Dépouillements

Issue Information in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1017-1020 Titre : Issue Information Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1017-1020 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Issue Information [Texte imprimé et/ou numérique] . - p.1017-1020. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1017-1020 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Associations between joint attention and language in autism spectrum disorder and typical development: A systematic review and meta-regression analysis / Kristen BOTTEMA-BEUTEL in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1021-1035 Titre : Associations between joint attention and language in autism spectrum disorder and typical development: A systematic review and meta-regression analysis Type de document : Texte imprimé et/ou numérique Auteurs : Kristen BOTTEMA-BEUTEL, Auteur Article en page(s) : p.1021-1035 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  joint attention  language  meta-analysis Index. décimale : PER Périodiques Résumé : Using a structured literature search and meta-regression procedures, this study sought to determine whether associations between joint attention and language are moderated by group (autism spectrum disorder [ASD] vs. typical development [TD]), joint attention type (responding to joint attention [RJA] vs. other), and other study design features and participant characteristics. Studies were located using database searches, hand searches, and electronic requests for data from experts in the field. This resulted in 71 reports or datasets and 605 effect sizes, representing 1,859 participants with ASD and 1,835 TD participants. Meta-regression was used to answer research questions regarding potential moderators of the effect sizes of interest, which were Pearson's r values quantifying the association between joint attention and language variables. In the final models, conducted separately for each language variable, effect sizes were significantly higher for the ASD group as compared to the TD group, and for RJA as compared to non-RJA joint attention types. Approximate mental age trended toward significance for the expressive language model. Joint attention may be more tightly tied to language in children with ASD as compared to TD children because TD children exhibit joint attention at sufficient thresholds so that language development becomes untethered to variations in joint attention. Conversely, children with ASD who exhibit deficits in joint attention develop language contingent upon their joint attention abilities. Because RJA was more strongly related to language than other types of joint attention, future research should involve careful consideration of the operationalization and measurement of joint attention constructs. En ligne : http://dx.doi.org/10.1002/aur.1624 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Associations between joint attention and language in autism spectrum disorder and typical development: A systematic review and meta-regression analysis [Texte imprimé et/ou numérique] / Kristen BOTTEMA-BEUTEL, Auteur . - p.1021-1035. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1021-1035 Mots-clés : autism spectrum disorder  joint attention  language  meta-analysis Index. décimale : PER Périodiques Résumé : Using a structured literature search and meta-regression procedures, this study sought to determine whether associations between joint attention and language are moderated by group (autism spectrum disorder [ASD] vs. typical development [TD]), joint attention type (responding to joint attention [RJA] vs. other), and other study design features and participant characteristics. Studies were located using database searches, hand searches, and electronic requests for data from experts in the field. This resulted in 71 reports or datasets and 605 effect sizes, representing 1,859 participants with ASD and 1,835 TD participants. Meta-regression was used to answer research questions regarding potential moderators of the effect sizes of interest, which were Pearson's r values quantifying the association between joint attention and language variables. In the final models, conducted separately for each language variable, effect sizes were significantly higher for the ASD group as compared to the TD group, and for RJA as compared to non-RJA joint attention types. Approximate mental age trended toward significance for the expressive language model. Joint attention may be more tightly tied to language in children with ASD as compared to TD children because TD children exhibit joint attention at sufficient thresholds so that language development becomes untethered to variations in joint attention. Conversely, children with ASD who exhibit deficits in joint attention develop language contingent upon their joint attention abilities. Because RJA was more strongly related to language than other types of joint attention, future research should involve careful consideration of the operationalization and measurement of joint attention constructs. En ligne : http://dx.doi.org/10.1002/aur.1624 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Meta-analysis and association of two common polymorphisms of the human oxytocin receptor gene in autism spectrum disorder / Thorsten M. KRANZ in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1036-1045 Titre : Meta-analysis and association of two common polymorphisms of the human oxytocin receptor gene in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Thorsten M. KRANZ, Auteur ; Marnie KOPP, Auteur ; Regina WALTES, Auteur ; Michael SACHSE, Auteur ; Eftichia DUKETIS, Auteur ; Tomasz A. JARCZOK, Auteur ; Franziska DEGENHARDT, Auteur ; Katharina GÖRGEN, Auteur ; Jobst MEYER, Auteur ; Christine M. FREITAG, Auteur ; Andreas G. CHIOCCHETTI, Auteur Article en page(s) : p.1036-1045 Langues : Anglais (eng) Mots-clés : meta-analysis  autism spectrum disorder  oxytocin receptor  genotyping  social interaction  endophenotype  genetics  oxytocin Index. décimale : PER Périodiques Résumé : Neuropeptides such as oxytocin (OXT) are known facilitators of social behavior across species. Variants of the OXT receptor gene (OXTR) have been tested for association with autism spectrum disorder (ASD) across manifold ethnicities, yielding both positive and negative findings. A recent meta-analysis, comprising 16 single nucleotide polymorphisms (SNPs), has corroborated the implication of OXTR in the etiology of ASD. Here, we genotyped and tested two additional variants (rs237889 and rs237897) for association with ASD in two German predominantly high-functioning ASD samples. We found nominal over-transmission (OR?=?1.48, CI95?=?1.06-2.08, P?=?0.022) for the minor A allele of variant rs237889G>A in sample 1 (N?=?135 complete parent-offspring trios, 29 parent child duos), but not in sample 2 (362 trios, 69 duos). Still, in a meta-analysis comprising four different studies including the two unreported German data sets (N?=?542 families), this finding was confirmed (OR?=?1.12; CI95?=?1.01–1.24, random effects P?=?0.012). In addition, carriers of the minor risk allele rs237889-A showed significantly increased severity scores, as assessed through the autism diagnostic interview – revised (ADI-R), with highly significant increases in social interaction deficits. Our results corroborate the implication of common OXTR variants in the etiology of ASD. There is a need for functional studies to delineate the neurobiological implications of this and other association findings. (172/250). En ligne : http://dx.doi.org/10.1002/aur.1597 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Meta-analysis and association of two common polymorphisms of the human oxytocin receptor gene in autism spectrum disorder [Texte imprimé et/ou numérique] / Thorsten M. KRANZ, Auteur ; Marnie KOPP, Auteur ; Regina WALTES, Auteur ; Michael SACHSE, Auteur ; Eftichia DUKETIS, Auteur ; Tomasz A. JARCZOK, Auteur ; Franziska DEGENHARDT, Auteur ; Katharina GÖRGEN, Auteur ; Jobst MEYER, Auteur ; Christine M. FREITAG, Auteur ; Andreas G. CHIOCCHETTI, Auteur . - p.1036-1045. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1036-1045 Mots-clés : meta-analysis  autism spectrum disorder  oxytocin receptor  genotyping  social interaction  endophenotype  genetics  oxytocin Index. décimale : PER Périodiques Résumé : Neuropeptides such as oxytocin (OXT) are known facilitators of social behavior across species. Variants of the OXT receptor gene (OXTR) have been tested for association with autism spectrum disorder (ASD) across manifold ethnicities, yielding both positive and negative findings. A recent meta-analysis, comprising 16 single nucleotide polymorphisms (SNPs), has corroborated the implication of OXTR in the etiology of ASD. Here, we genotyped and tested two additional variants (rs237889 and rs237897) for association with ASD in two German predominantly high-functioning ASD samples. We found nominal over-transmission (OR?=?1.48, CI95?=?1.06-2.08, P?=?0.022) for the minor A allele of variant rs237889G>A in sample 1 (N?=?135 complete parent-offspring trios, 29 parent child duos), but not in sample 2 (362 trios, 69 duos). Still, in a meta-analysis comprising four different studies including the two unreported German data sets (N?=?542 families), this finding was confirmed (OR?=?1.12; CI95?=?1.01–1.24, random effects P?=?0.012). In addition, carriers of the minor risk allele rs237889-A showed significantly increased severity scores, as assessed through the autism diagnostic interview – revised (ADI-R), with highly significant increases in social interaction deficits. Our results corroborate the implication of common OXTR variants in the etiology of ASD. There is a need for functional studies to delineate the neurobiological implications of this and other association findings. (172/250). En ligne : http://dx.doi.org/10.1002/aur.1597 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Hemispheric differences in language processing in autism spectrum disorders: A meta-analysis of neuroimaging studies / Abbey J. HERRINGSHAW in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1046-1057 Titre : Hemispheric differences in language processing in autism spectrum disorders: A meta-analysis of neuroimaging studies Type de document : Texte imprimé et/ou numérique Auteurs : Abbey J. HERRINGSHAW, Auteur ; Carla J. AMMONS, Auteur ; Thomas P. DERAMUS, Auteur ; Rajesh K. KANA, Auteur Article en page(s) : p.1046-1057 Langues : Anglais (eng) Mots-clés : activation likelihood estimation  language processing  language brain  meta-analysis  autism  neuroimaging  brain Index. décimale : PER Périodiques Résumé : Language impairments, a hallmark feature of autism spectrum disorders (ASD), have been related to neuroanatomical and functional abnormalities. Abnormal lateralization of the functional language network, increased reliance on visual processing areas, and increased posterior brain activation have all been reported in ASD and proposed as explanatory models of language difficulties. Nevertheless, inconsistent findings across studies have prevented a comprehensive characterization of the functional language network in ASD. The aim of this study was to quantify common and consistent patterns of brain activation during language processing in ASD and typically developing control (TD) participants using a meta-analytic approach. Activation likelihood estimation (ALE) meta-analysis was used to examine 22 previously published functional Magnetic Resonance Imaging (fMRI)/positron emission tomography studies of language processing (ASD: N?=?328; TD: N?=?324). Tasks included in this study addressed semantic processing, sentence comprehension, processing figurative language, and speech production. Within-group analysis showed largely overlapping patterns of language-related activation in ASD and TD groups. However, the ASD participants, relative to TD participants, showed: (1) more right hemisphere activity in core language areas (i.e., superior temporal gyrus and inferior frontal gyrus), particularly in tasks where they had poorer performance accuracy; (2) bilateral MTG hypo-activation across many different paradigms; and (3) increased activation of the left lingual gyrus in tasks where they had intact performance. These findings show that the hypotheses reviewed here address the neural and cognitive aspects of language difficulties in ASD across all tasks only in a limited way. Instead, our findings suggest the nuances of language and brain in ASD in terms of its context-dependency. En ligne : http://dx.doi.org/10.1002/aur.1599 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Hemispheric differences in language processing in autism spectrum disorders: A meta-analysis of neuroimaging studies [Texte imprimé et/ou numérique] / Abbey J. HERRINGSHAW, Auteur ; Carla J. AMMONS, Auteur ; Thomas P. DERAMUS, Auteur ; Rajesh K. KANA, Auteur . - p.1046-1057. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1046-1057 Mots-clés : activation likelihood estimation  language processing  language brain  meta-analysis  autism  neuroimaging  brain Index. décimale : PER Périodiques Résumé : Language impairments, a hallmark feature of autism spectrum disorders (ASD), have been related to neuroanatomical and functional abnormalities. Abnormal lateralization of the functional language network, increased reliance on visual processing areas, and increased posterior brain activation have all been reported in ASD and proposed as explanatory models of language difficulties. Nevertheless, inconsistent findings across studies have prevented a comprehensive characterization of the functional language network in ASD. The aim of this study was to quantify common and consistent patterns of brain activation during language processing in ASD and typically developing control (TD) participants using a meta-analytic approach. Activation likelihood estimation (ALE) meta-analysis was used to examine 22 previously published functional Magnetic Resonance Imaging (fMRI)/positron emission tomography studies of language processing (ASD: N?=?328; TD: N?=?324). Tasks included in this study addressed semantic processing, sentence comprehension, processing figurative language, and speech production. Within-group analysis showed largely overlapping patterns of language-related activation in ASD and TD groups. However, the ASD participants, relative to TD participants, showed: (1) more right hemisphere activity in core language areas (i.e., superior temporal gyrus and inferior frontal gyrus), particularly in tasks where they had poorer performance accuracy; (2) bilateral MTG hypo-activation across many different paradigms; and (3) increased activation of the left lingual gyrus in tasks where they had intact performance. These findings show that the hypotheses reviewed here address the neural and cognitive aspects of language difficulties in ASD across all tasks only in a limited way. Instead, our findings suggest the nuances of language and brain in ASD in terms of its context-dependency. En ligne : http://dx.doi.org/10.1002/aur.1599 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Deficient visuospatial working memory functions and neural correlates of the default-mode network in adolescents with autism spectrum disorder / Hsiang-Yun CHIEN in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1058-1072 Titre : Deficient visuospatial working memory functions and neural correlates of the default-mode network in adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Hsiang-Yun CHIEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Wen-Yih ISAAC TSENG, Auteur Article en page(s) : p.1058-1072 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  default-mode network  visuospatial working memory  structural connectivity  functional connectivity Index. décimale : PER Périodiques Résumé : In addition to the essential features of autism spectrum disorder (ASD), namely social communication deficits and repetitive behaviors, individuals with ASD may suffer from working memory deficits and an altered default-mode network (DMN). We hypothesized that an altered DMN is related to working memory deficits in those with ASD. A total of 37 adolescents with ASD and 36 age- and IQ-matched typically developing (TD) controls were analyzed. Visuospatial working memory performance was assessed using pattern recognition memory (PRM), spatial recognition memory (SRM), and paired-associates learning (PAL) tasks. The intrinsic functional connectivity (iFC) of the DMN was indexed by the temporal correlations between the resting-state functional magnetic resonance imaging signals of pairs of DMN regions, including those between the posterior cingulate cortex (PCC) and medial prefrontal cortex (mPFC) and between the PCC and parahippocampi (PHG). The corresponding structural connectivity of the DMN was indexed by the generalized fractional anisotropy (GFA) of the dorsal and ventral cingulum bundles on the basis of diffusion spectrum imaging data. The results showed that ASD adolescents exhibited delayed correct responses in PRM and SRM tasks and committed more errors in the PAL task than the TD controls did. The delayed responses during the PRM and SRM tasks were negatively correlated with bilateral PCC–mPFC iFCs, and PAL performance was negatively correlated with right PCC–PHG iFC in ASD adolescents. Furthermore, ASD adolescents showed significant lower GFA in the right cingulum bundles than the TD group did; the GFA value was negatively correlated with SRM performance in ASD. Our results provide empirical evidence for deficient visuospatial working memory and corresponding neural correlates within the DMN in adolescents with ASD. En ligne : http://dx.doi.org/10.1002/aur.1607 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Deficient visuospatial working memory functions and neural correlates of the default-mode network in adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Hsiang-Yun CHIEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Wen-Yih ISAAC TSENG, Auteur . - p.1058-1072. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1058-1072 Mots-clés : autism spectrum disorder  default-mode network  visuospatial working memory  structural connectivity  functional connectivity Index. décimale : PER Périodiques Résumé : In addition to the essential features of autism spectrum disorder (ASD), namely social communication deficits and repetitive behaviors, individuals with ASD may suffer from working memory deficits and an altered default-mode network (DMN). We hypothesized that an altered DMN is related to working memory deficits in those with ASD. A total of 37 adolescents with ASD and 36 age- and IQ-matched typically developing (TD) controls were analyzed. Visuospatial working memory performance was assessed using pattern recognition memory (PRM), spatial recognition memory (SRM), and paired-associates learning (PAL) tasks. The intrinsic functional connectivity (iFC) of the DMN was indexed by the temporal correlations between the resting-state functional magnetic resonance imaging signals of pairs of DMN regions, including those between the posterior cingulate cortex (PCC) and medial prefrontal cortex (mPFC) and between the PCC and parahippocampi (PHG). The corresponding structural connectivity of the DMN was indexed by the generalized fractional anisotropy (GFA) of the dorsal and ventral cingulum bundles on the basis of diffusion spectrum imaging data. The results showed that ASD adolescents exhibited delayed correct responses in PRM and SRM tasks and committed more errors in the PAL task than the TD controls did. The delayed responses during the PRM and SRM tasks were negatively correlated with bilateral PCC–mPFC iFCs, and PAL performance was negatively correlated with right PCC–PHG iFC in ASD adolescents. Furthermore, ASD adolescents showed significant lower GFA in the right cingulum bundles than the TD group did; the GFA value was negatively correlated with SRM performance in ASD. Our results provide empirical evidence for deficient visuospatial working memory and corresponding neural correlates within the DMN in adolescents with ASD. En ligne : http://dx.doi.org/10.1002/aur.1607 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Sensory subtypes and anxiety in older children and adolescents with autism spectrum disorder / Mirko ULJAREVIC in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1073-1078 Titre : Sensory subtypes and anxiety in older children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mirko ULJAREVIC, Auteur ; Alison LANE, Auteur ; Amanda KELLY, Auteur ; Susan LEEKAM, Auteur Article en page(s) : p.1073-1078 Langues : Anglais (eng) Mots-clés : sensory  subtypes  anxiety  autism Index. décimale : PER Périodiques Résumé : This study aimed to identify sensory subtypes in older children and adolescents with Autism Spectrum Disorders (ASD) and examine the relationship of sensory subtypes with anxiety levels in this group. Mothers of 57 children and adolescents with ASD aged 11–17 years (Mean age?=?14 years. 2.4 months, SD?=?1.81) completed the short sensory profile and Spence anxiety scales. Model-based cluster analysis was applied to sensory profile scores to identify sensory subtypes. Three sensory subtypes, sensory adaptive (N?=?19), sensory moderate (N?=?29) and sensory severe (N?=?9) were identified. The results indicated that the differences between the subtypes were well characterised by the severity of sensory symptoms and were not attributable to sensory modality or varying types of sensory-related behaviors. Children and adolescents from the adaptive subtype had significantly lower anxiety scores when compared with other two subtypes. There were no differences between subtypes based on chronological age, expressive language, or severity of autism diagnostic features as measured by the social communication questionnaire (SCQ total score). This is the first study to identify the existence of sensory subtypes among older children and adolescents with ASD and explore their association with anxiety levels. En ligne : http://dx.doi.org/10.1002/aur.1602 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Sensory subtypes and anxiety in older children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Mirko ULJAREVIC, Auteur ; Alison LANE, Auteur ; Amanda KELLY, Auteur ; Susan LEEKAM, Auteur . - p.1073-1078. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1073-1078 Mots-clés : sensory  subtypes  anxiety  autism Index. décimale : PER Périodiques Résumé : This study aimed to identify sensory subtypes in older children and adolescents with Autism Spectrum Disorders (ASD) and examine the relationship of sensory subtypes with anxiety levels in this group. Mothers of 57 children and adolescents with ASD aged 11–17 years (Mean age?=?14 years. 2.4 months, SD?=?1.81) completed the short sensory profile and Spence anxiety scales. Model-based cluster analysis was applied to sensory profile scores to identify sensory subtypes. Three sensory subtypes, sensory adaptive (N?=?19), sensory moderate (N?=?29) and sensory severe (N?=?9) were identified. The results indicated that the differences between the subtypes were well characterised by the severity of sensory symptoms and were not attributable to sensory modality or varying types of sensory-related behaviors. Children and adolescents from the adaptive subtype had significantly lower anxiety scores when compared with other two subtypes. There were no differences between subtypes based on chronological age, expressive language, or severity of autism diagnostic features as measured by the social communication questionnaire (SCQ total score). This is the first study to identify the existence of sensory subtypes among older children and adolescents with ASD and explore their association with anxiety levels. En ligne : http://dx.doi.org/10.1002/aur.1602 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Atypical sensory reactivity influences auditory attentional control in adults with autism spectrum disorders / Debra S. KARHSON in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1079-1092 Titre : Atypical sensory reactivity influences auditory attentional control in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Debra S. KARHSON, Auteur ; Edward J. GOLOB, Auteur Article en page(s) : p.1079-1092 Langues : Anglais (eng) Mots-clés : P50  P1  N100  autism  attention  EEG/ERP  sensory  reactivity Index. décimale : PER Périodiques Résumé : Frequent observations of atypical sensory reactivity in people with autism spectrum disorders (ASD) suggest that the perceptual experience of those on the Spectrum is dissimilar to neurotypicals. Moreover, variable attention abilities in people with ASD, ranging from good control to periods of high distractibility, may be related to atypical sensory reactivity. This study used auditory event-related potential (ERP) measures to evaluate top-down and bottom-up attentional processes as a function of perceptual load, and examined these factors with respect to sensory reactivity. Twenty-five age and IQ-matched participants (ASD: 22.5 year, SD?=?4.1 year; Controls: 22.8 year, SD?=?5.1 year) completed the Adolescent/Adult Sensory Profile prior to performing a modified 3-stimulus (target, non-target, and distractor) auditory oddball target detection task EEG was recorded during task completion. ERP analysis assessed early sensory processing (P50, ?50 ms latency; N100, ?100 ms latency), cognitive control (N200, ?200 ms latency), and attentional processing (P3a and P3b, ?300 ms latency). Behavioral data demonstrates participants with ASD and neurotypical performed similarly on auditory target detection, but diverged on sensory profiles. Target ERP measures associated with top-down control (P3b latency) significantly increased under greater load in controls, but not in participants with ASD. Early ERP responses associated with bottom-up attention (P50 amplitude) were positively correlated to increased sensory sensitivity. Findings suggest specific neural mechanisms for increased perceptual capacity and enhanced bottom-up processing of sensory stimuli in people with autism. Results from participants with ASD are consistent with load theory and enhanced perceptual functioning. En ligne : http://dx.doi.org/10.1002/aur.1593 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Atypical sensory reactivity influences auditory attentional control in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Debra S. KARHSON, Auteur ; Edward J. GOLOB, Auteur . - p.1079-1092. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1079-1092 Mots-clés : P50  P1  N100  autism  attention  EEG/ERP  sensory  reactivity Index. décimale : PER Périodiques Résumé : Frequent observations of atypical sensory reactivity in people with autism spectrum disorders (ASD) suggest that the perceptual experience of those on the Spectrum is dissimilar to neurotypicals. Moreover, variable attention abilities in people with ASD, ranging from good control to periods of high distractibility, may be related to atypical sensory reactivity. This study used auditory event-related potential (ERP) measures to evaluate top-down and bottom-up attentional processes as a function of perceptual load, and examined these factors with respect to sensory reactivity. Twenty-five age and IQ-matched participants (ASD: 22.5 year, SD?=?4.1 year; Controls: 22.8 year, SD?=?5.1 year) completed the Adolescent/Adult Sensory Profile prior to performing a modified 3-stimulus (target, non-target, and distractor) auditory oddball target detection task EEG was recorded during task completion. ERP analysis assessed early sensory processing (P50, ?50 ms latency; N100, ?100 ms latency), cognitive control (N200, ?200 ms latency), and attentional processing (P3a and P3b, ?300 ms latency). Behavioral data demonstrates participants with ASD and neurotypical performed similarly on auditory target detection, but diverged on sensory profiles. Target ERP measures associated with top-down control (P3b latency) significantly increased under greater load in controls, but not in participants with ASD. Early ERP responses associated with bottom-up attention (P50 amplitude) were positively correlated to increased sensory sensitivity. Findings suggest specific neural mechanisms for increased perceptual capacity and enhanced bottom-up processing of sensory stimuli in people with autism. Results from participants with ASD are consistent with load theory and enhanced perceptual functioning. En ligne : http://dx.doi.org/10.1002/aur.1593 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Communication growth in minimally verbal children with ASD: The importance of interaction / Charlotte DISTEFANO in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1093-1102 Titre : Communication growth in minimally verbal children with ASD: The importance of interaction Type de document : Texte imprimé et/ou numérique Auteurs : Charlotte DISTEFANO, Auteur ; Wendy SHIH, Auteur ; Ann P. KAISER, Auteur ; Rebecca LANDA, Auteur ; Connie KASARI, Auteur Article en page(s) : p.1093-1102 Langues : Anglais (eng) Mots-clés : minimally verbal  language  communication  intervention Index. décimale : PER Périodiques Résumé : Little is known about language development in children with Autism Spectrum Disorders (ASD) who remain minimally verbal past age 5. While there is evidence that children can develop language after age 5, we lack detailed information. Studies of this population generally focus on discrete language skills without addressing broader social-communication abilities. As communication and social deficits are both inherent to ASD, an examination of not only what language skills are acquired, but how those skills are used in interactions is relevant. Research in typical development has examined how communication interchanges (unbroken back-and-forth exchanges around a unified purpose) develop, which can be used as a framework for studying minimally verbal children. This study examined the interchange use by 55 children with ASD over the course of a 6-month play and engagement-based communication intervention. Half of the children received intervention sessions that also incorporated a speech-generating device (SGD). Interchanges were coded by: frequency, length, function, and initiator (child or adult). Results indicated that children initiated a large proportion of interchanges and this proportion increased over time. The average length and number of interchanges increased over time, with children in the SGD group showing even greater growth. Finally, children's total number of interchanges at baseline was positively associated with their spoken language gains over the course of intervention. This study supports the crucial relationship between social engagement and expressive language development, and highlights the need to include sustained communication interchanges as a target for intervention with this population. En ligne : http://dx.doi.org/10.1002/aur.1594 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Communication growth in minimally verbal children with ASD: The importance of interaction [Texte imprimé et/ou numérique] / Charlotte DISTEFANO, Auteur ; Wendy SHIH, Auteur ; Ann P. KAISER, Auteur ; Rebecca LANDA, Auteur ; Connie KASARI, Auteur . - p.1093-1102. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1093-1102 Mots-clés : minimally verbal  language  communication  intervention Index. décimale : PER Périodiques Résumé : Little is known about language development in children with Autism Spectrum Disorders (ASD) who remain minimally verbal past age 5. While there is evidence that children can develop language after age 5, we lack detailed information. Studies of this population generally focus on discrete language skills without addressing broader social-communication abilities. As communication and social deficits are both inherent to ASD, an examination of not only what language skills are acquired, but how those skills are used in interactions is relevant. Research in typical development has examined how communication interchanges (unbroken back-and-forth exchanges around a unified purpose) develop, which can be used as a framework for studying minimally verbal children. This study examined the interchange use by 55 children with ASD over the course of a 6-month play and engagement-based communication intervention. Half of the children received intervention sessions that also incorporated a speech-generating device (SGD). Interchanges were coded by: frequency, length, function, and initiator (child or adult). Results indicated that children initiated a large proportion of interchanges and this proportion increased over time. The average length and number of interchanges increased over time, with children in the SGD group showing even greater growth. Finally, children's total number of interchanges at baseline was positively associated with their spoken language gains over the course of intervention. This study supports the crucial relationship between social engagement and expressive language development, and highlights the need to include sustained communication interchanges as a target for intervention with this population. En ligne : http://dx.doi.org/10.1002/aur.1594 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Intact recognition, but attenuated adaptation, for biological motion in youth with autism spectrum disorder / Jeroen J. A. VAN BOXTEL in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1103-1113 Titre : Intact recognition, but attenuated adaptation, for biological motion in youth with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jeroen J. A. VAN BOXTEL, Auteur ; Mirella DAPRETTO, Auteur ; Hongjing LU, Auteur Article en page(s) : p.1103-1113 Langues : Anglais (eng) Mots-clés : biological motion  autism spectrum disorder  adaptation  context  global processing  local processing Index. décimale : PER Périodiques Résumé : Given the ecological importance of biological motion and its relevance to social cognition, considerable effort has been devoted over the past decade to studying biological motion perception in autism. However, previous studies have asked observers to detect or recognize briefly presented human actions placed in isolation, without spatial or temporal context. Research on typical populations has shown the influence of temporal context in biological motion perception: prolonged exposure to one action gives rise to an aftereffect that biases perception of a subsequently displayed action. Whether people with autism spectrum disorders (ASD) show such adaptation effects for biological motion stimuli remains unknown. To address this question, this study examined how well youth with ASD recognize ambiguous actions and adapt to recently-observed actions. Compared to typically-developing (TD) controls, youth with ASD showed no differences in perceptual boundaries between actions categories, indicating intact ability in recognizing actions. However, children with ASD showed weakened adaptation to biological motion. It is unlikely that the reduced action adaptability in autism was due to delayed developmental trajectory, as older children with ASD showed weaker adaptation to actions than younger children with ASD. Our results further suggest that high-level (i.e., action) processing weakens with age for children with ASD, but this change may be accompanied by a potentially compensatory mechanism based on more involvement of low-level (i.e., motion) processing. En ligne : http://dx.doi.org/10.1002/aur.1595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Intact recognition, but attenuated adaptation, for biological motion in youth with autism spectrum disorder [Texte imprimé et/ou numérique] / Jeroen J. A. VAN BOXTEL, Auteur ; Mirella DAPRETTO, Auteur ; Hongjing LU, Auteur . - p.1103-1113. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1103-1113 Mots-clés : biological motion  autism spectrum disorder  adaptation  context  global processing  local processing Index. décimale : PER Périodiques Résumé : Given the ecological importance of biological motion and its relevance to social cognition, considerable effort has been devoted over the past decade to studying biological motion perception in autism. However, previous studies have asked observers to detect or recognize briefly presented human actions placed in isolation, without spatial or temporal context. Research on typical populations has shown the influence of temporal context in biological motion perception: prolonged exposure to one action gives rise to an aftereffect that biases perception of a subsequently displayed action. Whether people with autism spectrum disorders (ASD) show such adaptation effects for biological motion stimuli remains unknown. To address this question, this study examined how well youth with ASD recognize ambiguous actions and adapt to recently-observed actions. Compared to typically-developing (TD) controls, youth with ASD showed no differences in perceptual boundaries between actions categories, indicating intact ability in recognizing actions. However, children with ASD showed weakened adaptation to biological motion. It is unlikely that the reduced action adaptability in autism was due to delayed developmental trajectory, as older children with ASD showed weaker adaptation to actions than younger children with ASD. Our results further suggest that high-level (i.e., action) processing weakens with age for children with ASD, but this change may be accompanied by a potentially compensatory mechanism based on more involvement of low-level (i.e., motion) processing. En ligne : http://dx.doi.org/10.1002/aur.1595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

The Autism-Spectrum Quotient in siblings of people with Autism / Emily RUZICH in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1114-1114 Titre : The Autism-Spectrum Quotient in siblings of people with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Emily RUZICH, Auteur ; Carrie ALLISON, Auteur ; Paula SMITH, Auteur ; Howard RING, Auteur ; Bonnie AUYEUNG, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : p.1114-1114 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1689 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] The Autism-Spectrum Quotient in siblings of people with Autism [Texte imprimé et/ou numérique] / Emily RUZICH, Auteur ; Carrie ALLISON, Auteur ; Paula SMITH, Auteur ; Howard RING, Auteur ; Bonnie AUYEUNG, Auteur ; Simon BARON-COHEN, Auteur . - p.1114-1114. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1114-1114 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1689 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Scientific Summaries for Families with ASD in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1115-1118 Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1115-1118 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.1115-1118. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1115-1118 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

International society for autism research news www.autism-insar.org in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1119-1119 Titre : International society for autism research news www.autism-insar.org Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1119-1119 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1719 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] International society for autism research news www.autism-insar.org [Texte imprimé et/ou numérique] . - p.1119-1119. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1119-1119 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1719 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294