Affective neural response to restricted interests in autism spectrum disorders / Carissa J. CASCIO in Journal of Child Psychology and Psychiatry, 55-2 (February 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.162-171 Titre : Affective neural response to restricted interests in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Carissa J. CASCIO, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Jessica L. HEACOCK, Auteur ; Kimberly B. SCHAUDER, Auteur ; Whitney A. LORING, Auteur ; Baxter P. ROGERS, Auteur ; Jennifer R. PRYWELLER, Auteur ; Cassandra R. NEWSOM, Auteur ; Jurnell COCKHREN, Auteur ; Aize CAO, Auteur ; Scott BOLTON, Auteur Article en page(s) : p.162-171 Langues : Anglais (eng) Mots-clés : Autism  restricted interests  reward  repetitive behavior  fMRI  insula  salience Index. décimale : PER Périodiques Résumé : Background Restricted interests are a class of repetitive behavior in autism spectrum disorders (ASD) whose intensity and narrow focus often contribute to significant interference with daily functioning. While numerous neuroimaging studies have investigated executive circuits as putative neural substrates of repetitive behavior, recent work implicates affective neural circuits in restricted interests. We sought to explore the role of affective neural circuits and determine how restricted interests are distinguished from hobbies or interests in typical development. Methods We compared a group of children with ASD to a typically developing (TD) group of children with strong interests or hobbies, employing parent report, an operant behavioral task, and functional imaging with personalized stimuli based on individual interests. Results While performance on the operant task was similar between the two groups, parent report of intensity and interference of interests was significantly higher in the ASD group. Both the ASD and TD groups showed increased BOLD response in widespread affective neural regions to the pictures of their own interest. When viewing pictures of other children's interests, the TD group showed a similar pattern, whereas BOLD response in the ASD group was much more limited. Increased BOLD response in the insula and anterior cingulate cortex distinguished the ASD from the TD group, and parent report of the intensity and interference with daily life of the child's restricted interest predicted insula response. Conclusions While affective neural network response and operant behavior are comparable in typical and restricted interests, the narrowness of focus that clinically distinguishes restricted interests in ASD is reflected in more interference in daily life and aberrantly enhanced insula and anterior cingulate response to individuals’ own interests in the ASD group. These results further support the involvement of affective neural networks in repetitive behaviors in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Affective neural response to restricted interests in autism spectrum disorders [Texte imprimé et/ou numérique] / Carissa J. CASCIO, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Jessica L. HEACOCK, Auteur ; Kimberly B. SCHAUDER, Auteur ; Whitney A. LORING, Auteur ; Baxter P. ROGERS, Auteur ; Jennifer R. PRYWELLER, Auteur ; Cassandra R. NEWSOM, Auteur ; Jurnell COCKHREN, Auteur ; Aize CAO, Auteur ; Scott BOLTON, Auteur . - p.162-171. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.162-171 Mots-clés : Autism  restricted interests  reward  repetitive behavior  fMRI  insula  salience Index. décimale : PER Périodiques Résumé : Background Restricted interests are a class of repetitive behavior in autism spectrum disorders (ASD) whose intensity and narrow focus often contribute to significant interference with daily functioning. While numerous neuroimaging studies have investigated executive circuits as putative neural substrates of repetitive behavior, recent work implicates affective neural circuits in restricted interests. We sought to explore the role of affective neural circuits and determine how restricted interests are distinguished from hobbies or interests in typical development. Methods We compared a group of children with ASD to a typically developing (TD) group of children with strong interests or hobbies, employing parent report, an operant behavioral task, and functional imaging with personalized stimuli based on individual interests. Results While performance on the operant task was similar between the two groups, parent report of intensity and interference of interests was significantly higher in the ASD group. Both the ASD and TD groups showed increased BOLD response in widespread affective neural regions to the pictures of their own interest. When viewing pictures of other children's interests, the TD group showed a similar pattern, whereas BOLD response in the ASD group was much more limited. Increased BOLD response in the insula and anterior cingulate cortex distinguished the ASD from the TD group, and parent report of the intensity and interference with daily life of the child's restricted interest predicted insula response. Conclusions While affective neural network response and operant behavior are comparable in typical and restricted interests, the narrowness of focus that clinically distinguishes restricted interests in ASD is reflected in more interference in daily life and aberrantly enhanced insula and anterior cingulate response to individuals’ own interests in the ASD group. These results further support the involvement of affective neural networks in repetitive behaviors in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

Tactile responsiveness patterns and their association with core features in autism spectrum disorders / Jennifer H. FOSS-FEIG in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.337-344 Titre : Tactile responsiveness patterns and their association with core features in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer H. FOSS-FEIG, Auteur ; Jessica L. HEACOCK, Auteur ; Carissa J. CASCIO, Auteur Année de publication : 2012 Article en page(s) : p.337-344 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Sensory  Tactile  Symptoms  Somatosensory Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are often associated with aberrant responses to sensory stimuli, which are thought to contribute to the social, communication, and repetitive behavior deficits that define ASD. However, there are few studies that separate aberrant sensory responses by individual sensory modality to assess modality-specific associations between sensory features and core symptoms. Differences in response to tactile stimuli are prevalent in ASD, and tactile contact early in infancy is a foundation for the development of social and communication skills affected by ASD. We assessed the association between three aberrant patterns of tactile responsiveness (hyper-responsiveness, hypo-responsiveness, sensory seeking) and core symptoms of ASD. Both sensory and core features were measured with converging methods including both parent-report and direct observation. Our results demonstrate that for the tactile modality, sensory hypo-responsiveness correlates strongly with increased social and communication impairments, and to a lesser degree, repetitive behaviors. Sensory seeking was found to correlate strongly with social impairment, nonverbal communication impairment, and repetitive behaviors. Surprisingly, tactile hyper-responsiveness did not significantly correlate with any core features of ASD. This differential association between specific tactile processing patterns and core features provides an important step in defining the significance of sensory symptoms in ASD, and may be useful in the development of sensory-based approaches for early detection and intervention. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.06.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Tactile responsiveness patterns and their association with core features in autism spectrum disorders [Texte imprimé et/ou numérique] / Jennifer H. FOSS-FEIG, Auteur ; Jessica L. HEACOCK, Auteur ; Carissa J. CASCIO, Auteur . - 2012 . - p.337-344. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.337-344 Mots-clés : Autism spectrum disorders  Sensory  Tactile  Symptoms  Somatosensory Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are often associated with aberrant responses to sensory stimuli, which are thought to contribute to the social, communication, and repetitive behavior deficits that define ASD. However, there are few studies that separate aberrant sensory responses by individual sensory modality to assess modality-specific associations between sensory features and core symptoms. Differences in response to tactile stimuli are prevalent in ASD, and tactile contact early in infancy is a foundation for the development of social and communication skills affected by ASD. We assessed the association between three aberrant patterns of tactile responsiveness (hyper-responsiveness, hypo-responsiveness, sensory seeking) and core symptoms of ASD. Both sensory and core features were measured with converging methods including both parent-report and direct observation. Our results demonstrate that for the tactile modality, sensory hypo-responsiveness correlates strongly with increased social and communication impairments, and to a lesser degree, repetitive behaviors. Sensory seeking was found to correlate strongly with social impairment, nonverbal communication impairment, and repetitive behaviors. Surprisingly, tactile hyper-responsiveness did not significantly correlate with any core features of ASD. This differential association between specific tactile processing patterns and core features provides an important step in defining the significance of sensory symptoms in ASD, and may be useful in the development of sensory-based approaches for early detection and intervention. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.06.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

The rubber hand illusion in children with autism spectrum disorders: delayed influence of combined tactile and visual input on proprioception / Carissa J. CASCIO in Autism, 16-4 (July 2012)  

Public ISBD [article]  inAutism > 16-4 (July 2012) . - p.406-419 Titre : The rubber hand illusion in children with autism spectrum disorders: delayed influence of combined tactile and visual input on proprioception Type de document : Texte imprimé et/ou numérique Auteurs : Carissa J. CASCIO, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Courtney BURNETTE, Auteur ; Jessica L. HEACOCK, Auteur ; Akua A. COSBY, Auteur Année de publication : 2012 Article en page(s) : p.406-419 Langues : Anglais (eng) Mots-clés : autism  proprioceptive  visual  tactile  multisensory integration  empathy  proprioréception Index. décimale : PER Périodiques Résumé : In the rubber hand illusion, perceived hand ownership can be transferred to a rubber hand after synchronous visual and tactile stimulation. Perceived body ownership and self–other relation are foundational for development of self-awareness, imitation, and empathy, which are all affected in autism spectrum disorders (ASD). We examined the rubber hand illusion in children with and without ASD. Children with ASD were initially less susceptible to the illusion than the comparison group, yet showed the effects of the illusion after 6 minutes. Delayed susceptibility to the illusion may result from atypical multisensory temporal integration and/or an unusually strong reliance on proprioception. Children with ASD who displayed less empathy were significantly less likely to experience the illusion than those with more intact ability to express empathy. A better understanding of body representation in ASD may elucidate neural underpinnings of social deficits, thus informing future intervention approaches. En ligne : http://dx.doi.org/10.1177/1362361311430404 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] The rubber hand illusion in children with autism spectrum disorders: delayed influence of combined tactile and visual input on proprioception [Texte imprimé et/ou numérique] / Carissa J. CASCIO, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Courtney BURNETTE, Auteur ; Jessica L. HEACOCK, Auteur ; Akua A. COSBY, Auteur . - 2012 . - p.406-419. Langues : Anglais (eng) in Autism > 16-4 (July 2012) . - p.406-419 Mots-clés : autism  proprioceptive  visual  tactile  multisensory integration  empathy  proprioréception Index. décimale : PER Périodiques Résumé : In the rubber hand illusion, perceived hand ownership can be transferred to a rubber hand after synchronous visual and tactile stimulation. Perceived body ownership and self–other relation are foundational for development of self-awareness, imitation, and empathy, which are all affected in autism spectrum disorders (ASD). We examined the rubber hand illusion in children with and without ASD. Children with ASD were initially less susceptible to the illusion than the comparison group, yet showed the effects of the illusion after 6 minutes. Delayed susceptibility to the illusion may result from atypical multisensory temporal integration and/or an unusually strong reliance on proprioception. Children with ASD who displayed less empathy were significantly less likely to experience the illusion than those with more intact ability to express empathy. A better understanding of body representation in ASD may elucidate neural underpinnings of social deficits, thus informing future intervention approaches. En ligne : http://dx.doi.org/10.1177/1362361311430404 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

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