Assessing Autism in Adults: An Evaluation of the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult) / William MANDY in Journal of Autism and Developmental Disorders, 48-2 (February 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.549-560 Titre : Assessing Autism in Adults: An Evaluation of the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult) Type de document : texte imprimé Auteurs : William MANDY, Auteur ; Kiri CLARKE, Auteur ; M. MCKENNER, Auteur ; Andre STRYDOM, Auteur ; Jason CRABTREE, Auteur ; Meng-Chuan LAI, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; David SKUSE, Auteur Article en page(s) : p.549-560 Langues : Anglais (eng) Mots-clés : Adults  Assessment and diagnosis  Autism spectrum conditions (ASC)  Autism spectrum disorder (ASD)  Diagnostic and statistical manual, fifth edition (DSM-5) Index. décimale : PER Périodiques Résumé : We developed a brief, informant-report interview for assessing autism spectrum conditions (ASC) in adults, called the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult); and completed a preliminary evaluation. Informant reports were collected for participants with ASC (n = 39), a non-clinical comparison group (n = 29) and a clinical comparison group (n = 20) who had non-autistic mental health conditions. Mean administration time was 38 min (50 min for ASC). Internal consistency (alphas >/= 0.93) and inter-rater agreement (ICCs >/= 0.99) were high. When discriminating ASC from non-ASC, the 3Di-Adult showed excellent sensitivity (95%) and specificity (92%). The 3Di-Adult shows promise as a psychometrically sound and time-efficient interview for collecting standardised informant reports for DSM-5 assessments of ASC in adults, in research and clinical practice. En ligne : https://doi.org/10.1007/s10803-017-3321-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338 [article] Assessing Autism in Adults: An Evaluation of the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult) [texte imprimé] / William MANDY, Auteur ; Kiri CLARKE, Auteur ; M. MCKENNER, Auteur ; Andre STRYDOM, Auteur ; Jason CRABTREE, Auteur ; Meng-Chuan LAI, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; David SKUSE, Auteur . - p.549-560. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.549-560 Mots-clés : Adults  Assessment and diagnosis  Autism spectrum conditions (ASC)  Autism spectrum disorder (ASD)  Diagnostic and statistical manual, fifth edition (DSM-5) Index. décimale : PER Périodiques Résumé : We developed a brief, informant-report interview for assessing autism spectrum conditions (ASC) in adults, called the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult); and completed a preliminary evaluation. Informant reports were collected for participants with ASC (n = 39), a non-clinical comparison group (n = 29) and a clinical comparison group (n = 20) who had non-autistic mental health conditions. Mean administration time was 38 min (50 min for ASC). Internal consistency (alphas >/= 0.93) and inter-rater agreement (ICCs >/= 0.99) were high. When discriminating ASC from non-ASC, the 3Di-Adult showed excellent sensitivity (95%) and specificity (92%). The 3Di-Adult shows promise as a psychometrically sound and time-efficient interview for collecting standardised informant reports for DSM-5 assessments of ASC in adults, in research and clinical practice. En ligne : https://doi.org/10.1007/s10803-017-3321-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338

Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review / Sarah HAMBURG in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 20 p. Titre : Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review Type de document : texte imprimé Auteurs : Sarah HAMBURG, Auteur ; Bryony LOWE, Auteur ; Carla Marie STARTIN, Auteur ; Concepcion PADILLA, Auteur ; Antonia COPPUS, Auteur ; Wendy SILVERMAN, Auteur ; Juan FORTEA, Auteur ; Shahid ZAMAN, Auteur ; Elizabeth HEAD, Auteur ; Benjamin L. HANDEN, Auteur ; Ira LOTT, Auteur ; Weihong SONG, Auteur ; Andre STRYDOM, Auteur Article en page(s) : 20 p. Langues : Anglais (eng) Mots-clés : Ab  Adaptive ability  Adaptive behaviour  Cognition  Down syndrome  General ability  Iq  Intelligence Index. décimale : PER Périodiques Résumé : BACKGROUND: Measures of general cognitive and adaptive ability in adults with Down syndrome (DS) used by previous studies vary substantially. This review summarises the different ability measures used previously, focusing on tests of intelligence quotient (IQ) and adaptive behaviour (AB), and where possible examines floor effects and differences between DS subpopulations. We aimed to use information regarding existing measures to provide recommendations for individual researchers and the DS research community. RESULTS: Nineteen studies reporting IQ test data met inclusion for this review, with 17 different IQ tests used. Twelve of these IQ tests were used in only one study while five were used in two different studies. Eleven studies reporting AB test data met inclusion for this review, with seven different AB tests used. The only AB scales to be used by more than one study were the Vineland Adaptive Behaviour Scale (VABS; used by three studies) and the Vineland Adaptive Behavior Scale 2nd Edition (VABS-II; used by two studies). A variety of additional factors were identified which make comparison of test scores between studies problematic, including different score types provided between studies (e.g. raw scores compared to age-equivalent scores) and different participant inclusion criteria (e.g. whether individuals with cognitive decline were excluded). Floor effects were common for IQ tests (particularly for standardised test scores). Data exists to suggest that floor effects may be minimised by the use of raw test scores rather than standardised test scores. Raw scores may, therefore, be particularly useful in longitudinal studies to track change in cognitive ability over time. CONCLUSIONS: Studies assessing general ability in adults with DS are likely to benefit from the use of both IQ and AB scales. The DS research community may benefit from the development of reporting standards for IQ and AB data, and from the sharing of raw study data enabling further in-depth investigation of issues highlighted by this review. En ligne : https://dx.doi.org/10.1186/s11689-019-9279-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review [texte imprimé] / Sarah HAMBURG, Auteur ; Bryony LOWE, Auteur ; Carla Marie STARTIN, Auteur ; Concepcion PADILLA, Auteur ; Antonia COPPUS, Auteur ; Wendy SILVERMAN, Auteur ; Juan FORTEA, Auteur ; Shahid ZAMAN, Auteur ; Elizabeth HEAD, Auteur ; Benjamin L. HANDEN, Auteur ; Ira LOTT, Auteur ; Weihong SONG, Auteur ; Andre STRYDOM, Auteur . - 20 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 20 p. Mots-clés : Ab  Adaptive ability  Adaptive behaviour  Cognition  Down syndrome  General ability  Iq  Intelligence Index. décimale : PER Périodiques Résumé : BACKGROUND: Measures of general cognitive and adaptive ability in adults with Down syndrome (DS) used by previous studies vary substantially. This review summarises the different ability measures used previously, focusing on tests of intelligence quotient (IQ) and adaptive behaviour (AB), and where possible examines floor effects and differences between DS subpopulations. We aimed to use information regarding existing measures to provide recommendations for individual researchers and the DS research community. RESULTS: Nineteen studies reporting IQ test data met inclusion for this review, with 17 different IQ tests used. Twelve of these IQ tests were used in only one study while five were used in two different studies. Eleven studies reporting AB test data met inclusion for this review, with seven different AB tests used. The only AB scales to be used by more than one study were the Vineland Adaptive Behaviour Scale (VABS; used by three studies) and the Vineland Adaptive Behavior Scale 2nd Edition (VABS-II; used by two studies). A variety of additional factors were identified which make comparison of test scores between studies problematic, including different score types provided between studies (e.g. raw scores compared to age-equivalent scores) and different participant inclusion criteria (e.g. whether individuals with cognitive decline were excluded). Floor effects were common for IQ tests (particularly for standardised test scores). Data exists to suggest that floor effects may be minimised by the use of raw test scores rather than standardised test scores. Raw scores may, therefore, be particularly useful in longitudinal studies to track change in cognitive ability over time. CONCLUSIONS: Studies assessing general ability in adults with DS are likely to benefit from the use of both IQ and AB scales. The DS research community may benefit from the development of reporting standards for IQ and AB data, and from the sharing of raw study data enabling further in-depth investigation of issues highlighted by this review. En ligne : https://dx.doi.org/10.1186/s11689-019-9279-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Community mental health professionals’ knowledge and understanding of Asperger Syndrome and the needs of this client group / Jason CRABTREE in Good Autism Practice - GAP, 12-2 (October 2011)

Public ISBD [article]  inGood Autism Practice - GAP > 12-2 (October 2011) . - p.56-61 Titre : Community mental health professionals’ knowledge and understanding of Asperger Syndrome and the needs of this client group Type de document : texte imprimé Auteurs : Jason CRABTREE, Auteur ; Andre STRYDOM, Auteur ; David KIRKPATRICK, Auteur Année de publication : 2011 Article en page(s) : p.56-61 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : With the publication of the statutory guidance of the Autism Act (2009), the needs and service requirements of adults with Asperger syndrome have never been under closer scrutiny. This article written by a Clinical Psychologist (JC) and his two colleagues, a Consultant Psychiatrist (AS) and an Assistant Psychologist (DK), describes the findings of a survey conducted in one London Borough to examine the understanding of Asperger syndrome amongst health and social care professionals working in Adult Mental Health Teams and to highlight the implications on the provision of mental health and social care to this population. Whilst the results of the survey are predictable, they act as a timely reminder of the reality for people with Asperger syndrome in trying to access services if professionals have not had sufficient training to understand their specific needs. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149 [article] Community mental health professionals’ knowledge and understanding of Asperger Syndrome and the needs of this client group [texte imprimé] / Jason CRABTREE, Auteur ; Andre STRYDOM, Auteur ; David KIRKPATRICK, Auteur . - 2011 . - p.56-61. Langues : Anglais (eng) in Good Autism Practice - GAP > 12-2 (October 2011) . - p.56-61 Index. décimale : PER Périodiques Résumé : With the publication of the statutory guidance of the Autism Act (2009), the needs and service requirements of adults with Asperger syndrome have never been under closer scrutiny. This article written by a Clinical Psychologist (JC) and his two colleagues, a Consultant Psychiatrist (AS) and an Assistant Psychologist (DK), describes the findings of a survey conducted in one London Borough to examine the understanding of Asperger syndrome amongst health and social care professionals working in Adult Mental Health Teams and to highlight the implications on the provision of mental health and social care to this population. Whilst the results of the survey are predictable, they act as a timely reminder of the reality for people with Asperger syndrome in trying to access services if professionals have not had sufficient training to understand their specific needs. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149

Comparison of resting-state EEG between adults with Down syndrome and typically developing controls / Sarah HAMBURG in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Comparison of resting-state EEG between adults with Down syndrome and typically developing controls Type de document : texte imprimé Auteurs : Sarah HAMBURG, Auteur ; Daniel BUSH, Auteur ; Andre STRYDOM, Auteur ; Carla M. STARTIN, Auteur Langues : Anglais (eng) Mots-clés : Adult  Cognitive Dysfunction/diagnosis  Down Syndrome/diagnosis  Electroencephalography  Humans  Intellectual Disability/diagnosis  Alpha peak  Down syndrome  Eeg  Resting state  Trisomy 21 Index. décimale : PER Périodiques Résumé : BACKGROUND: Down syndrome (DS) is the most common genetic cause of intellectual disability (ID) worldwide. Understanding electrophysiological characteristics associated with DS provides potential mechanistic insights into ID, helping inform biomarkers and targets for intervention. Currently, electrophysiological characteristics associated with DS remain unclear due to methodological differences between studies and inadequate controls for cognitive decline as a potential cofounder. METHODS: Eyes-closed resting-state EEG measures (specifically delta, theta, alpha, and beta absolute and relative powers, and alpha peak amplitude, frequency and frequency variance) in occipital and frontal regions were compared between adults with DS (with no diagnosis of dementia or evidence of cognitive decline) and typically developing (TD) matched controls (n = 25 per group). RESULTS: We report an overall 'slower' EEG spectrum, characterised by higher delta and theta power, and lower alpha and beta power, for both regions in people with DS. Alpha activity in particular showed strong group differences, including lower power, lower peak amplitude and greater peak frequency variance in people with DS. CONCLUSIONS: Such EEG 'slowing' has previously been associated with cognitive decline in both DS and TD populations. These findings indicate the potential existence of a universal EEG signature of cognitive impairment, regardless of origin (neurodevelopmental or neurodegenerative), warranting further exploration. En ligne : https://dx.doi.org/10.1186/s11689-021-09392-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Comparison of resting-state EEG between adults with Down syndrome and typically developing controls [texte imprimé] / Sarah HAMBURG, Auteur ; Daniel BUSH, Auteur ; Andre STRYDOM, Auteur ; Carla M. STARTIN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Adult  Cognitive Dysfunction/diagnosis  Down Syndrome/diagnosis  Electroencephalography  Humans  Intellectual Disability/diagnosis  Alpha peak  Down syndrome  Eeg  Resting state  Trisomy 21 Index. décimale : PER Périodiques Résumé : BACKGROUND: Down syndrome (DS) is the most common genetic cause of intellectual disability (ID) worldwide. Understanding electrophysiological characteristics associated with DS provides potential mechanistic insights into ID, helping inform biomarkers and targets for intervention. Currently, electrophysiological characteristics associated with DS remain unclear due to methodological differences between studies and inadequate controls for cognitive decline as a potential cofounder. METHODS: Eyes-closed resting-state EEG measures (specifically delta, theta, alpha, and beta absolute and relative powers, and alpha peak amplitude, frequency and frequency variance) in occipital and frontal regions were compared between adults with DS (with no diagnosis of dementia or evidence of cognitive decline) and typically developing (TD) matched controls (n = 25 per group). RESULTS: We report an overall 'slower' EEG spectrum, characterised by higher delta and theta power, and lower alpha and beta power, for both regions in people with DS. Alpha activity in particular showed strong group differences, including lower power, lower peak amplitude and greater peak frequency variance in people with DS. CONCLUSIONS: Such EEG 'slowing' has previously been associated with cognitive decline in both DS and TD populations. These findings indicate the potential existence of a universal EEG signature of cognitive impairment, regardless of origin (neurodevelopmental or neurodegenerative), warranting further exploration. En ligne : https://dx.doi.org/10.1186/s11689-021-09392-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group / Nicole T. BAUMER in Journal of Neurodevelopmental Disorders, 14 (2022)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 14 (2022) Titre : Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group Type de document : texte imprimé Auteurs : Nicole T. BAUMER, Auteur ; Mara L. BECKER, Auteur ; George T. CAPONE, Auteur ; Kathleen EGAN, Auteur ; Juan FORTEA, Auteur ; Benjamin L. HANDEN, Auteur ; Elizabeth HEAD, Auteur ; James E. HENDRIX, Auteur ; Ruth Y. LITOVSKY, Auteur ; Andre STRYDOM, Auteur ; Ignacio E. TAPIA, Auteur ; Michael S. RAFII, Auteur Langues : Anglais (eng) Mots-clés : Cohort Studies  Down Syndrome/complications/therapy  Humans  Clinical research  Clinical trials  Down syndrome  Intellectual disability  Recruitment  Research engagement Index. décimale : PER Périodiques Résumé : The recent National Institute of Health (NIH) INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has bolstered capacity for the current increase in clinical trials involving individuals with Down syndrome (DS). This new NIH funding mechanism offers new opportunities to expand and develop novel approaches in engaging and effectively enrolling a broader representation of clinical trials participants addressing current medical issues faced by individuals with DS. To address this opportunity, the NIH assembled leading clinicians, scientists, and representatives of advocacy groups to review existing methods and to identify those areas where new approaches are needed to engage and prepare DS populations for participation in clinical trial research. This paper summarizes the results of the Clinical Trial Readiness Working Group that was part of the INCLUDE Project Workshop: Planning a Virtual Down Syndrome Cohort Across the Lifespan Workshop held virtually September 23 and 24, 2019. En ligne : https://dx.doi.org/10.1186/s11689-022-09435-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group [texte imprimé] / Nicole T. BAUMER, Auteur ; Mara L. BECKER, Auteur ; George T. CAPONE, Auteur ; Kathleen EGAN, Auteur ; Juan FORTEA, Auteur ; Benjamin L. HANDEN, Auteur ; Elizabeth HEAD, Auteur ; James E. HENDRIX, Auteur ; Ruth Y. LITOVSKY, Auteur ; Andre STRYDOM, Auteur ; Ignacio E. TAPIA, Auteur ; Michael S. RAFII, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 14 (2022) Mots-clés : Cohort Studies  Down Syndrome/complications/therapy  Humans  Clinical research  Clinical trials  Down syndrome  Intellectual disability  Recruitment  Research engagement Index. décimale : PER Périodiques Résumé : The recent National Institute of Health (NIH) INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has bolstered capacity for the current increase in clinical trials involving individuals with Down syndrome (DS). This new NIH funding mechanism offers new opportunities to expand and develop novel approaches in engaging and effectively enrolling a broader representation of clinical trials participants addressing current medical issues faced by individuals with DS. To address this opportunity, the NIH assembled leading clinicians, scientists, and representatives of advocacy groups to review existing methods and to identify those areas where new approaches are needed to engage and prepare DS populations for participation in clinical trial research. This paper summarizes the results of the Clinical Trial Readiness Working Group that was part of the INCLUDE Project Workshop: Planning a Virtual Down Syndrome Cohort Across the Lifespan Workshop held virtually September 23 and 24, 2019. En ligne : https://dx.doi.org/10.1186/s11689-022-09435-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Health comorbidities and cognitive abilities across the lifespan in Down syndrome / Carla M. STARTIN in Journal of Neurodevelopmental Disorders, 12 (2020)  

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