Attentional functions in children and adolescents with ADHD, depressive disorders, and the comorbid condition / Thomas GUNTHER in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.324-331 Titre : Attentional functions in children and adolescents with ADHD, depressive disorders, and the comorbid condition Type de document : Texte imprimé et/ou numérique Auteurs : Thomas GUNTHER, Auteur ; Kerstin KONRAD, Auteur ; Stephane A. DE BRITO, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Timo D. VLOET, Auteur Année de publication : 2011 Article en page(s) : p.324-331 Langues : Anglais (eng) Mots-clés : ADHD  depression  attention  neuropsychology Index. décimale : PER Périodiques Résumé : Background:  Attention-deficit hyperactivity disorder (ADHD) and depressive disorders (DDs) often co-occur in children and adolescents, but evidence on the respective influence of these disorders on attention parameters is inconsistent. This study examines the influence of DDs on ADHD in a model-oriented approach that includes selectivity and intensity attention parameters. Methods:  Ten- to fifteen-year-olds with ADHD (n = 63), DDs (n = 61), ADHD+DDs (n = 64), and healthy controls (n = 64) completed a battery of tests including five neuropsychological tasks (i.e., alertness, sustained attention, divided attention, go/no-go, and attentional set-shifting). Results:  All clinical groups showed attentional problems, especially in more complex attentional tasks and in the intensity aspects of attention. We observed the most severe attentional impairments in children with ADHD that was independent from a comorbid DD. Conclusion:  The clinical groups were significantly different from the healthy control group, especially in more complex attentional tasks and in the intensity aspects of attention. Some differences between ADHD, DDs and ADHD+DDs groups were detected on neuropsychological attentional performance, but the effects were not strong enough to differentiate the clinical groups from each other. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02320.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Attentional functions in children and adolescents with ADHD, depressive disorders, and the comorbid condition [Texte imprimé et/ou numérique] / Thomas GUNTHER, Auteur ; Kerstin KONRAD, Auteur ; Stephane A. DE BRITO, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Timo D. VLOET, Auteur . - 2011 . - p.324-331. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.324-331 Mots-clés : ADHD  depression  attention  neuropsychology Index. décimale : PER Périodiques Résumé : Background:  Attention-deficit hyperactivity disorder (ADHD) and depressive disorders (DDs) often co-occur in children and adolescents, but evidence on the respective influence of these disorders on attention parameters is inconsistent. This study examines the influence of DDs on ADHD in a model-oriented approach that includes selectivity and intensity attention parameters. Methods:  Ten- to fifteen-year-olds with ADHD (n = 63), DDs (n = 61), ADHD+DDs (n = 64), and healthy controls (n = 64) completed a battery of tests including five neuropsychological tasks (i.e., alertness, sustained attention, divided attention, go/no-go, and attentional set-shifting). Results:  All clinical groups showed attentional problems, especially in more complex attentional tasks and in the intensity aspects of attention. We observed the most severe attentional impairments in children with ADHD that was independent from a comorbid DD. Conclusion:  The clinical groups were significantly different from the healthy control group, especially in more complex attentional tasks and in the intensity aspects of attention. Some differences between ADHD, DDs and ADHD+DDs groups were detected on neuropsychological attentional performance, but the effects were not strong enough to differentiate the clinical groups from each other. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02320.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys / Michael PLUESS in Development and Psychopathology, 34-3 (August 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-3 (August 2022) . - p.901-910 Titre : Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys Type de document : Texte imprimé et/ou numérique Auteurs : Michael PLUESS, Auteur ; Stephane A. DE BRITO, Auteur ; Alice Jones BARTOLI, Auteur ; Eamon MCCRORY, Auteur ; Essi VIDING, Auteur Article en page(s) : p.901-910 Langues : Anglais (eng) Mots-clés : amygdala  differential susceptibility  environmental sensitivity  hippocampus  vantage sensitivity Index. décimale : PER Périodiques Résumé : Children differ in their response to environmental exposures, with some being more sensitive to contextual factors than others. According to theory, such variability is the result of individual differences in neurobiological sensitivity to environmental features, with some individuals generally more affected by both negative and/or positive experiences. In this exploratory study we tested whether left and right amygdala and hippocampus volumes (corrected for total brain size) account for individual differences in response to environmental influences in a sample of 62 boys. Cumulative general environmental quality, ranging from low to high, was measured across the first 9 years and child behavior was reported by teachers when boys were 12 “13 years old. According to analyses, only the left amygdala volume “ not any of the other brain volumes “ emerged as an important brain region for sensitivity to positive environmental aspects. Boys with a larger left amygdala benefited significantly more from higher environmental quality than boys with a smaller left amygdala whilst not being more vulnerable to lower quality. Besides providing preliminary evidence for differences in environmental sensitivity due to brain structure, the results also point to the left amygdala as having a specific role regarding the response to environmental influences. En ligne : http://dx.doi.org/10.1017/S0954579420001698 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys [Texte imprimé et/ou numérique] / Michael PLUESS, Auteur ; Stephane A. DE BRITO, Auteur ; Alice Jones BARTOLI, Auteur ; Eamon MCCRORY, Auteur ; Essi VIDING, Auteur . - p.901-910. Langues : Anglais (eng) in Development and Psychopathology > 34-3 (August 2022) . - p.901-910 Mots-clés : amygdala  differential susceptibility  environmental sensitivity  hippocampus  vantage sensitivity Index. décimale : PER Périodiques Résumé : Children differ in their response to environmental exposures, with some being more sensitive to contextual factors than others. According to theory, such variability is the result of individual differences in neurobiological sensitivity to environmental features, with some individuals generally more affected by both negative and/or positive experiences. In this exploratory study we tested whether left and right amygdala and hippocampus volumes (corrected for total brain size) account for individual differences in response to environmental influences in a sample of 62 boys. Cumulative general environmental quality, ranging from low to high, was measured across the first 9 years and child behavior was reported by teachers when boys were 12 “13 years old. According to analyses, only the left amygdala volume “ not any of the other brain volumes “ emerged as an important brain region for sensitivity to positive environmental aspects. Boys with a larger left amygdala benefited significantly more from higher environmental quality than boys with a smaller left amygdala whilst not being more vulnerable to lower quality. Besides providing preliminary evidence for differences in environmental sensitivity due to brain structure, the results also point to the left amygdala as having a specific role regarding the response to environmental influences. En ligne : http://dx.doi.org/10.1017/S0954579420001698 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Positive and negative parenting in conduct disorder with high versus low levels of callous–unemotional traits / Ruth PAULI in Development and Psychopathology, 33-3 (August 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-3 (August 2021) . - p.980-991 Titre : Positive and negative parenting in conduct disorder with high versus low levels of callous–unemotional traits Type de document : Texte imprimé et/ou numérique Auteurs : Ruth PAULI, Auteur ; Peter TINO, Auteur ; Jack C. ROGERS, Auteur ; Rosalind BAKER, Auteur ; Roberta CLANTON, Auteur ; Philippa BIRCH, Auteur ; Abigail BROWN, Auteur ; Gemma DANIEL, Auteur ; Lisandra FERREIRA, Auteur ; Liam GRISLEY, Auteur ; Gregor KOHLS, Auteur ; Sarah BAUMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Katharina ACKERMANN, Auteur ; Helen LAZARATOU, Auteur ; Foteini TSIAKOULIA, Auteur ; Panagiota BALI, Auteur ; Helena OLDENHOF, Auteur ; Lucres JANSEN, Auteur ; Areti SMARAGDI, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Miguel Angel GONZALEZ-TORRES, Auteur ; Maider GONZALEZ DE ARTAZA-LAVESA, Auteur ; Martin STEPPAN, Auteur ; Noortje VRIENDS, Auteur ; Aitana BIGORRA, Auteur ; Reka SIKLOSI, Auteur ; Sreejita GHOSH, Auteur ; Kerstin BUNTE, Auteur ; Roberta DOCHNAL, Auteur ; Amaia HERVAS, Auteur ; Christina STADLER, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Graeme FAIRCHILD, Auteur ; Arne POPMA, Auteur ; Dimitris DIKEOS, Auteur ; Kerstin KONRAD, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Christine M. FREITAG, Auteur ; Pia ROTSHTEIN, Auteur ; Stephane A. DE BRITO, Auteur Article en page(s) : p.980-991 Langues : Anglais (eng) Mots-clés : angle-based generalized matrix learning vector quantization  callous–unemotional traits  conduct disorder  machine learning  parenting Index. décimale : PER Périodiques Résumé : Less is known about the relationship between conduct disorder (CD), callous–unemotional (CU) traits, and positive and negative parenting in youth compared to early childhood. We combined traditional univariate analyses with a novel machine learning classifier (Angle-based Generalized Matrix Learning Vector Quantization) to classify youth (N = 756; 9–18 years) into typically developing (TD) or CD groups with or without elevated CU traits (CD/HCU, CD/LCU, respectively) using youth- and parent-reports of parenting behavior. At the group level, both CD/HCU and CD/LCU were associated with high negative and low positive parenting relative to TD. However, only positive parenting differed between the CD/HCU and CD/LCU groups. In classification analyses, performance was best when distinguishing CD/HCU from TD groups and poorest when distinguishing CD/HCU from CD/LCU groups. Positive and negative parenting were both relevant when distinguishing CD/HCU from TD, negative parenting was most relevant when distinguishing between CD/LCU and TD, and positive parenting was most relevant when distinguishing CD/HCU from CD/LCU groups. These findings suggest that while positive parenting distinguishes between CD/HCU and CD/LCU, negative parenting is associated with both CD subtypes. These results highlight the importance of considering multiple parenting behaviors in CD with varying levels of CU traits in late childhood/adolescence. En ligne : http://dx.doi.org/10.1017/S0954579420000279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Positive and negative parenting in conduct disorder with high versus low levels of callous–unemotional traits [Texte imprimé et/ou numérique] / Ruth PAULI, Auteur ; Peter TINO, Auteur ; Jack C. ROGERS, Auteur ; Rosalind BAKER, Auteur ; Roberta CLANTON, Auteur ; Philippa BIRCH, Auteur ; Abigail BROWN, Auteur ; Gemma DANIEL, Auteur ; Lisandra FERREIRA, Auteur ; Liam GRISLEY, Auteur ; Gregor KOHLS, Auteur ; Sarah BAUMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Katharina ACKERMANN, Auteur ; Helen LAZARATOU, Auteur ; Foteini TSIAKOULIA, Auteur ; Panagiota BALI, Auteur ; Helena OLDENHOF, Auteur ; Lucres JANSEN, Auteur ; Areti SMARAGDI, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Miguel Angel GONZALEZ-TORRES, Auteur ; Maider GONZALEZ DE ARTAZA-LAVESA, Auteur ; Martin STEPPAN, Auteur ; Noortje VRIENDS, Auteur ; Aitana BIGORRA, Auteur ; Reka SIKLOSI, Auteur ; Sreejita GHOSH, Auteur ; Kerstin BUNTE, Auteur ; Roberta DOCHNAL, Auteur ; Amaia HERVAS, Auteur ; Christina STADLER, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Graeme FAIRCHILD, Auteur ; Arne POPMA, Auteur ; Dimitris DIKEOS, Auteur ; Kerstin KONRAD, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Christine M. FREITAG, Auteur ; Pia ROTSHTEIN, Auteur ; Stephane A. DE BRITO, Auteur . - p.980-991. Langues : Anglais (eng) in Development and Psychopathology > 33-3 (August 2021) . - p.980-991 Mots-clés : angle-based generalized matrix learning vector quantization  callous–unemotional traits  conduct disorder  machine learning  parenting Index. décimale : PER Périodiques Résumé : Less is known about the relationship between conduct disorder (CD), callous–unemotional (CU) traits, and positive and negative parenting in youth compared to early childhood. We combined traditional univariate analyses with a novel machine learning classifier (Angle-based Generalized Matrix Learning Vector Quantization) to classify youth (N = 756; 9–18 years) into typically developing (TD) or CD groups with or without elevated CU traits (CD/HCU, CD/LCU, respectively) using youth- and parent-reports of parenting behavior. At the group level, both CD/HCU and CD/LCU were associated with high negative and low positive parenting relative to TD. However, only positive parenting differed between the CD/HCU and CD/LCU groups. In classification analyses, performance was best when distinguishing CD/HCU from TD groups and poorest when distinguishing CD/HCU from CD/LCU groups. Positive and negative parenting were both relevant when distinguishing CD/HCU from TD, negative parenting was most relevant when distinguishing between CD/LCU and TD, and positive parenting was most relevant when distinguishing CD/HCU from CD/LCU groups. These findings suggest that while positive parenting distinguishes between CD/HCU and CD/LCU, negative parenting is associated with both CD subtypes. These results highlight the importance of considering multiple parenting behaviors in CD with varying levels of CU traits in late childhood/adolescence. En ligne : http://dx.doi.org/10.1017/S0954579420000279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children / Stephane A. DE BRITO in Journal of Child Psychology and Psychiatry, 54-1 (January 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 105-112 Titre : Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children Type de document : Texte imprimé et/ou numérique Auteurs : Stephane A. DE BRITO, Auteur ; Essi VIDING, Auteur ; Catherine L. SEBASTIAN, Auteur ; Philip A. KELLY, Auteur ; Andrea MECHELLI, Auteur ; Helen MARIS, Auteur ; Eamon J. MCCRORY, Auteur Article en page(s) : 105-112 Langues : Anglais (eng) Mots-clés : maltreatment  child abuse  orbitofrontal cortex  middle temporal gyrus  voxel-based morphometry Index. décimale : PER Périodiques Résumé : Background: Childhood maltreatment is strongly associated with increased risk of psychiatric disorder. Previous neuroimaging studies have reported atypical neural structure in the orbitofrontal cortex, temporal lobe, amygdala, hippocampus and cerebellum in maltreated samples. It has been hypothesised that these structural differences may relate to increased psychiatric vulnerability. However, previous studies have typically recruited clinical samples with concurrent psychiatric disorders, or have poorly characterised the range of maltreatment experiences and levels of concurrent anxiety or depression, limiting the interpretation of the observed structural differences. Methods: We used voxel-based morphometry to compare grey matter volume in a group of 18 children (mean age 12.01 years, SD = 1.4), referred to community social services, with documented and well-characterised experiences of maltreatment at home and a group of 20 nonmaltreated children (mean age 12.6 years, SD = 1.3). Both groups were comparable on age, gender, cognitive ability, ethnicity and levels of anxiety, depression and posttraumatic stress symptoms. We examined five a priori regions of interest: the prefrontal cortex, temporal lobes, amygdala, hippocampus and cerebellum. Results: Maltreated children, compared to nonmaltreated peers, presented with reduced grey matter in the medial orbitofrontal cortex and the left middle temporal gyrus. Conclusions: The medial orbitofrontal cortex and the middle temporal gyrus have been implicated in reinforcement-based decision-making, emotion regulation and autobiographical memory, processes that are impaired in a number of psychiatric disorders associated with maltreatment. We speculate that grey matter disturbance in these regions in a community sample of maltreated children may represent a latent neurobiological risk factor for later psychopathology and heightened risk taking. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02597.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 [article] Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children [Texte imprimé et/ou numérique] / Stephane A. DE BRITO, Auteur ; Essi VIDING, Auteur ; Catherine L. SEBASTIAN, Auteur ; Philip A. KELLY, Auteur ; Andrea MECHELLI, Auteur ; Helen MARIS, Auteur ; Eamon J. MCCRORY, Auteur . - 105-112. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 105-112 Mots-clés : maltreatment  child abuse  orbitofrontal cortex  middle temporal gyrus  voxel-based morphometry Index. décimale : PER Périodiques Résumé : Background: Childhood maltreatment is strongly associated with increased risk of psychiatric disorder. Previous neuroimaging studies have reported atypical neural structure in the orbitofrontal cortex, temporal lobe, amygdala, hippocampus and cerebellum in maltreated samples. It has been hypothesised that these structural differences may relate to increased psychiatric vulnerability. However, previous studies have typically recruited clinical samples with concurrent psychiatric disorders, or have poorly characterised the range of maltreatment experiences and levels of concurrent anxiety or depression, limiting the interpretation of the observed structural differences. Methods: We used voxel-based morphometry to compare grey matter volume in a group of 18 children (mean age 12.01 years, SD = 1.4), referred to community social services, with documented and well-characterised experiences of maltreatment at home and a group of 20 nonmaltreated children (mean age 12.6 years, SD = 1.3). Both groups were comparable on age, gender, cognitive ability, ethnicity and levels of anxiety, depression and posttraumatic stress symptoms. We examined five a priori regions of interest: the prefrontal cortex, temporal lobes, amygdala, hippocampus and cerebellum. Results: Maltreated children, compared to nonmaltreated peers, presented with reduced grey matter in the medial orbitofrontal cortex and the left middle temporal gyrus. Conclusions: The medial orbitofrontal cortex and the middle temporal gyrus have been implicated in reinforcement-based decision-making, emotion regulation and autobiographical memory, processes that are impaired in a number of psychiatric disorders associated with maltreatment. We speculate that grey matter disturbance in these regions in a community sample of maltreated children may represent a latent neurobiological risk factor for later psychopathology and heightened risk taking. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02597.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186

Research Review: The neurobiology and genetics of maltreatment and adversity / Eamon J. MCCRORY in Journal of Child Psychology and Psychiatry, 51-10 (October 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-10 (October 2010) . - p.1079-1095 Titre : Research Review: The neurobiology and genetics of maltreatment and adversity Type de document : Texte imprimé et/ou numérique Auteurs : Eamon J. MCCRORY, Auteur ; Stephane A. DE BRITO, Auteur Année de publication : 2010 Article en page(s) : p.1079-1095 Langues : Anglais (eng) Mots-clés : Child-abuse maltreatment neuroscience genetics HPA psychopathology resilience cortisol Index. décimale : PER Périodiques Résumé : The neurobiological mechanisms by which childhood maltreatment heightens vulnerability to psychopathology remain poorly understood. It is likely that a complex interaction between environmental experiences (including poor caregiving) and an individual’s genetic make-up influence neurobiological development across infancy and childhood, which in turn sets the stage for a child’s psychological and emotional development. This review provides a concise synopsis of those studies investigating the neurobiological and genetic factors associated with childhood maltreatment and adversity. We first provide an overview of the neuroendocrine findings, drawing from animal and human studies. These studies indicate an association between early adversity and atypical development of the hypothalamic-pituitary-adrenal (HPA) axis stress response, which can predispose to psychiatric vulnerability in adulthood. We then review the neuroimaging findings of structural and functional brain differences in children and adults who have experienced childhood maltreatment. These studies offer evidence of several structural differences associated with early stress, most notably in the corpus callosum in children and the hippocampus in adults; functional studies have reported atypical activation of several brain regions, including decreased activity of the prefrontal cortex. Next we consider studies that suggest that the effect of environmental adversity may be conditional on an individual’s genotype. We also briefly consider the possible role that epigenetic mechanisms might play in mediating the impact of early adversity. Finally we consider several ways in which the neurobiological and genetic research may be relevant to clinical practice and intervention. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02271.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110 [article] Research Review: The neurobiology and genetics of maltreatment and adversity [Texte imprimé et/ou numérique] / Eamon J. MCCRORY, Auteur ; Stephane A. DE BRITO, Auteur . - 2010 . - p.1079-1095. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-10 (October 2010) . - p.1079-1095 Mots-clés : Child-abuse maltreatment neuroscience genetics HPA psychopathology resilience cortisol Index. décimale : PER Périodiques Résumé : The neurobiological mechanisms by which childhood maltreatment heightens vulnerability to psychopathology remain poorly understood. It is likely that a complex interaction between environmental experiences (including poor caregiving) and an individual’s genetic make-up influence neurobiological development across infancy and childhood, which in turn sets the stage for a child’s psychological and emotional development. This review provides a concise synopsis of those studies investigating the neurobiological and genetic factors associated with childhood maltreatment and adversity. We first provide an overview of the neuroendocrine findings, drawing from animal and human studies. These studies indicate an association between early adversity and atypical development of the hypothalamic-pituitary-adrenal (HPA) axis stress response, which can predispose to psychiatric vulnerability in adulthood. We then review the neuroimaging findings of structural and functional brain differences in children and adults who have experienced childhood maltreatment. These studies offer evidence of several structural differences associated with early stress, most notably in the corpus callosum in children and the hippocampus in adults; functional studies have reported atypical activation of several brain regions, including decreased activity of the prefrontal cortex. Next we consider studies that suggest that the effect of environmental adversity may be conditional on an individual’s genotype. We also briefly consider the possible role that epigenetic mechanisms might play in mediating the impact of early adversity. Finally we consider several ways in which the neurobiological and genetic research may be relevant to clinical practice and intervention. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02271.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110

Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder / K. KONRAD in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)  

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