Head Circumferences in Twins With and Without Autism Spectrum Disorders / Wendy FROEHLICH in Journal of Autism and Developmental Disorders, 43-9 (September 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2026-2037 Titre : Head Circumferences in Twins With and Without Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Wendy FROEHLICH, Auteur ; Sue C. CLEVELAND, Auteur ; Andrea TORRES, Auteur ; Jennifer PHILLIPS, Auteur ; Brianne COHEN, Auteur ; Tiffany TORIGOE, Auteur ; Janet MILLER, Auteur ; Angie FEDELE, Auteur ; Jack COLLINS, Auteur ; Karen SMITH, Auteur ; Linda J. LOTSPEICH, Auteur ; Lisa A. CROEN, Auteur ; Sally OZONOFF, Auteur ; Clara LAJONCHERE, Auteur ; Judith K. GRETHER, Auteur ; Joachim F. HALLMAYER, Auteur Article en page(s) : p.2026-2037 Langues : Anglais (eng) Mots-clés : Macrocephaly  Head circumference  Twins  Endophenotype  Genetics Index. décimale : PER Périodiques Résumé : To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4–18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs. En ligne : http://dx.doi.org/10.1007/s10803-012-1751-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Head Circumferences in Twins With and Without Autism Spectrum Disorders [texte imprimé] / Wendy FROEHLICH, Auteur ; Sue C. CLEVELAND, Auteur ; Andrea TORRES, Auteur ; Jennifer PHILLIPS, Auteur ; Brianne COHEN, Auteur ; Tiffany TORIGOE, Auteur ; Janet MILLER, Auteur ; Angie FEDELE, Auteur ; Jack COLLINS, Auteur ; Karen SMITH, Auteur ; Linda J. LOTSPEICH, Auteur ; Lisa A. CROEN, Auteur ; Sally OZONOFF, Auteur ; Clara LAJONCHERE, Auteur ; Judith K. GRETHER, Auteur ; Joachim F. HALLMAYER, Auteur . - p.2026-2037. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2026-2037 Mots-clés : Macrocephaly  Head circumference  Twins  Endophenotype  Genetics Index. décimale : PER Périodiques Résumé : To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4–18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs. En ligne : http://dx.doi.org/10.1007/s10803-012-1751-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Incidental brain MRI findings in an autism twin study / Julio C. MONTERREY in Autism Research, 10-1 (January 2017)  

Public ISBD [article]  inAutism Research > 10-1 (January 2017) . - p.113-120 Titre : Incidental brain MRI findings in an autism twin study Type de document : texte imprimé Auteurs : Julio C. MONTERREY, Auteur ; Jennifer PHILIPS, Auteur ; Sue C. CLEVELAND, Auteur ; Serena TANAKA, Auteur ; Patrick BARNES, Auteur ; Joachim F. HALLMAYER, Auteur ; Alan L. REISS, Auteur ; Laura C. LAZZERONI, Auteur ; Antonio Y. HARDAN, Auteur Article en page(s) : p.113-120 Langues : Anglais (eng) Mots-clés : autism  incidental findings  neuroimaging  MRI  twins Index. décimale : PER Périodiques Résumé : Brain magnetic resonance imaging (MRI) studies suggest the prevalence of asymptomatic “incidental” findings (IF) in autism spectrum disorder (ASD) is similar to that of neurotypically developing (NT) controls. However, given the causes of IF may include both genetic and environmental factors, a twin study would facilitate comparing brain IF between ASD and NT subjects. MRI scans were examined to assess the prevalence of brain IF in twin “case pairs” (at least one twin with diagnosis of ASD) and twin “control pairs” (NT). Fifty case pairs and thirty-two control pairs were analyzed. IF were found in 68% of subjects with ASD, 71% of unaffected ASD siblings, and in 58% of control subjects (P = 0.4). IF requiring clinical follow-up occurred more frequently in subjects with ASD compared to NT controls (17% vs. 5%, respectively; P = 0.02). The concordance rate of IF in twins was 83%. A mixed effects model found younger age, male sex, and “family environment” to be significantly associated with IF. There was no difference in the prevalence rate of IF between ASD subjects and NT controls. More IF required clinical follow-up in ASD subjects compared to NT controls. The prevalence rate of IF observed in this twin study was higher than rates previously reported in singleton studies. Our results suggest the shared environment of twins – perhaps in utero – increases the risk of brain IF. Brain MRI in the initial work-up of ASD may be indicated in twins, especially in males. En ligne : http://dx.doi.org/10.1002/aur.1720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Incidental brain MRI findings in an autism twin study [texte imprimé] / Julio C. MONTERREY, Auteur ; Jennifer PHILIPS, Auteur ; Sue C. CLEVELAND, Auteur ; Serena TANAKA, Auteur ; Patrick BARNES, Auteur ; Joachim F. HALLMAYER, Auteur ; Alan L. REISS, Auteur ; Laura C. LAZZERONI, Auteur ; Antonio Y. HARDAN, Auteur . - p.113-120. Langues : Anglais (eng) in Autism Research > 10-1 (January 2017) . - p.113-120 Mots-clés : autism  incidental findings  neuroimaging  MRI  twins Index. décimale : PER Périodiques Résumé : Brain magnetic resonance imaging (MRI) studies suggest the prevalence of asymptomatic “incidental” findings (IF) in autism spectrum disorder (ASD) is similar to that of neurotypically developing (NT) controls. However, given the causes of IF may include both genetic and environmental factors, a twin study would facilitate comparing brain IF between ASD and NT subjects. MRI scans were examined to assess the prevalence of brain IF in twin “case pairs” (at least one twin with diagnosis of ASD) and twin “control pairs” (NT). Fifty case pairs and thirty-two control pairs were analyzed. IF were found in 68% of subjects with ASD, 71% of unaffected ASD siblings, and in 58% of control subjects (P = 0.4). IF requiring clinical follow-up occurred more frequently in subjects with ASD compared to NT controls (17% vs. 5%, respectively; P = 0.02). The concordance rate of IF in twins was 83%. A mixed effects model found younger age, male sex, and “family environment” to be significantly associated with IF. There was no difference in the prevalence rate of IF between ASD subjects and NT controls. More IF required clinical follow-up in ASD subjects compared to NT controls. The prevalence rate of IF observed in this twin study was higher than rates previously reported in singleton studies. Our results suggest the shared environment of twins – perhaps in utero – increases the risk of brain IF. Brain MRI in the initial work-up of ASD may be indicated in twins, especially in males. En ligne : http://dx.doi.org/10.1002/aur.1720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Twins with KBG Syndrome and Autism / Mina HAH in Journal of Autism and Developmental Disorders, 39-12 (December 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-12 (December 2009) . - p.1744-1746 Titre : Twins with KBG Syndrome and Autism Type de document : texte imprimé Auteurs : Mina HAH, Auteur ; Linda J. LOTSPEICH, Auteur ; Joachim F. HALLMAYER, Auteur ; Jennifer M. PHILLIPS, Auteur ; Andrea D. TORRES, Auteur ; Sue C. CLEVELAND, Auteur Année de publication : 2009 Article en page(s) : p.1744-1746 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-009-0811-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=885 [article] Twins with KBG Syndrome and Autism [texte imprimé] / Mina HAH, Auteur ; Linda J. LOTSPEICH, Auteur ; Joachim F. HALLMAYER, Auteur ; Jennifer M. PHILLIPS, Auteur ; Andrea D. TORRES, Auteur ; Sue C. CLEVELAND, Auteur . - 2009 . - p.1744-1746. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-12 (December 2009) . - p.1744-1746 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-009-0811-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=885

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