Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 12 (April 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 12 (April 2015) . - p.1-9 Titre : Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr HESSABI, Auteur ; Aisha S. DICKERSON, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur Article en page(s) : p.1-9 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Oxidative stress  Glutathione S-transferase (GST) genes  Modulating-factor  Gene–gene interaction Index. décimale : PER Périodiques Résumé : Abstract We investigated the role of glutathione S-transferase (GST) genes in Autism Spectrum Disorder (ASD). We used data from 111 pairs of age- and sex-matched ASD cases and typically developing (TD) controls between 2 and 8 years of age from Jamaica to investigate the role of GST pi 1 (GSTP1), GST theta 1 (GSTT1), and GST mu 1 (GSTM1) polymorphisms in susceptibility to ASD. In univariable conditional logistic regression models we did not observe significant associations between ASD status and GSTT1, GSTM1, or GSTP1 genotype (all P > 0.15). However, in multivariable conditional logistic regression models, we identified a significant interaction between GSTP1 and GSTT1 in relation to ASD. Specifically, in children heterozygous for the GSTP1 Ile105Val polymorphism, the odds of ASD was significantly higher in those with the null GSTT1 genotype than those with the other genotypes [matched odds ratio (MOR) = 2.97, 95% CI (1.09, 8.01), P = 0.03]. Replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr HESSABI, Auteur ; Aisha S. DICKERSON, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur . - p.1-9. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.1-9 Mots-clés : Autism spectrum disorder  Oxidative stress  Glutathione S-transferase (GST) genes  Modulating-factor  Gene–gene interaction Index. décimale : PER Périodiques Résumé : Abstract We investigated the role of glutathione S-transferase (GST) genes in Autism Spectrum Disorder (ASD). We used data from 111 pairs of age- and sex-matched ASD cases and typically developing (TD) controls between 2 and 8 years of age from Jamaica to investigate the role of GST pi 1 (GSTP1), GST theta 1 (GSTT1), and GST mu 1 (GSTM1) polymorphisms in susceptibility to ASD. In univariable conditional logistic regression models we did not observe significant associations between ASD status and GSTT1, GSTM1, or GSTP1 genotype (all P > 0.15). However, in multivariable conditional logistic regression models, we identified a significant interaction between GSTP1 and GSTT1 in relation to ASD. Specifically, in children heterozygous for the GSTP1 Ile105Val polymorphism, the odds of ASD was significantly higher in those with the null GSTT1 genotype than those with the other genotypes [matched odds ratio (MOR) = 2.97, 95% CI (1.09, 8.01), P = 0.03]. Replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Interaction between manganese and GSTP1 in relation to autism spectrum disorder while controlling for exposure to mixture of lead, mercury, arsenic, and cadmium / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 55 (November 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 55 (November 2018) . - p.50-63 Titre : Interaction between manganese and GSTP1 in relation to autism spectrum disorder while controlling for exposure to mixture of lead, mercury, arsenic, and cadmium Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; MacKinsey A. CHRISTIAN, Auteur ; Jan BRESSLER, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Charlene COORE DESAI, Auteur ; Jody-Ann REECE, Auteur ; Katherine A. LOVELAND, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur Article en page(s) : p.50-63 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Heavy metals  Interaction  Weighted quantile sum (WQS) regression Index. décimale : PER Périodiques Résumé : Background We previously reported a significant interactive association between polymorphisms of GSTP1 and blood manganese concentrations (BMC) with autism spectrum disorder (ASD) in Jamaican children. In this paper, we investigate the same interactive association with ASD while adjusting for the mixture of four metals (lead, mercury, cadmium, and arsenic). Method We used data from 163 case-control pairs of children 2–8 years of age from our autism project in Jamaica, in which we collected blood for heavy metals analysis at enrollment. To minimize potential multicollinearity between concentrations of the four metals, we generated a mixture index using generalized weighted quantile sum regression, which was used in conditional logistic regression models to control for the four metals while assessing the interactive association between GSTP1 and BMC with ASD. Results Similar to the findings we reported previously, we found that in co-dominant and dominant models for GSTP1, among children with the Ile/Ile genotype, those with BMC???12??g/L had 4.6 and 4.27 times higher odds of ASD compared to those with BMC? En ligne : https://doi.org/10.1016/j.rasd.2018.08.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Interaction between manganese and GSTP1 in relation to autism spectrum disorder while controlling for exposure to mixture of lead, mercury, arsenic, and cadmium [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; MacKinsey A. CHRISTIAN, Auteur ; Jan BRESSLER, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Charlene COORE DESAI, Auteur ; Jody-Ann REECE, Auteur ; Katherine A. LOVELAND, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur . - p.50-63. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 55 (November 2018) . - p.50-63 Mots-clés : Autism spectrum disorder (ASD)  Heavy metals  Interaction  Weighted quantile sum (WQS) regression Index. décimale : PER Périodiques Résumé : Background We previously reported a significant interactive association between polymorphisms of GSTP1 and blood manganese concentrations (BMC) with autism spectrum disorder (ASD) in Jamaican children. In this paper, we investigate the same interactive association with ASD while adjusting for the mixture of four metals (lead, mercury, cadmium, and arsenic). Method We used data from 163 case-control pairs of children 2–8 years of age from our autism project in Jamaica, in which we collected blood for heavy metals analysis at enrollment. To minimize potential multicollinearity between concentrations of the four metals, we generated a mixture index using generalized weighted quantile sum regression, which was used in conditional logistic regression models to control for the four metals while assessing the interactive association between GSTP1 and BMC with ASD. Results Similar to the findings we reported previously, we found that in co-dominant and dominant models for GSTP1, among children with the Ile/Ile genotype, those with BMC???12??g/L had 4.6 and 4.27 times higher odds of ASD compared to those with BMC? En ligne : https://doi.org/10.1016/j.rasd.2018.08.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica / Mohammad Hossein RAHBAR in Journal of Autism and Developmental Disorders, 42-9 (September 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1928-1938 Titre : Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad Hossein RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Katherine A. LOVELAND, Auteur ; Deborah A. PEARSON, Auteur ; Jan BRESSLER, Auteur ; Zhongxue CHEN, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Compton BEECHER, Auteur ; Kari BLOOM, Auteur ; Eric BOERWINKLE, Auteur Année de publication : 2012 Article en page(s) : p.1928-1938 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Maternal age  Paternal age  Multivariate General Linear Models  Multicollinearity Index. décimale : PER Périodiques Résumé : Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM. En ligne : http://dx.doi.org/10.1007/s10803-011-1438-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 [article] Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica [Texte imprimé et/ou numérique] / Mohammad Hossein RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Katherine A. LOVELAND, Auteur ; Deborah A. PEARSON, Auteur ; Jan BRESSLER, Auteur ; Zhongxue CHEN, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Compton BEECHER, Auteur ; Kari BLOOM, Auteur ; Eric BOERWINKLE, Auteur . - 2012 . - p.1928-1938. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1928-1938 Mots-clés : Autism spectrum disorders  Maternal age  Paternal age  Multivariate General Linear Models  Multicollinearity Index. décimale : PER Périodiques Résumé : Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM. En ligne : http://dx.doi.org/10.1007/s10803-011-1438-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180

Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children / M. A. CHRISTIAN in Journal of Autism and Developmental Disorders, 48-8 (August 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2766-2778 Titre : Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children Type de document : Texte imprimé et/ou numérique Auteurs : M. A. CHRISTIAN, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; M. LEE, Auteur ; Jan BRESSLER, Auteur ; M. HESSABI, Auteur ; M. L. GROVE, Auteur ; S. SHAKESPEARE-PELLINGTON, Auteur ; C. COORE DESAI, Auteur ; J. A. REECE, Auteur ; K. A. LOVELAND, Auteur ; Eric BOERWINKLE, Auteur ; M. H. RAHBAR, Auteur Article en page(s) : p.2766-2778 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Fever  Jamaica  Pesticides  Physical trauma  Volatile organic compounds Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3537-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children [Texte imprimé et/ou numérique] / M. A. CHRISTIAN, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; M. LEE, Auteur ; Jan BRESSLER, Auteur ; M. HESSABI, Auteur ; M. L. GROVE, Auteur ; S. SHAKESPEARE-PELLINGTON, Auteur ; C. COORE DESAI, Auteur ; J. A. REECE, Auteur ; K. A. LOVELAND, Auteur ; Eric BOERWINKLE, Auteur ; M. H. RAHBAR, Auteur . - p.2766-2778. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2766-2778 Mots-clés : Autism spectrum disorder  Fever  Jamaica  Pesticides  Physical trauma  Volatile organic compounds Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3537-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 8-9 (September 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-9 (September 2014) . - p.1134-1145 Titre : Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Aisha S. DICKERSON, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Deborah A. PEARSON, Auteur ; Eric BOERWINKLE, Auteur Article en page(s) : p.1134-1145 Langues : Anglais (eng) Mots-clés : Cadmium  Autism Spectrum Disorder  Grains  Fruits  Seafood  Jamaica Index. décimale : PER Périodiques Résumé : Abstract Human exposure to cadmium has adverse effects on the nervous system. Utilizing data from 110 age- and sex-matched case–control pairs (220 children) ages 2–8 years in Kingston, Jamaica, we compared the 75th percentile of blood cadmium concentrations in children with and without Autism Spectrum Disorder (ASD). In both univariable and multivariable Quantile Regression Models that controlled for potential confounding factors, we did not find any significant differences between ASD cases and typically developing (TD) controls with respect to the 75th percentile of blood cadmium concentrations (P gt; 0.22). However, we found a significantly higher 75th percentile of blood cadmium concentrations in TD Jamaican children who consumed shellfish (lobsters, crabs) (P lt; 0.05), fried plantain (P lt; 0.01), and boiled dumpling (P lt; 0.01). We also observed that children living in Jamaica have an arithmetic mean blood cadmium concentration of 0.16 ?g/L which is similar to that of the children in developed countries and much lower than that of children in developing countries. Although our results do not support an association between blood cadmium concentrations and ASD, to our knowledge, this study is the first to report levels of blood cadmium in TD children as well as those with ASD in Jamaica. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.06.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 [article] Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Aisha S. DICKERSON, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Deborah A. PEARSON, Auteur ; Eric BOERWINKLE, Auteur . - p.1134-1145. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-9 (September 2014) . - p.1134-1145 Mots-clés : Cadmium  Autism Spectrum Disorder  Grains  Fruits  Seafood  Jamaica Index. décimale : PER Périodiques Résumé : Abstract Human exposure to cadmium has adverse effects on the nervous system. Utilizing data from 110 age- and sex-matched case–control pairs (220 children) ages 2–8 years in Kingston, Jamaica, we compared the 75th percentile of blood cadmium concentrations in children with and without Autism Spectrum Disorder (ASD). In both univariable and multivariable Quantile Regression Models that controlled for potential confounding factors, we did not find any significant differences between ASD cases and typically developing (TD) controls with respect to the 75th percentile of blood cadmium concentrations (P gt; 0.22). However, we found a significantly higher 75th percentile of blood cadmium concentrations in TD Jamaican children who consumed shellfish (lobsters, crabs) (P lt; 0.05), fried plantain (P lt; 0.01), and boiled dumpling (P lt; 0.01). We also observed that children living in Jamaica have an arithmetic mean blood cadmium concentration of 0.16 ?g/L which is similar to that of the children in developed countries and much lower than that of children in developing countries. Although our results do not support an association between blood cadmium concentrations and ASD, to our knowledge, this study is the first to report levels of blood cadmium in TD children as well as those with ASD in Jamaica. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.06.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238

Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 18 (October 2015)  

Permalink

The diagnosis of autism and autism spectrum disorder in low- and middle-income countries: Experience from Jamaica / Maureen SAMMS-VAUGHAN in Autism, 21-5 (July 2017)  

Permalink

---

1 (1 - 7 / 7)