Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder / Jiang ZHU in Journal of Autism and Developmental Disorders, 52-7 (July 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3116-3128 Titre : Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jiang ZHU, Auteur ; Xueying HUA, Auteur ; Ting YANG, Auteur ; Min GUO, Auteur ; Qiu LI, Auteur ; Lu XIAO, Auteur ; Ling LI, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur Article en page(s) : p.3116-3128 Langues : Anglais (eng) Mots-clés : Amino Acids/metabolism  Autism Spectrum Disorder/diagnosis  Child  Humans  Intestines  Metabolome  Metabolomics/methods  Vitamins  Autism  Children  Metabolism  Metabolomics  Symptoms  Vitamin Index. décimale : PER Périodiques Résumé : Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism. En ligne : http://dx.doi.org/10.1007/s10803-021-05066-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Jiang ZHU, Auteur ; Xueying HUA, Auteur ; Ting YANG, Auteur ; Min GUO, Auteur ; Qiu LI, Auteur ; Lu XIAO, Auteur ; Ling LI, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur . - p.3116-3128. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3116-3128 Mots-clés : Amino Acids/metabolism  Autism Spectrum Disorder/diagnosis  Child  Humans  Intestines  Metabolome  Metabolomics/methods  Vitamins  Autism  Children  Metabolism  Metabolomics  Symptoms  Vitamin Index. décimale : PER Périodiques Résumé : Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism. En ligne : http://dx.doi.org/10.1007/s10803-021-05066-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Corpus Callosum Volumes in Children with Autism Spectrum Disorders: Sex-Associated Differences / Yun Zhang ; Bin Qin ; Longlun Wang ; Ke Zhang ; Cui Song ; Jie CHEN ; Jinhua Cai ; Tingyu LI in Journal of Autism and Developmental Disorders, 53-6 (June 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-6 (June 2023) . - p.2421-2429 Titre : Corpus Callosum Volumes in Children with Autism Spectrum Disorders: Sex-Associated Differences : Journal of Autism and Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Yun Zhang, Auteur ; Bin Qin, Auteur ; Longlun Wang, Auteur ; Ke Zhang, Auteur ; Cui Song, Auteur ; Jie CHEN, Auteur ; Jinhua Cai, Auteur ; Tingyu LI, Auteur Article en page(s) : p.2421-2429 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study aimed to analyze the relationship between sex and corpus callosum (CC) volume in children with autism spectrum disorders (ASD) aged 2-4 years. This prospective study included 50 children with ASD and 50 typically developing (TD) children aged 2-4 years. Midsagittal slices of the CCs of the participants were divided into five subregions using FreeSurfer software. The PMCC, AMCC and TCC volumes were significantly higher in ASD participants than in TD participants, and results were significant in females with ASD rather than in males with ASD (all P<0.05). In toddlers with ASD, the CC volumes were increased and more pronounced in females than in males. This could be due to overgrowth of axons or/and axonal pruning disorders. En ligne : https://doi.org/10.1007/s10803-022-05538-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=506 [article] Corpus Callosum Volumes in Children with Autism Spectrum Disorders: Sex-Associated Differences : Journal of Autism and Developmental Disorders [Texte imprimé et/ou numérique] / Yun Zhang, Auteur ; Bin Qin, Auteur ; Longlun Wang, Auteur ; Ke Zhang, Auteur ; Cui Song, Auteur ; Jie CHEN, Auteur ; Jinhua Cai, Auteur ; Tingyu LI, Auteur . - p.2421-2429. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-6 (June 2023) . - p.2421-2429 Index. décimale : PER Périodiques Résumé : This study aimed to analyze the relationship between sex and corpus callosum (CC) volume in children with autism spectrum disorders (ASD) aged 2-4 years. This prospective study included 50 children with ASD and 50 typically developing (TD) children aged 2-4 years. Midsagittal slices of the CCs of the participants were divided into five subregions using FreeSurfer software. The PMCC, AMCC and TCC volumes were significantly higher in ASD participants than in TD participants, and results were significant in females with ASD rather than in males with ASD (all P<0.05). In toddlers with ASD, the CC volumes were increased and more pronounced in females than in males. This could be due to overgrowth of axons or/and axonal pruning disorders. En ligne : https://doi.org/10.1007/s10803-022-05538-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=506

Developmental Language Differences in Children with Autism Spectrum Disorders and Possible Sex Difference / Haiyi XIONG in Journal of Autism and Developmental Disorders, 54-3 (March 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-3 (March 2024) . - p.841-851 Titre : Developmental Language Differences in Children with Autism Spectrum Disorders and Possible Sex Difference Type de document : Texte imprimé et/ou numérique Auteurs : Haiyi XIONG, Auteur ; Xiao LIU, Auteur ; Feng YANG, Auteur ; Ting YANG, Auteur ; Jinjin CHEN, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur Article en page(s) : p.841-851 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Developmental difference is a common characteristic of autism spectrum disorder (ASD) with unclear sex differences. The current study included 610 children with ASD, aged between 2 and 7 years, with completed language profiles. We used a nonparametric item response theory model called Mokken scale analysis to examine the order of acquisition of developmental language milestones in children with ASD. Our results demonstrated the developmental language differences in the expressive and receptive language dimensions in children with ASD compared with typical developmental sequences. Furthermore, The acquisition of gestures and pragmatics was more impaired in the female subgroup than in the male subgroup. The identified developmental language sequence could help provide a more comprehensive ASD developmental profile. En ligne : https://doi.org/10.1007/s10803-022-05806-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] Developmental Language Differences in Children with Autism Spectrum Disorders and Possible Sex Difference [Texte imprimé et/ou numérique] / Haiyi XIONG, Auteur ; Xiao LIU, Auteur ; Feng YANG, Auteur ; Ting YANG, Auteur ; Jinjin CHEN, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur . - p.841-851. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-3 (March 2024) . - p.841-851 Index. décimale : PER Périodiques Résumé : Developmental difference is a common characteristic of autism spectrum disorder (ASD) with unclear sex differences. The current study included 610 children with ASD, aged between 2 and 7 years, with completed language profiles. We used a nonparametric item response theory model called Mokken scale analysis to examine the order of acquisition of developmental language milestones in children with ASD. Our results demonstrated the developmental language differences in the expressive and receptive language dimensions in children with ASD compared with typical developmental sequences. Furthermore, The acquisition of gestures and pragmatics was more impaired in the female subgroup than in the male subgroup. The identified developmental language sequence could help provide a more comprehensive ASD developmental profile. En ligne : https://doi.org/10.1007/s10803-022-05806-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

Genetic and environmental contributions to anxiety among Chinese children and adolescents – a multi-informant twin study / Jie CHEN in Journal of Child Psychology and Psychiatry, 56-5 (May 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.586-594 Titre : Genetic and environmental contributions to anxiety among Chinese children and adolescents – a multi-informant twin study Type de document : Texte imprimé et/ou numérique Auteurs : Jie CHEN, Auteur ; Jing YU, Auteur ; Xinying LI, Auteur ; Jianxin ZHANG, Auteur Article en page(s) : p.586-594 Langues : Anglais (eng) Mots-clés : Anxiety  Chinese children and adolescents  genetic and environmental influence  heritability  twin study Index. décimale : PER Périodiques Résumé : Background Child and adolescent anxiety has become a major public health concern in China, but little was known about the etiology of anxiety in Chinese children and adolescents. The present study aimed to investigate genetic and environmental influences on trait anxiety among Chinese children and adolescents. Rater, sex, and age differences on these estimates were also examined. Methods Self-reported and parent-reported child's trait anxiety was collected from 1,104 pairs of same-sex twins aged 9–18 years. Genetic models were fitted to data from each informant to determine the genetic (A), shared (C), and non-shared environmental (E) influences on trait anxiety. Results The parameter estimates and 95% confidence intervals (CI) of A, C, E on self-reported trait anxiety were 50% [30%, 60%], 5% [0%, 24%], 45% [40%, 49%]. For parent-reported data, the corresponding parameter estimates were 63% [47%, 78%], 13% [1%, 28%], and 24% [22%, 27%], respectively. The heritability of anxiety was higher in girls for self-reported data, but higher in boys for parent-reported data. There was no significant age difference in genetic and environmental contributions for self-reported data, but a significant increase of heritability with age for parent-reported data. Conclusions The trait anxiety in Chinese children and adolescents was highly heritable. Non-shared environmental factors also played an important role. The estimates of genetic and environmental effects differed by rater, sex and age. Our findings largely suggest the cross-cultural generalizability of the etiological model of child and adolescent anxiety. En ligne : http://dx.doi.org/10.1111/jcpp.12310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Genetic and environmental contributions to anxiety among Chinese children and adolescents – a multi-informant twin study [Texte imprimé et/ou numérique] / Jie CHEN, Auteur ; Jing YU, Auteur ; Xinying LI, Auteur ; Jianxin ZHANG, Auteur . - p.586-594. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.586-594 Mots-clés : Anxiety  Chinese children and adolescents  genetic and environmental influence  heritability  twin study Index. décimale : PER Périodiques Résumé : Background Child and adolescent anxiety has become a major public health concern in China, but little was known about the etiology of anxiety in Chinese children and adolescents. The present study aimed to investigate genetic and environmental influences on trait anxiety among Chinese children and adolescents. Rater, sex, and age differences on these estimates were also examined. Methods Self-reported and parent-reported child's trait anxiety was collected from 1,104 pairs of same-sex twins aged 9–18 years. Genetic models were fitted to data from each informant to determine the genetic (A), shared (C), and non-shared environmental (E) influences on trait anxiety. Results The parameter estimates and 95% confidence intervals (CI) of A, C, E on self-reported trait anxiety were 50% [30%, 60%], 5% [0%, 24%], 45% [40%, 49%]. For parent-reported data, the corresponding parameter estimates were 63% [47%, 78%], 13% [1%, 28%], and 24% [22%, 27%], respectively. The heritability of anxiety was higher in girls for self-reported data, but higher in boys for parent-reported data. There was no significant age difference in genetic and environmental contributions for self-reported data, but a significant increase of heritability with age for parent-reported data. Conclusions The trait anxiety in Chinese children and adolescents was highly heritable. Non-shared environmental factors also played an important role. The estimates of genetic and environmental effects differed by rater, sex and age. Our findings largely suggest the cross-cultural generalizability of the etiological model of child and adolescent anxiety. En ligne : http://dx.doi.org/10.1111/jcpp.12310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China / Hua WEI in Research in Autism Spectrum Disorders, 54 (October 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 54 (October 2018) . - p.83-89 Titre : Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China Type de document : Texte imprimé et/ou numérique Auteurs : Hua WEI, Auteur ; Qian CHENG, Auteur ; Qixia MEI, Auteur ; Xuan ZHANG, Auteur ; Li CHEN, Auteur ; Xiao LIU, Auteur ; Ying DAI, Auteur ; Ting YU, Auteur ; Yan LI, Auteur ; Yu ZHANG, Auteur ; Jie CHEN, Auteur ; Yongjie MIAO, Auteur ; Tingyu LI, Auteur Article en page(s) : p.83-89 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Head circumference  Body height  Body weight  Development quotient Index. décimale : PER Périodiques Résumé : Background It is unclear whether increased head circumference (HC) is actually an artifact of an overall overgrowth phenomenon or specific to the brain at all in autism spectrum disorders. This study compared the head circumferences, body weight and height of ASD children with a control group. We also discuss whether HC, body weight and height are correlated with development quotients in ASD children. Method We recruited 83 children with ASD (aged 2–5 years); they were gender and age matched to typically developing children in Chongqing (China) from 2013 to 2015. Their head circumference, body weight and height were collected. The ASD group was tested for the developmental quotient (DQ), which includes gross motor, fine motor, linguistic, personal-social and adaptive functioning. Results Our results showed that head circumference in the ASD group is significantly different from HC in the control group. The rate of macrocephaly was higher in the children with ASD compared with the control group. Some domains of DQ have statistically significant negative correlation with head circumference, weight and height. After adjusting for confounding factors, the fine motor was associated negatively with HC. Personal-social ability was associated negatively with weight. Gross motor was correlated negatively with the height. Conclusions Based on our results, we found significant HC differences in ASD group while lack of effect of either height or weight at the age of 2–5. HC, weight and height were separately negative correlated with some domains of development quotients. Further research is needed to understand the relationship between physical indicators and development level in autism. En ligne : https://doi.org/10.1016/j.rasd.2018.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China [Texte imprimé et/ou numérique] / Hua WEI, Auteur ; Qian CHENG, Auteur ; Qixia MEI, Auteur ; Xuan ZHANG, Auteur ; Li CHEN, Auteur ; Xiao LIU, Auteur ; Ying DAI, Auteur ; Ting YU, Auteur ; Yan LI, Auteur ; Yu ZHANG, Auteur ; Jie CHEN, Auteur ; Yongjie MIAO, Auteur ; Tingyu LI, Auteur . - p.83-89. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 54 (October 2018) . - p.83-89 Mots-clés : Autism spectrum disorder  Head circumference  Body height  Body weight  Development quotient Index. décimale : PER Périodiques Résumé : Background It is unclear whether increased head circumference (HC) is actually an artifact of an overall overgrowth phenomenon or specific to the brain at all in autism spectrum disorders. This study compared the head circumferences, body weight and height of ASD children with a control group. We also discuss whether HC, body weight and height are correlated with development quotients in ASD children. Method We recruited 83 children with ASD (aged 2–5 years); they were gender and age matched to typically developing children in Chongqing (China) from 2013 to 2015. Their head circumference, body weight and height were collected. The ASD group was tested for the developmental quotient (DQ), which includes gross motor, fine motor, linguistic, personal-social and adaptive functioning. Results Our results showed that head circumference in the ASD group is significantly different from HC in the control group. The rate of macrocephaly was higher in the children with ASD compared with the control group. Some domains of DQ have statistically significant negative correlation with head circumference, weight and height. After adjusting for confounding factors, the fine motor was associated negatively with HC. Personal-social ability was associated negatively with weight. Gross motor was correlated negatively with the height. Conclusions Based on our results, we found significant HC differences in ASD group while lack of effect of either height or weight at the age of 2–5. HC, weight and height were separately negative correlated with some domains of development quotients. Further research is needed to understand the relationship between physical indicators and development level in autism. En ligne : https://doi.org/10.1016/j.rasd.2018.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Intestinal Symptoms Among Children aged 2-7 Years with Autism Spectrum Disorder in 13 Cities of China / Ting YANG in Journal of Autism and Developmental Disorders, 54-11 (November)  

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Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China / Ting YANG ; Jie CHEN ; Li CHEN ; Ying DAI ; Hua WEI ; Feiyong JIA ; Lijie WU ; Yan HAO ; Ling LI ; Jie ZHANG ; Xiaoyan KE ; Mingji YI ; Qi HONG ; Jinjin CHEN ; Shuanfeng FANG ; Yichao WANG ; Qi WANG ; Chunhua JIN ; Tingyu LI in Research in Autism Spectrum Disorders, 111 (March 2024)  

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The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene–environment correlation: evidence from a longitudinal twin study / Jie CHEN in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)  

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