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Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model / Alexia JOLICOEUR-MARTINEAU in Development and Psychopathology, 32-1 (February 2020)
[article]
Titre : Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model Type de document : Texte imprimé et/ou numérique Auteurs : Alexia JOLICOEUR-MARTINEAU, Auteur ; Jay BELSKY, Auteur ; Eszter SZEKELY, Auteur ; Keith F. WIDAMAN, Auteur ; Michael PLUESS, Auteur ; Celia M. T. GREENWOOD, Auteur ; Ashley WAZANA, Auteur Article en page(s) : p.73-83 Langues : Anglais (eng) Mots-clés : diathesis-stress differential-susceptibility gene-by-environment interaction regions of significance vantage sensitivity Index. décimale : PER Périodiques Résumé : Currently, two main approaches exist to distinguish differential susceptibility from diathesis-stress and vantage sensitivity in Genotype x Environment interaction (G x E) research: regions of significance (RoS) and competitive-confirmatory approaches. Each is limited by its single-gene/single-environment foci given that most phenotypes are the product of multiple interacting genetic and environmental factors. We thus addressed these two concerns in a recently developed R package (LEGIT) for constructing G x E interaction models with latent genetic and environmental scores using alternating optimization. Herein we test, by means of computer simulation, diverse G x E models in the context of both single and multiple genes and environments. Results indicate that the RoS and competitive-confirmatory approaches were highly accurate when the sample size was large, whereas the latter performed better in small samples and for small effect sizes. The competitive-confirmatory approach generally had good accuracy (a) when effect size was moderate and N >/= 500 and (b) when effect size was large and N >/= 250, whereas RoS performed poorly. Computational tools to determine the type of G x E of multiple genes and environments are provided as extensions in our LEGIT R package. En ligne : http://dx.doi.org/10.1017/s0954579418001438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Development and Psychopathology > 32-1 (February 2020) . - p.73-83[article] Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model [Texte imprimé et/ou numérique] / Alexia JOLICOEUR-MARTINEAU, Auteur ; Jay BELSKY, Auteur ; Eszter SZEKELY, Auteur ; Keith F. WIDAMAN, Auteur ; Michael PLUESS, Auteur ; Celia M. T. GREENWOOD, Auteur ; Ashley WAZANA, Auteur . - p.73-83.
Langues : Anglais (eng)
in Development and Psychopathology > 32-1 (February 2020) . - p.73-83
Mots-clés : diathesis-stress differential-susceptibility gene-by-environment interaction regions of significance vantage sensitivity Index. décimale : PER Périodiques Résumé : Currently, two main approaches exist to distinguish differential susceptibility from diathesis-stress and vantage sensitivity in Genotype x Environment interaction (G x E) research: regions of significance (RoS) and competitive-confirmatory approaches. Each is limited by its single-gene/single-environment foci given that most phenotypes are the product of multiple interacting genetic and environmental factors. We thus addressed these two concerns in a recently developed R package (LEGIT) for constructing G x E interaction models with latent genetic and environmental scores using alternating optimization. Herein we test, by means of computer simulation, diverse G x E models in the context of both single and multiple genes and environments. Results indicate that the RoS and competitive-confirmatory approaches were highly accurate when the sample size was large, whereas the latter performed better in small samples and for small effect sizes. The competitive-confirmatory approach generally had good accuracy (a) when effect size was moderate and N >/= 500 and (b) when effect size was large and N >/= 250, whereas RoS performed poorly. Computational tools to determine the type of G x E of multiple genes and environments are provided as extensions in our LEGIT R package. En ligne : http://dx.doi.org/10.1017/s0954579418001438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys / Michael PLUESS in Development and Psychopathology, 34-3 (August 2022)
[article]
Titre : Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys Type de document : Texte imprimé et/ou numérique Auteurs : Michael PLUESS, Auteur ; Stephane A. DE BRITO, Auteur ; Alice Jones BARTOLI, Auteur ; Eamon MCCRORY, Auteur ; Essi VIDING, Auteur Article en page(s) : p.901-910 Langues : Anglais (eng) Mots-clés : amygdala differential susceptibility environmental sensitivity hippocampus vantage sensitivity Index. décimale : PER Périodiques Résumé : Children differ in their response to environmental exposures, with some being more sensitive to contextual factors than others. According to theory, such variability is the result of individual differences in neurobiological sensitivity to environmental features, with some individuals generally more affected by both negative and/or positive experiences. In this exploratory study we tested whether left and right amygdala and hippocampus volumes (corrected for total brain size) account for individual differences in response to environmental influences in a sample of 62 boys. Cumulative general environmental quality, ranging from low to high, was measured across the first 9 years and child behavior was reported by teachers when boys were 12 “13 years old. According to analyses, only the left amygdala volume “ not any of the other brain volumes “ emerged as an important brain region for sensitivity to positive environmental aspects. Boys with a larger left amygdala benefited significantly more from higher environmental quality than boys with a smaller left amygdala whilst not being more vulnerable to lower quality. Besides providing preliminary evidence for differences in environmental sensitivity due to brain structure, the results also point to the left amygdala as having a specific role regarding the response to environmental influences. En ligne : http://dx.doi.org/10.1017/S0954579420001698 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485
in Development and Psychopathology > 34-3 (August 2022) . - p.901-910[article] Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys [Texte imprimé et/ou numérique] / Michael PLUESS, Auteur ; Stephane A. DE BRITO, Auteur ; Alice Jones BARTOLI, Auteur ; Eamon MCCRORY, Auteur ; Essi VIDING, Auteur . - p.901-910.
Langues : Anglais (eng)
in Development and Psychopathology > 34-3 (August 2022) . - p.901-910
Mots-clés : amygdala differential susceptibility environmental sensitivity hippocampus vantage sensitivity Index. décimale : PER Périodiques Résumé : Children differ in their response to environmental exposures, with some being more sensitive to contextual factors than others. According to theory, such variability is the result of individual differences in neurobiological sensitivity to environmental features, with some individuals generally more affected by both negative and/or positive experiences. In this exploratory study we tested whether left and right amygdala and hippocampus volumes (corrected for total brain size) account for individual differences in response to environmental influences in a sample of 62 boys. Cumulative general environmental quality, ranging from low to high, was measured across the first 9 years and child behavior was reported by teachers when boys were 12 “13 years old. According to analyses, only the left amygdala volume “ not any of the other brain volumes “ emerged as an important brain region for sensitivity to positive environmental aspects. Boys with a larger left amygdala benefited significantly more from higher environmental quality than boys with a smaller left amygdala whilst not being more vulnerable to lower quality. Besides providing preliminary evidence for differences in environmental sensitivity due to brain structure, the results also point to the left amygdala as having a specific role regarding the response to environmental influences. En ligne : http://dx.doi.org/10.1017/S0954579420001698 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485