Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia / Laura VAN KEY ; Pat BROSSEAU ; Shaun M. EACK ; David I. LEITMAN ; Dean F. SALISBURY ; Marlene BEHRMANN in Journal of Autism and Developmental Disorders, 53-12 (December 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-12 (December 2023) . - p.4856-4871 Titre : Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia Type de document : texte imprimé Auteurs : Laura VAN KEY, Auteur ; Pat BROSSEAU, Auteur ; Shaun M. EACK, Auteur ; David I. LEITMAN, Auteur ; Dean F. SALISBURY, Auteur ; Marlene BEHRMANN, Auteur Article en page(s) : p.4856-4871 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability. En ligne : https://doi.org/10.1007/s10803-022-05771-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515 [article] Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia [texte imprimé] / Laura VAN KEY, Auteur ; Pat BROSSEAU, Auteur ; Shaun M. EACK, Auteur ; David I. LEITMAN, Auteur ; Dean F. SALISBURY, Auteur ; Marlene BEHRMANN, Auteur . - p.4856-4871. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-12 (December 2023) . - p.4856-4871 Index. décimale : PER Périodiques Résumé : Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability. En ligne : https://doi.org/10.1007/s10803-022-05771-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515

Brief Report: Is Cognitive Rehabilitation Needed in Verbal Adults with Autism? Insights from Initial Enrollment in a Trial of Cognitive Enhancement Therapy / Shaun M. EACK in Journal of Autism and Developmental Disorders, 43-9 (September 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2233-2237 Titre : Brief Report: Is Cognitive Rehabilitation Needed in Verbal Adults with Autism? Insights from Initial Enrollment in a Trial of Cognitive Enhancement Therapy Type de document : texte imprimé Auteurs : Shaun M. EACK, Auteur ; Amber L. BAHORIK, Auteur ; Susan S. HOGARTY, Auteur ; Deborah P. GREENWALD, Auteur ; Maralee Y. LITSCHGE, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur Article en page(s) : p.2233-2237 Langues : Anglais (eng) Mots-clés : Cognition  Social cognition  Neurocognition  Cognitive rehabilitation  Adults Index. décimale : PER Périodiques Résumé : Cognitive rehabilitation is an emerging set of potentially effective interventions for the treatment of autism spectrum disorder, yet the applicability of these approaches for “high functioning” adults who have normative levels of intelligence remains unexplored. This study examined the initial cognitive performance characteristics of 40 verbal adults with autism enrolled in a pilot trial of Cognitive Enhancement Therapy to investigate the need for cognitive rehabilitation in this population. Results revealed marked and broad deficits across neurocognitive and social-cognitive domains, despite above-average IQ. Areas of greatest impairment included processing speed, cognitive flexibility, and emotion perception and management. These findings indicate the need for comprehensive interventions designed to enhance cognition among verbal adults with autism who have intact intellectual functioning. En ligne : http://dx.doi.org/10.1007/s10803-013-1774-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Brief Report: Is Cognitive Rehabilitation Needed in Verbal Adults with Autism? Insights from Initial Enrollment in a Trial of Cognitive Enhancement Therapy [texte imprimé] / Shaun M. EACK, Auteur ; Amber L. BAHORIK, Auteur ; Susan S. HOGARTY, Auteur ; Deborah P. GREENWALD, Auteur ; Maralee Y. LITSCHGE, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur . - p.2233-2237. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2233-2237 Mots-clés : Cognition  Social cognition  Neurocognition  Cognitive rehabilitation  Adults Index. décimale : PER Périodiques Résumé : Cognitive rehabilitation is an emerging set of potentially effective interventions for the treatment of autism spectrum disorder, yet the applicability of these approaches for “high functioning” adults who have normative levels of intelligence remains unexplored. This study examined the initial cognitive performance characteristics of 40 verbal adults with autism enrolled in a pilot trial of Cognitive Enhancement Therapy to investigate the need for cognitive rehabilitation in this population. Results revealed marked and broad deficits across neurocognitive and social-cognitive domains, despite above-average IQ. Areas of greatest impairment included processing speed, cognitive flexibility, and emotion perception and management. These findings indicate the need for comprehensive interventions designed to enhance cognition among verbal adults with autism who have intact intellectual functioning. En ligne : http://dx.doi.org/10.1007/s10803-013-1774-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18-month randomized clinical trial / Shaun M. EACK in Autism Research, 11-3 (March 2018)  

Public ISBD [article]  inAutism Research > 11-3 (March 2018) . - p.519-530 Titre : Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18-month randomized clinical trial Type de document : texte imprimé Auteurs : Shaun M. EACK, Auteur ; Susan S. HOGARTY, Auteur ; Deborah P. GREENWALD, Auteur ; Maralee Y. LITSCHGE, Auteur ; Shannondora A. PORTON, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur Article en page(s) : p.519-530 Langues : Anglais (eng) Mots-clés : adult autism  cognitive enhancement  cognitive remediation  neurocognition  social cognition Index. décimale : PER Périodiques Résumé : Cognitive remediation is a promising approach to treating core cognitive deficits in adults with autism, but rigorously controlled trials of comprehensive interventions that target both social and non-social cognition over a sufficient period of time to impact functioning are lacking. This study examined the efficacy of cognitive enhancement therapy (CET) for improving core cognitive and employment outcomes in adult autism. Verbal adult outpatients with autism spectrum disorder (N = 54) were randomized to an 18-month, single-blind trial of CET, a cognitive remediation approach that integrates computer-based neurocognitive training with group-based training in social cognition, or an active enriched supportive therapy (EST) comparison focused on psychoeducation and condition management. Primary outcomes were composite indexes of neurocognitive and social-cognitive change. Competitive employment was a secondary outcome. Intent-to-treat analyses indicated that CET produced significant differential increases in neurocognitive function relative to EST (d = .46, P = .013). Both CET and EST were associated with large social-cognitive improvements, with CET demonstrating an advantage at 9 (d = .58, P = 0.020), but not 18 months (d = .27, P = 0.298). Effects on employment indicated that participants treated with CET were significantly more likely to gain competitive employment than those in EST, OR = 6.21, P = 0.023, which was mediated by cognitive improvement. CET is a feasible and potentially effective treatment for core cognitive deficits in adult autism spectrum disorder. The treatment of cognitive impairments in this population can contribute to meaningful improvements in adult outcomes. Autism Res 2018, 11: 519-530. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Cognitive enhancement therapy (CET), an 18-month cognitive remediation intervention designed to improve thinking and social understanding, was found to be more effective than supportive therapy at improving mental quickness, attention, and employment in adults living with autism. Social understanding was equally improved in CET and supportive therapy. Cognitive remediation interventions are feasible and may confer significant functional benefits to adults with autism. En ligne : http://dx.doi.org/10.1002/aur.1913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 [article] Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18-month randomized clinical trial [texte imprimé] / Shaun M. EACK, Auteur ; Susan S. HOGARTY, Auteur ; Deborah P. GREENWALD, Auteur ; Maralee Y. LITSCHGE, Auteur ; Shannondora A. PORTON, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur . - p.519-530. Langues : Anglais (eng) in Autism Research > 11-3 (March 2018) . - p.519-530 Mots-clés : adult autism  cognitive enhancement  cognitive remediation  neurocognition  social cognition Index. décimale : PER Périodiques Résumé : Cognitive remediation is a promising approach to treating core cognitive deficits in adults with autism, but rigorously controlled trials of comprehensive interventions that target both social and non-social cognition over a sufficient period of time to impact functioning are lacking. This study examined the efficacy of cognitive enhancement therapy (CET) for improving core cognitive and employment outcomes in adult autism. Verbal adult outpatients with autism spectrum disorder (N = 54) were randomized to an 18-month, single-blind trial of CET, a cognitive remediation approach that integrates computer-based neurocognitive training with group-based training in social cognition, or an active enriched supportive therapy (EST) comparison focused on psychoeducation and condition management. Primary outcomes were composite indexes of neurocognitive and social-cognitive change. Competitive employment was a secondary outcome. Intent-to-treat analyses indicated that CET produced significant differential increases in neurocognitive function relative to EST (d = .46, P = .013). Both CET and EST were associated with large social-cognitive improvements, with CET demonstrating an advantage at 9 (d = .58, P = 0.020), but not 18 months (d = .27, P = 0.298). Effects on employment indicated that participants treated with CET were significantly more likely to gain competitive employment than those in EST, OR = 6.21, P = 0.023, which was mediated by cognitive improvement. CET is a feasible and potentially effective treatment for core cognitive deficits in adult autism spectrum disorder. The treatment of cognitive impairments in this population can contribute to meaningful improvements in adult outcomes. Autism Res 2018, 11: 519-530. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Cognitive enhancement therapy (CET), an 18-month cognitive remediation intervention designed to improve thinking and social understanding, was found to be more effective than supportive therapy at improving mental quickness, attention, and employment in adults living with autism. Social understanding was equally improved in CET and supportive therapy. Cognitive remediation interventions are feasible and may confer significant functional benefits to adults with autism. En ligne : http://dx.doi.org/10.1002/aur.1913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352

Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study / Shaun M. EACK in Journal of Autism and Developmental Disorders, 43-12 (December 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-12 (December 2013) . - p.2866-2877 Titre : Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study Type de document : texte imprimé Auteurs : Shaun M. EACK, Auteur ; Deborah P. GREENWALD, Auteur ; Susan S. HOGARTY, Auteur ; Amber L. BAHORIK, Auteur ; Maralee Y. LITSCHGE, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur Article en page(s) : p.2866-2877 Langues : Anglais (eng) Mots-clés : Cognitive Enhancement Therapy  Cognitive rehabilitation  Cognitive remediation  Psychosocial treatment  Cognitive therapy  Adult treatment  Autism  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Adults with autism experience significant impairments in social and non-social information processing for which few treatments have been developed. This study conducted an 18-month uncontrolled trial of Cognitive Enhancement Therapy (CET), a comprehensive cognitive rehabilitation intervention, in 14 verbal adults with autism spectrum disorder to investigate its feasibility, acceptability, and initial efficacy in treating these impairments. Results indicated that CET was satisfying to participants, with high treatment attendance and retention. Effects on cognitive deficits and social behavior were also large (d = 1.40–2.29) and statistically significant (all p .001). These findings suggest that CET is a feasible, acceptable, and potentially effective intervention for remediating the social and non-social cognitive impairments in verbal adults with autism. En ligne : http://dx.doi.org/10.1007/s10803-013-1834-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 [article] Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study [texte imprimé] / Shaun M. EACK, Auteur ; Deborah P. GREENWALD, Auteur ; Susan S. HOGARTY, Auteur ; Amber L. BAHORIK, Auteur ; Maralee Y. LITSCHGE, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur . - p.2866-2877. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-12 (December 2013) . - p.2866-2877 Mots-clés : Cognitive Enhancement Therapy  Cognitive rehabilitation  Cognitive remediation  Psychosocial treatment  Cognitive therapy  Adult treatment  Autism  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Adults with autism experience significant impairments in social and non-social information processing for which few treatments have been developed. This study conducted an 18-month uncontrolled trial of Cognitive Enhancement Therapy (CET), a comprehensive cognitive rehabilitation intervention, in 14 verbal adults with autism spectrum disorder to investigate its feasibility, acceptability, and initial efficacy in treating these impairments. Results indicated that CET was satisfying to participants, with high treatment attendance and retention. Effects on cognitive deficits and social behavior were also large (d = 1.40–2.29) and statistically significant (all p .001). These findings suggest that CET is a feasible, acceptable, and potentially effective intervention for remediating the social and non-social cognitive impairments in verbal adults with autism. En ligne : http://dx.doi.org/10.1007/s10803-013-1834-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218

Correlates of quality of life in autistic individuals / Anabelle THEODAT ; Kelly B. BECK ; Caitlin M. CONNER ; Carla A. MAZEFSKY ; Shaun M. EACK in Research in Autism Spectrum Disorders, 115 (July 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 115 (July 2024) . - p.102401 Titre : Correlates of quality of life in autistic individuals Type de document : texte imprimé Auteurs : Anabelle THEODAT, Auteur ; Kelly B. BECK, Auteur ; Caitlin M. CONNER, Auteur ; Carla A. MAZEFSKY, Auteur ; Shaun M. EACK, Auteur Article en page(s) : p.102401 Langues : Anglais (eng) Mots-clés : Autism  Quality of life  Social participation  Depression  Anxiety  Employment Index. décimale : PER Périodiques Résumé : Background Quality of life is an important outcome to autistic individuals. However, the correlates of quality of life in this population are not well known. The purpose of this project was to investigate the extent to which employment, depression, anxiety, and social participation were associated with quality of life in autistic individuals. We also explored potential associations between emotion dysregulation and quality of life. Method Baseline data from two randomized control trials were used for analysis. A total of 125 autistic adolescents and adults aged 16-45 (M = 25.40) participated. Linear regression models were constructed to investigate whether employment, depression, anxiety, and social participation were associated with five domains of quality of life: overall, physical health, psychological, social relationships, and environment. Additional linear regression models explored whether emotion dysregulation was associated with the same quality of life domains. Results Surprisingly, employment was not significantly associated with any quality of life domain. Greater depression severity was significantly associated with poorer quality of life across all domains. Greater social participation was associated with better quality of life, but only for individuals with lower anxiety. More severe dysphoria was associated with poorer overall quality of life and the psychological and physical health domains. Conclusions Results suggest that mental health and emotion dysregulation are important predictors of quality of life for autistic people. They also suggest that anxiety symptoms may attenuate the beneficial effects of social participation. This study provides insight into the unique experiences of autistic individuals and highlights potential unmet need. En ligne : https://doi.org/10.1016/j.rasd.2024.102401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Correlates of quality of life in autistic individuals [texte imprimé] / Anabelle THEODAT, Auteur ; Kelly B. BECK, Auteur ; Caitlin M. CONNER, Auteur ; Carla A. MAZEFSKY, Auteur ; Shaun M. EACK, Auteur . - p.102401. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 115 (July 2024) . - p.102401 Mots-clés : Autism  Quality of life  Social participation  Depression  Anxiety  Employment Index. décimale : PER Périodiques Résumé : Background Quality of life is an important outcome to autistic individuals. However, the correlates of quality of life in this population are not well known. The purpose of this project was to investigate the extent to which employment, depression, anxiety, and social participation were associated with quality of life in autistic individuals. We also explored potential associations between emotion dysregulation and quality of life. Method Baseline data from two randomized control trials were used for analysis. A total of 125 autistic adolescents and adults aged 16-45 (M = 25.40) participated. Linear regression models were constructed to investigate whether employment, depression, anxiety, and social participation were associated with five domains of quality of life: overall, physical health, psychological, social relationships, and environment. Additional linear regression models explored whether emotion dysregulation was associated with the same quality of life domains. Results Surprisingly, employment was not significantly associated with any quality of life domain. Greater depression severity was significantly associated with poorer quality of life across all domains. Greater social participation was associated with better quality of life, but only for individuals with lower anxiety. More severe dysphoria was associated with poorer overall quality of life and the psychological and physical health domains. Conclusions Results suggest that mental health and emotion dysregulation are important predictors of quality of life for autistic people. They also suggest that anxiety symptoms may attenuate the beneficial effects of social participation. This study provides insight into the unique experiences of autistic individuals and highlights potential unmet need. En ligne : https://doi.org/10.1016/j.rasd.2024.102401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

Correlates of social functioning in autism spectrum disorder: The role of social cognition / Lauren BISHOP-FITZPATRICK in Research in Autism Spectrum Disorders, 35 (March 2017)  

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Developing Inner Speech to Help Autistic Individuals Improve Their Self-Regulation Ability: A Pilot Randomized-Controlled Trial / Janice NATHAN ; Barry R. NATHAN ; Miriam SHEYNBLYUM ; Valire Carr COPELAND ; Carla A. MAZEFSKY ; Shaun M. EACK in Autism Research, 18-7 (July 2025)  

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Developing a Measure of Key Adult Outcomes in Adults with Developmental Disabilities: Conceptual Model and Item Generation of the REALS (Relationships, Employment, Autonomy, and Life Satisfaction) / Kristen T. MACKENZIE ; Kelly B. BECK ; Shaun M. EACK ; Katharine N. ZEGLEN ; Caitlin M. CONNER ; Carla A. MAZEFSKY in Journal of Autism and Developmental Disorders, 55-2 (February 2025)  

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Interventions to Improve Outcomes for Parents of Children with Autism Spectrum Disorder: A Meta-Analysis / Kristen T. MACKENZIE in Journal of Autism and Developmental Disorders, 52-7 (July 2022)  

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Misinterpretation of facial expressions of emotion in verbal adults with autism spectrum disorder / Shaun M. EACK in Autism, 19-3 (April 2015)  

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Obtaining a First Diagnosis of Autism Spectrum Disorder: Descriptions of the Diagnostic Process and Correlates of Parent Satisfaction from a National Sample / Kristen T. MACKENZIE in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

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Perception of Life as Stressful, Not Biological Response to Stress, is Associated with Greater Social Disability in Adults with Autism Spectrum Disorder / Lauren BISHOP-FITZPATRICK in Journal of Autism and Developmental Disorders, 47-1 (January 2017)  

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Processing Speed is Impaired in Adults with Autism Spectrum Disorder, and Relates to Social Communication Abilities / Sarah M. HAIGH in Journal of Autism and Developmental Disorders, 48-8 (August 2018)  

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Reduced White Matter Integrity and Deficits in Neuropsychological Functioning in Adults With Autism Spectrum Disorder / Sarah M. HAIGH in Autism Research, 13-5 (May 2020)  

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A Systematic Review of Psychosocial Interventions for Adults with Autism Spectrum Disorders / Lauren BISHOP-FITZPATRICK in Journal of Autism and Developmental Disorders, 43-3 (March 2013)  

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