Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia / Laura VAN KEY ; Pat BROSSEAU ; Shaun M. EACK ; David I. LEITMAN ; Dean F. SALISBURY ; Marlene BEHRMANN in Journal of Autism and Developmental Disorders, 53-12 (December 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-12 (December 2023) . - p.4856-4871 Titre : Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Laura VAN KEY, Auteur ; Pat BROSSEAU, Auteur ; Shaun M. EACK, Auteur ; David I. LEITMAN, Auteur ; Dean F. SALISBURY, Auteur ; Marlene BEHRMANN, Auteur Article en page(s) : p.4856-4871 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability. En ligne : https://doi.org/10.1007/s10803-022-05771-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515 [article] Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia [Texte imprimé et/ou numérique] / Laura VAN KEY, Auteur ; Pat BROSSEAU, Auteur ; Shaun M. EACK, Auteur ; David I. LEITMAN, Auteur ; Dean F. SALISBURY, Auteur ; Marlene BEHRMANN, Auteur . - p.4856-4871. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-12 (December 2023) . - p.4856-4871 Index. décimale : PER Périodiques Résumé : Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability. En ligne : https://doi.org/10.1007/s10803-022-05771-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515

Brief Report: Is Cognitive Rehabilitation Needed in Verbal Adults with Autism? Insights from Initial Enrollment in a Trial of Cognitive Enhancement Therapy / Shaun M. EACK in Journal of Autism and Developmental Disorders, 43-9 (September 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2233-2237 Titre : Brief Report: Is Cognitive Rehabilitation Needed in Verbal Adults with Autism? Insights from Initial Enrollment in a Trial of Cognitive Enhancement Therapy Type de document : Texte imprimé et/ou numérique Auteurs : Shaun M. EACK, Auteur ; Amber L. BAHORIK, Auteur ; Susan S. HOGARTY, Auteur ; Deborah P. GREENWALD, Auteur ; Maralee Y. LITSCHGE, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur Article en page(s) : p.2233-2237 Langues : Anglais (eng) Mots-clés : Cognition  Social cognition  Neurocognition  Cognitive rehabilitation  Adults Index. décimale : PER Périodiques Résumé : Cognitive rehabilitation is an emerging set of potentially effective interventions for the treatment of autism spectrum disorder, yet the applicability of these approaches for “high functioning” adults who have normative levels of intelligence remains unexplored. This study examined the initial cognitive performance characteristics of 40 verbal adults with autism enrolled in a pilot trial of Cognitive Enhancement Therapy to investigate the need for cognitive rehabilitation in this population. Results revealed marked and broad deficits across neurocognitive and social-cognitive domains, despite above-average IQ. Areas of greatest impairment included processing speed, cognitive flexibility, and emotion perception and management. These findings indicate the need for comprehensive interventions designed to enhance cognition among verbal adults with autism who have intact intellectual functioning. En ligne : http://dx.doi.org/10.1007/s10803-013-1774-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Brief Report: Is Cognitive Rehabilitation Needed in Verbal Adults with Autism? Insights from Initial Enrollment in a Trial of Cognitive Enhancement Therapy [Texte imprimé et/ou numérique] / Shaun M. EACK, Auteur ; Amber L. BAHORIK, Auteur ; Susan S. HOGARTY, Auteur ; Deborah P. GREENWALD, Auteur ; Maralee Y. LITSCHGE, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur . - p.2233-2237. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2233-2237 Mots-clés : Cognition  Social cognition  Neurocognition  Cognitive rehabilitation  Adults Index. décimale : PER Périodiques Résumé : Cognitive rehabilitation is an emerging set of potentially effective interventions for the treatment of autism spectrum disorder, yet the applicability of these approaches for “high functioning” adults who have normative levels of intelligence remains unexplored. This study examined the initial cognitive performance characteristics of 40 verbal adults with autism enrolled in a pilot trial of Cognitive Enhancement Therapy to investigate the need for cognitive rehabilitation in this population. Results revealed marked and broad deficits across neurocognitive and social-cognitive domains, despite above-average IQ. Areas of greatest impairment included processing speed, cognitive flexibility, and emotion perception and management. These findings indicate the need for comprehensive interventions designed to enhance cognition among verbal adults with autism who have intact intellectual functioning. En ligne : http://dx.doi.org/10.1007/s10803-013-1774-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study / Shaun M. EACK in Journal of Autism and Developmental Disorders, 43-12 (December 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-12 (December 2013) . - p.2866-2877 Titre : Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study Type de document : Texte imprimé et/ou numérique Auteurs : Shaun M. EACK, Auteur ; Deborah P. GREENWALD, Auteur ; Susan S. HOGARTY, Auteur ; Amber L. BAHORIK, Auteur ; Maralee Y. LITSCHGE, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur Article en page(s) : p.2866-2877 Langues : Anglais (eng) Mots-clés : Cognitive Enhancement Therapy  Cognitive rehabilitation  Cognitive remediation  Psychosocial treatment  Cognitive therapy  Adult treatment  Autism  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Adults with autism experience significant impairments in social and non-social information processing for which few treatments have been developed. This study conducted an 18-month uncontrolled trial of Cognitive Enhancement Therapy (CET), a comprehensive cognitive rehabilitation intervention, in 14 verbal adults with autism spectrum disorder to investigate its feasibility, acceptability, and initial efficacy in treating these impairments. Results indicated that CET was satisfying to participants, with high treatment attendance and retention. Effects on cognitive deficits and social behavior were also large (d = 1.40–2.29) and statistically significant (all p .001). These findings suggest that CET is a feasible, acceptable, and potentially effective intervention for remediating the social and non-social cognitive impairments in verbal adults with autism. En ligne : http://dx.doi.org/10.1007/s10803-013-1834-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 [article] Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study [Texte imprimé et/ou numérique] / Shaun M. EACK, Auteur ; Deborah P. GREENWALD, Auteur ; Susan S. HOGARTY, Auteur ; Amber L. BAHORIK, Auteur ; Maralee Y. LITSCHGE, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur . - p.2866-2877. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-12 (December 2013) . - p.2866-2877 Mots-clés : Cognitive Enhancement Therapy  Cognitive rehabilitation  Cognitive remediation  Psychosocial treatment  Cognitive therapy  Adult treatment  Autism  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Adults with autism experience significant impairments in social and non-social information processing for which few treatments have been developed. This study conducted an 18-month uncontrolled trial of Cognitive Enhancement Therapy (CET), a comprehensive cognitive rehabilitation intervention, in 14 verbal adults with autism spectrum disorder to investigate its feasibility, acceptability, and initial efficacy in treating these impairments. Results indicated that CET was satisfying to participants, with high treatment attendance and retention. Effects on cognitive deficits and social behavior were also large (d = 1.40–2.29) and statistically significant (all p .001). These findings suggest that CET is a feasible, acceptable, and potentially effective intervention for remediating the social and non-social cognitive impairments in verbal adults with autism. En ligne : http://dx.doi.org/10.1007/s10803-013-1834-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218

Correlates of quality of life in autistic individuals / Anabelle THEODAT ; Kelly B. BECK ; Caitlin M. CONNER ; Carla A. MAZEFSKY ; Shaun M. EACK in Research in Autism Spectrum Disorders, 115 (July 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 115 (July 2024) . - p.102401 Titre : Correlates of quality of life in autistic individuals Type de document : Texte imprimé et/ou numérique Auteurs : Anabelle THEODAT, Auteur ; Kelly B. BECK, Auteur ; Caitlin M. CONNER, Auteur ; Carla A. MAZEFSKY, Auteur ; Shaun M. EACK, Auteur Article en page(s) : p.102401 Langues : Anglais (eng) Mots-clés : Autism  Quality of life  Social participation  Depression  Anxiety  Employment Index. décimale : PER Périodiques Résumé : Background Quality of life is an important outcome to autistic individuals. However, the correlates of quality of life in this population are not well known. The purpose of this project was to investigate the extent to which employment, depression, anxiety, and social participation were associated with quality of life in autistic individuals. We also explored potential associations between emotion dysregulation and quality of life. Method Baseline data from two randomized control trials were used for analysis. A total of 125 autistic adolescents and adults aged 16-45 (M = 25.40) participated. Linear regression models were constructed to investigate whether employment, depression, anxiety, and social participation were associated with five domains of quality of life: overall, physical health, psychological, social relationships, and environment. Additional linear regression models explored whether emotion dysregulation was associated with the same quality of life domains. Results Surprisingly, employment was not significantly associated with any quality of life domain. Greater depression severity was significantly associated with poorer quality of life across all domains. Greater social participation was associated with better quality of life, but only for individuals with lower anxiety. More severe dysphoria was associated with poorer overall quality of life and the psychological and physical health domains. Conclusions Results suggest that mental health and emotion dysregulation are important predictors of quality of life for autistic people. They also suggest that anxiety symptoms may attenuate the beneficial effects of social participation. This study provides insight into the unique experiences of autistic individuals and highlights potential unmet need. En ligne : https://doi.org/10.1016/j.rasd.2024.102401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Correlates of quality of life in autistic individuals [Texte imprimé et/ou numérique] / Anabelle THEODAT, Auteur ; Kelly B. BECK, Auteur ; Caitlin M. CONNER, Auteur ; Carla A. MAZEFSKY, Auteur ; Shaun M. EACK, Auteur . - p.102401. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 115 (July 2024) . - p.102401 Mots-clés : Autism  Quality of life  Social participation  Depression  Anxiety  Employment Index. décimale : PER Périodiques Résumé : Background Quality of life is an important outcome to autistic individuals. However, the correlates of quality of life in this population are not well known. The purpose of this project was to investigate the extent to which employment, depression, anxiety, and social participation were associated with quality of life in autistic individuals. We also explored potential associations between emotion dysregulation and quality of life. Method Baseline data from two randomized control trials were used for analysis. A total of 125 autistic adolescents and adults aged 16-45 (M = 25.40) participated. Linear regression models were constructed to investigate whether employment, depression, anxiety, and social participation were associated with five domains of quality of life: overall, physical health, psychological, social relationships, and environment. Additional linear regression models explored whether emotion dysregulation was associated with the same quality of life domains. Results Surprisingly, employment was not significantly associated with any quality of life domain. Greater depression severity was significantly associated with poorer quality of life across all domains. Greater social participation was associated with better quality of life, but only for individuals with lower anxiety. More severe dysphoria was associated with poorer overall quality of life and the psychological and physical health domains. Conclusions Results suggest that mental health and emotion dysregulation are important predictors of quality of life for autistic people. They also suggest that anxiety symptoms may attenuate the beneficial effects of social participation. This study provides insight into the unique experiences of autistic individuals and highlights potential unmet need. En ligne : https://doi.org/10.1016/j.rasd.2024.102401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

Correlates of social functioning in autism spectrum disorder: The role of social cognition / Lauren BISHOP-FITZPATRICK in Research in Autism Spectrum Disorders, 35 (March 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 35 (March 2017) . - p.25-34 Titre : Correlates of social functioning in autism spectrum disorder: The role of social cognition Type de document : Texte imprimé et/ou numérique Auteurs : Lauren BISHOP-FITZPATRICK, Auteur ; Carla A. MAZEFSKY, Auteur ; Shaun M. EACK, Auteur ; Nancy J. MINSHEW, Auteur Article en page(s) : p.25-34 Langues : Anglais (eng) Mots-clés : Theory of mind  Motor function  Second-order false belief  Adaptive behavior  Social impairment  Manipulative dexterity Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) experience marked challenges with social function by definition, but few modifiable predictors of social functioning in ASD have been identified in extant research. This study hypothesized that deficits in social cognition and motor function may help to explain poor social functioning in individuals with ASD. Method Cross-sectional data from 108 individuals with ASD and without intellectual disability ages 9 through 27.5 were used to assess the relationship between social cognition and motor function, and social functioning. Results Results of hierarchical multiple regression analyses revealed that greater social cognition, but not motor function, was significantly associated with better social functioning when controlling for sex, age, and intelligence quotient. Post-hoc analyses revealed that better performance on second-order false belief tasks was associated with higher levels of socially adaptive behavior and lower levels of social problems. Our findings support the development and testing of interventions that target social cognition in order to improve social functioning in individuals with ASD. Interventions that teach generalizable skills to help people with ASD better understand social situations and develop competency in advanced perspective taking have the potential to create more durable change because their effects can be applied to a wide and varied set of situations and not simply a prescribed set of rehearsed situations. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.11.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Correlates of social functioning in autism spectrum disorder: The role of social cognition [Texte imprimé et/ou numérique] / Lauren BISHOP-FITZPATRICK, Auteur ; Carla A. MAZEFSKY, Auteur ; Shaun M. EACK, Auteur ; Nancy J. MINSHEW, Auteur . - p.25-34. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 35 (March 2017) . - p.25-34 Mots-clés : Theory of mind  Motor function  Second-order false belief  Adaptive behavior  Social impairment  Manipulative dexterity Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) experience marked challenges with social function by definition, but few modifiable predictors of social functioning in ASD have been identified in extant research. This study hypothesized that deficits in social cognition and motor function may help to explain poor social functioning in individuals with ASD. Method Cross-sectional data from 108 individuals with ASD and without intellectual disability ages 9 through 27.5 were used to assess the relationship between social cognition and motor function, and social functioning. Results Results of hierarchical multiple regression analyses revealed that greater social cognition, but not motor function, was significantly associated with better social functioning when controlling for sex, age, and intelligence quotient. Post-hoc analyses revealed that better performance on second-order false belief tasks was associated with higher levels of socially adaptive behavior and lower levels of social problems. Our findings support the development and testing of interventions that target social cognition in order to improve social functioning in individuals with ASD. Interventions that teach generalizable skills to help people with ASD better understand social situations and develop competency in advanced perspective taking have the potential to create more durable change because their effects can be applied to a wide and varied set of situations and not simply a prescribed set of rehearsed situations. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.11.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Developing a Measure of Key Adult Outcomes in Adults with Developmental Disabilities: Conceptual Model and Item Generation of the REALS (Relationships, Employment, Autonomy, and Life Satisfaction) / Kristen T. MACKENZIE ; Kelly B. BECK ; Shaun M. EACK ; Katharine N. Zeglen ; Caitlin M. CONNER ; Carla A. MAZEFSKY in Journal of Autism and Developmental Disorders, 55-2 (February 2025)  

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Interventions to Improve Outcomes for Parents of Children with Autism Spectrum Disorder: A Meta-Analysis / Kristen T. MACKENZIE in Journal of Autism and Developmental Disorders, 52-7 (July 2022)  

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Misinterpretation of facial expressions of emotion in verbal adults with autism spectrum disorder / Shaun M. EACK in Autism, 19-3 (April 2015)  

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Obtaining a First Diagnosis of Autism Spectrum Disorder: Descriptions of the Diagnostic Process and Correlates of Parent Satisfaction from a National Sample / Kristen T. MACKENZIE in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

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Perception of Life as Stressful, Not Biological Response to Stress, is Associated with Greater Social Disability in Adults with Autism Spectrum Disorder / Lauren BISHOP-FITZPATRICK in Journal of Autism and Developmental Disorders, 47-1 (January 2017)  

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A Systematic Review of Psychosocial Interventions for Adults with Autism Spectrum Disorders / Lauren BISHOP-FITZPATRICK in Journal of Autism and Developmental Disorders, 43-3 (March 2013)  

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The impact of sleep quality on quality of life for autistic adults / Kiley J. MCLEAN in Research in Autism Spectrum Disorders, 88 (October 2021)  

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The Relationship Between Stress and Social Functioning in Adults With Autism Spectrum Disorder and Without Intellectual Disability / Lauren BISHOP-FITZPATRICK in Autism Research, 8-2 (April 2015)  

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The Relationships, Employment, Autonomy, and Life Satisfaction (REALS) Measures for Autistic Adults and Adults With Other Intellectual and Developmental Disabilities: Psychometric Testing of the Self-Report and Proxy Versions / Caitlin M. CONNER in Autism Research, 18-3 (March 2025)  

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