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Auteur Martial MERMILLOD |
Documents disponibles écrits par cet auteur (5)



Cognitive flexibility in autism: How task predictability and sex influence performances / Adeline LACROIX ; Emma Torija ; Alexander Logemann ; Monica BACIU ; Renata CSERJESI ; Frédéric DUTHEIL ; Marie GOMOT ; Martial MERMILLOD in Autism Research, 18-2 (February 2025)
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[article]
inAutism Research > 18-2 (February 2025) . - p.281-294
Titre : Cognitive flexibility in autism: How task predictability and sex influence performances : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Adeline LACROIX, Auteur ; Emma Torija, Auteur ; Alexander Logemann, Auteur ; Monica BACIU, Auteur ; Renata CSERJESI, Auteur ; Frédéric DUTHEIL, Auteur ; Marie GOMOT, Auteur ; Martial MERMILLOD, Auteur Article en page(s) : p.281-294 Langues : Anglais (eng) Mots-clés : autism cognitive flexibility gender differences predictive brain sex differences Index. décimale : PER Périodiques Résumé : Abstract While cognitive flexibility challenges are frequently reported in autistic individuals, inconsistencies in the findings prompt further investigation into the factors influencing this flexibility. We suggest that unique aspects of the predictive brain in autistic individuals might contribute to these challenges, potentially varying by sex. Our study aimed to test these hypotheses by examining cognitive flexibility under different predictability conditions in a sample including a similar number of males and females. We conducted an online study with 263 adults (127 with an autism diagnosis), where participants completed a flexibility task under varying levels of predictability (unpredictable, moderately predictable, and predictable). Our results indicate that as task predictability increases, performance improves; however, the response time gap between autistic and non-autistic individuals also widens. Moreover, we observe significant differences between autistic males and females, which differ from non-autistic individuals, highlighting the need to consider sex differences in research related to the cognition of autistic individuals. Overall, our findings contribute to a better understanding of cognitive flexibility and sex differences in autism in light of predictive brain theories and suggest avenues for further research. En ligne : https://doi.org/10.1002/aur.3281 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Cognitive flexibility in autism: How task predictability and sex influence performances : Autism Research [Texte imprimé et/ou numérique] / Adeline LACROIX, Auteur ; Emma Torija, Auteur ; Alexander Logemann, Auteur ; Monica BACIU, Auteur ; Renata CSERJESI, Auteur ; Frédéric DUTHEIL, Auteur ; Marie GOMOT, Auteur ; Martial MERMILLOD, Auteur . - p.281-294.
Langues : Anglais (eng)
in Autism Research > 18-2 (February 2025) . - p.281-294
Mots-clés : autism cognitive flexibility gender differences predictive brain sex differences Index. décimale : PER Périodiques Résumé : Abstract While cognitive flexibility challenges are frequently reported in autistic individuals, inconsistencies in the findings prompt further investigation into the factors influencing this flexibility. We suggest that unique aspects of the predictive brain in autistic individuals might contribute to these challenges, potentially varying by sex. Our study aimed to test these hypotheses by examining cognitive flexibility under different predictability conditions in a sample including a similar number of males and females. We conducted an online study with 263 adults (127 with an autism diagnosis), where participants completed a flexibility task under varying levels of predictability (unpredictable, moderately predictable, and predictable). Our results indicate that as task predictability increases, performance improves; however, the response time gap between autistic and non-autistic individuals also widens. Moreover, we observe significant differences between autistic males and females, which differ from non-autistic individuals, highlighting the need to consider sex differences in research related to the cognition of autistic individuals. Overall, our findings contribute to a better understanding of cognitive flexibility and sex differences in autism in light of predictive brain theories and suggest avenues for further research. En ligne : https://doi.org/10.1002/aur.3281 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 Reduced spatial frequency differentiation and sex-related specificities in fearful face detection in autism: Insights from EEG and the predictive brain model / Sylvain HARQUEL ; Leonardo S. BARBOSA ; Klara KOVARSKI ; Marta I. GARRIDO ; Laurent VERCUEIL ; Louise KAUFFMANN ; Frédéric DUTHEIL ; Marie GOMOT ; Martial MERMILLOD in Autism Research, 17-9 (September 2024)
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[article]
inAutism Research > 17-9 (September 2024) . - p.1778-1795
Titre : Reduced spatial frequency differentiation and sex-related specificities in fearful face detection in autism: Insights from EEG and the predictive brain model Type de document : Texte imprimé et/ou numérique Auteurs : Sylvain HARQUEL, Auteur ; Leonardo S. BARBOSA, Auteur ; Klara KOVARSKI, Auteur ; Marta I. GARRIDO, Auteur ; Laurent VERCUEIL, Auteur ; Louise KAUFFMANN, Auteur ; Frédéric DUTHEIL, Auteur ; Marie GOMOT, Auteur ; Martial MERMILLOD, Auteur Article en page(s) : p.1778-1795 Langues : Anglais (eng) Mots-clés : autism EEG emotion recognition fusiform sex differences spatial frequencies Index. décimale : PER Périodiques Résumé : Abstract Face processing relies on predictive processes driven by low spatial frequencies (LSF) that convey coarse information prior to fine information conveyed by high spatial frequencies. However, autistic individuals might have atypical predictive processes, contributing to facial processing difficulties. This may be more normalized in autistic females, who often exhibit better socio-communicational abilities than males. We hypothesized that autistic females would display a more typical coarse-to-fine processing for socio-emotional stimuli compared to autistic males. To test this hypothesis, we asked adult participants (44 autistic, 51 non-autistic) to detect fearful faces among neutral faces, filtered in two orders: from coarse-to-fine (CtF) and from fine-to-coarse (FtC). Results show lower d? values and longer reaction times for fearful detection in autism compared to non-autistic (NA) individuals, regardless of the filtering order. Both groups presented shorter P100 latency after CtF compared to FtC, and larger amplitude for N170 after FtC compared to CtF. However, autistic participants presented a reduced difference in source activity between CtF and FtC in the fusiform. There was also a more spatially spread activation pattern in autistic females compared to NA females. Finally, females had faster P100 and N170 latencies, as well as larger occipital activation for FtC sequences than males, irrespective of the group. Overall, the results do not suggest impaired predictive processes from LSF in autism despite behavioral differences in fear detection. However, they do indicate reduced brain modulation by spatial frequency in autism. In addition, the findings highlight sex differences that warrant consideration in understanding autistic females. En ligne : https://doi.org/10.1002/aur.3209 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Reduced spatial frequency differentiation and sex-related specificities in fearful face detection in autism: Insights from EEG and the predictive brain model [Texte imprimé et/ou numérique] / Sylvain HARQUEL, Auteur ; Leonardo S. BARBOSA, Auteur ; Klara KOVARSKI, Auteur ; Marta I. GARRIDO, Auteur ; Laurent VERCUEIL, Auteur ; Louise KAUFFMANN, Auteur ; Frédéric DUTHEIL, Auteur ; Marie GOMOT, Auteur ; Martial MERMILLOD, Auteur . - p.1778-1795.
Langues : Anglais (eng)
in Autism Research > 17-9 (September 2024) . - p.1778-1795
Mots-clés : autism EEG emotion recognition fusiform sex differences spatial frequencies Index. décimale : PER Périodiques Résumé : Abstract Face processing relies on predictive processes driven by low spatial frequencies (LSF) that convey coarse information prior to fine information conveyed by high spatial frequencies. However, autistic individuals might have atypical predictive processes, contributing to facial processing difficulties. This may be more normalized in autistic females, who often exhibit better socio-communicational abilities than males. We hypothesized that autistic females would display a more typical coarse-to-fine processing for socio-emotional stimuli compared to autistic males. To test this hypothesis, we asked adult participants (44 autistic, 51 non-autistic) to detect fearful faces among neutral faces, filtered in two orders: from coarse-to-fine (CtF) and from fine-to-coarse (FtC). Results show lower d? values and longer reaction times for fearful detection in autism compared to non-autistic (NA) individuals, regardless of the filtering order. Both groups presented shorter P100 latency after CtF compared to FtC, and larger amplitude for N170 after FtC compared to CtF. However, autistic participants presented a reduced difference in source activity between CtF and FtC in the fusiform. There was also a more spatially spread activation pattern in autistic females compared to NA females. Finally, females had faster P100 and N170 latencies, as well as larger occipital activation for FtC sequences than males, irrespective of the group. Overall, the results do not suggest impaired predictive processes from LSF in autism despite behavioral differences in fear detection. However, they do indicate reduced brain modulation by spatial frequency in autism. In addition, the findings highlight sex differences that warrant consideration in understanding autistic females. En ligne : https://doi.org/10.1002/aur.3209 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 Repérage des situations anxiogènes chez les personnes avec autisme: détection de rupture dans un milieu écologique / Cédric HUFNAGEL in Bulletin Scientifique de l'arapi (Le), 37 (Eté 2016)
[article]
inBulletin Scientifique de l'arapi (Le) > 37 (Eté 2016) . - p.51-
Titre : Repérage des situations anxiogènes chez les personnes avec autisme: détection de rupture dans un milieu écologique Type de document : Texte imprimé et/ou numérique Auteurs : Cédric HUFNAGEL, Auteur ; Patrick CHAMBRES, Auteur ; Frédéric DUTHEIL, Auteur ; Catherine AUXIETTE, Auteur ; Pierre CHAUSSE, Auteur ; Martial MERMILLOD, Auteur ; Guillaume PAUGAM, Auteur ; Pierre Raphaël BERTRAND, Auteur Année de publication : 2016 Article en page(s) : p.51- Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 [article] Repérage des situations anxiogènes chez les personnes avec autisme: détection de rupture dans un milieu écologique [Texte imprimé et/ou numérique] / Cédric HUFNAGEL, Auteur ; Patrick CHAMBRES, Auteur ; Frédéric DUTHEIL, Auteur ; Catherine AUXIETTE, Auteur ; Pierre CHAUSSE, Auteur ; Martial MERMILLOD, Auteur ; Guillaume PAUGAM, Auteur ; Pierre Raphaël BERTRAND, Auteur . - 2016 . - p.51-.
Langues : Français (fre)
in Bulletin Scientifique de l'arapi (Le) > 37 (Eté 2016) . - p.51-
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 Troubles psychiatriques et stimulation cérébrale profonde : perspectives de recherche clinique et fondamentale / Martial MERMILLOD
Titre : Troubles psychiatriques et stimulation cérébrale profonde : perspectives de recherche clinique et fondamentale Type de document : Texte imprimé et/ou numérique Auteurs : Martial MERMILLOD, Auteur ; Fabienne GALLAND, Auteur ; Laurie MONDILLON, Auteur ; Franck DURIF, Auteur ; Isabelle CHEREAU, Auteur ; Isabelle JALENQUES, Auteur Année de publication : 2008 Importance : p.231-261 Langues : Français (fre) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=746 Troubles psychiatriques et stimulation cérébrale profonde : perspectives de recherche clinique et fondamentale [Texte imprimé et/ou numérique] / Martial MERMILLOD, Auteur ; Fabienne GALLAND, Auteur ; Laurie MONDILLON, Auteur ; Franck DURIF, Auteur ; Isabelle CHEREAU, Auteur ; Isabelle JALENQUES, Auteur . - 2008 . - p.231-261.
Langues : Français (fre)
Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=746 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context matters / Yoann BENNETOT-DEVERIA ; Monica BACIU ; Frédéric DUTHEIL ; Valentin MAGNON ; Marie GOMOT ; Martial MERMILLOD in Molecular Autism, 15 (2024)
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[article]
inMolecular Autism > 15 (2024) . - 49
Titre : Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context matters Type de document : Texte imprimé et/ou numérique Auteurs : Yoann BENNETOT-DEVERIA, Auteur ; Monica BACIU, Auteur ; Frédéric DUTHEIL, Auteur ; Valentin MAGNON, Auteur ; Marie GOMOT, Auteur ; Martial MERMILLOD, Auteur Article en page(s) : 49 Langues : Anglais (eng) Mots-clés : Humans Male Female *Emotions Adult *Autistic Disorder/psychology *Cognition Young Adult Social Behavior Social Environment Autism Emotional processing Flexibility Gender differences Predictive coding Sex differences Social processing study, participants were presented with an informed consent form, which they had to approve before proceeding. All procedures performed in this study involving human participants were conducted in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki) and the study was approved by the local ethics committee (CER-Grenoble Alpes, COMUE University Grenoble Alpes, IRB00010290). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals often have difficulty flexibly adjusting their behavior. However, laboratory experiments have yielded inconsistent results, potentially due to various influencing factors, which need to be examined in detail. This study aimed to investigate the hypothesis that the social content of stimuli could play a specific role in some of the flexibility challenges faced by autistic individuals. The second aim was to explore sex differences in this context. METHODS: We analyzed data from 256 adult participants (124 with autism), matched on age, gender, and sex, who performed an emotional shifting task involving unpredictable shifts between positive and negative stimuli. Additionally, the task included both social and non-social conditions. RESULTS: Our results revealed a larger switch cost in the social than in the non-social condition, and this was more pronounced in autistic than in non-autistic individuals. Furthermore, we observed that autistic females differed from autistic males in the non-social condition and from non-autistic females in the social condition. LIMITATIONS: The online nature of the study reduced the control over participant conditions. In addition, further studies are needed to investigate whether these results apply to the broader autism spectrum. CONCLUSIONS: Building on previous research demonstrating a greater switch cost in autistic than non-autistic individuals for socio-emotional stimuli, our study further extends these findings by highlighting that the social context, rather than the emotional nature of the stimuli alone, may play a significant role in the flexibility challenges faced by autistic individuals. Our findings also contribute to the literature on sex differences in autism. En ligne : https://dx.doi.org/10.1186/s13229-024-00622-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context matters [Texte imprimé et/ou numérique] / Yoann BENNETOT-DEVERIA, Auteur ; Monica BACIU, Auteur ; Frédéric DUTHEIL, Auteur ; Valentin MAGNON, Auteur ; Marie GOMOT, Auteur ; Martial MERMILLOD, Auteur . - 49.
Langues : Anglais (eng)
in Molecular Autism > 15 (2024) . - 49
Mots-clés : Humans Male Female *Emotions Adult *Autistic Disorder/psychology *Cognition Young Adult Social Behavior Social Environment Autism Emotional processing Flexibility Gender differences Predictive coding Sex differences Social processing study, participants were presented with an informed consent form, which they had to approve before proceeding. All procedures performed in this study involving human participants were conducted in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki) and the study was approved by the local ethics committee (CER-Grenoble Alpes, COMUE University Grenoble Alpes, IRB00010290). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals often have difficulty flexibly adjusting their behavior. However, laboratory experiments have yielded inconsistent results, potentially due to various influencing factors, which need to be examined in detail. This study aimed to investigate the hypothesis that the social content of stimuli could play a specific role in some of the flexibility challenges faced by autistic individuals. The second aim was to explore sex differences in this context. METHODS: We analyzed data from 256 adult participants (124 with autism), matched on age, gender, and sex, who performed an emotional shifting task involving unpredictable shifts between positive and negative stimuli. Additionally, the task included both social and non-social conditions. RESULTS: Our results revealed a larger switch cost in the social than in the non-social condition, and this was more pronounced in autistic than in non-autistic individuals. Furthermore, we observed that autistic females differed from autistic males in the non-social condition and from non-autistic females in the social condition. LIMITATIONS: The online nature of the study reduced the control over participant conditions. In addition, further studies are needed to investigate whether these results apply to the broader autism spectrum. CONCLUSIONS: Building on previous research demonstrating a greater switch cost in autistic than non-autistic individuals for socio-emotional stimuli, our study further extends these findings by highlighting that the social context, rather than the emotional nature of the stimuli alone, may play a significant role in the flexibility challenges faced by autistic individuals. Our findings also contribute to the literature on sex differences in autism. En ligne : https://dx.doi.org/10.1186/s13229-024-00622-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555