Dépouillements

Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 12 (April 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 12 (April 2015) . - p.1-9 Titre : Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr HESSABI, Auteur ; Aisha S. DICKERSON, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur Article en page(s) : p.1-9 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Oxidative stress  Glutathione S-transferase (GST) genes  Modulating-factor  Gene–gene interaction Index. décimale : PER Périodiques Résumé : Abstract We investigated the role of glutathione S-transferase (GST) genes in Autism Spectrum Disorder (ASD). We used data from 111 pairs of age- and sex-matched ASD cases and typically developing (TD) controls between 2 and 8 years of age from Jamaica to investigate the role of GST pi 1 (GSTP1), GST theta 1 (GSTT1), and GST mu 1 (GSTM1) polymorphisms in susceptibility to ASD. In univariable conditional logistic regression models we did not observe significant associations between ASD status and GSTT1, GSTM1, or GSTP1 genotype (all P > 0.15). However, in multivariable conditional logistic regression models, we identified a significant interaction between GSTP1 and GSTT1 in relation to ASD. Specifically, in children heterozygous for the GSTP1 Ile105Val polymorphism, the odds of ASD was significantly higher in those with the null GSTT1 genotype than those with the other genotypes [matched odds ratio (MOR) = 2.97, 95% CI (1.09, 8.01), P = 0.03]. Replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr HESSABI, Auteur ; Aisha S. DICKERSON, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur . - p.1-9. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.1-9 Mots-clés : Autism spectrum disorder  Oxidative stress  Glutathione S-transferase (GST) genes  Modulating-factor  Gene–gene interaction Index. décimale : PER Périodiques Résumé : Abstract We investigated the role of glutathione S-transferase (GST) genes in Autism Spectrum Disorder (ASD). We used data from 111 pairs of age- and sex-matched ASD cases and typically developing (TD) controls between 2 and 8 years of age from Jamaica to investigate the role of GST pi 1 (GSTP1), GST theta 1 (GSTT1), and GST mu 1 (GSTM1) polymorphisms in susceptibility to ASD. In univariable conditional logistic regression models we did not observe significant associations between ASD status and GSTT1, GSTM1, or GSTP1 genotype (all P > 0.15). However, in multivariable conditional logistic regression models, we identified a significant interaction between GSTP1 and GSTT1 in relation to ASD. Specifically, in children heterozygous for the GSTP1 Ile105Val polymorphism, the odds of ASD was significantly higher in those with the null GSTT1 genotype than those with the other genotypes [matched odds ratio (MOR) = 2.97, 95% CI (1.09, 8.01), P = 0.03]. Replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Eating and feeding problems and gastrointestinal dysfunction in Autism Spectrum Disorders / Roni Enten VISSOKER in Research in Autism Spectrum Disorders, 12 (April 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 12 (April 2015) . - p.10-21 Titre : Eating and feeding problems and gastrointestinal dysfunction in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Roni Enten VISSOKER, Auteur ; Yael LATZER, Auteur ; Eynat GAL, Auteur Article en page(s) : p.10-21 Langues : Anglais (eng) Mots-clés : Eating problems  Feeding problems  Gastrointestinal dysfunction  ASD  Autism Index. décimale : PER Périodiques Résumé : Abstract Eating and feeding problems, most commonly food selectivity or picky eating, are common among children with ASD. While these behaviors are typically addressed through occupational or behavior-based therapeutic approaches, increasing evidence shows than in many cases, such eating and feeding problems may be organic and stem from some form of underlying gastrointestinal dysfunction. This review highlights the literature on eating/feeding problems in children with ASD, as well as the contributing factors to eating problems and their nutritional implications in this population. In addition, the various manifestations and origins of gastrointestinal dysfunction in ASD are included. Ten relevant studies that address eating and feeding problems and gastrointestinal (GI) symptoms and dysfunction in children with ASD and the possible mechanisms underlying the eating/feeding problems in children with ASD are discussed. This review suggests a strong relationship and significant correlations between eating problems and gastrointestinal dysfunction. Further exploration of their relationship and etiology for the development of interventions are recommended. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Eating and feeding problems and gastrointestinal dysfunction in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Roni Enten VISSOKER, Auteur ; Yael LATZER, Auteur ; Eynat GAL, Auteur . - p.10-21. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.10-21 Mots-clés : Eating problems  Feeding problems  Gastrointestinal dysfunction  ASD  Autism Index. décimale : PER Périodiques Résumé : Abstract Eating and feeding problems, most commonly food selectivity or picky eating, are common among children with ASD. While these behaviors are typically addressed through occupational or behavior-based therapeutic approaches, increasing evidence shows than in many cases, such eating and feeding problems may be organic and stem from some form of underlying gastrointestinal dysfunction. This review highlights the literature on eating/feeding problems in children with ASD, as well as the contributing factors to eating problems and their nutritional implications in this population. In addition, the various manifestations and origins of gastrointestinal dysfunction in ASD are included. Ten relevant studies that address eating and feeding problems and gastrointestinal (GI) symptoms and dysfunction in children with ASD and the possible mechanisms underlying the eating/feeding problems in children with ASD are discussed. This review suggests a strong relationship and significant correlations between eating problems and gastrointestinal dysfunction. Further exploration of their relationship and etiology for the development of interventions are recommended. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

“I love the cute caterpillar!” autistic children's production of internal state language across contexts and relations to Joint Attention and theory of mind / Susanne KRISTEN in Research in Autism Spectrum Disorders, 12 (April 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 12 (April 2015) . - p.22-33 Titre : “I love the cute caterpillar!” autistic children's production of internal state language across contexts and relations to Joint Attention and theory of mind Type de document : Texte imprimé et/ou numérique Auteurs : Susanne KRISTEN, Auteur ; Maria VUORI, Auteur ; Beate SODIAN, Auteur Article en page(s) : p.22-33 Langues : Anglais (eng) Mots-clés : Internal state language  Joint attention  Theory of mind  Context effects Index. décimale : PER Périodiques Résumé : Abstract Research on internal state language in autistic children reveals an uneven pattern. While some studies show that high-ability autistic children are impaired across a broad range of internal state term categories (e.g., desires, emotions and cognitive terms), other research shows that autistic children are more selectively impaired in their talk about cognitive states. Finally, some studies even demonstrate no impairments. The different findings have largely been explained by context effects. However, to date, studies have yet to compare the same children across different contexts to corroborate this interpretation. Further, studies involving contexts where autistic children's reactivity is actively triggered by providing clear joint attention cues or by exploiting autistic children's intense interest in objects are lacking. Thus, this study tested internal state language from different categories across three different contexts (narrative context, motivating mechanical toy context, elicited interactive joint attention context) and related it to joint attention skills and children's theory of mind. Results revealed that deficits in autistic children's internal state language were highly specific and relation to theory of mind varied by context. In sum, this research suggests that both theorists and practitioners need to take into account context when studying or promoting autistic individuals’ psychological comprehension. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] “I love the cute caterpillar!” autistic children's production of internal state language across contexts and relations to Joint Attention and theory of mind [Texte imprimé et/ou numérique] / Susanne KRISTEN, Auteur ; Maria VUORI, Auteur ; Beate SODIAN, Auteur . - p.22-33. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.22-33 Mots-clés : Internal state language  Joint attention  Theory of mind  Context effects Index. décimale : PER Périodiques Résumé : Abstract Research on internal state language in autistic children reveals an uneven pattern. While some studies show that high-ability autistic children are impaired across a broad range of internal state term categories (e.g., desires, emotions and cognitive terms), other research shows that autistic children are more selectively impaired in their talk about cognitive states. Finally, some studies even demonstrate no impairments. The different findings have largely been explained by context effects. However, to date, studies have yet to compare the same children across different contexts to corroborate this interpretation. Further, studies involving contexts where autistic children's reactivity is actively triggered by providing clear joint attention cues or by exploiting autistic children's intense interest in objects are lacking. Thus, this study tested internal state language from different categories across three different contexts (narrative context, motivating mechanical toy context, elicited interactive joint attention context) and related it to joint attention skills and children's theory of mind. Results revealed that deficits in autistic children's internal state language were highly specific and relation to theory of mind varied by context. In sum, this research suggests that both theorists and practitioners need to take into account context when studying or promoting autistic individuals’ psychological comprehension. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Correlation between PEAK relational training system and one-word picture vocabulary tests / Autumn MCKEEL in Research in Autism Spectrum Disorders, 12 (April 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 12 (April 2015) . - p.34-39 Titre : Correlation between PEAK relational training system and one-word picture vocabulary tests Type de document : Texte imprimé et/ou numérique Auteurs : Autumn MCKEEL, Auteur ; Kyle ROWSEY, Auteur ; Mark R. DIXON, Auteur ; Jacob H. DAAR, Auteur Article en page(s) : p.34-39 Langues : Anglais (eng) Mots-clés : ABA therapy  Language skills  Discrete trial training  PEAK relational training system  Psychometric tests Index. décimale : PER Périodiques Résumé : Abstract The past few decades of research in autism spectrum disorders have been successful in developing effective behavioral treatments; however, the psychometrics of these strategies has not been documented well in applied settings. The current experiment evaluated the relationship between established measures of language skills (receptive and expressive one-word picture vocabulary test; ROWPVT-4 and EOWPVT-4, respectively) and a recently released assessment and curriculum tool designed to teach instructional skills using a behavior analytic approach (promoting the emergence of advanced knowledge relational training system; PEAK). Each participant was administered three assessments: The PEAK direct training module assessment, the ROWPVT-4 assessment, and the EOWPVT-4 assessment. Scores from all three assessments were compared to assess the relationship between each assessment. The results indicated both a strong correlation between the PEAK direct training module and commonly used language assessments (ROWPVT-4 and EOWPVT-4), as well as strong reliability in the administration of the assessments. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Correlation between PEAK relational training system and one-word picture vocabulary tests [Texte imprimé et/ou numérique] / Autumn MCKEEL, Auteur ; Kyle ROWSEY, Auteur ; Mark R. DIXON, Auteur ; Jacob H. DAAR, Auteur . - p.34-39. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.34-39 Mots-clés : ABA therapy  Language skills  Discrete trial training  PEAK relational training system  Psychometric tests Index. décimale : PER Périodiques Résumé : Abstract The past few decades of research in autism spectrum disorders have been successful in developing effective behavioral treatments; however, the psychometrics of these strategies has not been documented well in applied settings. The current experiment evaluated the relationship between established measures of language skills (receptive and expressive one-word picture vocabulary test; ROWPVT-4 and EOWPVT-4, respectively) and a recently released assessment and curriculum tool designed to teach instructional skills using a behavior analytic approach (promoting the emergence of advanced knowledge relational training system; PEAK). Each participant was administered three assessments: The PEAK direct training module assessment, the ROWPVT-4 assessment, and the EOWPVT-4 assessment. Scores from all three assessments were compared to assess the relationship between each assessment. The results indicated both a strong correlation between the PEAK direct training module and commonly used language assessments (ROWPVT-4 and EOWPVT-4), as well as strong reliability in the administration of the assessments. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

The underlying symptom structure of autism spectrum disorders: A factor analytic approach using the developmental, dimensional and diagnostic interview / Wouter DE LA MARCHE in Research in Autism Spectrum Disorders, 12 (April 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 12 (April 2015) . - p.40-51 Titre : The underlying symptom structure of autism spectrum disorders: A factor analytic approach using the developmental, dimensional and diagnostic interview Type de document : Texte imprimé et/ou numérique Auteurs : Wouter DE LA MARCHE, Auteur ; Ilse NOENS, Auteur ; Bart BOETS, Auteur ; Sofie KUPPENS, Auteur ; Jean STEYAERT, Auteur Article en page(s) : p.40-51 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  DSM-5  Factor analysis  3di Index. décimale : PER Périodiques Résumé : Abstract Several studies have focused on the underlying symptom structure of Autism Spectrum Disorders (ASD), but results have been equivocal. We performed a confirmatory factor analysis on data of the Developmental, Dimensional and Diagnostic Interview of 275 participants with ASD between 3 and 23 years of age, aimed at strengthening the empirical evidence of previously published factor structure solutions using the same instrument. As none of these hypothesised models fitted our data, an exploratory factor analysis was undertaken. Results pointed towards a five factor model. A ‘Restricted and Repetitive Behaviour and Interest’ factor could be separated from ‘Shaking and Nodding’, ‘Emotional Reciprocity’ and two other factors that both represented deficits in social interaction and communication. Although not completely confirming, our results are generally in favour of the present DSM-5 criteria. By showing that the items did not fully segregate according to theoretically postulated subdomains, we offer a possible explanation for the heterogeneity in proposed factor structures for ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.11.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] The underlying symptom structure of autism spectrum disorders: A factor analytic approach using the developmental, dimensional and diagnostic interview [Texte imprimé et/ou numérique] / Wouter DE LA MARCHE, Auteur ; Ilse NOENS, Auteur ; Bart BOETS, Auteur ; Sofie KUPPENS, Auteur ; Jean STEYAERT, Auteur . - p.40-51. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.40-51 Mots-clés : Autism spectrum disorders  DSM-5  Factor analysis  3di Index. décimale : PER Périodiques Résumé : Abstract Several studies have focused on the underlying symptom structure of Autism Spectrum Disorders (ASD), but results have been equivocal. We performed a confirmatory factor analysis on data of the Developmental, Dimensional and Diagnostic Interview of 275 participants with ASD between 3 and 23 years of age, aimed at strengthening the empirical evidence of previously published factor structure solutions using the same instrument. As none of these hypothesised models fitted our data, an exploratory factor analysis was undertaken. Results pointed towards a five factor model. A ‘Restricted and Repetitive Behaviour and Interest’ factor could be separated from ‘Shaking and Nodding’, ‘Emotional Reciprocity’ and two other factors that both represented deficits in social interaction and communication. Although not completely confirming, our results are generally in favour of the present DSM-5 criteria. By showing that the items did not fully segregate according to theoretically postulated subdomains, we offer a possible explanation for the heterogeneity in proposed factor structures for ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.11.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260