Autism Symptoms and Internalizing Psychopathology in Girls and Boys with Autism Spectrum Disorders / Marjorie SOLOMON in Journal of Autism and Developmental Disorders, 42-1 (January 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-1 (January 2012) . - p.48-59 Titre : Autism Symptoms and Internalizing Psychopathology in Girls and Boys with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Marjorie SOLOMON, Auteur ; Meghan MILLER, Auteur ; Sandra L. TAYLOR, Auteur ; Stephen P. HINSHAW, Auteur Année de publication : 2012 Article en page(s) : p.48-59 Langues : Anglais (eng) Mots-clés : Sex differences  Autism  Girls  Internalizing psychopathology  Gender paradox Index. décimale : PER Périodiques Résumé : Findings regarding phenotypic differences between boys and girls with ASD are mixed. We compared autism and internalizing symptoms in a sample of 8-18 year-old girls ( n = 20) and boys ( n = 20) with ASD and typically developing (TYP) girls ( n = 19) and boys ( n = 17). Girls with ASD were more impaired than TYP girls but did not differ from boys with ASD in autism symptoms. In adolescence, girls with ASD had higher internalizing symptoms than boys with ASD and TYP girls, and higher symptoms of depression than TYP girls. Girls ages 8-18 with ASD resemble boys with ASD and not TYP girls, and appear to be at increased risk for affective symptoms in the teen years. En ligne : http://dx.doi.org/10.1007/s10803-011-1215-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Autism Symptoms and Internalizing Psychopathology in Girls and Boys with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Marjorie SOLOMON, Auteur ; Meghan MILLER, Auteur ; Sandra L. TAYLOR, Auteur ; Stephen P. HINSHAW, Auteur . - 2012 . - p.48-59. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-1 (January 2012) . - p.48-59 Mots-clés : Sex differences  Autism  Girls  Internalizing psychopathology  Gender paradox Index. décimale : PER Périodiques Résumé : Findings regarding phenotypic differences between boys and girls with ASD are mixed. We compared autism and internalizing symptoms in a sample of 8-18 year-old girls ( n = 20) and boys ( n = 20) with ASD and typically developing (TYP) girls ( n = 19) and boys ( n = 17). Girls with ASD were more impaired than TYP girls but did not differ from boys with ASD in autism symptoms. In adolescence, girls with ASD had higher internalizing symptoms than boys with ASD and TYP girls, and higher symptoms of depression than TYP girls. Girls ages 8-18 with ASD resemble boys with ASD and not TYP girls, and appear to be at increased risk for affective symptoms in the teen years. En ligne : http://dx.doi.org/10.1007/s10803-011-1215-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Developmental-behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms / Bibiana RESTREPO in Autism Research, 13-10 (October 2020)  

Public ISBD [article]  inAutism Research > 13-10 (October 2020) . - p.1778-1789 Titre : Developmental-behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Bibiana RESTREPO, Auteur ; Kathleen ANGKUSTSIRI, Auteur ; Sandra L. TAYLOR, Auteur ; Sally J ROGERS, Auteur ; Jacqueline CABRAL, Auteur ; Brianna HEATH, Auteur ; Alexa HECHTMAN, Auteur ; Marjorie SOLOMON, Auteur ; Paul ASHWOOD, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur Article en page(s) : p.1778-1789 Langues : Anglais (eng) Mots-clés : GI dysfunction  GI symptoms  autism  autism spectrum disorder  co-occurring  coexisting  comorbidities  gastrointestinal problems  repetitive behavior Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) symptoms are frequently reported in children with autism spectrum disorder (ASD). We evaluated the frequency and severity of GI symptoms in preschool-aged children with ASD compared to participants with typical development (TD). Our goal was to ascertain whether GI symptoms are associated with differences in sex or developmental and behavioral measures. Participants were between 2 and 3.5?years of age and included 255 children with ASD (184 males/71 females) and 129 age-matched TD controls (75 males/54 females). A parent interview was used to assess GI symptoms (abdominal pain, gaseousness/bloating, diarrhea, constipation, pain on stooling, vomiting, difficulty swallowing, blood in stool or in vomit). Children with GI symptoms in each diagnostic group were compared to children without GI symptoms on measures of developmental, behavioral, and adaptive functioning. GI symptoms were reported more frequently in children with ASD compared to the TD group (47.8% vs. 17.8%, respectively). Children with ASD were also more likely to experience multiple GI symptoms (30.6% vs. 5.4%). GI symptoms were equally common in males and females across both diagnostic groups. There were no statistically significant differences in developmental or adaptive measures based on presence of GI symptoms in either ASD or TD children. Co-occurring GI symptoms were, however, associated with increased self-injurious behaviors, restricted stereotyped behaviors, aggressive behaviors, sleep problems and attention problems in both ASD and TD children. In children with ASD, a higher number of GI symptoms was associated with an increase in self-injurious behaviors, somatic complaints, reduced sleep duration, and increased parasomnias. LAY SUMMARY: ASD is characterized by challenges in social communication and repetitive behaviors. But, people with autism have many other difficulties including gastrointestinal problems. Children with ASD were three times more likely to experience GI symptoms than typically developing peers. Increased GI symptoms are associated with increased problem behaviors such as sleep problems, self-injury, and body aches. Since GI symptoms are often treatable, it is important to recognize them as soon as possible. Both clinicians and parents should become more aware of the high occurrence of GI problems in autistic people. Autism Res 2020, 13: 1778-1789. © 2020 International Society for Autism Research and Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Developmental-behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms [Texte imprimé et/ou numérique] / Bibiana RESTREPO, Auteur ; Kathleen ANGKUSTSIRI, Auteur ; Sandra L. TAYLOR, Auteur ; Sally J ROGERS, Auteur ; Jacqueline CABRAL, Auteur ; Brianna HEATH, Auteur ; Alexa HECHTMAN, Auteur ; Marjorie SOLOMON, Auteur ; Paul ASHWOOD, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur . - p.1778-1789. Langues : Anglais (eng) in Autism Research > 13-10 (October 2020) . - p.1778-1789 Mots-clés : GI dysfunction  GI symptoms  autism  autism spectrum disorder  co-occurring  coexisting  comorbidities  gastrointestinal problems  repetitive behavior Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) symptoms are frequently reported in children with autism spectrum disorder (ASD). We evaluated the frequency and severity of GI symptoms in preschool-aged children with ASD compared to participants with typical development (TD). Our goal was to ascertain whether GI symptoms are associated with differences in sex or developmental and behavioral measures. Participants were between 2 and 3.5?years of age and included 255 children with ASD (184 males/71 females) and 129 age-matched TD controls (75 males/54 females). A parent interview was used to assess GI symptoms (abdominal pain, gaseousness/bloating, diarrhea, constipation, pain on stooling, vomiting, difficulty swallowing, blood in stool or in vomit). Children with GI symptoms in each diagnostic group were compared to children without GI symptoms on measures of developmental, behavioral, and adaptive functioning. GI symptoms were reported more frequently in children with ASD compared to the TD group (47.8% vs. 17.8%, respectively). Children with ASD were also more likely to experience multiple GI symptoms (30.6% vs. 5.4%). GI symptoms were equally common in males and females across both diagnostic groups. There were no statistically significant differences in developmental or adaptive measures based on presence of GI symptoms in either ASD or TD children. Co-occurring GI symptoms were, however, associated with increased self-injurious behaviors, restricted stereotyped behaviors, aggressive behaviors, sleep problems and attention problems in both ASD and TD children. In children with ASD, a higher number of GI symptoms was associated with an increase in self-injurious behaviors, somatic complaints, reduced sleep duration, and increased parasomnias. LAY SUMMARY: ASD is characterized by challenges in social communication and repetitive behaviors. But, people with autism have many other difficulties including gastrointestinal problems. Children with ASD were three times more likely to experience GI symptoms than typically developing peers. Increased GI symptoms are associated with increased problem behaviors such as sleep problems, self-injury, and body aches. Since GI symptoms are often treatable, it is important to recognize them as soon as possible. Both clinicians and parents should become more aware of the high occurrence of GI problems in autistic people. Autism Res 2020, 13: 1778-1789. © 2020 International Society for Autism Research and Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms / Meghan MILLER in Autism Research, 6-2 (April 2013)  

Public ISBD [article]  inAutism Research > 6-2 (April 2013) . - p.91-102 Titre : Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Meghan MILLER, Auteur ; Karen L. BALES, Auteur ; Sandra L. TAYLOR, Auteur ; Jong YOON, Auteur ; Caroline M. HOSTETLER, Auteur ; Cameron S. CARTER, Auteur ; Marjorie SOLOMON, Auteur Année de publication : 2013 Article en page(s) : p.91-102 Langues : Anglais (eng) Mots-clés : neuropeptides  oxytocin  vasopressin  autism  sex differences  repetitive behaviors  anxiety Index. décimale : PER Périodiques Résumé : There has been intensified interest in the neuropeptides oxytocin (OT) and arginine vasopressin (AVP) in autism spectrum disorders (ASD) given their role in affiliative and social behavior in animals, positive results of treatment studies using OT, and findings that genetic polymorphisms in the AVP–OT pathway are present in individuals with ASD. Nearly all such studies in humans have focused only on males. With this preliminary study, we provide basic and novel information on the involvement of OT and AVP in autism, with an investigation of blood plasma levels of these neuropeptides in 75 preadolescent and adolescent girls and boys ages 8–18: 40 with high-functioning ASD (19 girls, 21 boys) and 35 typically developing children (16 girls, 19 boys). We related neuropeptide levels to social, language, repetitive behavior, and internalizing symptom measures in these individuals. There were significant gender effects: Girls showed higher levels of OT, while boys had significantly higher levels of AVP. There were no significant effects of diagnosis on OT or AVP. Higher OT values were associated with greater anxiety in all girls, and with better pragmatic language in all boys and girls. AVP levels were positively associated with restricted and repetitive behaviors in girls with ASD but negatively (nonsignificantly) associated with these behaviors in boys with ASD. Our results challenge the prevailing view that plasma OT levels are lower in individuals with ASD, and suggest that there are distinct and sexually dimorphic mechanisms of action for OT and AVP underlying anxiety and repetitive behaviors. En ligne : http://dx.doi.org/10.1002/aur.1270 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199 [article] Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms [Texte imprimé et/ou numérique] / Meghan MILLER, Auteur ; Karen L. BALES, Auteur ; Sandra L. TAYLOR, Auteur ; Jong YOON, Auteur ; Caroline M. HOSTETLER, Auteur ; Cameron S. CARTER, Auteur ; Marjorie SOLOMON, Auteur . - 2013 . - p.91-102. Langues : Anglais (eng) in Autism Research > 6-2 (April 2013) . - p.91-102 Mots-clés : neuropeptides  oxytocin  vasopressin  autism  sex differences  repetitive behaviors  anxiety Index. décimale : PER Périodiques Résumé : There has been intensified interest in the neuropeptides oxytocin (OT) and arginine vasopressin (AVP) in autism spectrum disorders (ASD) given their role in affiliative and social behavior in animals, positive results of treatment studies using OT, and findings that genetic polymorphisms in the AVP–OT pathway are present in individuals with ASD. Nearly all such studies in humans have focused only on males. With this preliminary study, we provide basic and novel information on the involvement of OT and AVP in autism, with an investigation of blood plasma levels of these neuropeptides in 75 preadolescent and adolescent girls and boys ages 8–18: 40 with high-functioning ASD (19 girls, 21 boys) and 35 typically developing children (16 girls, 19 boys). We related neuropeptide levels to social, language, repetitive behavior, and internalizing symptom measures in these individuals. There were significant gender effects: Girls showed higher levels of OT, while boys had significantly higher levels of AVP. There were no significant effects of diagnosis on OT or AVP. Higher OT values were associated with greater anxiety in all girls, and with better pragmatic language in all boys and girls. AVP levels were positively associated with restricted and repetitive behaviors in girls with ASD but negatively (nonsignificantly) associated with these behaviors in boys with ASD. Our results challenge the prevailing view that plasma OT levels are lower in individuals with ASD, and suggest that there are distinct and sexually dimorphic mechanisms of action for OT and AVP underlying anxiety and repetitive behaviors. En ligne : http://dx.doi.org/10.1002/aur.1270 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199

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