Dépouillements

Impaired antioxidant status and reduced energy metabolism in autistic children / M. M. ESSA in Research in Autism Spectrum Disorders, 7-5 (May 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-5 (May 2013) . - p.557-565 Titre : Impaired antioxidant status and reduced energy metabolism in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : M. M. ESSA, Auteur ; N. BRAIDY, Auteur ; M. I. WALY, Auteur ; Yahya M. AL-FARSI, Auteur ; Marwan M. AL-SHARBATI, Auteur ; S. SUBASH, Auteur ; A. AMANAT, Auteur ; M. A. AL-SHAFFAEE, Auteur ; G. J. GUILLEMIN, Auteur Article en page(s) : p.557-565 Mots-clés : Autism  ATP  Oxidative stress  NAD+  Antioxidants Index. décimale : PER Périodiques Résumé : Accumulating evidence suggests that oxidative stress induced mechanisms are believed to be associated with the pathophysiology of autism. In this study, we recruited 19 Omani autistic children with age-matched controls to analyze their plasma and serum redox status and the levels of ATP, NAD+ and NADH using well established spectrophotometric assays. A significant decrease was observed in the levels of plasma total antioxidants (TA), reduced glutathione (GSH), superoxide and catalase activity in Omani autistic children as compared to their age-matched controls. In contrary, the level of plasma glutathione peroxidase (GSH-Px) was significantly increased in autistic children. Reduced serum NAD+ and ATP levels and lower NAD+:NADH ratio were observedin patients with autism compared to controls. Finally, a significant inverse correlation was observed between plasma GSH, SOD, catalase activity, and serum NAD+ and ATP levels, and autism severity using Childhood Autism Rating Scale (CARS) scores. The levels of plasma GSH-Px and serum NADH correlated strongly with autism severity whilst no significant correlation was observed for plasma TA. Our data suggests that increased vulnerability to oxidative stress in autism may occur as a consequence of alterations in antioxidant enzymes leading to mitochondrial dysfunction. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] Impaired antioxidant status and reduced energy metabolism in autistic children [Texte imprimé et/ou numérique] / M. M. ESSA, Auteur ; N. BRAIDY, Auteur ; M. I. WALY, Auteur ; Yahya M. AL-FARSI, Auteur ; Marwan M. AL-SHARBATI, Auteur ; S. SUBASH, Auteur ; A. AMANAT, Auteur ; M. A. AL-SHAFFAEE, Auteur ; G. J. GUILLEMIN, Auteur . - p.557-565. in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.557-565 Mots-clés : Autism  ATP  Oxidative stress  NAD+  Antioxidants Index. décimale : PER Périodiques Résumé : Accumulating evidence suggests that oxidative stress induced mechanisms are believed to be associated with the pathophysiology of autism. In this study, we recruited 19 Omani autistic children with age-matched controls to analyze their plasma and serum redox status and the levels of ATP, NAD+ and NADH using well established spectrophotometric assays. A significant decrease was observed in the levels of plasma total antioxidants (TA), reduced glutathione (GSH), superoxide and catalase activity in Omani autistic children as compared to their age-matched controls. In contrary, the level of plasma glutathione peroxidase (GSH-Px) was significantly increased in autistic children. Reduced serum NAD+ and ATP levels and lower NAD+:NADH ratio were observedin patients with autism compared to controls. Finally, a significant inverse correlation was observed between plasma GSH, SOD, catalase activity, and serum NAD+ and ATP levels, and autism severity using Childhood Autism Rating Scale (CARS) scores. The levels of plasma GSH-Px and serum NADH correlated strongly with autism severity whilst no significant correlation was observed for plasma TA. Our data suggests that increased vulnerability to oxidative stress in autism may occur as a consequence of alterations in antioxidant enzymes leading to mitochondrial dysfunction. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194

Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders / Irina MANOUILENKO in Research in Autism Spectrum Disorders, 7-5 (May 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-5 (May 2013) . - p.566-578 Titre : Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Irina MANOUILENKO, Auteur ; Marco PAGANI, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Fredrik BROLIN, Auteur ; Robert HATHERLY, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur Article en page(s) : p.566-578 Mots-clés : Autism spectrum disorder  ADHD  Neurological soft signs  Temporo-parietal junction  Thalamus  Caudate Index. décimale : PER Périodiques Résumé : The resting regional cerebral blood flow (rCBF) patterns related to co-occurring symptoms such as inattention, hyperactivity, neurological soft signs and motor problems have not yet been disclosed in autism spectrum disorders (ASD). In this study thirteen adults with ASD and ten matched neurotypical controls underwent PET. The scores of rating scales for autistic traits, attention deficit hyperactivity disorder (ADHD) and neurological soft signs were included in a factorial analysis and correlated with rCBF. Factors corresponding to “autistic/ADHD traits”, “sensory-motor integration” and “Intelligence/Motor sequencing” were identified. In the ASD group, positive correlations with CBF were found for “autistic/ADHD traits” in caudate bilaterally and the inferior parietal lobule, for “sensory-motor integration” in parieto-occipital cortex and for “Intelligence/Motor sequencing” in the right temporal cortex. Notably, CBF in the left thalamus correlated negatively with all three factors. Autistic traits and ADHD symptoms were associated with shared neural substrates. The correlation between “autistic/ADHD traits” and rCBF in the caudate is possibly associated with the executive impairments and ritualistic/stereotyped behaviors apparent in ASD. Furthermore, sensory-motor deficits were correlated with rCBF in the occipital visual cortex, involved in atypical visual perception in ASD. Various behavioral and neurological symptoms are suggested to converge into the ASD phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Irina MANOUILENKO, Auteur ; Marco PAGANI, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Fredrik BROLIN, Auteur ; Robert HATHERLY, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur . - p.566-578. in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.566-578 Mots-clés : Autism spectrum disorder  ADHD  Neurological soft signs  Temporo-parietal junction  Thalamus  Caudate Index. décimale : PER Périodiques Résumé : The resting regional cerebral blood flow (rCBF) patterns related to co-occurring symptoms such as inattention, hyperactivity, neurological soft signs and motor problems have not yet been disclosed in autism spectrum disorders (ASD). In this study thirteen adults with ASD and ten matched neurotypical controls underwent PET. The scores of rating scales for autistic traits, attention deficit hyperactivity disorder (ADHD) and neurological soft signs were included in a factorial analysis and correlated with rCBF. Factors corresponding to “autistic/ADHD traits”, “sensory-motor integration” and “Intelligence/Motor sequencing” were identified. In the ASD group, positive correlations with CBF were found for “autistic/ADHD traits” in caudate bilaterally and the inferior parietal lobule, for “sensory-motor integration” in parieto-occipital cortex and for “Intelligence/Motor sequencing” in the right temporal cortex. Notably, CBF in the left thalamus correlated negatively with all three factors. Autistic traits and ADHD symptoms were associated with shared neural substrates. The correlation between “autistic/ADHD traits” and rCBF in the caudate is possibly associated with the executive impairments and ritualistic/stereotyped behaviors apparent in ASD. Furthermore, sensory-motor deficits were correlated with rCBF in the occipital visual cortex, involved in atypical visual perception in ASD. Various behavioral and neurological symptoms are suggested to converge into the ASD phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194

What is available for case identification in autism research in mainland China? / Xiang SUN in Research in Autism Spectrum Disorders, 7-5 (May 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-5 (May 2013) . - p.579-590 Titre : What is available for case identification in autism research in mainland China? Type de document : Texte imprimé et/ou numérique Auteurs : Xiang SUN, Auteur ; Carrie ALLISON, Auteur ; Bonnie AUYEUNG, Auteur ; Fiona E. MATTHEWS, Auteur ; Simon BARON-COHEN, Auteur ; Carol BRAYNE, Auteur Article en page(s) : p.579-590 Mots-clés : Autism  Screening instrument  Diagnostic instrument  Mainland China Index. décimale : PER Périodiques Résumé : Little is known about research on Autism Spectrum Conditions (ASC) in mainland China. The few available studies in mainland China have shown the screening and diagnostic instruments for ASC used in mainland China were different from the West. Literature on screening and diagnostic instruments and criteria were reviewed and current available instruments were identified and evaluated. Eight screening instruments and two diagnostic instruments were identified. The Clancy Autism Behaviour Scale (CABS), the Autism Behaviour Checklist (ABC) and the Childhood Autism Rating Scale (CARS) were the most frequently used instruments in mainland China. They were adopted from the West more than two decades ago for detecting individuals with Childhood Autism but not the whole autism spectrum. Standardised instruments need to be validated and adopted into autism research in mainland China. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.11.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] What is available for case identification in autism research in mainland China? [Texte imprimé et/ou numérique] / Xiang SUN, Auteur ; Carrie ALLISON, Auteur ; Bonnie AUYEUNG, Auteur ; Fiona E. MATTHEWS, Auteur ; Simon BARON-COHEN, Auteur ; Carol BRAYNE, Auteur . - p.579-590. in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.579-590 Mots-clés : Autism  Screening instrument  Diagnostic instrument  Mainland China Index. décimale : PER Périodiques Résumé : Little is known about research on Autism Spectrum Conditions (ASC) in mainland China. The few available studies in mainland China have shown the screening and diagnostic instruments for ASC used in mainland China were different from the West. Literature on screening and diagnostic instruments and criteria were reviewed and current available instruments were identified and evaluated. Eight screening instruments and two diagnostic instruments were identified. The Clancy Autism Behaviour Scale (CABS), the Autism Behaviour Checklist (ABC) and the Childhood Autism Rating Scale (CARS) were the most frequently used instruments in mainland China. They were adopted from the West more than two decades ago for detecting individuals with Childhood Autism but not the whole autism spectrum. Standardised instruments need to be validated and adopted into autism research in mainland China. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.11.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194

Screening accuracy for risk of autism spectrum disorder using the Brief Infant-Toddler Social and Emotional Assessment (BITSEA) / Lauren M. GARDNER in Research in Autism Spectrum Disorders, 7-5 (May 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-5 (May 2013) . - p.591-600 Titre : Screening accuracy for risk of autism spectrum disorder using the Brief Infant-Toddler Social and Emotional Assessment (BITSEA) Type de document : Texte imprimé et/ou numérique Auteurs : Lauren M. GARDNER, Auteur ; Laura MURPHY, Auteur ; Jonathan M. CAMPBELL, Auteur ; Frances TYLAVSKY, Auteur ; Frederick B. PALMER, Auteur ; J. Carolyn GRAFF, Auteur Article en page(s) : p.591-600 Mots-clés : Autism spectrum disorders  Developmental screening  BITSEA  M-CHAT Index. décimale : PER Périodiques Résumé : Early identification of autism spectrum disorders (ASDs) is facilitated by the use of standardized screening scales that assess the social emotional behaviors associated with ASD. Authors examined accuracy of Brief Infant-Toddler Social and Emotional Assessment (BITSEA) subscales in detecting Modified Checklist for Autism in Toddlers (M-CHAT) risk for 456 toddlers. An ASD-specific screener, Total ASD, was developed from BITSEA subscales incorporating both behavioral and social communicative features of ASD. Results indicated that Total ASD is more accurate in detecting autism risk than scales measuring general behavior problems or social competence. Results provide support for the BITSEA as a Level I screener for social emotional problems and a Level II screener for ASD symptoms at community sites such as well child clinics. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.01.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] Screening accuracy for risk of autism spectrum disorder using the Brief Infant-Toddler Social and Emotional Assessment (BITSEA) [Texte imprimé et/ou numérique] / Lauren M. GARDNER, Auteur ; Laura MURPHY, Auteur ; Jonathan M. CAMPBELL, Auteur ; Frances TYLAVSKY, Auteur ; Frederick B. PALMER, Auteur ; J. Carolyn GRAFF, Auteur . - p.591-600. in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.591-600 Mots-clés : Autism spectrum disorders  Developmental screening  BITSEA  M-CHAT Index. décimale : PER Périodiques Résumé : Early identification of autism spectrum disorders (ASDs) is facilitated by the use of standardized screening scales that assess the social emotional behaviors associated with ASD. Authors examined accuracy of Brief Infant-Toddler Social and Emotional Assessment (BITSEA) subscales in detecting Modified Checklist for Autism in Toddlers (M-CHAT) risk for 456 toddlers. An ASD-specific screener, Total ASD, was developed from BITSEA subscales incorporating both behavioral and social communicative features of ASD. Results indicated that Total ASD is more accurate in detecting autism risk than scales measuring general behavior problems or social competence. Results provide support for the BITSEA as a Level I screener for social emotional problems and a Level II screener for ASD symptoms at community sites such as well child clinics. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.01.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194

Red dermographism in autism spectrum disorders: A clinical sign of cholinergic dysfunction? / Eric LEMONNIER in Research in Autism Spectrum Disorders, 7-5 (May 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-5 (May 2013) . - p.601-605 Titre : Red dermographism in autism spectrum disorders: A clinical sign of cholinergic dysfunction? Type de document : Texte imprimé et/ou numérique Auteurs : Eric LEMONNIER, Auteur ; Marine GRANDGEORGE, Auteur ; C. JACOBZONE-LEVEQUE, Auteur ; C. BESSAGUET, Auteur ; S. PEUDENIER, Auteur ; L. MISERY, Auteur Article en page(s) : p.601-605 Mots-clés : Autism spectrum disorders  ASD  Dermatology  Red dermographism  Acetylcholine Index. décimale : PER Périodiques Résumé : The authors hypothesised that red dermographism – a skin reaction involving the cholinergic system – is more frequent in children with autism spectrum disorders (ASDs) than in children exhibiting typical development. We used a dermatological examination to study red dermographism in this transverse study, which compared forty six children with ASDs with seventy one children exhibiting typical development. Both univariate and stratified statistical analyses were performed. In comparison with the control group, children with ASDs had a greater prevalence of red dermographism, especially the subgroup of children with autism and Asperger syndrome. Our results reflect a probable difference in the functionality of the cholinergic system. Indeed, ASDs are usually considered neurodevelopmental disorders caused by several factors. Cholinergic system abnormalities may be involved in the pathophysiology of ASDs, at least for a subgroup of individuals. The implications for a possible treatment strategy and a potential biomarker for ASDs are discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.01.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] Red dermographism in autism spectrum disorders: A clinical sign of cholinergic dysfunction? [Texte imprimé et/ou numérique] / Eric LEMONNIER, Auteur ; Marine GRANDGEORGE, Auteur ; C. JACOBZONE-LEVEQUE, Auteur ; C. BESSAGUET, Auteur ; S. PEUDENIER, Auteur ; L. MISERY, Auteur . - p.601-605. in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.601-605 Mots-clés : Autism spectrum disorders  ASD  Dermatology  Red dermographism  Acetylcholine Index. décimale : PER Périodiques Résumé : The authors hypothesised that red dermographism – a skin reaction involving the cholinergic system – is more frequent in children with autism spectrum disorders (ASDs) than in children exhibiting typical development. We used a dermatological examination to study red dermographism in this transverse study, which compared forty six children with ASDs with seventy one children exhibiting typical development. Both univariate and stratified statistical analyses were performed. In comparison with the control group, children with ASDs had a greater prevalence of red dermographism, especially the subgroup of children with autism and Asperger syndrome. Our results reflect a probable difference in the functionality of the cholinergic system. Indeed, ASDs are usually considered neurodevelopmental disorders caused by several factors. Cholinergic system abnormalities may be involved in the pathophysiology of ASDs, at least for a subgroup of individuals. The implications for a possible treatment strategy and a potential biomarker for ASDs are discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.01.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194

Examining the relationship between Autism spectrum disorders and technical professions in high functioning adults / Annelies A. SPEK in Research in Autism Spectrum Disorders, 7-5 (May 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-5 (May 2013) . - p.606-612 Titre : Examining the relationship between Autism spectrum disorders and technical professions in high functioning adults Type de document : Texte imprimé et/ou numérique Auteurs : Annelies A. SPEK, Auteur ; E. VELDERMAN, Auteur Article en page(s) : p.606-612 Mots-clés : Autism  Technical skills  Attention to detail  Attention switching  Social skill Index. décimale : PER Périodiques Résumé : A relationship has been hypothesized between Autism and technical professions. This has been attributed to superior folk physics in individuals with Autism. Folk physics can be described as the capability to understand physical causality. Since all the previous studies in this area were focused on family members of individuals with Autism, it was unclear if there is a direct relationship between Autism and technical professions. Therefore, we examined the degree to which the professions of high functioning adults with Autism (N = 29) encompass technical skills and compared the results to adults with Schizophrenia (N = 17) and a neurotypical control group (N = 30). Furthermore, we examined whether the degree of technical skills in the professions of the Autism group was related to their autistic traits. The results showed that the last and longest attained professions of the adults with Autism require more technical skills than those of the Schizophrenia and neurotypical group. Furthermore, the degree of technical skills in the professions of the adults with Autism is related to impairments in social skills, but not to strengths in detailed information processing. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.02.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] Examining the relationship between Autism spectrum disorders and technical professions in high functioning adults [Texte imprimé et/ou numérique] / Annelies A. SPEK, Auteur ; E. VELDERMAN, Auteur . - p.606-612. in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.606-612 Mots-clés : Autism  Technical skills  Attention to detail  Attention switching  Social skill Index. décimale : PER Périodiques Résumé : A relationship has been hypothesized between Autism and technical professions. This has been attributed to superior folk physics in individuals with Autism. Folk physics can be described as the capability to understand physical causality. Since all the previous studies in this area were focused on family members of individuals with Autism, it was unclear if there is a direct relationship between Autism and technical professions. Therefore, we examined the degree to which the professions of high functioning adults with Autism (N = 29) encompass technical skills and compared the results to adults with Schizophrenia (N = 17) and a neurotypical control group (N = 30). Furthermore, we examined whether the degree of technical skills in the professions of the Autism group was related to their autistic traits. The results showed that the last and longest attained professions of the adults with Autism require more technical skills than those of the Schizophrenia and neurotypical group. Furthermore, the degree of technical skills in the professions of the adults with Autism is related to impairments in social skills, but not to strengths in detailed information processing. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.02.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194

Interceptive skills in children aged 9–11 years, diagnosed with Autism Spectrum Disorder / Caroline P. WHYATT in Research in Autism Spectrum Disorders, 7-5 (May 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-5 (May 2013) . - p.613-623 Titre : Interceptive skills in children aged 9–11 years, diagnosed with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Caroline P. WHYATT, Auteur ; Cathy M. CRAIG, Auteur Article en page(s) : p.613-623 Mots-clés : Catching  Tau-coupling  Motor Control  Timing  ASD Index. décimale : PER Périodiques Résumé : Growing evidence suggests that significant motor problems are associated with a diagnosis of Autism Spectrum Disorders (ASD), particularly in catching tasks. Catching is a complex, dynamic skill that involves the ability to synchronise one's own movement to that of a moving target. To successfully complete the task, the participant must pick up and use perceptual information about the moving target to arrive at the catching place at the right time. This study looks at catching ability in children diagnosed with ASD (mean age 10.16 ± 0.9 years) and age-matched non-verbal (9.72 ± 0.79 years) and receptive language (9.51 ± 0.46) control groups. Participants were asked to “catch” a ball as it rolled down a fixed ramp. Two ramp heights provided two levels of task difficulty, whilst the sensory information (audio and visual) specifying ball arrival time was varied. Results showed children with ASD performed significantly worse than both the receptive language (p = .02) and non-verbal (p = .02) control groups in terms of total number of balls caught. A detailed analysis of the movement kinematics showed that difficulties with picking up and using the sensory information to guide the action may be the source of the problem. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.01.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] Interceptive skills in children aged 9–11 years, diagnosed with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Caroline P. WHYATT, Auteur ; Cathy M. CRAIG, Auteur . - p.613-623. in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.613-623 Mots-clés : Catching  Tau-coupling  Motor Control  Timing  ASD Index. décimale : PER Périodiques Résumé : Growing evidence suggests that significant motor problems are associated with a diagnosis of Autism Spectrum Disorders (ASD), particularly in catching tasks. Catching is a complex, dynamic skill that involves the ability to synchronise one's own movement to that of a moving target. To successfully complete the task, the participant must pick up and use perceptual information about the moving target to arrive at the catching place at the right time. This study looks at catching ability in children diagnosed with ASD (mean age 10.16 ± 0.9 years) and age-matched non-verbal (9.72 ± 0.79 years) and receptive language (9.51 ± 0.46) control groups. Participants were asked to “catch” a ball as it rolled down a fixed ramp. Two ramp heights provided two levels of task difficulty, whilst the sensory information (audio and visual) specifying ball arrival time was varied. Results showed children with ASD performed significantly worse than both the receptive language (p = .02) and non-verbal (p = .02) control groups in terms of total number of balls caught. A detailed analysis of the movement kinematics showed that difficulties with picking up and using the sensory information to guide the action may be the source of the problem. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.01.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194

Quality of life as a mediator between behavioral challenges and autistic traits for adults with intellectual disabilities / Domingo GARCIA-VILLAMISAR in Research in Autism Spectrum Disorders, 7-5 (May 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-5 (May 2013) . - p.624-629 Titre : Quality of life as a mediator between behavioral challenges and autistic traits for adults with intellectual disabilities Type de document : Texte imprimé et/ou numérique Auteurs : Domingo GARCIA-VILLAMISAR, Auteur ; John DATTILO, Auteur ; Johnny L. MATSON, Auteur Article en page(s) : p.624-629 Mots-clés : Autism spectrum disorders  Intellectual disabilities  Behavioral challenges  Quality of life Index. décimale : PER Périodiques Résumé : A multiple mediation model was proposed to integrate core concepts of challenging behaviors with autistic traits to increase understanding of their relationship to quality of life (QoL). It was hypothesized that QoL is a possible mediator between the severity of challenging behaviors and autistic traits in adults with intellectual disability. These constructs are of vital importance because they are essential variables for people with autism, and obviously they influence their psychosocial development. Participants were 70 adults with autism spectrum disorders (ASD) and moderate intellectual disabilities (ID). Results indicated that several dimensions of QoL mediated the relationships between autistic traits and challenging behaviors. The dimensions of QoL, Satisfaction, Competence/Productivity, and Autonomy/Independence are mediators between autistic traits and challenging behaviors. Implications of these data are discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] Quality of life as a mediator between behavioral challenges and autistic traits for adults with intellectual disabilities [Texte imprimé et/ou numérique] / Domingo GARCIA-VILLAMISAR, Auteur ; John DATTILO, Auteur ; Johnny L. MATSON, Auteur . - p.624-629. in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.624-629 Mots-clés : Autism spectrum disorders  Intellectual disabilities  Behavioral challenges  Quality of life Index. décimale : PER Périodiques Résumé : A multiple mediation model was proposed to integrate core concepts of challenging behaviors with autistic traits to increase understanding of their relationship to quality of life (QoL). It was hypothesized that QoL is a possible mediator between the severity of challenging behaviors and autistic traits in adults with intellectual disability. These constructs are of vital importance because they are essential variables for people with autism, and obviously they influence their psychosocial development. Participants were 70 adults with autism spectrum disorders (ASD) and moderate intellectual disabilities (ID). Results indicated that several dimensions of QoL mediated the relationships between autistic traits and challenging behaviors. The dimensions of QoL, Satisfaction, Competence/Productivity, and Autonomy/Independence are mediators between autistic traits and challenging behaviors. Implications of these data are discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194