Beyond comorbidity: Toward a dimensional and hierarchical approach to understanding psychopathology across the life span / Miriam K. FORBES in Development and Psychopathology, 28-4 pt1 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt1 (November 2016) . - p.971-986 Titre : Beyond comorbidity: Toward a dimensional and hierarchical approach to understanding psychopathology across the life span Type de document : Texte imprimé et/ou numérique Auteurs : Miriam K. FORBES, Auteur ; Jennifer L. TACKETT, Auteur ; Kristian E. MARKON, Auteur ; Robert F. KRUEGER, Auteur Article en page(s) : p.971-986 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We propose a novel developmentally informed framework to push research beyond a focus on comorbidity between discrete diagnostic categories and to move toward research based on the well-validated dimensional and hierarchical structure of psychopathology. For example, a large body of research speaks to the validity and utility of the internalizing and externalizing spectra as organizing constructs for research on common forms of psychopathology. The internalizing and externalizing spectra act as powerful explanatory variables that channel the psychopathological effects of genetic and environmental risk factors, predict adaptive functioning, and account for the likelihood of disorder-level manifestations of psychopathology. As such, our proposed theoretical framework uses the internalizing and externalizing spectra as central constructs to guide future psychopathology research across the life span. The framework is particularly flexible, because any of the facets or factors from the dimensional and hierarchical structure of psychopathology can form the focus of research. We describe the utility and strengths of this framework for developmental psychopathology in particular and explore avenues for future research. En ligne : http://dx.doi.org/10.1017/s0954579416000651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Beyond comorbidity: Toward a dimensional and hierarchical approach to understanding psychopathology across the life span [Texte imprimé et/ou numérique] / Miriam K. FORBES, Auteur ; Jennifer L. TACKETT, Auteur ; Kristian E. MARKON, Auteur ; Robert F. KRUEGER, Auteur . - p.971-986. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt1 (November 2016) . - p.971-986 Index. décimale : PER Périodiques Résumé : We propose a novel developmentally informed framework to push research beyond a focus on comorbidity between discrete diagnostic categories and to move toward research based on the well-validated dimensional and hierarchical structure of psychopathology. For example, a large body of research speaks to the validity and utility of the internalizing and externalizing spectra as organizing constructs for research on common forms of psychopathology. The internalizing and externalizing spectra act as powerful explanatory variables that channel the psychopathological effects of genetic and environmental risk factors, predict adaptive functioning, and account for the likelihood of disorder-level manifestations of psychopathology. As such, our proposed theoretical framework uses the internalizing and externalizing spectra as central constructs to guide future psychopathology research across the life span. The framework is particularly flexible, because any of the facets or factors from the dimensional and hierarchical structure of psychopathology can form the focus of research. We describe the utility and strengths of this framework for developmental psychopathology in particular and explore avenues for future research. En ligne : http://dx.doi.org/10.1017/s0954579416000651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

The relationship between brain structure and general psychopathology in preadolescents / Louise MEWTON in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.734-744 Titre : The relationship between brain structure and general psychopathology in preadolescents Type de document : Texte imprimé et/ou numérique Auteurs : Louise MEWTON, Auteur ; Briana LEES, Auteur ; Lindsay M. SQUEGLIA, Auteur ; Miriam K. FORBES, Auteur ; Matthew SUNDERLAND, Auteur ; Robert F. KRUEGER, Auteur ; Forrest C. KOCH, Auteur ; Andrew BAILLIE, Auteur ; Tim SLADE, Auteur ; Nicholas HOY, Auteur ; Maree TEESSON, Auteur Article en page(s) : p.734-744 Langues : Anglais (eng) Mots-clés : Adolescent  Bayes Theorem  Brain  Child  Cognition  Humans  Male  Mental Disorders/psychology  Psychopathology  Generalized psychopathology  brain structure  externalizing  internalizing  preadolescence  interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: An emerging body of literature has indicated that broad, transdiagnostic dimensions of psychopathology are associated with alterations in brain structure across the life span. The current study aimed to investigate the relationship between brain structure and broad dimensions of psychopathology in the critical preadolescent period when psychopathology is emerging. METHODS: This study included baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study(®) (n=11,875; age range=9-10?years; male=52.2%). General psychopathology, externalizing, internalizing, and thought disorder dimensions were based on a higher-order model of psychopathology and estimated using Bayesian plausible values. Outcome variables included global and regional cortical volume, thickness, and surface area. RESULTS: Higher levels of psychopathology across all dimensions were associated with lower volume and surface area globally, as well as widespread and pervasive alterations across the majority of cortical and subcortical regions studied, after adjusting for sex, race/ethnicity, parental education, income, and maternal psychopathology. The relationships between general psychopathology and brain structure were attenuated when adjusting for cognitive functioning. There were no statistically significant relationships between psychopathology and cortical thickness in this sample of preadolescents. CONCLUSIONS: The current study identified lower cortical volume and surface area as transdiagnostic biomarkers for general psychopathology in preadolescence. Future research may focus on whether the widespread and pervasive relationships between general psychopathology and brain structure reflect cognitive dysfunction that is a feature across a range of mental illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.13513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] The relationship between brain structure and general psychopathology in preadolescents [Texte imprimé et/ou numérique] / Louise MEWTON, Auteur ; Briana LEES, Auteur ; Lindsay M. SQUEGLIA, Auteur ; Miriam K. FORBES, Auteur ; Matthew SUNDERLAND, Auteur ; Robert F. KRUEGER, Auteur ; Forrest C. KOCH, Auteur ; Andrew BAILLIE, Auteur ; Tim SLADE, Auteur ; Nicholas HOY, Auteur ; Maree TEESSON, Auteur . - p.734-744. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.734-744 Mots-clés : Adolescent  Bayes Theorem  Brain  Child  Cognition  Humans  Male  Mental Disorders/psychology  Psychopathology  Generalized psychopathology  brain structure  externalizing  internalizing  preadolescence  interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: An emerging body of literature has indicated that broad, transdiagnostic dimensions of psychopathology are associated with alterations in brain structure across the life span. The current study aimed to investigate the relationship between brain structure and broad dimensions of psychopathology in the critical preadolescent period when psychopathology is emerging. METHODS: This study included baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study(®) (n=11,875; age range=9-10?years; male=52.2%). General psychopathology, externalizing, internalizing, and thought disorder dimensions were based on a higher-order model of psychopathology and estimated using Bayesian plausible values. Outcome variables included global and regional cortical volume, thickness, and surface area. RESULTS: Higher levels of psychopathology across all dimensions were associated with lower volume and surface area globally, as well as widespread and pervasive alterations across the majority of cortical and subcortical regions studied, after adjusting for sex, race/ethnicity, parental education, income, and maternal psychopathology. The relationships between general psychopathology and brain structure were attenuated when adjusting for cognitive functioning. There were no statistically significant relationships between psychopathology and cortical thickness in this sample of preadolescents. CONCLUSIONS: The current study identified lower cortical volume and surface area as transdiagnostic biomarkers for general psychopathology in preadolescence. Future research may focus on whether the widespread and pervasive relationships between general psychopathology and brain structure reflect cognitive dysfunction that is a feature across a range of mental illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.13513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

The role of parental marital discord in the etiology of externalizing problems during childhood and adolescence / Amber M. JARNECKE in Development and Psychopathology, 29-4 (October 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-4 (October 2017) . - p.1177-1188 Titre : The role of parental marital discord in the etiology of externalizing problems during childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Amber M. JARNECKE, Auteur ; Susan C. SOUTH, Auteur ; Irene J. ELKINS, Auteur ; Robert F. KRUEGER, Auteur ; Erin C. TULLY, Auteur ; William G. IACONO, Auteur Article en page(s) : p.1177-1188 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Previous research has established that parental marital discord is associated with higher levels of offspring externalizing behaviors, but it is unclear how parental relationship functioning is associated with the genetic and environmental variance on a factor of externalizing problems. Thus, the current study assessed how parental marital discord moderates genetic and environmental variance on offspring externalizing problems at two different ages: childhood and late adolescence. That is, the magnitude of genetic and environmental influences on offspring externalizing at ages 11 and 17 was examined as a function of parental marital discord. Consistent with a diathesis–stress model of psychopathology, it was hypothesized that with increasing marital discord, genetic influences on externalizing would be more pronounced. Rather, results indicated that for the 11-year-old sample, nonshared environmental influences were greater when parental marital discord was low, and comparatively, shared environmental influences contributed more to the variance in externalizing problems when parental marital discord was high. No moderation was found for the 17-year-old cohort. In contrast to studies that do not find an effect of the shared environment, these results provide evidence that the common rearing environment has an impact on externalizing problems in preadolescent children. En ligne : http://dx.doi.org/10.1017/s095457941600122x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=312 [article] The role of parental marital discord in the etiology of externalizing problems during childhood and adolescence [Texte imprimé et/ou numérique] / Amber M. JARNECKE, Auteur ; Susan C. SOUTH, Auteur ; Irene J. ELKINS, Auteur ; Robert F. KRUEGER, Auteur ; Erin C. TULLY, Auteur ; William G. IACONO, Auteur . - p.1177-1188. Langues : Anglais (eng) in Development and Psychopathology > 29-4 (October 2017) . - p.1177-1188 Index. décimale : PER Périodiques Résumé : Abstract Previous research has established that parental marital discord is associated with higher levels of offspring externalizing behaviors, but it is unclear how parental relationship functioning is associated with the genetic and environmental variance on a factor of externalizing problems. Thus, the current study assessed how parental marital discord moderates genetic and environmental variance on offspring externalizing problems at two different ages: childhood and late adolescence. That is, the magnitude of genetic and environmental influences on offspring externalizing at ages 11 and 17 was examined as a function of parental marital discord. Consistent with a diathesis–stress model of psychopathology, it was hypothesized that with increasing marital discord, genetic influences on externalizing would be more pronounced. Rather, results indicated that for the 11-year-old sample, nonshared environmental influences were greater when parental marital discord was low, and comparatively, shared environmental influences contributed more to the variance in externalizing problems when parental marital discord was high. No moderation was found for the 17-year-old cohort. In contrast to studies that do not find an effect of the shared environment, these results provide evidence that the common rearing environment has an impact on externalizing problems in preadolescent children. En ligne : http://dx.doi.org/10.1017/s095457941600122x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=312

Towards a contemporary approach for understanding personality pathology in developmental context: An integrative model / Melody R. ALTSCHULER in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1793-1802 Titre : Towards a contemporary approach for understanding personality pathology in developmental context: An integrative model Type de document : Texte imprimé et/ou numérique Auteurs : Melody R. ALTSCHULER, Auteur ; Robert F. KRUEGER, Auteur Article en page(s) : p.1793-1802 Langues : Anglais (eng) Mots-clés : development  dimension  personality disorders  personality pathology  Research Domain Criteria (RDoC) Index. décimale : PER Périodiques Résumé : Traditional categorical approaches to classifying personality disorders are limited in important ways, leading to a shift in the field to dimensional approaches to conceptualizing personality pathology. Different areas of psychology – personality, developmental, and psychopathology – can be leveraged to understand personality pathology by examining its structure, development, and underlying mechanisms. However, an integrative model that encompasses these distinct lines of inquiry has not yet been proposed. In order to address this gap, we review the latest evidence for dimensional classification of personality disorders based on structural models of maladaptive personality traits, provide an overview of developmental theories of pathological personality, and summarize the Research Domain Criteria (RDoC) initiative, which seeks to understand underlying mechanisms of psychopathology. We conclude by proposing an integrative model of personality pathology development that aims to elucidate the developmental pathways of personality pathology and its underlying mechanisms. En ligne : http://dx.doi.org/10.1017/S0954579421000869 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Towards a contemporary approach for understanding personality pathology in developmental context: An integrative model [Texte imprimé et/ou numérique] / Melody R. ALTSCHULER, Auteur ; Robert F. KRUEGER, Auteur . - p.1793-1802. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1793-1802 Mots-clés : development  dimension  personality disorders  personality pathology  Research Domain Criteria (RDoC) Index. décimale : PER Périodiques Résumé : Traditional categorical approaches to classifying personality disorders are limited in important ways, leading to a shift in the field to dimensional approaches to conceptualizing personality pathology. Different areas of psychology – personality, developmental, and psychopathology – can be leveraged to understand personality pathology by examining its structure, development, and underlying mechanisms. However, an integrative model that encompasses these distinct lines of inquiry has not yet been proposed. In order to address this gap, we review the latest evidence for dimensional classification of personality disorders based on structural models of maladaptive personality traits, provide an overview of developmental theories of pathological personality, and summarize the Research Domain Criteria (RDoC) initiative, which seeks to understand underlying mechanisms of psychopathology. We conclude by proposing an integrative model of personality pathology development that aims to elucidate the developmental pathways of personality pathology and its underlying mechanisms. En ligne : http://dx.doi.org/10.1017/S0954579421000869 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Trait neuroticism and emotion neurocircuitry: Functional magnetic resonance imaging evidence for a failure in emotion regulation / Merav H. SILVERMAN in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.1085-1099 Titre : Trait neuroticism and emotion neurocircuitry: Functional magnetic resonance imaging evidence for a failure in emotion regulation Type de document : Texte imprimé et/ou numérique Auteurs : Merav H. SILVERMAN, Auteur ; Sylia WILSON, Auteur ; Ian S. RAMSAY, Auteur ; Ruskin H. HUNT, Auteur ; Kathleen M. THOMAS, Auteur ; Robert F. KRUEGER, Auteur ; William G. IACONO, Auteur Article en page(s) : p.1085-1099 Langues : Anglais (eng) Mots-clés : amygdala  emotion dysregulation  functional magnetic resonance imaging  negative emotion processing  neuroticism Index. décimale : PER Périodiques Résumé : Though theory suggests that individual differences in neuroticism (a tendency to experience negative emotions) would be associated with altered functioning of the amygdala (which has been linked with emotionality and emotion dysregulation in childhood, adolescence, and adulthood), results of functional neuroimaging studies have been contradictory and inconclusive. We aimed to clarify the relationship between neuroticism and three hypothesized neural markers derived from functional magnetic resonance imaging during negative emotion face processing: amygdala activation, amygdala habituation, and amygdala-prefrontal connectivity, each of which plays an important role in the experience and regulation of emotions. We used general linear models to examine the relationship between trait neuroticism and the hypothesized neural markers in a large sample of over 500 young adults. Although neuroticism was not significantly associated with magnitude of amygdala activation or amygdala habituation, it was associated with amygdala–ventromedial prefrontal cortex connectivity, which has been implicated in emotion regulation. Results suggest that trait neuroticism may represent a failure in top-down control and regulation of emotional reactions, rather than overactive emotion generation processes, per se. These findings suggest that neuroticism, which has been associated with increased rates of transdiagnostic psychopathology, may represent a failure in the inhibitory neurocircuitry associated with emotion regulation. En ligne : http://dx.doi.org/10.1017/S0954579419000610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Trait neuroticism and emotion neurocircuitry: Functional magnetic resonance imaging evidence for a failure in emotion regulation [Texte imprimé et/ou numérique] / Merav H. SILVERMAN, Auteur ; Sylia WILSON, Auteur ; Ian S. RAMSAY, Auteur ; Ruskin H. HUNT, Auteur ; Kathleen M. THOMAS, Auteur ; Robert F. KRUEGER, Auteur ; William G. IACONO, Auteur . - p.1085-1099. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.1085-1099 Mots-clés : amygdala  emotion dysregulation  functional magnetic resonance imaging  negative emotion processing  neuroticism Index. décimale : PER Périodiques Résumé : Though theory suggests that individual differences in neuroticism (a tendency to experience negative emotions) would be associated with altered functioning of the amygdala (which has been linked with emotionality and emotion dysregulation in childhood, adolescence, and adulthood), results of functional neuroimaging studies have been contradictory and inconclusive. We aimed to clarify the relationship between neuroticism and three hypothesized neural markers derived from functional magnetic resonance imaging during negative emotion face processing: amygdala activation, amygdala habituation, and amygdala-prefrontal connectivity, each of which plays an important role in the experience and regulation of emotions. We used general linear models to examine the relationship between trait neuroticism and the hypothesized neural markers in a large sample of over 500 young adults. Although neuroticism was not significantly associated with magnitude of amygdala activation or amygdala habituation, it was associated with amygdala–ventromedial prefrontal cortex connectivity, which has been implicated in emotion regulation. Results suggest that trait neuroticism may represent a failure in top-down control and regulation of emotional reactions, rather than overactive emotion generation processes, per se. These findings suggest that neuroticism, which has been associated with increased rates of transdiagnostic psychopathology, may represent a failure in the inhibitory neurocircuitry associated with emotion regulation. En ligne : http://dx.doi.org/10.1017/S0954579419000610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Triarchic conceptualization of psychopathy: Developmental origins of disinhibition, boldness, and meanness / Christopher J. PATRICK in Development and Psychopathology, 21-3 (August 2009)  

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A unifying perspective on personality pathology across the life span: Developmental considerations for the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders / Jennifer L. TACKETT in Development and Psychopathology, 21-3 (August 2009)  

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