Annual Research Review: The state of autism intervention science: progress, target psychological and biological mechanisms and future prospects / J. GREEN in Journal of Child Psychology and Psychiatry, 59-4 (April 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.424-443 Titre : Annual Research Review: The state of autism intervention science: progress, target psychological and biological mechanisms and future prospects Type de document : Texte imprimé et/ou numérique Auteurs : J. GREEN, Auteur ; S. GARG, Auteur Article en page(s) : p.424-443 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  intervention  neurobiology  parent training  parent-child interaction Index. décimale : PER Périodiques Résumé : BACKGROUND: There has been recent systematic review of key evidence in psychosocial intervention in autism but little review of biological treatments. METHODS: We analyse the current literature from the perspective of intervention and mechanism targets across social and biological development. RESULTS: The overall quality of trials evidence in autism intervention remains relatively low, despite some recent progress. Many treatments in common use have little or no evidence base. This is very concerning in such an important disorder. A variety of psychosocial interventions can show effect to improve some short-term effects on children's immediate dyadic social interactions, for instance with caregivers. But showing true effectiveness in this developmental disorder requires generalisation of such effects into wider social contexts, on autism symptoms and in long-term progress in development. Only a few interventions so far have begun to show this. A number of early phase interventions on biological targets have shown real promise, but none has yet progressed to larger scale effectiveness trials on behavioural or symptom outcomes. CONCLUSIONS: There has been enough progress in psychosocial intervention research now to be able to begin to identify some evidence-based practice in autism treatment. To consolidate and improve outcomes, the next phase of intervention research needs improved trial design, and an iterative approach building on success. It may also include the testing of potential synergies between promising biological and psychosocial interventions. En ligne : http://dx.doi.org/10.1111/jcpp.12892 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353 [article] Annual Research Review: The state of autism intervention science: progress, target psychological and biological mechanisms and future prospects [Texte imprimé et/ou numérique] / J. GREEN, Auteur ; S. GARG, Auteur . - p.424-443. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.424-443 Mots-clés : Autism spectrum disorders  intervention  neurobiology  parent training  parent-child interaction Index. décimale : PER Périodiques Résumé : BACKGROUND: There has been recent systematic review of key evidence in psychosocial intervention in autism but little review of biological treatments. METHODS: We analyse the current literature from the perspective of intervention and mechanism targets across social and biological development. RESULTS: The overall quality of trials evidence in autism intervention remains relatively low, despite some recent progress. Many treatments in common use have little or no evidence base. This is very concerning in such an important disorder. A variety of psychosocial interventions can show effect to improve some short-term effects on children's immediate dyadic social interactions, for instance with caregivers. But showing true effectiveness in this developmental disorder requires generalisation of such effects into wider social contexts, on autism symptoms and in long-term progress in development. Only a few interventions so far have begun to show this. A number of early phase interventions on biological targets have shown real promise, but none has yet progressed to larger scale effectiveness trials on behavioural or symptom outcomes. CONCLUSIONS: There has been enough progress in psychosocial intervention research now to be able to begin to identify some evidence-based practice in autism treatment. To consolidate and improve outcomes, the next phase of intervention research needs improved trial design, and an iterative approach building on success. It may also include the testing of potential synergies between promising biological and psychosocial interventions. En ligne : http://dx.doi.org/10.1111/jcpp.12892 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353

Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis / L. A. FISH in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1308-1319 Titre : Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : L. A. FISH, Auteur ; P. NYSTROM, Auteur ; T. GLIGA, Auteur ; A. GUI, Auteur ; Jannath BEGUM ALI, Auteur ; L. MASON, Auteur ; S. GARG, Auteur ; J. GREEN, Auteur ; M. H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; R. HARRISON, Auteur ; E. MEABURN, Auteur ; T. FALCK-YTTER, Auteur ; E. J. H. JONES, Auteur Article en page(s) : p.1308-1319 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/genetics  Humans  Infant  Phenotype  Reflex  Autism spectrum disorder  infancy  neurodevelopment  pupillary light reflex Index. décimale : PER Périodiques Résumé : BACKGROUND: Although autism spectrum disorder (ASD) is heritable, the mechanisms through which genes contribute to symptom emergence remain unclear. Investigating candidate intermediate phenotypes such as the pupillary light reflex (PLR) prospectively from early in development could bridge genotype and behavioural phenotype. METHODS: Using eye tracking, we longitudinally measured the PLR at 9, 14 and 24 months in a sample of infants (N = 264) enriched for a family history of ASD; 27 infants received an ASD diagnosis at 3 years. We examined the 9- to 24-month developmental trajectories of PLR constriction latency (onset; ms) and amplitude (%) and explored their relation to categorical 3-year ASD outcome, polygenic liability for ASD and dimensional 3-year social affect (SA) and repetitive/restrictive behaviour (RRB) traits. Polygenic scores for ASD (PGS(ASD) ) were calculated for 190 infants. RESULTS: While infants showed a decrease in latency between 9 and 14 months, higher PGS(ASD) was associated with a smaller decrease in latency in the first year (? = -.16, 95% CI = -0.31, -0.002); infants with later ASD showed a significantly steeper decrease in latency (a putative 'catch-up') between 14 and 24 months relative to those with other outcomes (typical: ? = .54, 95% CI = 0.08, 0.99; other: ? = .53, 95% CI = 0.02, 1.04). Latency development did not associate with later dimensional variation in ASD-related traits. In contrast, change in amplitude was not related to categorical ASD or genetics, but decreasing 9- to 14-month amplitude was associated with higher SA (? = .08, 95% CI = 0.01, 0.14) and RRB (? = .05, 95% CI = 0.004, 0.11) traits. CONCLUSIONS: These findings corroborate PLR development as possible intermediate phenotypes being linked to both genetic liability and phenotypic outcomes. Future work should incorporate alternative measures (e.g. functionally informed structural and genetic measures) to test whether distinct neural mechanisms underpin PLR alterations. En ligne : http://dx.doi.org/10.1111/jcpp.13518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis [Texte imprimé et/ou numérique] / L. A. FISH, Auteur ; P. NYSTROM, Auteur ; T. GLIGA, Auteur ; A. GUI, Auteur ; Jannath BEGUM ALI, Auteur ; L. MASON, Auteur ; S. GARG, Auteur ; J. GREEN, Auteur ; M. H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; R. HARRISON, Auteur ; E. MEABURN, Auteur ; T. FALCK-YTTER, Auteur ; E. J. H. JONES, Auteur . - p.1308-1319. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1308-1319 Mots-clés : Autism Spectrum Disorder/diagnosis/genetics  Humans  Infant  Phenotype  Reflex  Autism spectrum disorder  infancy  neurodevelopment  pupillary light reflex Index. décimale : PER Périodiques Résumé : BACKGROUND: Although autism spectrum disorder (ASD) is heritable, the mechanisms through which genes contribute to symptom emergence remain unclear. Investigating candidate intermediate phenotypes such as the pupillary light reflex (PLR) prospectively from early in development could bridge genotype and behavioural phenotype. METHODS: Using eye tracking, we longitudinally measured the PLR at 9, 14 and 24 months in a sample of infants (N = 264) enriched for a family history of ASD; 27 infants received an ASD diagnosis at 3 years. We examined the 9- to 24-month developmental trajectories of PLR constriction latency (onset; ms) and amplitude (%) and explored their relation to categorical 3-year ASD outcome, polygenic liability for ASD and dimensional 3-year social affect (SA) and repetitive/restrictive behaviour (RRB) traits. Polygenic scores for ASD (PGS(ASD) ) were calculated for 190 infants. RESULTS: While infants showed a decrease in latency between 9 and 14 months, higher PGS(ASD) was associated with a smaller decrease in latency in the first year (? = -.16, 95% CI = -0.31, -0.002); infants with later ASD showed a significantly steeper decrease in latency (a putative 'catch-up') between 14 and 24 months relative to those with other outcomes (typical: ? = .54, 95% CI = 0.08, 0.99; other: ? = .53, 95% CI = 0.02, 1.04). Latency development did not associate with later dimensional variation in ASD-related traits. In contrast, change in amplitude was not related to categorical ASD or genetics, but decreasing 9- to 14-month amplitude was associated with higher SA (? = .08, 95% CI = 0.01, 0.14) and RRB (? = .05, 95% CI = 0.004, 0.11) traits. CONCLUSIONS: These findings corroborate PLR development as possible intermediate phenotypes being linked to both genetic liability and phenotypic outcomes. Future work should incorporate alternative measures (e.g. functionally informed structural and genetic measures) to test whether distinct neural mechanisms underpin PLR alterations. En ligne : http://dx.doi.org/10.1111/jcpp.13518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Early development of infants with neurofibromatosis type 1: a case series / A. M. KOLESNIK in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 62p. Titre : Early development of infants with neurofibromatosis type 1: a case series Type de document : Texte imprimé et/ou numérique Auteurs : A. M. KOLESNIK, Auteur ; E. J. H. JONES, Auteur ; S. GARG, Auteur ; J. GREEN, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur Article en page(s) : 62p. Langues : Anglais (eng) Mots-clés : Adaptive functioning  Autism  Cognition  Development  Infant  Nf1  Prospective longitudinal  Sensory processing  Social engagement  Translational neurodevelopment Index. décimale : PER Périodiques Résumé : Background: Prospective studies of infants at familial risk for autism spectrum disorder (ASD) have yielded insights into the earliest signs of the disorder but represent heterogeneous samples of unclear aetiology. Complementing this approach by studying cohorts of infants with monogenic syndromes associated with high rates of ASD offers the opportunity to elucidate the factors that lead to ASD. Methods: We present the first report from a prospective study of ten 10-month-old infants with neurofibromatosis type 1 (NF1), a monogenic disorder with high prevalence of ASD or ASD symptomatology. We compared data from infants with NF1 to a large cohort of infants at familial risk for ASD, separated by outcome at age 3 of ASD (n = 34), atypical development (n = 44), or typical development (n = 89), and low-risk controls (n = 75). Domains assessed at 10 months by parent report and examiner observation include cognitive and adaptive function, sensory processing, social engagement, and temperament. Results: Infants with NF1 showed striking impairments in motor functioning relative to low-risk infants; this pattern was seen in infants with later ASD from the familial cohort (HR-ASD). Both infants with NF1 and the HR-ASD group showed communication delays relative to low-risk infants. Conclusions: Ten-month-old infants with NF1 show a range of developmental difficulties that were particularly striking in motor and communication domains. As with HR-ASD infants, social skills at this age were not notably impaired. This is some of the first information on early neurodevelopment in NF1. Strong inferences are limited by the sample size, but the findings suggest implications for early comparative developmental science and highlight motor functioning as an important domain to inform the development of relevant animal models. The findings have clinical implications in indicating an important focus for early surveillance and remediation in this early diagnosed genetic disorder. En ligne : http://dx.doi.org/10.1186/s13229-017-0178-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Early development of infants with neurofibromatosis type 1: a case series [Texte imprimé et/ou numérique] / A. M. KOLESNIK, Auteur ; E. J. H. JONES, Auteur ; S. GARG, Auteur ; J. GREEN, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur . - 62p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 62p. Mots-clés : Adaptive functioning  Autism  Cognition  Development  Infant  Nf1  Prospective longitudinal  Sensory processing  Social engagement  Translational neurodevelopment Index. décimale : PER Périodiques Résumé : Background: Prospective studies of infants at familial risk for autism spectrum disorder (ASD) have yielded insights into the earliest signs of the disorder but represent heterogeneous samples of unclear aetiology. Complementing this approach by studying cohorts of infants with monogenic syndromes associated with high rates of ASD offers the opportunity to elucidate the factors that lead to ASD. Methods: We present the first report from a prospective study of ten 10-month-old infants with neurofibromatosis type 1 (NF1), a monogenic disorder with high prevalence of ASD or ASD symptomatology. We compared data from infants with NF1 to a large cohort of infants at familial risk for ASD, separated by outcome at age 3 of ASD (n = 34), atypical development (n = 44), or typical development (n = 89), and low-risk controls (n = 75). Domains assessed at 10 months by parent report and examiner observation include cognitive and adaptive function, sensory processing, social engagement, and temperament. Results: Infants with NF1 showed striking impairments in motor functioning relative to low-risk infants; this pattern was seen in infants with later ASD from the familial cohort (HR-ASD). Both infants with NF1 and the HR-ASD group showed communication delays relative to low-risk infants. Conclusions: Ten-month-old infants with NF1 show a range of developmental difficulties that were particularly striking in motor and communication domains. As with HR-ASD infants, social skills at this age were not notably impaired. This is some of the first information on early neurodevelopment in NF1. Strong inferences are limited by the sample size, but the findings suggest implications for early comparative developmental science and highlight motor functioning as an important domain to inform the development of relevant animal models. The findings have clinical implications in indicating an important focus for early surveillance and remediation in this early diagnosed genetic disorder. En ligne : http://dx.doi.org/10.1186/s13229-017-0178-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Editorial Perspective: Delivering autism intervention through development / J. GREEN in Journal of Child Psychology and Psychiatry, 60-12 (December 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1353-1356 Titre : Editorial Perspective: Delivering autism intervention through development Type de document : Texte imprimé et/ou numérique Auteurs : J. GREEN, Auteur Article en page(s) : p.1353-1356 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism is a priority condition within global health and represents a significant public health challenge. In this Editorial, I argue for a new perspective on how this challenge might be met, based on the idea of autism as an enduring developmental condition and focused on the family as a key resource. Drawing on models from management of enduring conditions elsewhere in health and on recent autism intervention science, I make the case for a developmental sequence of pulsed interventions, initially focused on early family resilience and self-management, along with case management and timely step-up care to specialist management. En ligne : http://dx.doi.org/10.1111/jcpp.13110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Editorial Perspective: Delivering autism intervention through development [Texte imprimé et/ou numérique] / J. GREEN, Auteur . - p.1353-1356. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1353-1356 Index. décimale : PER Périodiques Résumé : Autism is a priority condition within global health and represents a significant public health challenge. In this Editorial, I argue for a new perspective on how this challenge might be met, based on the idea of autism as an enduring developmental condition and focused on the family as a key resource. Drawing on models from management of enduring conditions elsewhere in health and on recent autism intervention science, I make the case for a developmental sequence of pulsed interventions, initially focused on early family resilience and self-management, along with case management and timely step-up care to specialist management. En ligne : http://dx.doi.org/10.1111/jcpp.13110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

New Interview and Observation Measures of the Broader Autism Phenotype: Impressions of Interviewee Measure / A. PICKLES in Journal of Autism and Developmental Disorders, 43-9 (September 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2082-2089 Titre : New Interview and Observation Measures of the Broader Autism Phenotype: Impressions of Interviewee Measure Type de document : Texte imprimé et/ou numérique Auteurs : A. PICKLES, Auteur ; Jeremy R. PARR, Auteur ; Michael L. RUTTER, Auteur ; M. V. JONGE, Auteur ; S. WALLACE, Auteur ; A. S. COUTEUR, Auteur ; Herman VAN ENGELAND, Auteur ; K. WITTEMEYER, Auteur ; H. MCCONACHIE, Auteur ; Bernadette ROGE, Auteur ; Carine MANTOULAN, Auteur ; L. PEDERSEN, Auteur ; T. ISAGER, Auteur ; F. POUSTKA, Auteur ; Sven BÖLTE, Auteur ; Patrick BOLTON, Auteur ; E. WEISBLATT, Auteur ; J. GREEN, Auteur ; Katerina PAPANIKOLAOU, Auteur ; A. J. BAILEY, Auteur Article en page(s) : p.2082-2089 Langues : Anglais (eng) Mots-clés : Broader autism phenotype  Observer rating  Test–retest  Factor analysis  Social functioning Index. décimale : PER Périodiques Résumé : A 20 item observational measure of social functioning, the Impression of Interviewee rating scale, is one of three measures devised to assess the broader autism phenotype. The sample studied included families containing at least two individuals with autism spectrum disorder; observations were undertaken by the researcher who interviewed the subject. An exploratory factor analysis suggested a single factor was most appropriate (Cronbach’s ? of 0.78). There was a modest but significant retest correlation of 0.42. Correlations between live ratings and blind consensus ratings of vignettes were high (0.93). Correlations with the interview measures were moderate but statistically significant. In conclusion, the observational scale provides a promising start but further work is required before general use can be recommended. En ligne : http://dx.doi.org/10.1007/s10803-013-1810-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] New Interview and Observation Measures of the Broader Autism Phenotype: Impressions of Interviewee Measure [Texte imprimé et/ou numérique] / A. PICKLES, Auteur ; Jeremy R. PARR, Auteur ; Michael L. RUTTER, Auteur ; M. V. JONGE, Auteur ; S. WALLACE, Auteur ; A. S. COUTEUR, Auteur ; Herman VAN ENGELAND, Auteur ; K. WITTEMEYER, Auteur ; H. MCCONACHIE, Auteur ; Bernadette ROGE, Auteur ; Carine MANTOULAN, Auteur ; L. PEDERSEN, Auteur ; T. ISAGER, Auteur ; F. POUSTKA, Auteur ; Sven BÖLTE, Auteur ; Patrick BOLTON, Auteur ; E. WEISBLATT, Auteur ; J. GREEN, Auteur ; Katerina PAPANIKOLAOU, Auteur ; A. J. BAILEY, Auteur . - p.2082-2089. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2082-2089 Mots-clés : Broader autism phenotype  Observer rating  Test–retest  Factor analysis  Social functioning Index. décimale : PER Périodiques Résumé : A 20 item observational measure of social functioning, the Impression of Interviewee rating scale, is one of three measures devised to assess the broader autism phenotype. The sample studied included families containing at least two individuals with autism spectrum disorder; observations were undertaken by the researcher who interviewed the subject. An exploratory factor analysis suggested a single factor was most appropriate (Cronbach’s ? of 0.78). There was a modest but significant retest correlation of 0.42. Correlations between live ratings and blind consensus ratings of vignettes were high (0.93). Correlations with the interview measures were moderate but statistically significant. In conclusion, the observational scale provides a promising start but further work is required before general use can be recommended. En ligne : http://dx.doi.org/10.1007/s10803-013-1810-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA) / S. STIVAROS in Molecular Autism, 9 (2018)  

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Sex bias in autism spectrum disorder in neurofibromatosis type 1 / S. GARG in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

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Special Editorial: Open science and the Journal of Child Psychology & Psychiatry - next steps? / J. ASARNOW in Journal of Child Psychology and Psychiatry, 59-7 (July 2018)  

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A systematic review of parent-infant interaction in infants at risk of autism / M. W. WAN in Autism, 23-4 (May 2019)  

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The Association Between Child and Family Characteristics and the Mental Health and Wellbeing of Caregivers of Children with Autism in Mid-Childhood / E. SALOMONE in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

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The Autism Family Experience Questionnaire (AFEQ): An Ecologically-Valid, Parent-Nominated Measure of Family Experience, Quality of Life and Prioritised Outcomes for Early Intervention / K. LEADBITTER in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

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The Feasibility and Effectiveness of PASS Plus, A Lay Health Worker Delivered Comprehensive Intervention for Autism Spectrum Disorders: Pilot RCT in a Rural Low and Middle Income Country Setting / G. DIVAN in Autism Research, 12-2 (February 2019)  

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Which Factors Influence Teacher Report of Adaptive Functioning in Autistic Children? / H. L. MOORE in Journal of Autism and Developmental Disorders, 52-1 (January 2022)  

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