Measures of Cortical Grey Matter Structure and Development in Children with Autism Spectrum Disorder / Kathleen M. MAK-FAN in Journal of Autism and Developmental Disorders, 42-3 (March 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.419-427 Titre : Measures of Cortical Grey Matter Structure and Development in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kathleen M. MAK-FAN, Auteur ; Margot J. TAYLOR, Auteur ; Wendy ROBERTS, Auteur ; Jason LERCH, Auteur Année de publication : 2012 Article en page(s) : p.419-427 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Brain structure  Volume  Surface area  Cortical thickness  Development Index. décimale : PER Périodiques Résumé : The current study examined group differences in cortical volume, surface area, and thickness with age, in a group of typically developing children and a group of children with ASD aged 6–15 years. Results showed evidence of age by group interactions, suggesting atypicalities in the relation between these measures and age in the ASD group. Additional vertex-based analyses of cortical thickness revealed that specific regions in the left inferior frontal gyrus (BA 44) and left precuneus showed thicker cortex for the ASD group at younger ages only. These data support the hypothesis of an abnormal developmental trajectory of the cortex in ASD, which could have profound effects on other aspects of neural development in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1261-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Measures of Cortical Grey Matter Structure and Development in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Kathleen M. MAK-FAN, Auteur ; Margot J. TAYLOR, Auteur ; Wendy ROBERTS, Auteur ; Jason LERCH, Auteur . - 2012 . - p.419-427. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.419-427 Mots-clés : Autism spectrum disorder  Brain structure  Volume  Surface area  Cortical thickness  Development Index. décimale : PER Périodiques Résumé : The current study examined group differences in cortical volume, surface area, and thickness with age, in a group of typically developing children and a group of children with ASD aged 6–15 years. Results showed evidence of age by group interactions, suggesting atypicalities in the relation between these measures and age in the ASD group. Additional vertex-based analyses of cortical thickness revealed that specific regions in the left inferior frontal gyrus (BA 44) and left precuneus showed thicker cortex for the ASD group at younger ages only. These data support the hypothesis of an abnormal developmental trajectory of the cortex in ASD, which could have profound effects on other aspects of neural development in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1261-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Regional differences in grey and white matter in children and adults with autism spectrum disorders: an activation likelihood estimate (ALE) meta-analysis / Emma G. DUERDEN in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.49-66 Titre : Regional differences in grey and white matter in children and adults with autism spectrum disorders: an activation likelihood estimate (ALE) meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Emma G. DUERDEN, Auteur ; Kathleen M. MAK-FAN, Auteur ; Margot J. TAYLOR, Auteur ; Wendy ROBERTS, Auteur Année de publication : 2012 Article en page(s) : p.49-66 Langues : Anglais (eng) Mots-clés : structural MRI  pediatrics Index. décimale : PER Périodiques Résumé : Structural alterations in brain morphology have been inconsistently reported in children compared to adults with autism spectrum disorder (ASD). We assessed these differences by performing meta-analysis on the data from 19 voxel-based morphometry studies. Common findings across the age groups were grey matter reduction in left putamen and medial prefrontal cortex (mPFC) and grey matter increases in the lateral PFC, while white matter decreases were seen mainly in the children in frontostriatal pathways. In the ASD sample, children/adolescents were more likely than adults to have increased grey matter in bilateral fusiform gyrus, right cingulate and insula. Results show that clear maturational differences exist in social cognition and limbic processing regions only in children/adolescents and not in adults with ASD, and may underlie the emotional regulation that improves with age in this population. En ligne : http://dx.doi.org/10.1002/aur.235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Regional differences in grey and white matter in children and adults with autism spectrum disorders: an activation likelihood estimate (ALE) meta-analysis [Texte imprimé et/ou numérique] / Emma G. DUERDEN, Auteur ; Kathleen M. MAK-FAN, Auteur ; Margot J. TAYLOR, Auteur ; Wendy ROBERTS, Auteur . - 2012 . - p.49-66. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.49-66 Mots-clés : structural MRI  pediatrics Index. décimale : PER Périodiques Résumé : Structural alterations in brain morphology have been inconsistently reported in children compared to adults with autism spectrum disorder (ASD). We assessed these differences by performing meta-analysis on the data from 19 voxel-based morphometry studies. Common findings across the age groups were grey matter reduction in left putamen and medial prefrontal cortex (mPFC) and grey matter increases in the lateral PFC, while white matter decreases were seen mainly in the children in frontostriatal pathways. In the ASD sample, children/adolescents were more likely than adults to have increased grey matter in bilateral fusiform gyrus, right cingulate and insula. Results show that clear maturational differences exist in social cognition and limbic processing regions only in children/adolescents and not in adults with ASD, and may underlie the emotional regulation that improves with age in this population. En ligne : http://dx.doi.org/10.1002/aur.235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Risk Factors Associated with Self-Injurious Behaviors in Children and Adolescents with Autism Spectrum Disorders / Emma G. DUERDEN in Journal of Autism and Developmental Disorders, 42-11 (November 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2460-2470 Titre : Risk Factors Associated with Self-Injurious Behaviors in Children and Adolescents with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Emma G. DUERDEN, Auteur ; Hannah OATLEY, Auteur ; Kathleen M. MAK-FAN, Auteur ; Patricia MCGRATH, Auteur ; Margot J. TAYLOR, Auteur ; Peter SZATMARI, Auteur ; S. ROBERTS, Auteur Article en page(s) : p.2460-2470 Langues : Anglais (eng) Mots-clés : Pain  Sensory  Self-injury  Autism  Human Index. décimale : PER Périodiques Résumé : While self-injurious behaviors (SIB) can cause significant morbidity for children with autism spectrum disorders (ASD), little is known about its associated risk factors. We assessed 7 factors that may influence self-injury in a large cohort of children with ASD: (a) atypical sensory processing; (b) impaired cognitive ability; (c) abnormal functional communication; (d) abnormal social functioning; (e) age; (f) the need for sameness; (g) rituals and compulsions. Half (52.3%, n = 126) of the children (n = 241, aged 2–19 years) demonstrated SIB. Abnormal sensory processing was the strongest single predictor of self-injury followed by sameness, impaired cognitive ability and social functioning. Since atypical sensory processing and sameness have a greater relative impact on SIB, treatment approaches that focus on these factors may be beneficial in reducing self-harm in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1497-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 [article] Risk Factors Associated with Self-Injurious Behaviors in Children and Adolescents with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Emma G. DUERDEN, Auteur ; Hannah OATLEY, Auteur ; Kathleen M. MAK-FAN, Auteur ; Patricia MCGRATH, Auteur ; Margot J. TAYLOR, Auteur ; Peter SZATMARI, Auteur ; S. ROBERTS, Auteur . - p.2460-2470. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2460-2470 Mots-clés : Pain  Sensory  Self-injury  Autism  Human Index. décimale : PER Périodiques Résumé : While self-injurious behaviors (SIB) can cause significant morbidity for children with autism spectrum disorders (ASD), little is known about its associated risk factors. We assessed 7 factors that may influence self-injury in a large cohort of children with ASD: (a) atypical sensory processing; (b) impaired cognitive ability; (c) abnormal functional communication; (d) abnormal social functioning; (e) age; (f) the need for sameness; (g) rituals and compulsions. Half (52.3%, n = 126) of the children (n = 241, aged 2–19 years) demonstrated SIB. Abnormal sensory processing was the strongest single predictor of self-injury followed by sameness, impaired cognitive ability and social functioning. Since atypical sensory processing and sameness have a greater relative impact on SIB, treatment approaches that focus on these factors may be beneficial in reducing self-harm in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1497-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183

White matter and development in children with an autism spectrum disorder / Kathleen M. MAK-FAN in Autism, 17-5 (September 2013)  

Public ISBD [article]  inAutism > 17-5 (September 2013) . - p.541-557 Titre : White matter and development in children with an autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kathleen M. MAK-FAN, Auteur ; Drew MORRIS, Auteur ; Julie VIDAL, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Wendy ROBERTS, Auteur ; Margot J. TAYLOR, Auteur Article en page(s) : p.541-557 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  brain structure  development  white matter  diffusion tensor imaging  diffusivity Index. décimale : PER Périodiques Résumé : Recent research suggests that brain development follows an abnormal trajectory in children with autism spectrum disorders (ASD). The current study examined changes in diffusivity with age within defined white matter tracts in a group of typically developing children and a group of children with an ASD, aged 6 to 14 years. Age by group interactions were observed for frontal, long distant, interhemispheric and posterior tracts, for longitudinal, radial and mean diffusivity, but not for fractional anisotropy. In all cases, these measures of diffusivity decreased with age in the typically developing group, but showed little or no change in the ASD group. This supports the hypothesis of an abnormal developmental trajectory of white matter in this population, which could have profound effects on the development of neural connectivity and contribute to atypical cognitive development in children with ASD. En ligne : http://dx.doi.org/10.1177/1362361312442596 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 [article] White matter and development in children with an autism spectrum disorder [Texte imprimé et/ou numérique] / Kathleen M. MAK-FAN, Auteur ; Drew MORRIS, Auteur ; Julie VIDAL, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Wendy ROBERTS, Auteur ; Margot J. TAYLOR, Auteur . - p.541-557. Langues : Anglais (eng) in Autism > 17-5 (September 2013) . - p.541-557 Mots-clés : autism spectrum disorder  brain structure  development  white matter  diffusion tensor imaging  diffusivity Index. décimale : PER Périodiques Résumé : Recent research suggests that brain development follows an abnormal trajectory in children with autism spectrum disorders (ASD). The current study examined changes in diffusivity with age within defined white matter tracts in a group of typically developing children and a group of children with an ASD, aged 6 to 14 years. Age by group interactions were observed for frontal, long distant, interhemispheric and posterior tracts, for longitudinal, radial and mean diffusivity, but not for fractional anisotropy. In all cases, these measures of diffusivity decreased with age in the typically developing group, but showed little or no change in the ASD group. This supports the hypothesis of an abnormal developmental trajectory of white matter in this population, which could have profound effects on the development of neural connectivity and contribute to atypical cognitive development in children with ASD. En ligne : http://dx.doi.org/10.1177/1362361312442596 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211

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