with autism made significantly more mistakes than boys with autism on the Faces Test. All children with autism had high scores in AQ Child, which confirmed the presence of autistic traits in this group. The current communication skills of boys with autism reported by parents in SCQ were significantly better than those of girls with autism. However, both girls with autism and boys with autism improved in the social and communication abilities over the lifetime. The number of stereotypic behaviours in boys significantly decreased over life whereas it remained at a comparable level in girls with autism. CONCLUSIONS: High-functioning females with autism might present better on non-verbal (gestures) mode of communication than boys with autism. It may camouflage other diagnostic features. It poses risk of under-diagnosis or not receiving the appropriate diagnosis for this population. Further research is required to examine this phenomenon so appropriate gender revisions to the diagnostic assessments might be implemented. En ligne : http://dx.doi.org/10.1186/s13229-016-0073-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 Application of Airy beam light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids / Dwaipayan ADHYA in Molecular Autism, 12 (2021)
[article]
Titre : Application of Airy beam light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids Type de document : Texte imprimé et/ou numérique Auteurs : Dwaipayan ADHYA, Auteur ; George CHENNELL, Auteur ; James A. CROWE, Auteur ; Eva P. VALENCIA-ALARCON, Auteur ; James SEYFORTH, Auteur ; Neveen A. HOSNY, Auteur ; Marina V. YASVOINA, Auteur ; Robert FORSTER, Auteur ; Simon BARON-COHEN, Auteur ; Anthony C. VERNON, Auteur ; Deepak P. SRIVASTAVA, Auteur Article en page(s) : 4p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: The inability to observe relevant biological processes in vivo significantly restricts human neurodevelopmental research. Advances in appropriate in vitro model systems, including patient-specific human brain organoids and human cortical spheroids (hCSs), offer a pragmatic solution to this issue. In particular, hCSs are an accessible method for generating homogenous organoids of dorsal telencephalic fate, which recapitulate key aspects of human corticogenesis, including the formation of neural rosettes-in vitro correlates of the neural tube. These neurogenic niches give rise to neural progenitors that subsequently differentiate into neurons. Studies differentiating induced pluripotent stem cells (hiPSCs) in 2D have linked atypical formation of neural rosettes with neurodevelopmental disorders such as autism spectrum conditions. Thus far, however, conventional methods of tissue preparation in this field limit the ability to image these structures in three-dimensions within intact hCS or other 3D preparations. To overcome this limitation, we have sought to optimise a methodological approach to process hCSs to maximise the utility of a novel Airy-beam light sheet microscope (ALSM) to acquire high resolution volumetric images of internal structures within hCS representative of early developmental time points. RESULTS: Conventional approaches to imaging hCS by confocal microscopy were limited in their ability to image effectively into intact spheroids. Conversely, volumetric acquisition by ALSM offered superior imaging through intact, non-clarified, in vitro tissues, in both speed and resolution when compared to conventional confocal imaging systems. Furthermore, optimised immunohistochemistry and optical clearing of hCSs afforded improved imaging at depth. This permitted visualization of the morphology of the inner lumen of neural rosettes. CONCLUSION: We present an optimized methodology that takes advantage of an ALSM system that can rapidly image intact 3D brain organoids at high resolution while retaining a large field of view. This imaging modality can be applied to both non-cleared and cleared in vitro human brain spheroids derived from hiPSCs for precise examination of their internal 3D structures. This process represents a rapid, highly efficient method to examine and quantify in 3D the formation of key structures required for the coordination of neurodevelopmental processes in both health and disease states. We posit that this approach would facilitate investigation of human neurodevelopmental processes in vitro. En ligne : http://dx.doi.org/10.1186/s13229-021-00413-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442
in Molecular Autism > 12 (2021) . - 4p.[article] Application of Airy beam light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids [Texte imprimé et/ou numérique] / Dwaipayan ADHYA, Auteur ; George CHENNELL, Auteur ; James A. CROWE, Auteur ; Eva P. VALENCIA-ALARCON, Auteur ; James SEYFORTH, Auteur ; Neveen A. HOSNY, Auteur ; Marina V. YASVOINA, Auteur ; Robert FORSTER, Auteur ; Simon BARON-COHEN, Auteur ; Anthony C. VERNON, Auteur ; Deepak P. SRIVASTAVA, Auteur . - 4p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 4p.
Index. décimale : PER Périodiques Résumé : BACKGROUND: The inability to observe relevant biological processes in vivo significantly restricts human neurodevelopmental research. Advances in appropriate in vitro model systems, including patient-specific human brain organoids and human cortical spheroids (hCSs), offer a pragmatic solution to this issue. In particular, hCSs are an accessible method for generating homogenous organoids of dorsal telencephalic fate, which recapitulate key aspects of human corticogenesis, including the formation of neural rosettes-in vitro correlates of the neural tube. These neurogenic niches give rise to neural progenitors that subsequently differentiate into neurons. Studies differentiating induced pluripotent stem cells (hiPSCs) in 2D have linked atypical formation of neural rosettes with neurodevelopmental disorders such as autism spectrum conditions. Thus far, however, conventional methods of tissue preparation in this field limit the ability to image these structures in three-dimensions within intact hCS or other 3D preparations. To overcome this limitation, we have sought to optimise a methodological approach to process hCSs to maximise the utility of a novel Airy-beam light sheet microscope (ALSM) to acquire high resolution volumetric images of internal structures within hCS representative of early developmental time points. RESULTS: Conventional approaches to imaging hCS by confocal microscopy were limited in their ability to image effectively into intact spheroids. Conversely, volumetric acquisition by ALSM offered superior imaging through intact, non-clarified, in vitro tissues, in both speed and resolution when compared to conventional confocal imaging systems. Furthermore, optimised immunohistochemistry and optical clearing of hCSs afforded improved imaging at depth. This permitted visualization of the morphology of the inner lumen of neural rosettes. CONCLUSION: We present an optimized methodology that takes advantage of an ALSM system that can rapidly image intact 3D brain organoids at high resolution while retaining a large field of view. This imaging modality can be applied to both non-cleared and cleared in vitro human brain spheroids derived from hiPSCs for precise examination of their internal 3D structures. This process represents a rapid, highly efficient method to examine and quantify in 3D the formation of key structures required for the coordination of neurodevelopmental processes in both health and disease states. We posit that this approach would facilitate investigation of human neurodevelopmental processes in vitro. En ligne : http://dx.doi.org/10.1186/s13229-021-00413-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 Apprendre aux enfants autistes à comprendre la pensée des autres / Patricia HOWLIN
PermalinkApprendre aux enfants autistes à comprendre la pensée des autres / Patricia HOWLIN
PermalinkApprendre aux enfants autistes à comprendre la pensée des autres / Patricia HOWLIN
PermalinkApprendre aux enfants autistes à comprendre la pensée des autres / Patricia HOWLIN
PermalinkAre Autism Spectrum Conditions More Prevalent in an Information-Technology Region? A School-Based Study of Three Regions in the Netherlands / Martine T. ROELFSEMA in Journal of Autism and Developmental Disorders, 42-5 (May 2012)
PermalinkAre autistic people disadvantaged by the criminal justice system? A case comparison / Rachel SLAVNY-CROSS in Autism, 27-5 (July 2023)
PermalinkAsperger Syndrome / Simon BARON-COHEN
PermalinkAssessing Autism in Adults: An Evaluation of the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult) / W. MANDY in Journal of Autism and Developmental Disorders, 48-2 (February 2018)
PermalinkAtypical integration of social cues for orienting to gaze direction in adults with autism / Chris ASHWIN in Molecular Autism, (January 2015)
PermalinkAtypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits / D. L. FLORIS in Molecular Autism, 7 (2016)
PermalinkAutism and Asperger Syndrome / Simon BARON-COHEN
PermalinkAutism and family involvement in the right to education in the EU: policy mapping in the Netherlands, Belgium and Germany / R. VAN KESSEL in Molecular Autism, 10 (2019)
PermalinkAutism and the criminal justice system: An analysis of 93 cases / Rachel SLAVNY-CROSS in Autism Research, 15-5 (May 2022)
PermalinkAutism and the Grand Challenges in Global Mental Health / Naila Z. KHAN ; Lilia ALBORES-GALLO ; Aurora ARGHIR ; Bogdan BUDISTEANU ; Magdalena BUDISTEANU ; Iuliana DOBRESCU ; Kirsty DONALD ; Samia EL-TABARI ; Michelle HOOGENHOUT ; Fidelie KALAMBAYI ; Rafal KAWA ; Isaac LEMUS ESPINOZA ; Rosane LOWENTHAL ; Susan MALCOLM-SMITH ; Cecilia MONTIEL-NAVA ; Jumana ODEH ; Cristiane S. DE PAULA ; Florina RAD ; Adelaide Katerine TARPAN ; Kevin G. F. THOMAS ; Chongying WANG ; Vikram PATEL ; Simon BARON-COHEN ; Mayada ELSABBAGH in Autism Research, 5-3 (June 2012)
PermalinkAutism and the right to education in the EU: policy mapping and scoping review of Nordic countries Denmark, Finland, and Sweden / R. VAN KESSEL in Molecular Autism, 10 (2019)
PermalinkAutism: Deficits in folk psychology exist alongside superiority in folk physics / Simon BARON-COHEN
PermalinkAutism prevalence in China is comparable to Western prevalence / X. SUN in Molecular Autism, 10 (2019)
PermalinkAutism screening and conditional cash transfers in Chile: Using the Quantitative Checklist (Q-CHAT) for early autism detection in a low resource setting / Andres ROMAN-URRESTARAZU in Autism, 25-4 (May 2021)
PermalinkAutism screening at 18 months of age: a comparison of the Q-CHAT-10 and M-CHAT screeners / R. STURNER in Molecular Autism, 13 (2022)
PermalinkAutism Spectrum Disorders at 20 and 42 Months of Age: Stability of Clinical and ADI-R Diagnosis / Antony COX in Journal of Child Psychology and Psychiatry, 40-5 (July 1999)
PermalinkAutism Traits in Individuals with Agenesis of the Corpus Callosum / Yolanda C. LAU in Journal of Autism and Developmental Disorders, 43-5 (May 2013)
PermalinkL’autisme peut-il être détecté à l’âge de 18 mois? L’aiguille, la meule de foin et le CHAT / Simon BARON-COHEN in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., HS 3-4 (Novembre 1997)
PermalinkAutisme : un trouble cognitif spécifique, la "cécité mentale" / Simon BARON-COHEN in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., 3-4 (Septembre-Décembre 1993)
PermalinkAutistic adults have poorer quality healthcare and worse health based on self-report data / Elizabeth WEIR in Molecular Autism, 13 (2022)
PermalinkAutistic People?s Perinatal Experiences I: A Survey of Pregnancy Experiences / Carrie ALLISON ; Simon BARON-COHEN ; Rosemary HOLT in Journal of Autism and Developmental Disorders, 54-1 (January 2024)
PermalinkPermalinkAutistic Traits in Treatment-Seeking Transgender Adults / A. NOBILI in Journal of Autism and Developmental Disorders, 48-12 (December 2018)
PermalinkAutistic traits, resting-state connectivity, and absolute pitch in professional musicians: shared and distinct neural features / T. WENHART in Molecular Autism, 10 (2019)
PermalinkBasic and complex emotion recognition in children with autism: cross-cultural findings / S. FRIDENSON-HAYO in Molecular Autism, 7 (2016)
PermalinkBrain Routes for Reading in Adults with and without Autism: EMEG Evidence / Rachel L. MOSELEY in Journal of Autism and Developmental Disorders, 44-1 (January 2014)
PermalinkBrief Report: Development of the Adolescent Empathy and Systemizing Quotients / Bonnie AUYEUNG in Journal of Autism and Developmental Disorders, 42-10 (October 2012)
PermalinkBrief Report: Female-To-Male Transsexual People and Autistic Traits / Rebecca M. JONES in Journal of Autism and Developmental Disorders, 42-2 (February 2012)
PermalinkBrief Report Prevalence of Autism Spectrum Conditions in Children Aged 5-11 Years in Cambridgeshire, UK / Fiona J. SCOTT in Autism, 6-3 (September 2002)
PermalinkBrief Report: The Go/No-Go Task Online: Inhibitory Control Deficits in Autism in a Large Sample / F. UZEFOVSKY in Journal of Autism and Developmental Disorders, 46-8 (August 2016)
PermalinkCapping four years of growth of Molecular Autism: impact factor coming in 2014 / Joseph D. BUXBAUM in Molecular Autism, (December 2013)
PermalinkLa cécité mentale / Simon BARON-COHEN
PermalinkChild, Maternal and Demographic Factors Influencing Caregiver-Reported Autistic Trait Symptomatology in Toddlers / D. A. GOH in Journal of Autism and Developmental Disorders, 48-4 (April 2018)
PermalinkA "choice", an "addiction", a way "out of the lost": exploring self-injury in autistic people without intellectual disability / R. L. MOSELEY in Molecular Autism, 10 (2019)
PermalinkCommentary: 'Camouflaging' in autistic people - reflection on Fombonne (2020) / Meng-Chuan LAI in Journal of Child Psychology and Psychiatry, 62-8 (August 2021)
PermalinkCommentary: How Social is Social Cognition? / Simon BARON-COHEN
PermalinkA comparative study of autistic and non-autistic women's experience of motherhood / A. L. POHL in Molecular Autism, 11 (2020)
PermalinkComparison of Parent Questionnaires, Examiner-Led Assessment and Parents' Concerns at 14 Months of Age as Indicators of Later Diagnosis of Autism / Greg PASCO in Journal of Autism and Developmental Disorders, 51-3 (March 2021)
PermalinkA comprehensive meta-analysis of common genetic variants in autism spectrum conditions / Varun WARRIER in Molecular Autism, (August 2015)
PermalinkCorrection to: The relevance of the interpersonal theory of suicide for predicting past-year and lifetime suicidality in autistic adults / R. L. MOSELEY in Molecular Autism, 13 (2022)
PermalinkA cross-cultural study of autistic traits across India, Japan and the UK / S. CARRUTHERS in Molecular Autism, 9 (2018)
PermalinkDefining the broader, medium and narrow autism phenotype among parents using the Autism Spectrum Quotient (AQ) / Sally WHEELWRIGHT in Molecular Autism, (June 2010)
PermalinkDemographic and psychological predictors of alcohol use and misuse in autistic adults / Maya BOWRI in Autism, 25-5 (July 2021)
PermalinkDemographic and psychological predictors of alcohol use and misuse in autistic adults / Maya BOWRI in Autism, 26-5 (July 2022)
PermalinkDevelopment and Validation of the Camouflaging Autistic Traits Questionnaire (CAT-Q) / L. HULL in Journal of Autism and Developmental Disorders, 49-3 (March 2019)
PermalinkDid Hans Asperger actively assist the Nazi euthanasia program? / Simon BARON-COHEN in Molecular Autism, 9 (2018)
PermalinkDo Adults with High Functioning Autism or Asperger Syndrome Differ in Empathy and Emotion Recognition? / Charlotte B. MONTGOMERY in Journal of Autism and Developmental Disorders, 46-6 (June 2016)
PermalinkDo Children with Autism have a Theory of Mind? A Non-verbal Test of Autism vs. Specific Language Impairment / Livia COLLE in Journal of Autism and Developmental Disorders, 37-4 (April 2007)
PermalinkDo girls with anorexia nervosa have elevated autistic traits? / Simon BARON-COHEN in Molecular Autism, (August 2013)
PermalinkDo the traits of autism-spectrum overlap with those of schizophrenia or obsessive-compulsive disorder in the general population? / Akio WAKABAYASHI in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)
PermalinkPermalinkDoes Autism Occur More Often in Families of Physicists, Engineers, and Mathematicians? / Simon BARON-COHEN in Autism, 2-3 (September 1998)
PermalinkPermalinkDyspraxia and autistic traits in adults with and without autism spectrum conditions / Sarah A. CASSIDY in Molecular Autism, 7 (2016)
PermalinkEditorial Perspective: Neurodiversity – a revolutionary concept for autism and psychiatry / Simon BARON-COHEN in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)
PermalinkEffects of oxytocin administration on salivary sex hormone levels in autistic and neurotypical women / Tanya L. PROCYSHYN in Molecular Autism, 11 (2020)
PermalinkEmpathizing and Systemizing in Adults with and without Autism Spectrum Conditions: Cross-Cultural Stability / Akio WAKABAYASHI in Journal of Autism and Developmental Disorders, 37-10 (November 2007)
PermalinkEmpathizing and Systemizing in Autism Spectrum Conditions / Simon BARON-COHEN
PermalinkEngineering and Autism: Exploring the Link Further: Reply to Wolff, Braunsberg and Islam / Simon BARON-COHEN in Autism, 2-1 (March 1998)
PermalinkEnhanced Discrimination of Novel, Highly Similar Stimuli by Adults with Autism During a Perceptual Learning Task / Kate C. PLAISTED in Journal of Child Psychology and Psychiatry, 39-5 (July 1998)
PermalinkEnhanced olfactory sensitivity in autism spectrum conditions / Chris ASHWIN in Molecular Autism, (November 2014)
PermalinkEnhanced Visual Search for a Conjunctive Target in Autism: A Research Note / Kate C. PLAISTED in Journal of Child Psychology and Psychiatry, 39-5 (July 1998)
PermalinkEnhancing Emotion Recognition in Children with Autism Spectrum Conditions: An Intervention Using Animated Vehicles with Real Emotional Faces / Ofer GOLAN in Journal of Autism and Developmental Disorders, 40-3 (March 2010)
PermalinkEnhancing emotion recognition in young autistic children with or without attention-deficit/hyperactivity disorder in Hong Kong using a Chinese App version of The Transporters / Janice Ka-Yan CHAN in Autism, 28-4 (April 2024)
PermalinkErratum: Measuring autistic traits in the general population: a systematic review of the Autism-Spectrum Quotient (AQ) in a nonclinical population sample of 6,900 typical adult males and females / Emily RUZICH in Molecular Autism, (August 2015)
PermalinkExperience of mental health diagnosis and perceived misdiagnosis in autistic, possibly autistic and non-autistic adults / S. K. AU-YEUNG in Autism, 23-6 (August 2019)
PermalinkExploring autistic traits in anorexia: a clinical study / Kate TCHANTURIA in Molecular Autism, (November 2013)
PermalinkExploring the Underdiagnosis and Prevalence of Autism Spectrum Conditions in Beijing / Xiang SUN in Autism Research, 8-3 (June 2015)
PermalinkFace individual identity recognition: a potential endophenotype in autism / Ilaria MINIO-PALUELLO in Molecular Autism, 11 (2020)
PermalinkFacial expression recognition is linked to clinical and neurofunctional differences in autism / Hannah MEYER-LINDENBERG in Molecular Autism, 13 (2022)
PermalinkFailure to deactivate the default mode network indicates a possible endophenotype of autism / Michael D. SPENCER in Molecular Autism, (December 2012)
PermalinkFoetal testosterone and autistic traits in 18 to 24-month-old children / Bonnie AUYEUNG in Molecular Autism, (July 2010)
PermalinkFrom molecules to neural morphology: understanding neuroinflammation in autism spectrum condition / A. M. YOUNG in Molecular Autism, 7 (2016)
PermalinkGender differences in self-reported camouflaging in autistic and non-autistic adults / Laura HULL in Autism, 24-2 (February 2020)
PermalinkGenes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome / Bhismadev CHAKRABARTI in Autism Research, 2-3 (June 2009)
PermalinkGenetic variant rs17225178 in the ARNT2 gene is associated with Asperger Syndrome / Agnese DI NAPOLI in Molecular Autism, (February 2015)
PermalinkGenetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism / Varun WARRIER in Molecular Autism, (December 2013)
PermalinkGenetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome / Agnese DI NAPOLI in Molecular Autism, (September 2014)
PermalinkGenetics in psychiatry: common variant association studies / Joseph D. BUXBAUM in Molecular Autism, (March 2010)
PermalinkGiving Cambridge University students with Asperger syndrome a voice: a qualitative, interview-based study towards developing a model of best practice / Joanna HASTWELL in Good Autism Practice - GAP, 13-1 (May 2012)
PermalinkGray matter covariations and core symptoms of autism: the EU-AIMS Longitudinal European Autism Project / Ting MEI in Molecular Autism, 11 (2020)
PermalinkHormonal Influences in Typical Development: Implications for Autism / Bonnie AUYEUNG
PermalinkHow to Test the Extreme Male Brain Theory of Autism in Terms of Foetal Androgens? / Rebecca C. KNICKMEYER in Journal of Autism and Developmental Disorders, 38-5 (May 2008)
PermalinkL'hypothèse de la théorie de l'esprit : les enfants autistes parlent-ils de leurs rêves ? / Jaime CRAIG in Psychologie Française, 43-2 (Juin 1998)
PermalinkIncreased prevalence of non-communicable physical health conditions among autistic adults / Elizabeth WEIR in Autism, 25-3 (April 2021)
PermalinkIncreased rates of chronic physical health conditions across all organ systems in autistic adolescents and adults / Elizabeth WEIR ; Carrie ALLISON ; Simon BARON-COHEN in Molecular Autism, 14 (2023)
PermalinkInitial evidence that non-clinical autistic traits are associated with lower income / W. J. SKYLARK in Molecular Autism, 8 (2017)
PermalinkIntact priors for gaze direction in adults with high-functioning autism spectrum conditions / P. J. PELL in Molecular Autism, 7 (2016)
PermalinkIntegrated genetic and methylomic analyses identify shared biology between autism and autistic traits / A. MASSRALI in Molecular Autism, 10 (2019)
PermalinkInvestigating diagnostic bias in autism spectrum conditions: An item response theory analysis of sex bias in the AQ-10 / Aja Louise MURRAY in Autism Research, 10-5 (May 2017)
PermalinkInvestigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project / J. TILLMANN in Autism Research, 12-4 (April 2019)
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