Familial aggregation of attention-deficit/hyperactivity disorder / Qi CHEN in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.231-239 Titre : Familial aggregation of attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Qi CHEN, Auteur ; Isabell BRIKELL, Auteur ; Paul LICHTENSTEIN, Auteur ; Eva SERLACHIUS, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Sven SANDIN, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.231-239 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  diagnosis  family factor  sex differences  adulthood Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) aggregates in families. To date, the strength, pattern, and characteristics of the familial aggregation have not been thoroughly assessed in a population-based family sample. Methods In this cohort study, we identified relative pairs of twins, full and half-siblings, and full and half cousins from 1,656,943 unique individuals born in Sweden between 1985 and 2006. The relatives of index persons were followed from their third birthday to 31 December 2009 for ADHD diagnosis. Birth year adjusted hazard ratio (HR), that is, the rate of ADHD in relatives of ADHD-affected index persons compared with the rate of ADHD in relatives of unaffected index persons, was estimated in the different types of relatives using Cox proportional hazards model. Results During the follow-up, 31,865 individuals were diagnosed with ADHD (male to female ratio was 3.7). The birth year adjusted HRs were as follows: 70.45 for monozygotic twins; 8.44 for dizygotic twins; 8.27 for full siblings; 2.86 for maternal half-siblings; 2.31 for paternal half-siblings; 2.24 for full cousins; 1.47 for half cousins. Maternal half-siblings had significantly higher HR than in paternal half-siblings. The HR did not seem to be affected by index person's sex. Full siblings of index persons with ADHD diagnosis present at age 18 or older had a higher rate of ADHD (HR: 11.49) than full siblings of index persons with ADHD diagnosis only before age 18 (HR: 4.68). Conclusions Familial aggregation of ADHD increases with increasing genetic relatedness. The familial aggregation is driven by not only genetic factors but also a small amount of shared environmental factors. Persistence of ADHD into adulthood indexes stronger familial aggregation of ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Familial aggregation of attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Qi CHEN, Auteur ; Isabell BRIKELL, Auteur ; Paul LICHTENSTEIN, Auteur ; Eva SERLACHIUS, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Sven SANDIN, Auteur ; Henrik LARSSON, Auteur . - p.231-239. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.231-239 Mots-clés : Attention-deficit/hyperactivity disorder  diagnosis  family factor  sex differences  adulthood Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) aggregates in families. To date, the strength, pattern, and characteristics of the familial aggregation have not been thoroughly assessed in a population-based family sample. Methods In this cohort study, we identified relative pairs of twins, full and half-siblings, and full and half cousins from 1,656,943 unique individuals born in Sweden between 1985 and 2006. The relatives of index persons were followed from their third birthday to 31 December 2009 for ADHD diagnosis. Birth year adjusted hazard ratio (HR), that is, the rate of ADHD in relatives of ADHD-affected index persons compared with the rate of ADHD in relatives of unaffected index persons, was estimated in the different types of relatives using Cox proportional hazards model. Results During the follow-up, 31,865 individuals were diagnosed with ADHD (male to female ratio was 3.7). The birth year adjusted HRs were as follows: 70.45 for monozygotic twins; 8.44 for dizygotic twins; 8.27 for full siblings; 2.86 for maternal half-siblings; 2.31 for paternal half-siblings; 2.24 for full cousins; 1.47 for half cousins. Maternal half-siblings had significantly higher HR than in paternal half-siblings. The HR did not seem to be affected by index person's sex. Full siblings of index persons with ADHD diagnosis present at age 18 or older had a higher rate of ADHD (HR: 11.49) than full siblings of index persons with ADHD diagnosis only before age 18 (HR: 4.68). Conclusions Familial aggregation of ADHD increases with increasing genetic relatedness. The familial aggregation is driven by not only genetic factors but also a small amount of shared environmental factors. Persistence of ADHD into adulthood indexes stronger familial aggregation of ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Parental and Perinatal Risk Factors for Autism: Epidemiological Findings and Potential Mechanisms / Sven SANDIN

Public ISBD in The Neuroscience of Autism Spectrum Disorders / Joseph D. BUXBAUM Titre : Parental and Perinatal Risk Factors for Autism: Epidemiological Findings and Potential Mechanisms Type de document : Texte imprimé et/ou numérique Auteurs : Sven SANDIN, Auteur ; Alexander KOLEVZON, Auteur ; Stephen Z. LEVINE, Auteur ; Christina M. HULTMAN, Auteur ; Abraham REICHENBERG, Auteur Année de publication : 2013 Importance : p.195-202 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : There is evidence that non-heritable familial pre- or perinatal factors play a role in the etiology of autism and autism spectrum disorders (ASD). According to current evidence from epidemiological studies, two groups of factors show a consistent relationship with ASD: advancing parental age and preterm birth and intrauterine growth restriction. Using a systematic review and meta-analysis of epidemiological studies incorporating a comprehensive assessment of risk factors, we have examined the evidence for an association between advancing parental age, low birth weight, preterm birth and being born small for gestational age, and risk for ASD in the offspring. Advancing maternal age (35 or older), and paternal age (40 or older), show a consistent relationship with ASD. Current evidence also supports a relationship between low birth weight (lt; 2,500 grams), preterm birth (lt; 37 weeks) and being born small for gestational age, and ASD. Future research should continue to examine these variables using large, population-based cohorts in order to offer a more refined modeling of risk and potential confounders, and to attempt to distinguish between autism and spectrum disorders. Identifying common and unique risk factors may be important to understand shared and non-shared etiologies. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 in The Neuroscience of Autism Spectrum Disorders / Joseph D. BUXBAUM Parental and Perinatal Risk Factors for Autism: Epidemiological Findings and Potential Mechanisms [Texte imprimé et/ou numérique] / Sven SANDIN, Auteur ; Alexander KOLEVZON, Auteur ; Stephen Z. LEVINE, Auteur ; Christina M. HULTMAN, Auteur ; Abraham REICHENBERG, Auteur . - 2013 . - p.195-202. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : There is evidence that non-heritable familial pre- or perinatal factors play a role in the etiology of autism and autism spectrum disorders (ASD). According to current evidence from epidemiological studies, two groups of factors show a consistent relationship with ASD: advancing parental age and preterm birth and intrauterine growth restriction. Using a systematic review and meta-analysis of epidemiological studies incorporating a comprehensive assessment of risk factors, we have examined the evidence for an association between advancing parental age, low birth weight, preterm birth and being born small for gestational age, and risk for ASD in the offspring. Advancing maternal age (35 or older), and paternal age (40 or older), show a consistent relationship with ASD. Current evidence also supports a relationship between low birth weight (lt; 2,500 grams), preterm birth (lt; 37 weeks) and being born small for gestational age, and ASD. Future research should continue to examine these variables using large, population-based cohorts in order to offer a more refined modeling of risk and potential confounders, and to attempt to distinguish between autism and spectrum disorders. Identifying common and unique risk factors may be important to understand shared and non-shared etiologies. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189

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The Familial Risk of Autism Spectrum Disorder with and without Intellectual Disability / Sherlly XIE in Autism Research, 13-12 (December 2020)  

Public ISBD [article]  inAutism Research > 13-12 (December 2020) . - p.2242-2250 Titre : The Familial Risk of Autism Spectrum Disorder with and without Intellectual Disability Type de document : Texte imprimé et/ou numérique Auteurs : Sherlly XIE, Auteur ; Håkan KARLSSON, Auteur ; Christina DALMAN, Auteur ; Linnea WIDMAN, Auteur ; Dheeraj RAI, Auteur ; Renee M. GARDNER, Auteur ; Cecilia MAGNUSSON, Auteur ; Sven SANDIN, Auteur ; Loni P. TABB, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Brian K. LEE, Auteur Article en page(s) : p.2242-2250 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  familial risk  family study  heritability  intellectual disability Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is highly heritable, yet how its familial risk and heritability may vary by cognitive ability is not well understood. In this population-based cohort study, we examined the familial risk and heritability of ASD with and without co-occurring intellectual disability (ID). We estimated odds ratios and heritability of ASD with ID (ASD+ID) and ASD without ID (ASD-ID) using register-based diagnosis data of 567,436 index persons born in 1984-2009 in Stockholm County, Sweden, and their parents, siblings, cousins, aunts, and uncles. The familial risk profile exhibited differences between ASD-ID and ASD+ID, most notably for index persons with affected parents. For example, for an index person who had at least one parent with ASD, the child's odds of ASD-ID and ASD+ID (95% confidence interval (CI)) increased by 16.2 (14.2-18.6) and 7.4 (5.5-10.0) folds, respectively. The more closely related a family member with ASD was, the greater the observed risk was of ASD in the index person, especially for ASD-ID. The broad-sense heritability (95% CI) for ASD?-?ID and ASD+ID were 64.6% (46.0-100.0%) and 33.4% (14.4-58.4%), respectively. Familial risk and heritability of ASD may vary by intellectual ability, which implies that risk factors between these ASD phenotypes may differ. Our findings from the heritability analysis and familial risk analysis suggest that ASD-ID may have a greater genetic basis than ASD+ID, although this should be verified in future studies. LAY SUMMARY: Autism spectrum disorder (ASD) is highly heritable, yet how its familial risk and heritability may vary by cognitive ability is not well-understood. In a population-based cohort study on families of 567,436 index persons using Swedish registers data, we found that the familial risk profile differed between ASD with and without intellectual disability. Our findings from the heritability analysis and familial risk analysis suggest that ASD-ID may have a greater genetic basis than ASD+ID, although this should be verified in future studies. En ligne : http://dx.doi.org/10.1002/aur.2417 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] The Familial Risk of Autism Spectrum Disorder with and without Intellectual Disability [Texte imprimé et/ou numérique] / Sherlly XIE, Auteur ; Håkan KARLSSON, Auteur ; Christina DALMAN, Auteur ; Linnea WIDMAN, Auteur ; Dheeraj RAI, Auteur ; Renee M. GARDNER, Auteur ; Cecilia MAGNUSSON, Auteur ; Sven SANDIN, Auteur ; Loni P. TABB, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Brian K. LEE, Auteur . - p.2242-2250. Langues : Anglais (eng) in Autism Research > 13-12 (December 2020) . - p.2242-2250 Mots-clés : autism spectrum disorders  familial risk  family study  heritability  intellectual disability Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is highly heritable, yet how its familial risk and heritability may vary by cognitive ability is not well understood. In this population-based cohort study, we examined the familial risk and heritability of ASD with and without co-occurring intellectual disability (ID). We estimated odds ratios and heritability of ASD with ID (ASD+ID) and ASD without ID (ASD-ID) using register-based diagnosis data of 567,436 index persons born in 1984-2009 in Stockholm County, Sweden, and their parents, siblings, cousins, aunts, and uncles. The familial risk profile exhibited differences between ASD-ID and ASD+ID, most notably for index persons with affected parents. For example, for an index person who had at least one parent with ASD, the child's odds of ASD-ID and ASD+ID (95% confidence interval (CI)) increased by 16.2 (14.2-18.6) and 7.4 (5.5-10.0) folds, respectively. The more closely related a family member with ASD was, the greater the observed risk was of ASD in the index person, especially for ASD-ID. The broad-sense heritability (95% CI) for ASD?-?ID and ASD+ID were 64.6% (46.0-100.0%) and 33.4% (14.4-58.4%), respectively. Familial risk and heritability of ASD may vary by intellectual ability, which implies that risk factors between these ASD phenotypes may differ. Our findings from the heritability analysis and familial risk analysis suggest that ASD-ID may have a greater genetic basis than ASD+ID, although this should be verified in future studies. LAY SUMMARY: Autism spectrum disorder (ASD) is highly heritable, yet how its familial risk and heritability may vary by cognitive ability is not well-understood. In a population-based cohort study on families of 567,436 index persons using Swedish registers data, we found that the familial risk profile differed between ASD with and without intellectual disability. Our findings from the heritability analysis and familial risk analysis suggest that ASD-ID may have a greater genetic basis than ASD+ID, although this should be verified in future studies. En ligne : http://dx.doi.org/10.1002/aur.2417 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

The International Collaboration for Autism Registry Epidemiology (iCARE): Multinational Registry-Based Investigations of Autism Risk Factors and Trends / Diana SCHENDEL in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2650-2663 Titre : The International Collaboration for Autism Registry Epidemiology (iCARE): Multinational Registry-Based Investigations of Autism Risk Factors and Trends Type de document : Texte imprimé et/ou numérique Auteurs : Diana SCHENDEL, Auteur ; Michaeline BRESNAHAN, Auteur ; Kim W. CARTER, Auteur ; Richard W. FRANCIS, Auteur ; Mika GISSLER, Auteur ; Therese K. GRONBORG, Auteur ; Raz GROSS, Auteur ; Nina GUNNES, Auteur ; Mady HORNIG, Auteur ; Christina M. HULTMAN, Auteur ; Amanda LANGRIDGE, Auteur ; Marlene B. LAURITSEN, Auteur ; Helen LEONARD, Auteur ; Erik T. PARNER, Auteur ; Abraham REICHENBERG, Auteur ; Sven SANDIN, Auteur ; Andre SOURANDER, Auteur ; Camilla STOLTENBERG, Auteur ; Auli SUOMINEN, Auteur ; Pål SUREN, Auteur ; Ezra SUSSER, Auteur Article en page(s) : p.2650-2663 Langues : Anglais (eng) Mots-clés : Autism  Epidemiology  Study methods  Risk factors  Multinational Index. décimale : PER Périodiques Résumé : The International Collaboration for Autism Registry Epidemiology (iCARE) is the first multinational research consortium (Australia, Denmark, Finland, Israel, Norway, Sweden, USA) to promote research in autism geographical and temporal heterogeneity, phenotype, family and life course patterns, and etiology. iCARE devised solutions to challenges in multinational collaboration concerning data access security, confidentiality and management. Data are obtained by integrating existing national or state-wide, population-based, individual-level data systems and undergo rigorous harmonization and quality control processes. Analyses are performed using database federation via a computational infrastructure with a secure, web-based, interface. iCARE provides a unique, unprecedented resource in autism research that will significantly enhance the ability to detect environmental and genetic contributions to the causes and life course of autism. En ligne : http://dx.doi.org/10.1007/s10803-013-1815-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217 [article] The International Collaboration for Autism Registry Epidemiology (iCARE): Multinational Registry-Based Investigations of Autism Risk Factors and Trends [Texte imprimé et/ou numérique] / Diana SCHENDEL, Auteur ; Michaeline BRESNAHAN, Auteur ; Kim W. CARTER, Auteur ; Richard W. FRANCIS, Auteur ; Mika GISSLER, Auteur ; Therese K. GRONBORG, Auteur ; Raz GROSS, Auteur ; Nina GUNNES, Auteur ; Mady HORNIG, Auteur ; Christina M. HULTMAN, Auteur ; Amanda LANGRIDGE, Auteur ; Marlene B. LAURITSEN, Auteur ; Helen LEONARD, Auteur ; Erik T. PARNER, Auteur ; Abraham REICHENBERG, Auteur ; Sven SANDIN, Auteur ; Andre SOURANDER, Auteur ; Camilla STOLTENBERG, Auteur ; Auli SUOMINEN, Auteur ; Pål SUREN, Auteur ; Ezra SUSSER, Auteur . - p.2650-2663. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2650-2663 Mots-clés : Autism  Epidemiology  Study methods  Risk factors  Multinational Index. décimale : PER Périodiques Résumé : The International Collaboration for Autism Registry Epidemiology (iCARE) is the first multinational research consortium (Australia, Denmark, Finland, Israel, Norway, Sweden, USA) to promote research in autism geographical and temporal heterogeneity, phenotype, family and life course patterns, and etiology. iCARE devised solutions to challenges in multinational collaboration concerning data access security, confidentiality and management. Data are obtained by integrating existing national or state-wide, population-based, individual-level data systems and undergo rigorous harmonization and quality control processes. Analyses are performed using database federation via a computational infrastructure with a secure, web-based, interface. iCARE provides a unique, unprecedented resource in autism research that will significantly enhance the ability to detect environmental and genetic contributions to the causes and life course of autism. En ligne : http://dx.doi.org/10.1007/s10803-013-1815-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217

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