Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms / Gisela SUGRANYES in Journal of Child Psychology and Psychiatry, 62-6 (June 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.780-789 Titre : Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms Type de document : texte imprimé Auteurs : Gisela SUGRANYES, Auteur ; Elena DE LA SERNA, Auteur ; Daniel ILZARBE, Auteur ; Jose Carlos PARIENTE, Auteur ; Roger BORRAS, Auteur ; Soledad ROMERO, Auteur ; Mireia ROSA, Auteur ; Inmaculada BAEZA, Auteur ; Maria Dolores MORENO, Auteur ; Miguel BERNARDO, Auteur ; Eduard VIETA, Auteur ; Josefina CASTRO-FORNIELES, Auteur Article en page(s) : p.780-789 Langues : Anglais (eng) Mots-clés : Adolescent  Bipolar Disorder/diagnostic imaging  Brain/diagnostic imaging  Cross-Sectional Studies  Genetic Predisposition to Disease  Humans  Magnetic Resonance Imaging  Psychotic Disorders/diagnostic imaging  Schizophrenia/diagnostic imaging/genetics  High-risk studies  bipolar  psychosis  schizophrenia  structural MRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The evaluation of child and adolescent offspring of patients with schizophrenia (SzO) or bipolar disorder (BpO) may help understand changes taking place in the brain in individuals at heightened risk for disease during a key developmental period. METHODS: One hundred twenty-eight individuals (33 SzO and 46 BpO, considered jointly as 'Familial High Risk' (FHR), and 49 controls) aged 6-17 years underwent clinical, cognitive and neuroimaging assessment at baseline, 2- and 4-year follow-up. Twenty FHR participants (11 SzO and 9 BpO) developed psychotic spectrum symptoms during follow-up, while 59 FHR participants did not. Magnetic resonance imaging was performed on a 3Tesla scanner; cortical surface reconstruction was applied to measure cortical thickness, surface area and grey matter volume. RESULTS: FHR participants who developed psychotic spectrum symptoms over time showed greater time-related mean cortical thinning than those who did not and than controls. By subgroups, this effect was present in both BpO and SzO in the occipital cortex. At baseline, FHR participants who developed psychotic spectrum symptoms over time had smaller total surface area and grey matter volume than those who did not and than controls. Over time, all FHR participants showed less longitudinal decrease in surface area than controls. In those who developed psychotic spectrum symptoms over time, this effect was driven by BpO, while in those who did not, this was due to SzO, who also showed less grey matter volume reduction. CONCLUSION: The emergence of psychotic spectrum symptoms in FHR was indexed by smaller cross-sectional surface area and progressive cortical thinning. Relative preservation of surface area over time may signal different processes according to familial risk. These findings lay the foundation for future studies aimed at stratification of FHR youth. En ligne : http://dx.doi.org/10.1111/jcpp.13321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms [texte imprimé] / Gisela SUGRANYES, Auteur ; Elena DE LA SERNA, Auteur ; Daniel ILZARBE, Auteur ; Jose Carlos PARIENTE, Auteur ; Roger BORRAS, Auteur ; Soledad ROMERO, Auteur ; Mireia ROSA, Auteur ; Inmaculada BAEZA, Auteur ; Maria Dolores MORENO, Auteur ; Miguel BERNARDO, Auteur ; Eduard VIETA, Auteur ; Josefina CASTRO-FORNIELES, Auteur . - p.780-789. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.780-789 Mots-clés : Adolescent  Bipolar Disorder/diagnostic imaging  Brain/diagnostic imaging  Cross-Sectional Studies  Genetic Predisposition to Disease  Humans  Magnetic Resonance Imaging  Psychotic Disorders/diagnostic imaging  Schizophrenia/diagnostic imaging/genetics  High-risk studies  bipolar  psychosis  schizophrenia  structural MRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The evaluation of child and adolescent offspring of patients with schizophrenia (SzO) or bipolar disorder (BpO) may help understand changes taking place in the brain in individuals at heightened risk for disease during a key developmental period. METHODS: One hundred twenty-eight individuals (33 SzO and 46 BpO, considered jointly as 'Familial High Risk' (FHR), and 49 controls) aged 6-17 years underwent clinical, cognitive and neuroimaging assessment at baseline, 2- and 4-year follow-up. Twenty FHR participants (11 SzO and 9 BpO) developed psychotic spectrum symptoms during follow-up, while 59 FHR participants did not. Magnetic resonance imaging was performed on a 3Tesla scanner; cortical surface reconstruction was applied to measure cortical thickness, surface area and grey matter volume. RESULTS: FHR participants who developed psychotic spectrum symptoms over time showed greater time-related mean cortical thinning than those who did not and than controls. By subgroups, this effect was present in both BpO and SzO in the occipital cortex. At baseline, FHR participants who developed psychotic spectrum symptoms over time had smaller total surface area and grey matter volume than those who did not and than controls. Over time, all FHR participants showed less longitudinal decrease in surface area than controls. In those who developed psychotic spectrum symptoms over time, this effect was driven by BpO, while in those who did not, this was due to SzO, who also showed less grey matter volume reduction. CONCLUSION: The emergence of psychotic spectrum symptoms in FHR was indexed by smaller cross-sectional surface area and progressive cortical thinning. Relative preservation of surface area over time may signal different processes according to familial risk. These findings lay the foundation for future studies aimed at stratification of FHR youth. En ligne : http://dx.doi.org/10.1111/jcpp.13321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Sex differences and implications in outcome in children and adolescents at clinical high risk for psychosis / Jordina TOR in Journal of Child Psychology and Psychiatry, 66-10 (October 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1461-1472 Titre : Sex differences and implications in outcome in children and adolescents at clinical high risk for psychosis Type de document : texte imprimé Auteurs : Jordina TOR, Auteur ; Inmaculada BAEZA, Auteur ; Xavier ALVAREZ-SUBIELA, Auteur ; Marta RODRIGUEZ-PASCUAL, Auteur ; Daniel MUÑOZ-SAMONS, Auteur ; Anna SINTES-ESTEVEZ, Auteur ; Elena DE LA SERNA, Auteur ; Olga PUIG, Auteur ; Gisela SUGRANYES, Auteur ; Daniel ILZARBE, Auteur ; Josep Maria HARO, Auteur ; Montserrat DOLZ, Auteur Article en page(s) : p.1461-1472 Langues : Anglais (eng) Mots-clés : Sex differences  clinical high risk for psychosis  children and adolescents  psychosis  outcome Index. décimale : PER Périodiques Résumé : Background Sex differences have been identified in young adults along the psychosis continuum, but studies in children and adolescents are scarce. This study aimed to evaluate possible sex differences in clinical characteristics and outcomes in children and adolescents with clinical high risk for psychosis (CHR). Methods A naturalistic longitudinal cohort study assessed sociodemographics, CHR symptoms, functioning, and mood at baseline and at 18 months' follow-up in 221 CHR participants (154 females and 67 males) and 159 controls (93 females and 66 males). Regression analyses were performed to test baseline differences, and multinominal regression was used to test the implication of sex in outcome. Results Despite initial pairwise differences in attenuated positive symptoms, regression analyses failed to show sex differences in CHR symptoms when control group was added to the analyses. The interaction between sex and group significantly predicted depressive symptoms (B 2.907, p .040, 95% CI: [ 5.681, 0.133]) and caffeine use lifetime (OR 0.36, 95% CI: [0.138, 0.924], p .034). A significant interaction between age and sex showed that the older the age in females, the greater the probability of non-remission of CHR at follow-up, as compared to males (B 0.338, IC 95%: [0.123, 0.933], p .036), but no relevant associations with sex were found in psychosis outcome. Conclusions No sex-related differences in CHR symptoms were observed in a CHR children and adolescent population. Outcomes related to non-remission of CHR state in older females could reflect the greater prevalence of psychosis-like experiences in adolescent females. These results invite us to reconsider the usefulness of the current CHR criteria in young populations, especially if we do not take into account a gender perspective and how age might affect it. En ligne : https://doi.org/10.1111/jcpp.14148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Sex differences and implications in outcome in children and adolescents at clinical high risk for psychosis [texte imprimé] / Jordina TOR, Auteur ; Inmaculada BAEZA, Auteur ; Xavier ALVAREZ-SUBIELA, Auteur ; Marta RODRIGUEZ-PASCUAL, Auteur ; Daniel MUÑOZ-SAMONS, Auteur ; Anna SINTES-ESTEVEZ, Auteur ; Elena DE LA SERNA, Auteur ; Olga PUIG, Auteur ; Gisela SUGRANYES, Auteur ; Daniel ILZARBE, Auteur ; Josep Maria HARO, Auteur ; Montserrat DOLZ, Auteur . - p.1461-1472. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1461-1472 Mots-clés : Sex differences  clinical high risk for psychosis  children and adolescents  psychosis  outcome Index. décimale : PER Périodiques Résumé : Background Sex differences have been identified in young adults along the psychosis continuum, but studies in children and adolescents are scarce. This study aimed to evaluate possible sex differences in clinical characteristics and outcomes in children and adolescents with clinical high risk for psychosis (CHR). Methods A naturalistic longitudinal cohort study assessed sociodemographics, CHR symptoms, functioning, and mood at baseline and at 18 months' follow-up in 221 CHR participants (154 females and 67 males) and 159 controls (93 females and 66 males). Regression analyses were performed to test baseline differences, and multinominal regression was used to test the implication of sex in outcome. Results Despite initial pairwise differences in attenuated positive symptoms, regression analyses failed to show sex differences in CHR symptoms when control group was added to the analyses. The interaction between sex and group significantly predicted depressive symptoms (B 2.907, p .040, 95% CI: [ 5.681, 0.133]) and caffeine use lifetime (OR 0.36, 95% CI: [0.138, 0.924], p .034). A significant interaction between age and sex showed that the older the age in females, the greater the probability of non-remission of CHR at follow-up, as compared to males (B 0.338, IC 95%: [0.123, 0.933], p .036), but no relevant associations with sex were found in psychosis outcome. Conclusions No sex-related differences in CHR symptoms were observed in a CHR children and adolescent population. Outcomes related to non-remission of CHR state in older females could reflect the greater prevalence of psychosis-like experiences in adolescent females. These results invite us to reconsider the usefulness of the current CHR criteria in young populations, especially if we do not take into account a gender perspective and how age might affect it. En ligne : https://doi.org/10.1111/jcpp.14148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

The affective dimension of early-onset psychosis and its relationship with suicide / Vanessa SANCHEZ-GISTAU in Journal of Child Psychology and Psychiatry, 56-7 (July 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.747-755 Titre : The affective dimension of early-onset psychosis and its relationship with suicide Type de document : texte imprimé Auteurs : Vanessa SANCHEZ-GISTAU, Auteur ; Inmaculada BAEZA, Auteur ; Celso ARANGO, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Elena DE LA SERNA, Auteur ; Mara PARELLADA, Auteur ; Montserrat GRAELL, Auteur ; Beatriz PAYA, Auteur ; Cloe LLORENTE, Auteur ; Josefina CASTRO-FORNIELES, Auteur Article en page(s) : p.747-755 Langues : Anglais (eng) Mots-clés : Psychosis  suicidality  depression Index. décimale : PER Périodiques Résumé : Background The affective dimension has scarcely been studied in early-onset psychosis. Our aims were to investigate the prevalence and type of affective symptoms in the prodromal and acute phases of early-onset psychosis and to examine their relationship with suicide. We also sought to establish whether the presence of premorbid antecedents or the presence of affective symptoms during the prodromal and acute phase might predict a later diagnosis of bipolar disorder (BP) or schizophrenia (SZ). Method Participants were 95 youths, aged 9–17 years, experiencing a first episode of a psychotic disorder (FEP) according to DSM-IV criteria. Prodromal affective symptoms in the year prior to the onset of full-blown psychosis were assessed by means of the K-SADS. Affective symptoms during the acute episode were evaluated using the Hamilton Depression Rating Scale and the Young Mania Rating Scale. Suicidality was assessed during the acute episode and at 6 and 12 months. Results Half of the patients experienced affective symptoms during the prodrome, with depressive symptoms being the most frequently reported. During the acute episode, 23.2% presented depressive, 41.4% mixed and 18.9% manic symptoms. After logistic regression analysis, only the presence of depressive symptoms was significantly associated with suicidality during the 12 months following the FEP. Neither early premorbid antecedents nor the prevalence or type of affective symptoms during the FEP predicted a diagnosis of BP or SZ at 12 months. However, both depressive and manic prodromal symptoms were associated with a later diagnosis of BP. Conclusions The FEP of both SZ and BP is preceded by an identifiable prodromal phase. Early detection programs should target young people at clinical risk for the extended psychosis phenotype. The high prevalence of affective symptoms during the early phases of psychosis may encourage clinicians to identify and treat them in order to prevent suicide behaviour. En ligne : http://dx.doi.org/10.1111/jcpp.12332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] The affective dimension of early-onset psychosis and its relationship with suicide [texte imprimé] / Vanessa SANCHEZ-GISTAU, Auteur ; Inmaculada BAEZA, Auteur ; Celso ARANGO, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Elena DE LA SERNA, Auteur ; Mara PARELLADA, Auteur ; Montserrat GRAELL, Auteur ; Beatriz PAYA, Auteur ; Cloe LLORENTE, Auteur ; Josefina CASTRO-FORNIELES, Auteur . - p.747-755. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.747-755 Mots-clés : Psychosis  suicidality  depression Index. décimale : PER Périodiques Résumé : Background The affective dimension has scarcely been studied in early-onset psychosis. Our aims were to investigate the prevalence and type of affective symptoms in the prodromal and acute phases of early-onset psychosis and to examine their relationship with suicide. We also sought to establish whether the presence of premorbid antecedents or the presence of affective symptoms during the prodromal and acute phase might predict a later diagnosis of bipolar disorder (BP) or schizophrenia (SZ). Method Participants were 95 youths, aged 9–17 years, experiencing a first episode of a psychotic disorder (FEP) according to DSM-IV criteria. Prodromal affective symptoms in the year prior to the onset of full-blown psychosis were assessed by means of the K-SADS. Affective symptoms during the acute episode were evaluated using the Hamilton Depression Rating Scale and the Young Mania Rating Scale. Suicidality was assessed during the acute episode and at 6 and 12 months. Results Half of the patients experienced affective symptoms during the prodrome, with depressive symptoms being the most frequently reported. During the acute episode, 23.2% presented depressive, 41.4% mixed and 18.9% manic symptoms. After logistic regression analysis, only the presence of depressive symptoms was significantly associated with suicidality during the 12 months following the FEP. Neither early premorbid antecedents nor the prevalence or type of affective symptoms during the FEP predicted a diagnosis of BP or SZ at 12 months. However, both depressive and manic prodromal symptoms were associated with a later diagnosis of BP. Conclusions The FEP of both SZ and BP is preceded by an identifiable prodromal phase. Early detection programs should target young people at clinical risk for the extended psychosis phenotype. The high prevalence of affective symptoms during the early phases of psychosis may encourage clinicians to identify and treat them in order to prevent suicide behaviour. En ligne : http://dx.doi.org/10.1111/jcpp.12332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Two-year diagnostic stability in early-onset first-episode psychosis / Josefina CASTRO-FORNIELES in Journal of Child Psychology and Psychiatry, 52-10 (October 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1089-1098 Titre : Two-year diagnostic stability in early-onset first-episode psychosis Type de document : texte imprimé Auteurs : Josefina CASTRO-FORNIELES, Auteur ; Elena DE LA SERNA, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Mara PARELLADA, Auteur ; Montserrat GRAELL, Auteur ; Dolores MORENO, Auteur ; Soraya OTERO, Auteur ; Celso ARANGO, Auteur Année de publication : 2011 Article en page(s) : p.1089-1098 Langues : Anglais (eng) Mots-clés : psychosis  diagnosis  schizophrenia  bipolar disorder Index. décimale : PER Périodiques Résumé : Background:  Only one study has used a prospective method to analyze the diagnostic stability of first psychotic episodes in children and adolescents. The Child and Adolescent First-Episode Psychosis Study (CAFEPS) is a 2-year, prospective longitudinal study of early-onset first episodes of psychosis (EO-FEP). Aim:  To describe diagnostic stability and the variables related to diagnostic changes. Methods:  Participants were 83 patients (aged 9–17 years) with an EO-FEP consecutively attended. They were assessed with a structured interview (Kiddie-Schedule for Affective Disorders and Schizophrenia, Present and Lifetime version) and clinical scales at baseline and after 2 years. Results:  The global consistency for all diagnoses was 63.9%. The small group of bipolar disorder had high stability (92.31%) as did the group with schizophrenia spectrum disorders (90.00%). Depressive disorder had lower stability (37.50%) and the lowest values were for psychotic disorder not otherwise specified (11.76%) and brief psychotic disorder (0%).The most frequent diagnostic shift was to schizophrenia spectrum and bipolar disorders. One group of patients did not meet the criteria for any diagnosis at follow-up. Independent predictors of change to schizophrenia spectrum disorders were lower scores on the Children’s Global Assessment Scale (CGAS) and the Hamilton Depression Rating Scale. Predictors of not having a diagnosis at follow-up were the CGAS and the Strauss–Carpenter Outcome Scale. Conclusions:  Global diagnostic stability was 63.9%. Bipolar and schizophrenia spectrum disorders were the most stable diagnoses, while depressive disorder and other psychosis the least stable. Psychosocial functioning at baseline was a good predictor of diagnosis at follow-up. These data show the need for longitudinal follow-up in EO-FEP before a stable diagnosis is reached. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02443.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142 [article] Two-year diagnostic stability in early-onset first-episode psychosis [texte imprimé] / Josefina CASTRO-FORNIELES, Auteur ; Elena DE LA SERNA, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Mara PARELLADA, Auteur ; Montserrat GRAELL, Auteur ; Dolores MORENO, Auteur ; Soraya OTERO, Auteur ; Celso ARANGO, Auteur . - 2011 . - p.1089-1098. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1089-1098 Mots-clés : psychosis  diagnosis  schizophrenia  bipolar disorder Index. décimale : PER Périodiques Résumé : Background:  Only one study has used a prospective method to analyze the diagnostic stability of first psychotic episodes in children and adolescents. The Child and Adolescent First-Episode Psychosis Study (CAFEPS) is a 2-year, prospective longitudinal study of early-onset first episodes of psychosis (EO-FEP). Aim:  To describe diagnostic stability and the variables related to diagnostic changes. Methods:  Participants were 83 patients (aged 9–17 years) with an EO-FEP consecutively attended. They were assessed with a structured interview (Kiddie-Schedule for Affective Disorders and Schizophrenia, Present and Lifetime version) and clinical scales at baseline and after 2 years. Results:  The global consistency for all diagnoses was 63.9%. The small group of bipolar disorder had high stability (92.31%) as did the group with schizophrenia spectrum disorders (90.00%). Depressive disorder had lower stability (37.50%) and the lowest values were for psychotic disorder not otherwise specified (11.76%) and brief psychotic disorder (0%).The most frequent diagnostic shift was to schizophrenia spectrum and bipolar disorders. One group of patients did not meet the criteria for any diagnosis at follow-up. Independent predictors of change to schizophrenia spectrum disorders were lower scores on the Children’s Global Assessment Scale (CGAS) and the Hamilton Depression Rating Scale. Predictors of not having a diagnosis at follow-up were the CGAS and the Strauss–Carpenter Outcome Scale. Conclusions:  Global diagnostic stability was 63.9%. Bipolar and schizophrenia spectrum disorders were the most stable diagnoses, while depressive disorder and other psychosis the least stable. Psychosocial functioning at baseline was a good predictor of diagnosis at follow-up. These data show the need for longitudinal follow-up in EO-FEP before a stable diagnosis is reached. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02443.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142

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