3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: An open-source catalog of findings / Diana SCHENDEL in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2144-2155 Titre : 3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: An open-source catalog of findings Type de document : Texte imprimé et/ou numérique Auteurs : Diana SCHENDEL, Auteur ; Linda EJLSKOV, Auteur ; Morten OVERGAARD, Auteur ; Zeal JINWALA, Auteur ; Viktor KIM, Auteur ; Erik PARNER, Auteur ; Amy E. KALKBRENNER, Auteur ; Christine LADD ACOSTA, Auteur ; M. Danielle FALLIN, Auteur ; Sherlly XIE, Auteur ; Preben Bo MORTENSEN, Auteur ; Brian K. LEE, Auteur Article en page(s) : p.2144-2155 Langues : Anglais (eng) Mots-clés : allergy  asthma  autism  autoimmune  birth defect  cardiometabolic  family history  mental disorder  neurologic Index. décimale : PER Périodiques Résumé : Abstract The relatively few conditions and family member types (e.g., sibling, parent) considered in investigations of family health history in autism spectrum disorder (ASD, or autism) limits understanding of the role of family history in autism etiology. For more comprehensive understanding and hypothesis-generation, we produced an open-source catalog of autism associations with family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions. All live births in Denmark, 1980?2012, of Denmark-born parents (1,697,231 births), and their 3-generation family members were followed through April 10, 2017 for each of 90 diagnoses (including autism), emigration or death. Adjusted hazard ratios (aHR) were estimated via Cox regression for each diagnosis-family member type combination, adjusting for birth year, sex, birth weight, gestational age, parental ages at birth, and number of family member types of index person; aHRs also calculated for sex-specific co-occurrence of each disorder. We obtained 6462 individual family history aHRS across autism overall (26,840 autistic persons; 1.6% of births), by sex, and considering intellectual disability (ID); and 350 individual co-occurrence aHRS. Results are cataloged in interactive heat maps and down-loadable data files: https://ncrr-au.shinyapps.io/asd-riskatlas/ and interactive graphic summaries: https://public.tableau.com/app/profile/diana.schendel/viz/ASDPlots_16918786403110/e-Figure5. While primarily for reference material or use in other studies (e.g., meta-analyses), results revealed considerable breadth and variation in magnitude of familial health history associations with autism by type of condition, family member type, sex of the family member, side of the family, sex of the index person, and ID status, indicative of diverse genetic, familial, and nongenetic autism etiologic pathways. Careful attention to sources of autism likelihood in family health history, aided by our open data resource, may accelerate understanding of factors underlying neurodiversity. En ligne : https://doi.org/10.1002/aur.3232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] 3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: An open-source catalog of findings [Texte imprimé et/ou numérique] / Diana SCHENDEL, Auteur ; Linda EJLSKOV, Auteur ; Morten OVERGAARD, Auteur ; Zeal JINWALA, Auteur ; Viktor KIM, Auteur ; Erik PARNER, Auteur ; Amy E. KALKBRENNER, Auteur ; Christine LADD ACOSTA, Auteur ; M. Danielle FALLIN, Auteur ; Sherlly XIE, Auteur ; Preben Bo MORTENSEN, Auteur ; Brian K. LEE, Auteur . - p.2144-2155. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2144-2155 Mots-clés : allergy  asthma  autism  autoimmune  birth defect  cardiometabolic  family history  mental disorder  neurologic Index. décimale : PER Périodiques Résumé : Abstract The relatively few conditions and family member types (e.g., sibling, parent) considered in investigations of family health history in autism spectrum disorder (ASD, or autism) limits understanding of the role of family history in autism etiology. For more comprehensive understanding and hypothesis-generation, we produced an open-source catalog of autism associations with family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions. All live births in Denmark, 1980?2012, of Denmark-born parents (1,697,231 births), and their 3-generation family members were followed through April 10, 2017 for each of 90 diagnoses (including autism), emigration or death. Adjusted hazard ratios (aHR) were estimated via Cox regression for each diagnosis-family member type combination, adjusting for birth year, sex, birth weight, gestational age, parental ages at birth, and number of family member types of index person; aHRs also calculated for sex-specific co-occurrence of each disorder. We obtained 6462 individual family history aHRS across autism overall (26,840 autistic persons; 1.6% of births), by sex, and considering intellectual disability (ID); and 350 individual co-occurrence aHRS. Results are cataloged in interactive heat maps and down-loadable data files: https://ncrr-au.shinyapps.io/asd-riskatlas/ and interactive graphic summaries: https://public.tableau.com/app/profile/diana.schendel/viz/ASDPlots_16918786403110/e-Figure5. While primarily for reference material or use in other studies (e.g., meta-analyses), results revealed considerable breadth and variation in magnitude of familial health history associations with autism by type of condition, family member type, sex of the family member, side of the family, sex of the index person, and ID status, indicative of diverse genetic, familial, and nongenetic autism etiologic pathways. Careful attention to sources of autism likelihood in family health history, aided by our open data resource, may accelerate understanding of factors underlying neurodiversity. En ligne : https://doi.org/10.1002/aur.3232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Big data in autism research: Methodological challenges and solutions / Brian K. LEE in Autism Research, 16-10 (October 2023)  

Public ISBD [article]  inAutism Research > 16-10 (October 2023) . - p.1852-1858 Titre : Big data in autism research: Methodological challenges and solutions Type de document : Texte imprimé et/ou numérique Auteurs : Brian K. LEE, Auteur ; Diana E. SCHENDEL, Auteur ; Lindsay L. SHEA, Auteur Article en page(s) : p.1852-1858 Index. décimale : PER Périodiques Résumé : Abstract While the concept of big data has emerged over the past decade as a hot topic in nearly all areas of scientific inquiry, it has rarely been discussed in the context of autism research. In this commentary we describe aspects of big data that are relevant to autism research and methodological issues such as confounding and data error that can hamper scientific investigation. Although big data studies can have transformative impact, bigger is not always better, and big data require the same methodological considerations and interdisciplinary collaboration as "small data" to extract useful scientific insight. En ligne : https://doi.org/10.1002/aur.3007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Big data in autism research: Methodological challenges and solutions [Texte imprimé et/ou numérique] / Brian K. LEE, Auteur ; Diana E. SCHENDEL, Auteur ; Lindsay L. SHEA, Auteur . - p.1852-1858. in Autism Research > 16-10 (October 2023) . - p.1852-1858 Index. décimale : PER Périodiques Résumé : Abstract While the concept of big data has emerged over the past decade as a hot topic in nearly all areas of scientific inquiry, it has rarely been discussed in the context of autism research. In this commentary we describe aspects of big data that are relevant to autism research and methodological issues such as confounding and data error that can hamper scientific investigation. Although big data studies can have transformative impact, bigger is not always better, and big data require the same methodological considerations and interdisciplinary collaboration as "small data" to extract useful scientific insight. En ligne : https://doi.org/10.1002/aur.3007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Brief Report: Examining the Association of Autism and Adverse Childhood Experiences in the National Survey of Children’s Health: The Important Role of Income and Co-occurring Mental Health Conditions / Connor M. KERNS in Journal of Autism and Developmental Disorders, 47-7 (July 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2275-2281 Titre : Brief Report: Examining the Association of Autism and Adverse Childhood Experiences in the National Survey of Children’s Health: The Important Role of Income and Co-occurring Mental Health Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Connor M. KERNS, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Steven J. BERKOWITZ, Auteur ; Brian K. LEE, Auteur Article en page(s) : p.2275-2281 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Adverse childhood experiences  Comorbidity  Anxiety  Depression  Attention problems  Behavioral problems Index. décimale : PER Périodiques Résumé : Adverse childhood experiences (ACEs) are risk factors for mental and physical illness and more likely to occur for children with autism spectrum disorder (ASD). The present study aimed to clarify the contribution of poverty, intellectual disability and mental health conditions to this disparity. Data on child and family characteristics, mental health conditions and ACEs were analyzed in 67,067 youth from the 2011–2012 National Survey of Children’s Health. In an income-stratified sample, the association of ASD and ACEs was greater for lower income children and significantly diminished after controlling for child mental health conditions, but not intellectual disability. Findings suggest that the association of ACEs and ASD is moderated by family income and contingent on co-occurring mental health conditions. En ligne : https://doi.org/10.1007/s10803-017-3111-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314 [article] Brief Report: Examining the Association of Autism and Adverse Childhood Experiences in the National Survey of Children’s Health: The Important Role of Income and Co-occurring Mental Health Conditions [Texte imprimé et/ou numérique] / Connor M. KERNS, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Steven J. BERKOWITZ, Auteur ; Brian K. LEE, Auteur . - p.2275-2281. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2275-2281 Mots-clés : Autism spectrum disorder  Adverse childhood experiences  Comorbidity  Anxiety  Depression  Attention problems  Behavioral problems Index. décimale : PER Périodiques Résumé : Adverse childhood experiences (ACEs) are risk factors for mental and physical illness and more likely to occur for children with autism spectrum disorder (ASD). The present study aimed to clarify the contribution of poverty, intellectual disability and mental health conditions to this disparity. Data on child and family characteristics, mental health conditions and ACEs were analyzed in 67,067 youth from the 2011–2012 National Survey of Children’s Health. In an income-stratified sample, the association of ASD and ACEs was greater for lower income children and significantly diminished after controlling for child mental health conditions, but not intellectual disability. Findings suggest that the association of ACEs and ASD is moderated by family income and contingent on co-occurring mental health conditions. En ligne : https://doi.org/10.1007/s10803-017-3111-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314

Brief Report: Maternal Smoking During Pregnancy and Autism Spectrum Disorders / Brian K. LEE in Journal of Autism and Developmental Disorders, 42-9 (September 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.2000-2005 Titre : Brief Report: Maternal Smoking During Pregnancy and Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Brian K. LEE, Auteur ; Renee M. GARDNER, Auteur ; Henrik DAL, Auteur ; Anna SVENSSON, Auteur ; Maria Rosaria GALANTI, Auteur ; Dheeraj RAI, Auteur ; Christina DALMAN, Auteur ; Cecilia MAGNUSSON, Auteur Année de publication : 2012 Article en page(s) : p.2000-2005 Langues : Anglais (eng) Mots-clés : Autism  Population register  Smoking  Sweden  Tobacco Index. décimale : PER Périodiques Résumé : Prenatal exposure to tobacco smoke is suggested as a potential risk factor for autism spectrum disorders (ASD). Previous epidemiological studies of this topic have yielded mixed findings. We performed a case–control study of 3,958 ASD cases and 38,983 controls nested in a large register-based cohort in Sweden. ASD case status was measured using a multisource case ascertainment system. In adjusted results, we found that maternal smoking during pregnancy is not associated with increased risk of ASD regardless of presence or absence of comorbid intellectual disability. Apparent associations were attributable to confounding by sociodemographic characteristics of parents such as education, income, and occupation. En ligne : http://dx.doi.org/10.1007/s10803-011-1425-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 [article] Brief Report: Maternal Smoking During Pregnancy and Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Brian K. LEE, Auteur ; Renee M. GARDNER, Auteur ; Henrik DAL, Auteur ; Anna SVENSSON, Auteur ; Maria Rosaria GALANTI, Auteur ; Dheeraj RAI, Auteur ; Christina DALMAN, Auteur ; Cecilia MAGNUSSON, Auteur . - 2012 . - p.2000-2005. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.2000-2005 Mots-clés : Autism  Population register  Smoking  Sweden  Tobacco Index. décimale : PER Périodiques Résumé : Prenatal exposure to tobacco smoke is suggested as a potential risk factor for autism spectrum disorders (ASD). Previous epidemiological studies of this topic have yielded mixed findings. We performed a case–control study of 3,958 ASD cases and 38,983 controls nested in a large register-based cohort in Sweden. ASD case status was measured using a multisource case ascertainment system. In adjusted results, we found that maternal smoking during pregnancy is not associated with increased risk of ASD regardless of presence or absence of comorbid intellectual disability. Apparent associations were attributable to confounding by sociodemographic characteristics of parents such as education, income, and occupation. En ligne : http://dx.doi.org/10.1007/s10803-011-1425-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180

Brief Report: Prevalence of Co-occurring Epilepsy and Autism Spectrum Disorder: The U.S. National Survey of Children’s Health 2011–2012 / Shiny THOMAS in Journal of Autism and Developmental Disorders, 47-1 (January 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-1 (January 2017) . - p.224-229 Titre : Brief Report: Prevalence of Co-occurring Epilepsy and Autism Spectrum Disorder: The U.S. National Survey of Children’s Health 2011–2012 Type de document : Texte imprimé et/ou numérique Auteurs : Shiny THOMAS, Auteur ; Mary E. HOVINGA, Auteur ; Dheeraj RAI, Auteur ; Brian K. LEE, Auteur Article en page(s) : p.224-229 Langues : Anglais (eng) Mots-clés : Autism  Epilepsy  Comorbid  Epidemiology Index. décimale : PER Périodiques Résumé : Epilepsy is reported to co-occur in individuals with autism spectrum disorder (ASD). Previous studies across the world have found prevalence estimates ranging from 4 to 38?%. We examined parent-reported prevalence of co-occurring epilepsy and ASD in the most recent U.S. National Survey of Children’s Health, 2011–2012. All analyses accounted for survey weights to account for the complex sampling design. In the overall analytic sample of 85,248 children ages 2–17, there were 1604 children with ASD (prevalence of 1.8?%) and 1083 children with epilepsy (prevalence of 1.2?%). Epilepsy was reported to co-occur in 8.6?% of ASD cases. In children with ASD, the co-occurrence of epilepsy was associated with increasing child age, female gender, intellectual disability, speech problems and lower socioeconomic status. En ligne : http://dx.doi.org/10.1007/s10803-016-2938-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Brief Report: Prevalence of Co-occurring Epilepsy and Autism Spectrum Disorder: The U.S. National Survey of Children’s Health 2011–2012 [Texte imprimé et/ou numérique] / Shiny THOMAS, Auteur ; Mary E. HOVINGA, Auteur ; Dheeraj RAI, Auteur ; Brian K. LEE, Auteur . - p.224-229. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-1 (January 2017) . - p.224-229 Mots-clés : Autism  Epilepsy  Comorbid  Epidemiology Index. décimale : PER Périodiques Résumé : Epilepsy is reported to co-occur in individuals with autism spectrum disorder (ASD). Previous studies across the world have found prevalence estimates ranging from 4 to 38?%. We examined parent-reported prevalence of co-occurring epilepsy and ASD in the most recent U.S. National Survey of Children’s Health, 2011–2012. All analyses accounted for survey weights to account for the complex sampling design. In the overall analytic sample of 85,248 children ages 2–17, there were 1604 children with ASD (prevalence of 1.8?%) and 1083 children with epilepsy (prevalence of 1.2?%). Epilepsy was reported to co-occur in 8.6?% of ASD cases. In children with ASD, the co-occurrence of epilepsy was associated with increasing child age, female gender, intellectual disability, speech problems and lower socioeconomic status. En ligne : http://dx.doi.org/10.1007/s10803-016-2938-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Brief Report: Trends in U.S. National Autism Awareness from 2004 to 2014: The Impact of National Autism Awareness Month / Elizabeth A. DE VILBISS in Journal of Autism and Developmental Disorders, 44-12 (December 2014)  

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Changes in Prevalence of Autism Spectrum Disorders in 2001–2011: Findings from the Stockholm Youth Cohort / Selma IDRING in Journal of Autism and Developmental Disorders, 45-6 (June 2015)  

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Exploring the relationship between COVID-19 and autistic adults' community participation: Findings from a two-timepoint longitudinal study / Mark S. SALZER ; Alec BECKER ; David J. VANNESS ; Brian K. LEE ; Dylan COOPER ; Jonas VENTIMIGLIA ; Lindsay L. SHEA in Research in Autism Spectrum Disorders, 109 (November 2023)  

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In Utero Exposure to Selective Serotonin Reuptake Inhibitors and Risk for Autism Spectrum Disorder / Nicole B. GIDAYA in Journal of Autism and Developmental Disorders, 44-10 (October 2014)  

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Mapping Collaboration Networks in the World of Autism Research / Neal D. GOLDSTEIN in Autism Research, 8-1 (February 2015)  

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Maternal Dietary Factors and the Risk of Autism Spectrum Disorders: A Systematic Review of Existing Evidence / Caichen ZHONG in Autism Research, 13-10 (October 2020)  

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Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development / Alison B. SINGER in Journal of Autism and Developmental Disorders, 46-11 (November 2016)  

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Maternal hirsutism and autism spectrum disorders in offspring / Brian K. LEE in Autism Research, 10-9 (September 2017)  

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Maternal Smoking and Autism Spectrum Disorder: A Meta-analysis / Brittany N. ROSEN in Journal of Autism and Developmental Disorders, 45-6 (June 2015)  

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Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort / Dina TERLOYEVA in Molecular Autism, 11 (2020)  

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